FlyBase Allele Report: Dmel\D[87]

General Information

Symbol

Dmel\D⁸⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0045117

Feature type

allele

Associated gene

Dmel\D

Associated Insertion(s)

Carried in Construct

Also Known As

fish⁸⁷, Dichaete⁸⁷

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Nambu and Nambu, 1996)

Mutagen

P-element activity

(Nambu, 1996.4.28)

Delta2-3 transposase

(Nambu and Nambu, 1996)

Progenitor genotype

P{PZ}D^rJ375

(Nambu, 1996.4.28, Nambu and Nambu, 1996)

Cytology

Description

Deletion derivative of P{PZ}rJ375 deleting D sequences.

(Nambu, 1996.4.28)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal 2 ventral denticle belt

(Nambu and Nambu, 1996)

abdominal 3 ventral denticle belt

(Nambu and Nambu, 1996)

abdominal 4 ventral denticle belt

(Nambu and Nambu, 1996)

abdominal 5 ventral denticle belt

(Nambu and Nambu, 1996)

abdominal 6 ventral denticle belt

(Nambu and Nambu, 1996)

abdominal 7 ventral denticle belt

(Nambu and Nambu, 1996)

abdominal 8 ventral denticle belt

(Nambu and Nambu, 1996)

adult cuticle & adult head | somatic clone

(Mukherjee et al., 2000)

dorsal appendage | germline clone

(Mukherjee et al., 2006)

egg chorion | germline clone

(Mukherjee et al., 2006)

embryonic head

(Nambu and Nambu, 1996)

embryonic neuroblast | embryonic stage 14 (with Df(3L)Exel6120)

(Bahrampour et al., 2017)

first segment of antenna | somatic clone

(Mukherjee et al., 2000)

larval RP2 motor neuron

(Zhao and Skeath, 2002)

midline glial cell

(Ma et al., 2000)

neuroblast NB1-1

(Buescher et al., 2002)

neuroblast NB4-1

(Zhao and Skeath, 2002)

neuroblast NB5-3

(Buescher et al., 2002)

neuroblast NB6-1

(Zhao and Skeath, 2002)

presumptive embryonic/larval central nervous system

(Nambu and Nambu, 1996)

tarsal segment | somatic clone

(Mukherjee et al., 2000)

tibia | somatic clone

(Mukherjee et al., 2000)

Detailed Description

Statement

Reference

D⁸⁷/Df(3L)Exel6120 transheterozygotes present a significant decrease in the number of dividing neuroblasts, but not of dividing neuroblast daughters, during stage 14 of embryogenesis, as compared to controls.

(Bahrampour et al., 2017)

Viability of transheterozygotes is as follows: D⁸⁷/D¹⁰⁷ - 12.2%, D⁸⁷/D¹⁷⁵ - 1.9%.

Homozygous mutant adPN, lPN and vPN neuroblast clones have normal patterns of dendritic arborizations and normal axon trajectories.

(Melnattur et al., 2013)

Targeting of dendrites to antennal lobe glomeruli occurs normally in antennal lobe projection neurons that are part of D⁸⁷ homozygous somatic clones.

(Komiyama and Luo, 2007)

Approximately 40% of eggs derived from females containing homozygous germline clones fail to hatch. Of the non-hatching eggs, approximately 25% have significant chorion defects, including malformation or duplication of the dorsal appendages. Some of the mutant eggs have dorsal appendages that are thicker, shorter and more widely spaced than normal, while others have 3 or 4 dorsal appendages.

(Mukherjee et al., 2006)

The formation of neuroblasts NB1-1 and NB5-3 is hardly affected in D⁸⁷ single mutant embryos (2% and 1% loss respectively).

(Buescher et al., 2002)

NB 6-1 is not formed in 7.9% of hemisegments, NB 4-1 is not formed in 30.9% of thoracic hemisegments and RP2 is not formed in 12.9% of hemisegments.

(Zhao and Skeath, 2002)

Mutant embryos show a misplacement and loss of midline glia.

(Ma et al., 2000)

Somatic clones induced during the first and second instar have not been recovered in adults. Somatic clones induced during the third instar appear morphologically normal. Large clones are never detected in the head capsule or legs. Small patches of black necrotic cells are seen in the first antennal segment, the ventral head cuticle surrounding the eye and the leg tibial/tarsal boundary region.

(Mukherjee et al., 2000)

Embryos exhibit severe segmentation defects, including loss or fusion of abdominal denticle belts (does not correspond to a segmentally repeated pattern). Also exhibit defects in the organisation of head structures. Thoracic segments appear largely unaffected. Embryos exhibit severe and variable defects in CNS organisation; fusions between several adjacent neuromeres resulting in 3-4 fewer ganglia, moderate to severe narrowing of the longitudinal axon connectives in some segments and fusion of the anterior and posterior axon commissures.

(Nambu and Nambu, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

D⁸⁷ has abnormal neuroanatomy phenotype, enhanceable by ind[+]/ind^16.2

(Zhao and Skeath, 2002)

D⁸⁷ has abnormal neuroanatomy phenotype, enhanceable by ind[+]/ind^RR108

(Zhao and Skeath, 2002)

Suppressor of

Statement

Reference

D⁸⁷ is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

D⁸⁷, vnd^D38 has abnormal neuroanatomy phenotype

(Zhao and Skeath, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

D⁸⁷ has neuroblast NB5-3 phenotype, enhanceable by SoxN^GA1192

(Buescher et al., 2002)

D⁸⁷ has neuroblast NB1-1 phenotype, enhanceable by SoxN^GA1192

(Buescher et al., 2002)

D⁸⁷ has larval RP2 motor neuron phenotype, enhanceable by ind[+]/ind^16.2

(Zhao and Skeath, 2002)

D⁸⁷ has larval RP2 motor neuron phenotype, enhanceable by ind[+]/ind^RR108

(Zhao and Skeath, 2002)

Enhancer of

Statement

Reference

D⁸⁷ is an enhancer of neuroblast NB5-3 phenotype of SoxN^GA1192

(Buescher et al., 2002)

D⁸⁷ is an enhancer of neuroblast NB1-1 phenotype of SoxN^GA1192

(Buescher et al., 2002)

Suppressor of

Statement

Reference

D⁸⁷ is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

D⁸⁷, vnd^D38 has neuroblast NB6-1 phenotype

(Zhao and Skeath, 2002)

D⁸⁷, vnd^D38 has neuroblast NB4-1 phenotype

(Zhao and Skeath, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The NB1-1 neuroblast fails to form in 48% of hemisegments in D⁸⁷ SoxN^GA1192 double mutant embryos. The NB5-3 neuroblast fails to form in 25% of hemisegments in D⁸⁷ SoxN^GA1192 double mutant embryos.

(Buescher et al., 2002)

vnd^D38 ; D⁸⁷ double mutant embryos lack 90.9% of NB 6-1 and 89.2% of NB 4-1. D⁸⁷ ind^RR108/D⁸⁷ + embryos lack 36.4% of RP2 neurons. D⁸⁷ ind^16.2/D⁸⁷ + embryos lack 42.4% of RP2 neurons.

(Zhao and Skeath, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

600371

w^*; D⁸⁷/TM3, P{ActGFP}JMR2, Ser¹

36504

y¹ w^*; D⁸⁷ P{neoFRT}80B e^s/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

D (fsh)⁸⁷

(Estes et al., 2008)

D⁸⁷

(Konstantinides et al., 2022, Bahrampour et al., 2017, Bertet et al., 2014, Melnattur et al., 2013)

Sox70D⁸⁷

fish⁸⁷

(Melnattur et al., 2013, Mukherjee et al., 2006, Bach et al., 2003, Ma et al., 2000, Mukherjee et al., 2000, Fujioka et al., 1999, Ma et al., 1998, Nambu, 1996.4.28, Nambu and Nambu, 1996)

Name Synonyms

Dichaete87

(Moses et al., 2011, Komiyama and Luo, 2007)

fish-hook87

(Mukherjee et al., 2006)

Secondary FlyBase IDs

References (18)

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