FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\slp2
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General Information
Symbol
Dmel\slp2
Species
D. melanogaster
Name
sloppy paired 2
Annotation Symbol
CG2939
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004567
Gene Model Status
Current
Stock Availability
26 publicly available
Gene Summary
sloppy paired 2 (slp2) encodes a transcription factor of the fork-head family. Together with the product of slp1, it regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

slp, sloppy-paired, sloppy paired, FD7, FoxG

Key Links
Genomic Location
Cytogenetic map
24C7-24C7
Sequence location
Recombination map
2-11
RefSeq locus
NT_033779 REGION:3836840..3839185
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
enables sequence-specific DNA binding
(InterPro Project Members, 2004-)
enables sequence-specific double-stranded DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000216104
(GO Reference Genome Project, 2011-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000216104
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000216104
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
sloppy paired 2 (slp2) encodes a transcription factor of the fork-head family. Together with the product of slp1, it regulates a wide variety of developmental processes including embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Protein Function (UniProtKB)
Transcription factor involved in segmentation. May function primarily as a segment polarity gene. Different levels of slp activity seem to be required in different segments.
(UniProt, P32031)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
slp: sloppy paired
Embryonic lethal. Embryos lack parts of naked cuticle of T2, A1, A3, A5, and A7 in an irregular fashion. No effect of ftz expression (Carroll and Scott, 1986, Cell 45: 113-26).
Summary (Interactive Fly)

transcription factor - forkhead domain - has combined characteristics of a gap, pair rule and segment polarity gene - regulates embryonic segmentation, ventral fate specification in the retina, and temporal patterning of the neuroblasts that produce medulla neurons

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\slp2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P32031)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
slp2-RA
FBtr0077500
NM_057486
2346
451
Additional Transcript Data and Comments
Reported size (kB)

2.2 (northern blot)

(Grossniklaus et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
slp2-PA
FBpp0077189
49.2
451
6.51
P32031
NP_476834
AAF51057
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

445 (aa)

(Grossniklaus et al., 1992)
Comments

The antibody used detects both slp1 and slp2.

(Suzuki et al., 2013)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\slp2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.58

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | gap expression pattern
(Hacker et al., 1992)
organism | segment polarity expression pattern
(Hacker et al., 1992)
organism | pair rule expression pattern
(Hacker et al., 1992)
embryonic stage 4
organism | 70-90% egg length | ventral

Comment: late stage 4; reference states 71-85% egg length

(Grossniklaus et al., 1992)
embryonic stage 6
organism | segment polarity expression pattern
(Grossniklaus et al., 1992)
embryonic stage 8 -- 17
mandibular segment
(Grossniklaus et al., 1992)
labral segment
(Grossniklaus et al., 1992)
embryonic stage 13 -- 17
larval ventral nerve cord
(Grossniklaus et al., 1992)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
mesectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
organism | even pair rule expression pattern
(Grossniklaus et al., 1992)
embryonic stage 5 -- 6
mesectoderm | subset
(Kearney et al., 2004)
gastrula stage
organism | segment polarity expression pattern
(Prazak et al., 2010)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
mesectoderm anlage | subset
(Kearney et al., 2004)
embryonic stage 9
midline primordium

Comment: rows D, E, F

(Wheeler et al., 2006)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
mesectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
larval ventral midline glial cell
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
larval labral sensory complex
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
organism | 70-80% egg length | dorsal

Comment: late embryonic stage 4

(Grossniklaus et al., 1992)
embryonic stage 8 -- 17
embryonic procephalic segment | lateral
(Grossniklaus et al., 1992)
intercalary segment
(Grossniklaus et al., 1992)
embryonic stage 13 -- 17
proventriculus
(Grossniklaus et al., 1992)
Additional Descriptive Data

slp2 transcripts are expressed in a gap gene pattern, then a pair-rule stripe pattern, then a segment polarity gene pattern in early embryos. The same pattern is observed for slp1 transcripts.

(Hacker et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 7
organism | pair rule expression pattern
(Cadigan et al., 1994)
embryonic stage 8
organism | segment polarity expression pattern
(Cadigan et al., 1994)
embryonic stage 10
organism | striped
(Lee and Frasch, 2000)
larval stage
medulla forming neuroblast | subset
(Li et al., 2013)
neuron | subset of medulla anlage
(Li et al., 2013)
third instar larval stage
medulla forming neuroblast | subset
(Suzuki et al., 2013)
Additional Descriptive Data

slp2 protein is expressed in the same subset of medulla forming neuroblasts as slp1.

(Li et al., 2013)

slp2-protein is expressed in the developing larval medulla in intermediate neuroblasts, which weakly co-express klu-protein. The expression level of slp2-protein gradually decreases from lateral to medial neuroblasts.

(Suzuki et al., 2013)

Stripes alternate with bap and coincide with eve.

(Lee and Frasch, 2000)

slp2 protein is first detected in seven stripes at late gastrulation. Secondary stripes arise during germband extension.

(Cadigan et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{lArB}A208.1M2
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | segmentally repeated
(Grossniklaus et al., 1992)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\slp2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of slp2
Transgenic constructs containing regulatory region of slp2
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal - all die during embryonic stage
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
some die during embryonic stage
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
abdominal 1 ventral denticle belt | embryonic stage
abdominal 2 ventral denticle belt | embryonic stage
abdominal 3 ventral denticle belt | embryonic stage
abdominal 4 ventral denticle belt | embryonic stage
abdominal 5 ventral denticle belt | embryonic stage
abdominal 6 ventral denticle belt | embryonic stage
abdominal 7 ventral denticle belt | embryonic stage
abdominal 8 ventral denticle belt | embryonic stage
abdominal segment 1
abdominal segment 2
abdominal segment 3
abdominal segment 4
axon | embryonic stage 17 | heat sensitive
cuticle
embryonic/larval dorsal vessel
fascicle | embryonic stage 17 | heat sensitive
larval longitudinal connective | embryonic stage 17 | heat sensitive
larval RP2 motor neuron | ectopic
neuroblast NB4-2 | ectopic
RP2sib neuron | ectopic
ventral denticle belt
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (52)
Hsap\FOXG1
11 of 14
Yes
Yes
Hsap\FOXD1
4 of 14
No
No
Hsap\FOXD2
4 of 14
No
No
Hsap\FOXD3
4 of 14
No
No
1  
Hsap\FOXD4
4 of 14
No
No
Hsap\FOXD4L1
4 of 14
No
No
Hsap\FOXD4L3
4 of 14
No
No
Hsap\FOXD4L4
4 of 14
No
No
Hsap\FOXD4L5
4 of 14
No
No
Hsap\FOXD4L6
4 of 14
No
No
Hsap\FOXE1
4 of 14
No
No
Hsap\FOXE3
4 of 14
No
No
Hsap\FOXI1
4 of 14
No
No
Hsap\FOXI2
4 of 14
No
No
Hsap\FOXI3
4 of 14
No
No
Hsap\FOXK1
4 of 14
No
No
Hsap\FOXK2
4 of 14
No
No
Hsap\FOXL1
4 of 14
No
No
Hsap\FOXS1
4 of 14
No
No
Hsap\FOXC1
3 of 14
No
No
Hsap\FOXC2
3 of 14
No
No
Hsap\FOXF1
3 of 14
No
No
Hsap\FOXH1
3 of 14
No
Yes
Hsap\FOXJ1
3 of 14
No
Yes
Hsap\FOXJ2
3 of 14
No
No
Hsap\FOXJ3
3 of 14
No
No
Hsap\FOXL2
3 of 14
No
No
Hsap\FOXM1
3 of 14
No
Yes
1  
Hsap\FOXQ1
3 of 14
No
Yes
Hsap\FOXA2
2 of 14
No
No
Hsap\FOXA3
2 of 14
No
No
Hsap\FOXB1
2 of 14
No
No
1  
Hsap\FOXB2
2 of 14
No
No
1  
Hsap\FOXF2
2 of 14
No
No
Hsap\FOXL3
2 of 14
No
No
Hsap\FOXL3-OT1
2 of 14
No
Yes
Hsap\FOXN1
2 of 14
No
No
1  
Hsap\FOXN2
2 of 14
No
No
Hsap\FOXN3
2 of 14
No
No
1  
Hsap\FOXN4
2 of 14
No
No
Hsap\FOXO1
2 of 14
No
No
0  
Hsap\FOXO3
2 of 14
No
No
2  
Hsap\FOXO4
2 of 14
No
No
Hsap\FOXR1
2 of 14
No
Yes
Hsap\FOXR2
2 of 14
No
Yes
Hsap\FOXA1
1 of 14
No
No
Hsap\FOXO6
1 of 14
No
No
Hsap\FOXP1
1 of 14
No
No
1  
Hsap\FOXP2
1 of 14
No
No
1  
Hsap\FOXP3
1 of 14
No
No
Hsap\FOXP4
1 of 14
No
No
Hsap\UPK2
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
Rnor\Foxg1
11 of 14
Yes
Yes
Rnor\Foxc1
4 of 14
No
No
Rnor\Foxc2
4 of 14
No
No
Rnor\Foxd1
4 of 14
No
No
Rnor\Foxe1
4 of 14
No
No
Rnor\Foxe3
4 of 14
No
No
Rnor\Foxi1
4 of 14
No
No
Rnor\Foxi3
4 of 14
No
No
Rnor\Foxk1
4 of 14
No
No
Rnor\Foxk2
4 of 14
No
No
Rnor\Foxl1
4 of 14
No
No
Rnor\Foxl2
4 of 14
No
No
Rnor\Foxs1
4 of 14
No
No
Rnor\Foxd2
3 of 14
No
No
Rnor\Foxd3
3 of 14
No
No
Rnor\Foxd4
3 of 14
No
Yes
Rnor\Foxh1
3 of 14
No
Yes
Rnor\Foxi2
3 of 14
No
Yes
Rnor\Foxj2
3 of 14
No
No
Rnor\Foxl3
3 of 14
No
No
Rnor\Foxm1
3 of 14
No
Yes
Rnor\Foxa2
2 of 14
No
No
Rnor\Foxa3
2 of 14
No
No
Rnor\Foxb2
2 of 14
No
No
Rnor\Foxf1
2 of 14
No
No
Rnor\Foxj1
2 of 14
No
Yes
Rnor\Foxj3
2 of 14
No
No
Rnor\Foxn1
2 of 14
No
No
Rnor\Foxn3
2 of 14
No
No
Rnor\Foxo1
2 of 14
No
No
Rnor\Foxo4
2 of 14
No
No
Rnor\Foxq1
2 of 14
No
Yes
Rnor\Foxr1
2 of 14
No
Yes
Rnor\Foxa1
1 of 14
No
No
Rnor\Foxb1
1 of 14
No
No
Rnor\Foxn2
1 of 14
No
No
Rnor\Foxn4
1 of 14
No
No
Rnor\Foxo3
1 of 14
No
No
Rnor\Foxo6
1 of 14
No
No
Rnor\Foxp1
1 of 14
No
No
Rnor\Foxp2
1 of 14
No
No
Rnor\Foxp3
1 of 14
No
No
Rnor\Foxp4
1 of 14
No
No
Rnor\Foxr2
1 of 14
No
Yes
Rnor\Upk2
1 of 14
No
Yes
Mus musculus (laboratory mouse) (47)
Mmus\Foxg1
11 of 14
Yes
Yes
Mmus\Foxc1
4 of 14
No
No
Mmus\Foxc2
4 of 14
No
No
Mmus\Foxd1
4 of 14
No
No
Mmus\Foxd2
4 of 14
No
No
Mmus\Foxd3
4 of 14
No
No
Mmus\Foxd4
4 of 14
No
No
Mmus\Foxe1
4 of 14
No
No
Mmus\Foxe3
4 of 14
No
No
Mmus\Foxi1
4 of 14
No
No
Mmus\Foxi2
4 of 14
No
No
Mmus\Foxk1
4 of 14
No
No
Mmus\Foxk2
4 of 14
No
No
Mmus\Foxl1
4 of 14
No
No
Mmus\Foxl2
4 of 14
No
No
Mmus\Foxl3
4 of 14
No
No
Mmus\Foxf1
3 of 14
No
No
Mmus\Foxf2
3 of 14
No
No
Mmus\Foxh1
3 of 14
No
Yes
Mmus\Foxi3
3 of 14
No
No
Mmus\Foxj1
3 of 14
No
Yes
Mmus\Foxj2
3 of 14
No
No
Mmus\Foxj3
3 of 14
No
No
Mmus\Foxm1
3 of 14
No
Yes
Mmus\Foxq1
3 of 14
No
Yes
Mmus\Foxs1
3 of 14
No
No
Mmus\Foxa2
2 of 14
No
No
Mmus\Foxa3
2 of 14
No
No
Mmus\Foxb1
2 of 14
No
No
Mmus\Foxb2
2 of 14
No
No
Mmus\Foxn1
2 of 14
No
No
Mmus\Foxn2
2 of 14
No
No
Mmus\Foxn4
2 of 14
No
No
Mmus\Foxo1
2 of 14
No
No
2  
Mmus\Foxo4
2 of 14
No
No
Mmus\Foxo6
2 of 14
No
No
Mmus\Foxr1
2 of 14
No
Yes
Mmus\Foxr2
2 of 14
No
Yes
Mmus\Cntrl
1 of 14
No
No
Mmus\Foxa1
1 of 14
No
No
Mmus\Foxn3
1 of 14
No
No
Mmus\Foxo3
1 of 14
No
No
Mmus\Foxp1
1 of 14
No
No
Mmus\Foxp2
1 of 14
No
No
Mmus\Foxp3
1 of 14
No
No
Mmus\Foxp4
1 of 14
No
No
Mmus\Upk2
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (55)
Xtro\foxg1
9 of 13
Yes
Yes
Xtro\brap
3 of 13
No
No
Xtro\foxc1
3 of 13
No
No
Xtro\foxc2
3 of 13
No
No
Xtro\foxd1
3 of 13
No
No
Xtro\foxd2
3 of 13
No
No
Xtro\foxd3
3 of 13
No
No
Xtro\foxd4l1.1
3 of 13
No
No
Xtro\foxd4l1.2
3 of 13
No
No
Xtro\foxi1
3 of 13
No
No
Xtro\foxi2
3 of 13
No
No
Xtro\foxi4.1
3 of 13
No
No
Xtro\foxi4.2
3 of 13
No
No
Xtro\foxl1
3 of 13
No
No
Xtro\foxl2
3 of 13
No
No
Xtro\crip2
2 of 13
No
No
Xtro\foxa2
2 of 13
No
No
Xtro\foxa4
2 of 13
No
No
Xtro\foxb1
2 of 13
No
No
Xtro\foxe1
2 of 13
No
Yes
Xtro\foxe3
2 of 13
No
No
Xtro\foxf1
2 of 13
No
No
Xtro\foxh1
2 of 13
No
No
Xtro\foxj1
2 of 13
No
Yes
Xtro\foxj2
2 of 13
No
No
Xtro\foxk2
2 of 13
No
No
Xtro\foxl3-ot1
2 of 13
No
Yes
Xtro\foxm1
2 of 13
No
Yes
Xtro\gcdh
2 of 13
No
No
Xtro\nr2f6
2 of 13
No
No
Xtro\qrich2
2 of 13
No
No
Xtro\arhgap5
1 of 13
No
No
Xtro\ctsw
1 of 13
No
No
Xtro\erh
1 of 13
No
No
Xtro\esrra
1 of 13
No
No
Xtro\fam161a
1 of 13
No
No
Xtro\foxa1
1 of 13
No
No
Xtro\foxb2
1 of 13
No
No
Xtro\foxf2
1 of 13
No
No
Xtro\foxj1.2
1 of 13
No
Yes
Xtro\foxj3
1 of 13
No
No
Xtro\foxn1
1 of 13
No
No
Xtro\foxn2
1 of 13
No
No
Xtro\foxn3
1 of 13
No
No
Xtro\foxo1
1 of 13
No
No
Xtro\foxo3
1 of 13
No
No
Xtro\foxo4
1 of 13
No
No
Xtro\foxo6
1 of 13
No
No
Xtro\foxp3
1 of 13
No
No
Xtro\foxq1
1 of 13
No
Yes
Xtro\foxr1
1 of 13
No
Yes
Xtro\LOC101730723
1 of 13
No
Yes
Xtro\nop2
1 of 13
No
No
Xtro\ppard
1 of 13
No
Yes
Xtro\vegfd
1 of 13
No
No
Danio rerio (Zebrafish) (67)
Drer\foxg1a
11 of 14
Yes
Yes
Drer\foxg1b
11 of 14
Yes
Yes
Drer\foxg1c
10 of 14
No
Yes
Drer\foxg1d
10 of 14
No
Yes
Drer\foxc1a
4 of 14
No
No
Drer\foxc1b
4 of 14
No
No
Drer\foxd1
4 of 14
No
No
Drer\foxd2
4 of 14
No
No
Drer\foxd3
4 of 14
No
No
Drer\foxd5
4 of 14
No
No
Drer\foxd7
4 of 14
No
No
Drer\foxe1
4 of 14
No
No
Drer\foxe3
4 of 14
No
No
Drer\foxi2
4 of 14
No
No
Drer\foxi3a
4 of 14
No
No
Drer\foxi3b
4 of 14
No
No
Drer\foxj2
4 of 14
No
No
Drer\foxk1
4 of 14
No
No
Drer\foxk2a
4 of 14
No
No
Drer\foxk2b
4 of 14
No
No
Drer\foxl1
4 of 14
No
No
Drer\foxl2a
4 of 14
No
No
Drer\foxl2b
4 of 14
No
No
Drer\foxl2l
4 of 14
No
No
Drer\foxl3
4 of 14
No
No
Drer\foxq2
4 of 14
No
No
Drer\foxf1
3 of 14
No
No
Drer\foxf2a
3 of 14
No
No
Drer\foxf2b
3 of 14
No
No
Drer\foxh1
3 of 14
No
No
Drer\foxi1
3 of 14
No
No
Drer\foxj1b
3 of 14
No
Yes
Drer\foxj3
3 of 14
No
No
Drer\foxm1
3 of 14
No
Yes
Drer\si:ch211-145o7.3
3 of 14
No
No
Drer\foxa2
2 of 14
No
No
Drer\foxa3
2 of 14
No
No
Drer\foxa
2 of 14
No
No
Drer\foxb1a
2 of 14
No
No
Drer\foxb1b
2 of 14
No
No
Drer\foxb2
2 of 14
No
No
Drer\foxj1a
2 of 14
No
Yes
Drer\foxn1
2 of 14
No
No
Drer\foxn2a
2 of 14
No
No
Drer\foxn2b
2 of 14
No
No
Drer\foxn3
2 of 14
No
No
Drer\foxn4
2 of 14
No
No
Drer\foxo1b
2 of 14
No
No
Drer\foxo4
2 of 14
No
No
Drer\foxo6b
2 of 14
No
No
Drer\foxq1a
2 of 14
No
Yes
Drer\foxq1b
2 of 14
No
Yes
Drer\foxr1
2 of 14
No
Yes
Drer\si:rp71-45k5.2
2 of 14
No
No
Drer\zgc:113424
2 of 14
No
No
Drer\ches1
1 of 14
No
No
Drer\foxa1
1 of 14
No
No
Drer\foxo1a
1 of 14
No
No
Drer\foxo3a
1 of 14
No
No
Drer\foxo3b
1 of 14
No
No
Drer\foxo6a
1 of 14
No
No
Drer\foxp1a
1 of 14
No
No
Drer\foxp1b
1 of 14
No
No
Drer\foxp2
1 of 14
No
No
Drer\foxp3a
1 of 14
No
No
Drer\foxp3b
1 of 14
No
No
Drer\foxp4
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\fkh-2
10 of 14
Yes
Yes
Cele\fkh-10
4 of 14
No
No
Cele\let-381
4 of 14
No
No
Cele\unc-130
4 of 14
No
No
Cele\fkh-6
3 of 14
No
No
Cele\lin-31
3 of 14
No
No
Cele\pes-1
3 of 14
No
No
Cele\pha-4
3 of 14
No
No
Cele\fkh-5
2 of 14
No
No
Cele\fkh-8
2 of 14
No
No
Cele\fkh-9
2 of 14
No
No
Cele\C29F7.10
1 of 14
No
Yes
Cele\daf-16
1 of 14
No
No
Cele\fkh-3
1 of 14
No
No
Cele\fkh-4
1 of 14
No
No
Cele\fkh-7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (19)
Agam\AgaP_AGAP009147
10 of 12
Yes
Yes
Agam\AgaP_AGAP000069
4 of 12
No
No
Agam\AgaP_AGAP005902
4 of 12
No
No
Agam\AgaP_AGAP002903
3 of 12
No
No
Agam\AgaP_AGAP003940
3 of 12
No
No
Agam\AgaP_AGAP005804
3 of 12
No
No
Agam\AgaP_AGAP006786
3 of 12
No
No
Agam\AgaP_AGAP008155
3 of 12
No
No
Agam\AgaP_AGAP008606
3 of 12
No
Yes
Agam\AgaP_AGAP013178
3 of 12
No
No
Agam\AgaP_AGAP000662
2 of 12
No
No
Agam\AgaP_AGAP001577
2 of 12
No
No
Agam\AgaP_AGAP001671
2 of 12
No
No
Agam\AgaP_AGAP002460
2 of 12
No
No
Agam\AgaP_AGAP012976
2 of 12
No
No
Agam\AgaP_AGAP013032
2 of 12
No
No
Agam\AgaP_AGAP013297
2 of 12
No
No
Agam\AgaP_AGAP000569
1 of 12
No
No
Agam\AgaP_AGAP005903
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G07260
1 of 13
Yes
Yes
Atha\FHA2
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\FKH1
6 of 13
Yes
No
Scer\FKH2
5 of 13
No
No
Scer\HCM1
4 of 13
No
No
Scer\FHL1
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\fkh2
5 of 12
Yes
No
Spom\mei4
5 of 12
Yes
No
Spom\sep1
5 of 12
Yes
No
Spom\fhl1
4 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:slp2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
slp1
9 of 13
fd19B
8 of 13
croc
7 of 13
FoxK
7 of 13
FoxL1
7 of 13
fd59A
6 of 13
fd96Ca
5 of 13
fd96Cb
5 of 13
fd102C
5 of 13
fkh
5 of 13
jumu
4 of 13
bin
3 of 13
CG32006
3 of 13
CHES-1-like
3 of 13
foxo
3 of 13
FoxP
2 of 13
fd3F
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FOXG1; forkhead box G1
    11 of 14
    164874
    FOXD1; forkhead box D1
    4 of 14
    601091
        FOXD2; forkhead box D2
        4 of 14
        602211
            FOXD3; forkhead box D3
            4 of 14
            611539
               
              FOXD4; forkhead box D4
              4 of 14
              601092
                  FOXD4L1; forkhead box D4 like 1
                  4 of 14
                  611084
                      FOXD4L3; forkhead box D4 like 3
                      4 of 14
                      611086
                          FOXD4L4; forkhead box D4 like 4
                          4 of 14
                          611085
                              FOXD4L5; forkhead box D4 like 5
                              4 of 14
                                  FOXD4L6; forkhead box D4 like 6
                                  4 of 14
                                      FOXE1; forkhead box E1
                                      4 of 14
                                      602617
                                      FOXE3; forkhead box E3
                                      4 of 14
                                      601094
                                      FOXI1; forkhead box I1
                                      4 of 14
                                      601093
                                      FOXI2; forkhead box I2
                                      4 of 14
                                      617202
                                          FOXI3; forkhead box I3
                                          4 of 14
                                          612351
                                            FOXK1; forkhead box K1
                                            4 of 14
                                            616302
                                                FOXK2; forkhead box K2
                                                4 of 14
                                                147685
                                                    FOXL1; forkhead box L1
                                                    4 of 14
                                                    603252
                                                    FOXS1; forkhead box S1
                                                    4 of 14
                                                    602939
                                                        FOXC1; forkhead box C1
                                                        3 of 14
                                                        601090
                                                        FOXC2; forkhead box C2
                                                        3 of 14
                                                        602402
                                                        FOXF1; forkhead box F1
                                                        3 of 14
                                                        601089
                                                        FOXH1; forkhead box H1
                                                        3 of 14
                                                        603621
                                                            FOXJ1; forkhead box J1
                                                            3 of 14
                                                            602291
                                                            FOXJ2; forkhead box J2
                                                            3 of 14
                                                            619162
                                                                FOXJ3; forkhead box J3
                                                                3 of 14
                                                                616035
                                                                    FOXL2; forkhead box L2
                                                                    3 of 14
                                                                    605597
                                                                    FOXM1; forkhead box M1
                                                                    3 of 14
                                                                    602341
                                                                         
                                                                        FOXQ1; forkhead box Q1
                                                                        3 of 14
                                                                        612788
                                                                            Functional Complementation Data
                                                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                            Interactions
                                                                            Summary of Physical Interactions
                                                                            Summary of Genetic Interactions
                                                                            Interaction Browsers
                                                                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                                            Please look at the allele data for full details of the genetic interactions
                                                                            Starting gene(s)
                                                                            Interaction type
                                                                            Interacting gene(s)
                                                                            Reference
                                                                            Starting gene(s)
                                                                            Interaction type
                                                                            Interacting gene(s)
                                                                            Reference
                                                                            wg
                                                                            suppressible
                                                                            slp2
                                                                            (Bhat et al., 2000)
                                                                            External Data
                                                                            Linkouts
                                                                            BioGRID - A database of protein and genetic interactions.
                                                                            DroID - A comprehensive database of gene and protein interactions.
                                                                            MIST (genetic) - An integrated Molecular Interaction Database
                                                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                            Pathways
                                                                            Signaling Pathways (FlyBase)
                                                                            Metabolic Pathways
                                                                            FlyBase
                                                                            External Links
                                                                            External Data
                                                                            Linkouts
                                                                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                            Class of Gene
                                                                            Genomic Location and Detailed Mapping Data
                                                                            Chromosome (arm)
                                                                            2L
                                                                            Recombination map
                                                                            2-11
                                                                            Cytogenetic map
                                                                            24C7-24C7
                                                                            Sequence location
                                                                            FlyBase Computed Cytological Location
                                                                            Cytogenetic map
                                                                            Evidence for location
                                                                            24C7-24C7
                                                                            Limits computationally determined from genome sequence between P{EP}EP2595EP2595 and P{lacW}edk01102
                                                                            Experimentally Determined Cytological Location
                                                                            Cytogenetic map
                                                                            Notes
                                                                            References
                                                                            24D-24D
                                                                            (determined by in situ hybridisation)
                                                                            (Hacker et al., 1992)
                                                                            Experimentally Determined Recombination Data
                                                                            Location

                                                                            2-11

                                                                            (FlyBase, 2016)

                                                                            2-10.1

                                                                            (Comeron et al., 2012)

                                                                            2-8

                                                                            Left of (cM)
                                                                            Right of (cM)
                                                                            Notes
                                                                            Stocks and Reagents
                                                                            Stocks (26)
                                                                            Genomic Clones (16)
                                                                             

                                                                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                            cDNA Clones (14)
                                                                             

                                                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                            cDNA clones, fully sequenced
                                                                            BDGP DGC clones
                                                                            Other clones
                                                                            Drosophila Genomics Resource Center cDNA clones

                                                                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                            cDNA Clones, End Sequenced (ESTs)
                                                                            BDGP DGC clones
                                                                            Other clones
                                                                            RNAi and Array Information
                                                                            Linkouts
                                                                            DRSC - Results frm RNAi screens
                                                                            Antibody Information
                                                                            Laboratory Generated Antibodies
                                                                             

                                                                            polyclonal

                                                                            (Konstantinides et al., 2022, Uhl et al., 2016, Cadigan et al., 1994)
                                                                            Commercially Available Antibodies
                                                                             
                                                                            Cell Line Information
                                                                            Publicly Available Cell Lines
                                                                             
                                                                              Other Stable Cell Lines
                                                                               
                                                                                Other Comments

                                                                                slp1 and slp2 function downstream of wg signaling to generate the NB4-2 cell.

                                                                                (Bhat et al., 2000)

                                                                                wg signalling induces striped expression of slp1/slp2 in the mesoderm, providing striped mesodermal domains competent to respond to subsequent slp1/slp2-independent wg signals that induce somatic muscle and heart progenitors. In wg expressing ectodermal cells, slp1/slp2 is an integral component in an autocrine feedback loop of wg signalling.

                                                                                (Lee and Frasch, 2000)

                                                                                wg and slp1/slp2 act in a common pathway in which slp1/slp2 serves as a direct target of wg signals that mediates wg effects in both ectoderm and mesoderm. slp1/slp2 act downstream of wg to repress bap and visceral mesoderm formation.

                                                                                (Lee and Frasch, 2000)

                                                                                slp1 and slp2 control all aspects of differentiation in the slp domain, including segmental repression of bap, maintenance of high levels of twi and hence myogenesis.

                                                                                (Riechmann et al., 1997)

                                                                                Gsc expression is controlled by dpp, oc, slp1/slp2 and tll.

                                                                                (Goriely et al., 1996)

                                                                                slp2 is an activator of wg and a repressor of en and through these activities the distribution of slp2 defines en-competent cells (lacking slp2 protein) and wg-competent cells (containing slp2 protein). The localised expression of slp2 is required to maintain the proper anterior border of the en stripes and restrict wg expression to one side of the en/hh domain.

                                                                                (Cadigan et al., 1994)

                                                                                One of the major targets of slp2 action is the wg gene, slp2 alone can maintain wg expression.

                                                                                (Cadigan et al., 1994)

                                                                                slp1 and slp2 are regulated by a common enhancer region upstream of slp1. slp1/slp2 act as a head-specific gap gene in addition to the function as a pair-rule and segment polarity gene in the trunk. slp1 plays a predominent role in head formation while slp2 is largely dispensible. slp1/slp2 expression depends on bcd, suggesting that the slp genes are candidates for gene X. Head specific expression of the slp genes is generated in response to complex interactions between the anterior, terminal and dorsoventral systems.

                                                                                (Grossniklaus et al., 1994)

                                                                                Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

                                                                                (Clark et al., 1993)

                                                                                One copy of slp2 is sufficient to ensure proper segmentation of the even numbered abdominal segments in a slp1- background. slp1 and slp2 are not equivalent as only one copy of each is required for viability.

                                                                                (Grossniklaus et al., 1992)

                                                                                One of seven genes identified on basis of sequence similarity to the 110 amino acid forkhead domain that is conserved in the rodent hepatocyte enriched nuclear transcription factor.

                                                                                (Hacker et al., 1992)

                                                                                Embryonic lethal. Embryos lack parts of naked cuticle of T2, A1, A3, A5 and A7 in an irregular fashion. No effect of ftz expression.

                                                                                (Lindsley and Zimm, 1992)

                                                                                Mutant analysis shows that wild type slp2 function is required to set up expression of ac in row B of the embryonic proneural cluster.

                                                                                (Skeath et al., 1992)
                                                                                Relationship to Other Genes
                                                                                Source for database merge of
                                                                                Additional comments
                                                                                Nomenclature History
                                                                                Source for database identify of
                                                                                Nomenclature comments
                                                                                Etymology
                                                                                Synonyms and Secondary IDs (17)
                                                                                Reported As
                                                                                Symbol Synonym
                                                                                CG2939
                                                                                (National Institute of Genetics Fly Stocks, 2022-, Lin et al., 2015, McEachern et al., 2014, Ni et al., 2010.12.1)
                                                                                Dmslp2
                                                                                (Mazet et al., 2003)
                                                                                FD7
                                                                                (Kaufmann and Knoechel, 1996, Hacker et al., 1992)
                                                                                FoxG
                                                                                (Janssen et al., 2022, Zandvakili et al., 2019, Mazet et al., 2006)
                                                                                SLP
                                                                                (Samee and Sinha, 2013, Stoll et al., 2010, Chaves and Albert, 2008)
                                                                                Sloppy-paired
                                                                                (Sharrock and Sanson, 2020)
                                                                                Slp
                                                                                (Malin and Desplan, 2021, Maurange, 2020, Doe, 2017, Suzuki and Sato, 2017, Wernet et al., 2015, Martinez et al., 2014, Li et al., 2013, Lee and Frasch, 2005)
                                                                                Slp2
                                                                                (Khalili et al., 2023, Pollington et al., 2023, Bostock et al., 2022, Rossi et al., 2021, Mira and Morante, 2020, Zandvakili et al., 2019, Bischof et al., 2018, Uhl et al., 2016, Baëza et al., 2015, Kazemian et al., 2010)
                                                                                slp
                                                                                (Naidu et al., 2020, Clark et al., 2019, Sapar and Han, 2019, Clark and Peel, 2018, Bertet et al., 2014, Suzuki et al., 2013, Kaplan et al., 2011, Itasaki and Hoppler, 2010, Kozlov et al., 2009, Pisarev et al., 2009, Schaaf et al., 2009, Larsen et al., 2008, Surkova et al., 2008, Gebelein and Mann, 2007, Lindner et al., 2007, Sandmann et al., 2007, Sato and Tomlinson, 2007, Goldstein et al., 2005, Buescher et al., 2004, Ingolia, 2004, Albert and Othmer, 2003, Kobayashi et al., 2003, Sanchez and Thieffry, 2003, Thieffry and Sanchez, 2003, Vander Zwan and Gergen, 2003, Vander Zwan et al., 2003, Fujioka et al., 2002, Galis et al., 2002, Walrad et al., 2002, Kobayashi et al., 2001, Kobayashi et al., 2001, Lee and Frasch, 2000, Lee and Frasch, 2000, Nasiadka et al., 2000, Piepenburg et al., 2000, Bowler et al., 1999, Kobayashi et al., 1999, Muller et al., 1999, Paululat et al., 1999, Wilson, 1999, Baylies et al., 1998, Kosman et al., 1998, Ruiz-Gomez, 1998, Saulier-Le Drean et al., 1998, Goriely et al., 1996, Miskiewicz et al., 1996, Fujioka et al., 1995, Harbecke and Lengyel, 1995, Baumgartner et al., 1994, Fietz et al., 1994, Jackle and Sauer, 1993, Kornberg and Tabata, 1993, Martinez Arias, 1993, Pankratz and Jäckle, 1993)
                                                                                slp2
                                                                                (Yun et al., 2025, Petrosky et al., 2024, Baltruk et al., 2022, Deshpande et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Schomburg et al., 2022, Irizarry and Stathopoulos, 2021, Ma et al., 2021, McLaughlin et al., 2021, Santiago et al., 2021, Fogerson et al., 2020, Shokri et al., 2019, Bischof et al., 2018, Gene Disruption Project members, 2018-, Andrioli et al., 2017, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Sarov et al., 2016, Schertel et al., 2015, Combs and Eisen, 2013, Saunders et al., 2013, Fujioka and Jaynes, 2012, Nikulova et al., 2012, Chatterjee et al., 2011, Prazak et al., 2010, Gutierrez-Aviño et al., 2009, Liu et al., 2009, Löhr et al., 2009, Ochoa-Espinosa et al., 2009, Venken et al., 2009, Venken et al., 2009, Segal et al., 2008, Halfon and Arnosti, 2007, Magalhaes et al., 2007, Mondal et al., 2007, Sato and Tomlinson, 2007, Stuart et al., 2007, Wheeler et al., 2006, Copley, 2005, Grad et al., 2004, Gurunathan et al., 2004, Lee and Frasch, 2004, Wang et al., 2004)
                                                                                Name Synonyms
                                                                                SLOPPY-PAIRED
                                                                                (Samee and Sinha, 2013)
                                                                                Sloppy paired 2
                                                                                (McEachern et al., 2014, Venken et al., 2009)
                                                                                Sloppy-paired
                                                                                (Sato and Tomlinson, 2007)
                                                                                sloppy pair
                                                                                (Gutierrez-Aviño et al., 2009)
                                                                                sloppy paired
                                                                                (Lindner et al., 2007, Goldstein et al., 2005)
                                                                                sloppy paired 2
                                                                                (Schomburg et al., 2022, Baëza et al., 2015, Biehs et al., 2010, Wheeler et al., 2006, Grossniklaus, 1992.5.20)
                                                                                sloppy-paired
                                                                                (Chipman, 2020, Löhr et al., 2009, Pisarev et al., 2009, Zamparo and Perkins, 2009, Ishihara and Shibata, 2008, Surkova et al., 2008, Gebelein and Mann, 2007, Schwartz and Pirrotta, 2007, Anonymous, 2004, Papatsenko and Small, 2004, Walrad et al., 2004)
                                                                                sloppy-paired 2
                                                                                (Ochoa-Espinosa et al., 2009, Alexandre and Vincent, 2002)
                                                                                Secondary FlyBase IDs
                                                                                  Datasets (0)
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                                                                                  External Crossreferences and Linkouts ( 48 )
                                                                                  Sequence Crossreferences
                                                                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                                  Other crossreferences
                                                                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                                  FlyMine - An integrated database for Drosophila genomics
                                                                                  InterPro - A database of protein families, domains and functional sites
                                                                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                                  Linkouts
                                                                                  BioGRID - A database of protein and genetic interactions.
                                                                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                  DroID - A comprehensive database of gene and protein interactions.
                                                                                  DRSC - Results frm RNAi screens
                                                                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                                  Flygut - An atlas of the Drosophila adult midgut
                                                                                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                                                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                                  MIST (genetic) - An integrated Molecular Interaction Database
                                                                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                                  References (223)