FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\D107
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General Information
Symbol
Dmel\D107
Species
D. melanogaster
Name
FlyBase ID
FBal0288210
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Internal deletion within the P{PZ}DrJ375 insertion (genomic D sequence is unaffected). The deletion spans 9.6kb and extends from nucleotides 4421 to 14528 of the P{PZ} element, removing the ry+t7.2 marker and most of the 3' P-element repeat.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
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Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
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Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes show 76.1% viability. Viability of transheterozygotes is as follows: D89/D107 - 71.2%, D107/D175 - 53.9%, D87/D107 - 12.2%, D3/D107 - 14.4%.

Mutant adult brains show defects in dendritic patterns of Scer\GAL4Mz19-expressing projection neurons (PNs) in approximately 25% of cases. In some flies, only a single glomerulus is innervated. Although it is often aberrantly shaped, the location is generally in a position consistent with DA1. In other cases, the dendrites show ectopic innervation of glomeruli that are generally adjacent to VA1d and frequently include VA1lm. The Scer\GAL4Mz19-expressing PNs are occasionally spatially restricted within a glomerulus in contrast to wild type where they generally fill the entire glomerulus volume.

The cell bodies of Scer\GAL4c305a-expressing local interneurons are slightly displaced to a more anterodorsal position in mutant brains.

Or47b-expressing olfactory receptor neuron (ORN) axons show aberrant ipsilateral innervation of both the VA1lm and a neighbouring glomerulus (possibly VA1d) in approximately 60% of mutant brains. Or47b- and Or88a-expressing ORN axons fail to cross the midline in more than 40% of mutant brains.

External Data
Interactions
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Xenogenetic Interactions
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Complementation and Rescue Data
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Mutant
Wild-type
Stocks (0)
Notes on Origin
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External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)