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Citation
Li, X., Erclik, T., Bertet, C., Chen, Z., Voutev, R., Venkatesh, S., Morante, J., Celik, A., Desplan, C. (2013). Temporal patterning of Drosophila medulla neuroblasts controls neural fates.  Nature 498(7455): 456--462.
FlyBase ID
FBrf0222036
Publication Type
Research paper
Abstract

In the Drosophila optic lobes, the medulla processes visual information coming from inner photoreceptors R7 and R8 and from lamina neurons. It contains approximately 40,000 neurons belonging to more than 70 different types. Here we describe how precise temporal patterning of neural progenitors generates these different neural types. Five transcription factors-Homothorax, Eyeless, Sloppy paired, Dichaete and Tailless-are sequentially expressed in a temporal cascade in each of the medulla neuroblasts as they age. Loss of Eyeless, Sloppy paired or Dichaete blocks further progression of the temporal sequence. We provide evidence that this temporal sequence in neuroblasts, together with Notch-dependent binary fate choice, controls the diversification of the neuronal progeny. Although a temporal sequence of transcription factors had been identified in Drosophila embryonic neuroblasts, our work illustrates the generality of this strategy, with different sequences of transcription factors being used in different contexts.

PubMed ID
PubMed Central ID
PMC3701960 (PMC) (EuropePMC)
Related Publication(s)
Note

Neuroscience: stem cells in multiple time zones.
Thor, 2013, Nature 498(7455): 441--443 [FBrf0222131]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Aberrations (1)
    Alleles (10)
    Genes (24)
    Natural transposons (1)
    Insertions (1)
    Transgenic Constructs (5)
    Transcripts (1)