FlyBase Gene Report: Dmel\FoxP

General Information

Symbol

Dmel\FoxP

Species

D. melanogaster

Name

Forkhead box P

Annotation Symbol

CG43067

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262477

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Forkhead box P (FoxP) encodes a transcription factor expressed in the nervous system. It is involved in locomotion, operant self-learning and courtship behavior. [Date last reviewed: 2019-05-16] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

fd85E, forkhead domain 85E

Key Links

Genomic Location

Cytogenetic map

85E5-85E5

Sequence location

3R:9,726,020..9,730,872 [-]

Recombination map

3-49

RefSeq locus

NT_033777 REGION:9726020..9730872

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein homodimerization activity

inferred from direct assay

(Castells-Nobau et al., 2019)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(GO Reference Genome Project, 2011-)

enables DNA-binding transcription factor activity

inferred from electronic annotation with InterPro:IPR001766

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR030456

(InterPro Project Members, 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(GO Reference Genome Project, 2011-)

enables sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR001766

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR030456

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in locomotion

inferred from mutant phenotype

(Lawton et al., 2014)

involved_in male courtship behavior, veined wing generated song production

inferred from mutant phenotype

(Lawton et al., 2014)

involved_in operant conditioning

inferred from mutant phenotype

(Mendoza et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR001766

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR030456

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000215041

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Forkhead box P (FoxP) encodes a transcription factor expressed in the nervous system. It is involved in locomotion, operant self-learning and courtship behavior. [Date last reviewed: 2019-05-16]

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS -: The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).

Summary (Interactive Fly)

forkhead domain transcription factor - a highly conserved transcription factor known for its importance in human speech and language production - reduced expression in Drosophila leads to decreased levels of courtship behavior, altered pulse-song structure, and sex-specific motor impairments in walking and flight

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\FoxP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4K6N2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.44

Gene model reviewed during 5.41

Gene model reviewed during 5.39

Gene model reviewed during 5.56

Gene model reviewed during 6.05

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FoxP-RC

FBtr0304869

NM_001260082

3552

520

FoxP-RD

FBtr0329937

NM_001104256

2428

442

FoxP-RE

FBtr0433516

NM_001316572

2800

393

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FoxP-PC

FBpp0293409

59.5

520

6.84

FBpp0302969

50.9

442

7.98

FBpp0390648

45.3

393

7.43

A0A126GUS5

NP_001303501

ALI30549

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FoxP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FoxP_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.72

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 13

organism

• yolk plasma

(Lee and Frasch, 2004)

embryonic stage 12 -- 17

larval central nervous system

(Lee and Frasch, 2004)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

FoxP transcript is localized to the yolk cytoplasm from blastoderm stages through embryonic stage 13. FoxP is also expressed in the developing embryonic CNS beginning at embryonic stage 12.

(Lee and Frasch, 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval nervous system | restricted

(Lawton et al., 2014)

adult stage

adult central nervous system | restricted

(Lawton et al., 2014)

Additional Descriptive Data

Expression of FoxP protein overlaps with the expression of ScerGAL4^FoxP.1.5 except for cells in the posterior region of the ventral nerve cord that are not detected by the antibody against FoxP.

(Lawton et al., 2014)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{FoxP-GAL4.1.5}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

neuron | subset of larval brain

(Lawton et al., 2014)

neuron | subset of larval ventral nerve cord

(Lawton et al., 2014)

adult stage

neuron | subset of protocerebral bridge

(Lawton et al., 2014)

adult central nervous system

(Lawton et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FoxP in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FoxP

View exonic expression by tissue for Dmel\FoxP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262477

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41182/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262477

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262477

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FoxP

Transgenic constructs containing regulatory region of FoxP

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)ED5438

(Mendoza et al., 2014)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during pupal stage, with Scer\GAL4^Act5C.PI

FoxP^GD4320

partially lethal - majority die, with Scer\GAL4^Act5C.PI

FoxP^GD4320

partially lethal - majority die | recessive

FoxP^del

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

FoxP^GD4320

viable, with Scer\GAL4^pnr-MD237

FoxP^GD4320

viable, with Scer\GAL4^tin.CΔ4

FoxP^GD4320

Sterility

Allele

sterile

FoxP^del

Other Phenotypes

Allele

abnormal behavior | adult stage

FoxP^del

abnormal behavior | adult stage, with Scer\GAL4^elav.PLu

abnormal courtship behavior | male | heat sensitive, with Scer\GAL4^elav-C155

FoxP^GD4320

abnormal flight

abnormal flight, with Scer\GAL4^Act5C.PI

FoxP^GD4320

abnormal flight, with Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal flight | male limited, with Scer\GAL4^elav-C155

FoxP^GD4320

abnormal flight | recessive

FoxP^del

abnormal jump response

FoxP^del

abnormal learning, with Scer\GAL4^elav.PU

FoxP^GD15847

abnormal learning (with Df(3R)ED5438)

FoxP^5-SZ-3955

abnormal learning | adult stage, with Scer\GAL4^elav.PLu

abnormal learning | adult stage (with FoxP^5-SZ-3955)

FoxP^del

abnormal learning | adult stage (with FoxP^del)

FoxP^5-SZ-3955

abnormal learning | recessive

FoxP^5-SZ-3955

abnormal locomotor behavior | adult stage

abnormal locomotor behavior | adult stage, with Scer\GAL4^Act5C.PI

FoxP^GD4320

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

FoxP^GD4320

abnormal locomotor behavior | adult stage, with Scer\GAL4^futsch-C380, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR55G08, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

abnormal locomotor behavior | adult stage, with Scer\GAL4^Toll-6-D42, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

abnormal locomotor behavior | adult stage | dominant

FoxP^del

abnormal locomotor behavior | adult stage | recessive

FoxP^iB-Gal4

abnormal neuroanatomy

FoxP^del

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal neuroanatomy, with Scer\GAL4^Mef2.247

abnormal neuroanatomy | third instar larval stage

FoxP^del

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4⁴⁷⁷

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal neurophysiology | adult stage

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal size

FoxP^del

abnormal size, with Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal size, with Scer\GAL4^Mef2.247

abnormal size | third instar larval stage

FoxP^del

abnormal size | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

abnormal song, with Scer\GAL4^elav-C155

FoxP^GD4320

decreased efficacy of learning | adult stage | RU486 conditional, with Scer\GAL4^GS.nSyb.PB, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

decreased rate of movement | adult stage

FoxP^5-SZ-3955

decreased rate of movement | adult stage, with Scer\GAL4^elav.PU, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

decreased rate of movement | adult stage, with Scer\GAL4^futsch-C380, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

decreased rate of movement | adult stage, with Scer\GAL4^GMR55G08, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

decreased rate of movement | adult stage, with Scer\GAL4^Toll-6-D42, Spyo\Cas9^UAS.cUa

FoxP^UAS.4xgRNA

majority die during pupal stage, with Scer\GAL4^Act5C.PI

FoxP^GD4320

majority die during pupal stage | recessive

FoxP^del

short lived, with Scer\GAL4^Act5C.PI

FoxP^GD4320

short lived | recessive

FoxP^del

visible | male limited, with Scer\GAL4^Bx-MS1096

FoxP^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

adult brain

FoxP^5-SZ-3955

adult mushroom body alpha-lobe

FoxP^del

adult mushroom body alpha-lobe, with Scer\GAL4^elav.PLu

FoxP^GD4320

adult mushroom body alpha-lobe, with Scer\GAL4^Mef2.247

alpha/beta Kenyon cell | adult stage

dendritic branch | third instar larval stage

FoxP^del

dendritic branch | third instar larval stage, with Scer\GAL4⁴⁷⁷

dendritic tree | third instar larval stage

FoxP^del

dendritic tree | third instar larval stage, with Scer\GAL4⁴⁷⁷

embryonic/larval neuromuscular junction | third instar larval stage

FoxP^del

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

end plate | third instar larval stage

FoxP^del

end plate | third instar larval stage, with Scer\GAL4^elav.PLu

FoxP^GD4320

larval multidendritic class IV neuron | third instar larval stage

FoxP^del

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4⁴⁷⁷

mitochondrial crista | third instar larval stage

FoxP^del

mitochondrion | third instar larval stage

FoxP^del

neuropil

FoxP^5-SZ-3955

optic glomerulus

FoxP^5-SZ-3955

subsynaptic reticulum | third instar larval stage

FoxP^del

wing | male limited, with Scer\GAL4^Bx-MS1096

FoxP^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (42)

Hsap\FOXP1

8 of 14

Yes

Hsap\FOXP2

8 of 14

Yes

Hsap\FOXP4

7 of 14

Yes

Hsap\FOXP3

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Foxp1

8 of 14

Yes

Rnor\Foxp2

7 of 14

Yes

Rnor\Foxp4

7 of 14

Yes

Rnor\Foxp3

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Foxs1

1 of 14

Mus musculus (laboratory mouse) (39)

Mmus\Foxp1

8 of 14

Yes

Mmus\Foxp2

8 of 14

Yes

Mmus\Foxp4

8 of 14

Yes

Mmus\Foxp3

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (38)

Xtro\foxp2

5 of 13

Yes

Xtro\bves

4 of 13

Xtro\foxp1

4 of 13

Yes

Xtro\foxp4

4 of 13

Yes

Xtro\foxp3

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (61)

Drer\foxp1b

8 of 14

Yes

Drer\foxp2

8 of 14

Yes

Drer\foxp1a

7 of 14

Yes

Drer\foxp4

7 of 14

Yes

Drer\foxp3a

4 of 14

Yes

Drer\foxp3b

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-145o7.3

1 of 14

Drer\si:rp71-45k5.2

1 of 14

Drer\zgc:113424

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\fkh-7

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP000569

5 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\FHL1

1 of 13

Yes

Scer\FKH1

1 of 13

Yes

Scer\FKH2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\fhl1

1 of 12

Yes

Spom\fkh2

1 of 12

Yes

Spom\mei4

1 of 12

Yes

Spom\sep1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:FoxP. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

bin

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

fkh

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

FoxP^5-SZ-3955

model of specific developmental disorder

CEA

(Mendoza et al., 2014)

FoxP^GD15847

model of specific developmental disorder

CEA

(Mendoza et al., 2014)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

FOXP2; forkhead box P2

model of speech-language disorder-1

IEA

(FlyBase, 2019-)

FOXP1; forkhead box P1

model of intellectual disability-severe speech delay-mild dysmorphism syndrome

IEA

(FlyBase, 2019-)

FOXP3; forkhead box P3

model of immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FOXP1; forkhead box P1

8 of 14

FORKHEAD BOX P1; FOXP1

INTELLECTUAL DEVELOPMENTAL DISORDER WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES; IDDLA

intellectual disability-severe speech delay-mild dysmorphism syndrome

FOXP2; forkhead box P2

8 of 14

605317

SPEECH-LANGUAGE DISORDER 1; SPCH1

speech-language disorder-1

FOXP4; forkhead box P4

7 of 14

608924

FOXP3; forkhead box P3

5 of 14

300292

IMMUNODYSREGULATION, POLYENDOCRINOPATHY, AND ENTEROPATHY, X-LINKED; IPEX

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

FoxP

two hybrid

(Castells-Nobau et al., 2019)

FoxP - B-H2

two hybrid array

(Shokri et al., 2019)

FoxP - CG13887

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

FoxP - GATAe

two hybrid array

(Shokri et al., 2019)

FoxP - Unr

two hybrid array

(Shokri et al., 2019)

FoxP - org-1

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262477

MIST (protein-protein) - An integrated Molecular Interaction Database

41182

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-49

Cytogenetic map

85E5-85E5

Sequence location

3R:9,726,020..9,730,872 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85E5-85E5

Limits computationally determined from genome sequence between P{EP}Crc^EP3006 and P{lacW}s2681

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-49

(FlyBase, 2016)

3-46.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262477

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0262477

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lawton et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

New annotation (CG32937) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: fd85E CG32937

(FlyBase Genome Annotators, 2010)

Additional comments

Annotations CG16899 and CG32937 merged as CG43067 in release 5.31 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Nomenclature History

Source for database identify of

Source for identity of: fd85E CG16899

(Lee and Frasch, 2004)

Source for identity of: FoxP fd85E

(Santos et al., 2011)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG16899

(Sarov et al., 2016, Mendoza et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Santos et al., 2011, Schenck, 2010.9.8, Perkins et al., 2009.3.31, Hoskins et al., 2005, Lee and Frasch, 2004)

CG32937

(Mendoza et al., 2014, Santos et al., 2011, Schenck, 2010.9.8)

CG43067

(Mendoza et al., 2014, FlyBase Genome Annotators, 2010)

DmFoxP

(Santos et al., 2011)

Dmcg16899

(Mazet et al., 2003)

dFoxP

(Mendoza et al., 2014)

fd85E

(Schenck, 2010.9.8, Lee and Frasch, 2004)

Name Synonyms

Forkhead box P

forkhead box P

(Groschner et al., 2018)

forkhead domain 85E

(Schenck, 2010.9.8)

Secondary FlyBase IDs

FBgn0037735
FBgn0052937

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41182

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K6N2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K6N2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262477

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41182/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262477

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262477

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43067

MARRVEL_MODEL - MARRVEL (model organism gene)

41182

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262477

DroID - A comprehensive database of gene and protein interactions.

FBgn0262477

DRSC - Results frm RNAi screens

FBgn0262477

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FoxP_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262477

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031528

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

41182

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

-0.72

Report Sections