FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\fd102C
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General Information
Symbol
Dmel\fd102C
Species
D. melanogaster
Name
forkhead domain 102C
Annotation Symbol
CG11152
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039937
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
102E3-102E3
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:836986..844529
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(GO Reference Genome Project, 2011-)
enables sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in anatomical structure morphogenesis
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(GO Reference Genome Project, 2011-)
involved_in cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\fd102C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V481)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fd102C-RA
FBtr0089251
NM_143694
2324
599
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
fd102C-PA
FBpp0088311
66.3
599
6.23
Q9V481
NP_651951
AAF59407
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fd102C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.36

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
organism | 90-100% egg length

Comment: reference states 92-100%

(Lee and Frasch, 2004)
central brain anlage in statu nascendi | anterior
(Lee and Frasch, 2004)
epipharynx primordium
(Lee and Frasch, 2004)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 4 -- 13
organism | anterior
(Lee and Frasch, 2004)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
embryonic stage 9
procephalic neurogenic region
(Lee and Frasch, 2004)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
clypeo-labral primordium
(Fisher et al., 2012)
pars intercerebralis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic pars intercerebralis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic stage 14 -- 17
larval brain
(Lee and Frasch, 2004)
embryonic/larval pharynx
(Lee and Frasch, 2004)
Additional Descriptive Data

fd102C transcript has no maternal component. Immediately prior to cellularization, fd102C transcript is expressed in a small anterior domain between ~92 and 100% egg length, including the anlagen of the pharynx and anterior portions of the procephalic neuroectoderm. Anterior expression continues through later stages. During and after stage 14, fd102C expression is seen in a large number of neurons within the brain hemispheres and in dorsolateral pharyngeal areas.

(Lee and Frasch, 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fd102C in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fd102C
Transgenic constructs containing regulatory region of fd102C
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(4)C3
(Podemski et al., 2004)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Sterility
Allele
female fertile (with Df(4)ED6382)
female fertile (with Df(4)O2)
Other Phenotypes
Allele
visible, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (51)
Hsap\FOXD1
4 of 14
Yes
No
Hsap\FOXD2
4 of 14
Yes
No
Hsap\FOXD3
4 of 14
Yes
No
1  
Hsap\FOXD4
4 of 14
Yes
No
Hsap\FOXD4L1
4 of 14
Yes
No
Hsap\FOXD4L3
4 of 14
Yes
No
Hsap\FOXD4L4
4 of 14
Yes
No
Hsap\FOXD4L5
4 of 14
Yes
No
Hsap\FOXD4L6
4 of 14
Yes
No
Hsap\FOXE1
4 of 14
Yes
No
Hsap\FOXE3
4 of 14
Yes
No
Hsap\FOXG1
4 of 14
Yes
No
Hsap\FOXI1
4 of 14
Yes
No
Hsap\FOXI2
4 of 14
Yes
No
Hsap\FOXI3
4 of 14
Yes
No
Hsap\FOXJ2
4 of 14
Yes
Yes
Hsap\FOXJ3
4 of 14
Yes
Yes
Hsap\FOXK1
4 of 14
Yes
No
Hsap\FOXK2
4 of 14
Yes
No
Hsap\FOXL1
4 of 14
Yes
No
Hsap\FOXS1
4 of 14
Yes
No
Hsap\FOXB1
3 of 14
No
No
1  
Hsap\FOXB2
3 of 14
No
No
1  
Hsap\FOXC1
3 of 14
No
No
Hsap\FOXC2
3 of 14
No
No
Hsap\FOXF1
3 of 14
No
No
Hsap\FOXH1
3 of 14
No
Yes
Hsap\FOXJ1
3 of 14
No
Yes
Hsap\FOXL2
3 of 14
No
No
Hsap\FOXM1
3 of 14
No
Yes
1  
Hsap\FOXQ1
3 of 14
No
Yes
Hsap\FOXA2
2 of 14
No
No
Hsap\FOXA3
2 of 14
No
No
Hsap\FOXF2
2 of 14
No
No
Hsap\FOXL3
2 of 14
No
No
Hsap\FOXL3-OT1
2 of 14
No
Yes
Hsap\FOXN1
2 of 14
No
No
1  
Hsap\FOXN2
2 of 14
No
No
Hsap\FOXN3
2 of 14
No
No
1  
Hsap\FOXN4
2 of 14
No
No
Hsap\FOXO1
2 of 14
No
No
0  
Hsap\FOXO3
2 of 14
No
No
2  
Hsap\FOXO4
2 of 14
No
No
Hsap\FOXR1
2 of 14
No
Yes
Hsap\FOXR2
2 of 14
No
Yes
Hsap\FOXA1
1 of 14
No
No
Hsap\FOXO6
1 of 14
No
No
Hsap\FOXP1
1 of 14
No
No
1  
Hsap\FOXP2
1 of 14
No
No
1  
Hsap\FOXP4
1 of 14
No
No
Hsap\UPK2
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
Rnor\Foxc1
4 of 14
Yes
No
Rnor\Foxc2
4 of 14
Yes
No
Rnor\Foxd1
4 of 14
Yes
No
Rnor\Foxe3
4 of 14
Yes
No
Rnor\Foxg1
4 of 14
Yes
No
Rnor\Foxi1
4 of 14
Yes
No
Rnor\Foxi3
4 of 14
Yes
No
Rnor\Foxj2
4 of 14
Yes
Yes
Rnor\Foxk1
4 of 14
Yes
No
Rnor\Foxk2
4 of 14
Yes
No
Rnor\Foxl1
4 of 14
Yes
No
Rnor\Foxl2
4 of 14
Yes
No
Rnor\Foxs1
4 of 14
Yes
No
Rnor\Foxb2
3 of 14
No
No
Rnor\Foxd3
3 of 14
No
No
Rnor\Foxe1
3 of 14
No
No
Rnor\Foxh1
3 of 14
No
Yes
Rnor\Foxi2
3 of 14
No
Yes
Rnor\Foxj3
3 of 14
No
Yes
Rnor\Foxl3
3 of 14
No
No
Rnor\Foxm1
3 of 14
No
Yes
Rnor\Foxa2
2 of 14
No
No
Rnor\Foxa3
2 of 14
No
No
Rnor\Foxd2
2 of 14
No
No
Rnor\Foxd4
2 of 14
No
No
Rnor\Foxf1
2 of 14
No
No
Rnor\Foxj1
2 of 14
No
Yes
Rnor\Foxn1
2 of 14
No
No
Rnor\Foxn3
2 of 14
No
No
Rnor\Foxo1
2 of 14
No
No
Rnor\Foxo3
2 of 14
No
No
Rnor\Foxo4
2 of 14
No
No
Rnor\Foxq1
2 of 14
No
Yes
Rnor\Foxr1
2 of 14
No
Yes
Rnor\Foxa1
1 of 14
No
No
Rnor\Foxb1
1 of 14
No
No
Rnor\Foxn2
1 of 14
No
No
Rnor\Foxn4
1 of 14
No
No
Rnor\Foxo6
1 of 14
No
No
Rnor\Foxp1
1 of 14
No
No
Rnor\Foxp2
1 of 14
No
No
Rnor\Foxp3
1 of 14
No
No
Rnor\Foxp4
1 of 14
No
No
Rnor\Foxr2
1 of 14
No
Yes
Rnor\Upk2
1 of 14
No
Yes
Mus musculus (laboratory mouse) (46)
Mmus\Foxc1
4 of 14
Yes
No
Mmus\Foxc2
4 of 14
Yes
No
Mmus\Foxd1
4 of 14
Yes
No
Mmus\Foxd2
4 of 14
Yes
No
Mmus\Foxd4
4 of 14
Yes
No
Mmus\Foxe3
4 of 14
Yes
No
Mmus\Foxg1
4 of 14
Yes
No
Mmus\Foxi1
4 of 14
Yes
No
Mmus\Foxi2
4 of 14
Yes
No
Mmus\Foxj2
4 of 14
Yes
Yes
Mmus\Foxj3
4 of 14
Yes
Yes
Mmus\Foxk1
4 of 14
Yes
No
Mmus\Foxk2
4 of 14
Yes
No
Mmus\Foxl1
4 of 14
Yes
No
Mmus\Foxl2
4 of 14
Yes
No
Mmus\Foxl3
4 of 14
Yes
No
Mmus\Foxb1
3 of 14
No
No
Mmus\Foxb2
3 of 14
No
No
Mmus\Foxd3
3 of 14
No
No
Mmus\Foxe1
3 of 14
No
No
Mmus\Foxf1
3 of 14
No
No
Mmus\Foxf2
3 of 14
No
No
Mmus\Foxh1
3 of 14
No
Yes
Mmus\Foxi3
3 of 14
No
No
Mmus\Foxj1
3 of 14
No
Yes
Mmus\Foxm1
3 of 14
No
Yes
Mmus\Foxq1
3 of 14
No
Yes
Mmus\Foxs1
3 of 14
No
No
Mmus\Foxa2
2 of 14
No
No
Mmus\Foxa3
2 of 14
No
No
Mmus\Foxn1
2 of 14
No
No
Mmus\Foxn2
2 of 14
No
No
Mmus\Foxn4
2 of 14
No
No
Mmus\Foxo1
2 of 14
No
No
2  
Mmus\Foxo3
2 of 14
No
No
Mmus\Foxo4
2 of 14
No
No
Mmus\Foxo6
2 of 14
No
No
Mmus\Foxr1
2 of 14
No
Yes
Mmus\Foxr2
2 of 14
No
Yes
Mmus\Foxa1
1 of 14
No
No
Mmus\Foxn3
1 of 14
No
No
Mmus\Foxp1
1 of 14
No
No
Mmus\Foxp2
1 of 14
No
No
Mmus\Foxp3
1 of 14
No
No
Mmus\Foxp4
1 of 14
No
No
Mmus\Upk2
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (54)
Xtro\brap
3 of 13
Yes
No
Xtro\foxb1
3 of 13
Yes
No
Xtro\foxc1
3 of 13
Yes
No
Xtro\foxc2
3 of 13
Yes
No
Xtro\foxd1
3 of 13
Yes
No
Xtro\foxd2
3 of 13
Yes
No
Xtro\foxd3
3 of 13
Yes
No
Xtro\foxd4l1.1
3 of 13
Yes
No
Xtro\foxd4l1.2
3 of 13
Yes
No
Xtro\foxe3
3 of 13
Yes
Yes
Xtro\foxg1
3 of 13
Yes
No
Xtro\foxi1
3 of 13
Yes
No
Xtro\foxi2
3 of 13
Yes
No
Xtro\foxi4.1
3 of 13
Yes
No
Xtro\foxi4.2
3 of 13
Yes
No
Xtro\foxj2
3 of 13
Yes
Yes
Xtro\foxl1
3 of 13
Yes
No
Xtro\foxl2
3 of 13
Yes
No
Xtro\crip2
2 of 13
No
No
Xtro\foxa2
2 of 13
No
No
Xtro\foxa4
2 of 13
No
No
Xtro\foxe1
2 of 13
No
Yes
Xtro\foxf1
2 of 13
No
No
Xtro\foxh1
2 of 13
No
No
Xtro\foxj1
2 of 13
No
Yes
Xtro\foxk2
2 of 13
No
No
Xtro\foxl3-ot1
2 of 13
No
Yes
Xtro\foxm1
2 of 13
No
Yes
Xtro\gcdh
2 of 13
No
No
Xtro\nr2f6
2 of 13
No
No
Xtro\qrich2
2 of 13
No
No
Xtro\arhgap5
1 of 13
No
No
Xtro\ctsw
1 of 13
No
No
Xtro\erh
1 of 13
No
No
Xtro\esrra
1 of 13
No
No
Xtro\fam161a
1 of 13
No
No
Xtro\foxa1
1 of 13
No
No
Xtro\foxb2
1 of 13
No
No
Xtro\foxf2
1 of 13
No
No
Xtro\foxj1.2
1 of 13
No
Yes
Xtro\foxj3
1 of 13
No
No
Xtro\foxn1
1 of 13
No
No
Xtro\foxn2
1 of 13
No
No
Xtro\foxn3
1 of 13
No
No
Xtro\foxo1
1 of 13
No
No
Xtro\foxo3
1 of 13
No
No
Xtro\foxo4
1 of 13
No
No
Xtro\foxo6
1 of 13
No
No
Xtro\foxq1
1 of 13
No
Yes
Xtro\foxr1
1 of 13
No
Yes
Xtro\LOC101730723
1 of 13
No
Yes
Xtro\nop2
1 of 13
No
No
Xtro\ppard
1 of 13
No
Yes
Xtro\vegfd
1 of 13
No
No
Danio rerio (Zebrafish) (64)
Drer\foxq2
8 of 14
Yes
Yes
Drer\foxj2
5 of 14
No
Yes
Drer\foxc1a
4 of 14
No
No
Drer\foxc1b
4 of 14
No
No
Drer\foxd1
4 of 14
No
No
Drer\foxd2
4 of 14
No
No
Drer\foxd3
4 of 14
No
No
Drer\foxd5
4 of 14
No
No
Drer\foxd7
4 of 14
No
No
Drer\foxe1
4 of 14
No
No
Drer\foxe3
4 of 14
No
No
Drer\foxg1a
4 of 14
No
No
Drer\foxg1b
4 of 14
No
No
Drer\foxg1c
4 of 14
No
No
Drer\foxg1d
4 of 14
No
No
Drer\foxi2
4 of 14
No
No
Drer\foxi3a
4 of 14
No
No
Drer\foxi3b
4 of 14
No
No
Drer\foxj3
4 of 14
No
Yes
Drer\foxk1
4 of 14
No
No
Drer\foxk2a
4 of 14
No
No
Drer\foxk2b
4 of 14
No
No
Drer\foxl1
4 of 14
No
No
Drer\foxl2a
4 of 14
No
No
Drer\foxl2b
4 of 14
No
No
Drer\foxl2l
4 of 14
No
No
Drer\foxl3
4 of 14
No
No
Drer\foxb1a
3 of 14
No
No
Drer\foxb1b
3 of 14
No
No
Drer\foxb2
3 of 14
No
No
Drer\foxf1
3 of 14
No
No
Drer\foxf2a
3 of 14
No
No
Drer\foxf2b
3 of 14
No
No
Drer\foxh1
3 of 14
No
No
Drer\foxi1
3 of 14
No
No
Drer\foxj1b
3 of 14
No
Yes
Drer\foxm1
3 of 14
No
Yes
Drer\si:ch211-145o7.3
3 of 14
No
No
Drer\foxa2
2 of 14
No
No
Drer\foxa3
2 of 14
No
No
Drer\foxa
2 of 14
No
No
Drer\foxj1a
2 of 14
No
Yes
Drer\foxn1
2 of 14
No
No
Drer\foxn2a
2 of 14
No
No
Drer\foxn2b
2 of 14
No
No
Drer\foxn3
2 of 14
No
No
Drer\foxn4
2 of 14
No
No
Drer\foxo1b
2 of 14
No
No
Drer\foxo4
2 of 14
No
No
Drer\foxo6b
2 of 14
No
No
Drer\foxq1a
2 of 14
No
Yes
Drer\foxq1b
2 of 14
No
Yes
Drer\foxr1
2 of 14
No
Yes
Drer\zgc:113424
2 of 14
No
No
Drer\ches1
1 of 14
No
No
Drer\foxa1
1 of 14
No
No
Drer\foxo1a
1 of 14
No
No
Drer\foxo3a
1 of 14
No
No
Drer\foxo6a
1 of 14
No
No
Drer\foxp1b
1 of 14
No
No
Drer\foxp2
1 of 14
No
No
Drer\foxp3a
1 of 14
No
No
Drer\foxp4
1 of 14
No
No
Drer\si:rp71-45k5.2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\fkh-10
9 of 14
Yes
Yes
Cele\let-381
5 of 14
No
No
Cele\unc-130
4 of 14
No
No
Cele\fkh-2
3 of 14
No
No
Cele\fkh-6
3 of 14
No
No
Cele\lin-31
3 of 14
No
No
Cele\pes-1
3 of 14
No
No
Cele\pha-4
3 of 14
No
No
Cele\fkh-5
2 of 14
No
No
Cele\fkh-8
2 of 14
No
No
Cele\fkh-9
2 of 14
No
No
Cele\C29F7.10
1 of 14
No
Yes
Cele\daf-16
1 of 14
No
No
Cele\fkh-3
1 of 14
No
No
Cele\fkh-4
1 of 14
No
No
Cele\fkh-7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (19)
Agam\AgaP_AGAP000069
9 of 12
Yes
Yes
Agam\AgaP_AGAP005902
4 of 12
No
No
Agam\AgaP_AGAP009147
4 of 12
No
No
Agam\AgaP_AGAP002903
3 of 12
No
No
Agam\AgaP_AGAP003940
3 of 12
No
No
Agam\AgaP_AGAP005804
3 of 12
No
No
Agam\AgaP_AGAP006786
3 of 12
No
No
Agam\AgaP_AGAP008155
3 of 12
No
No
Agam\AgaP_AGAP008606
3 of 12
No
Yes
Agam\AgaP_AGAP013178
3 of 12
No
No
Agam\AgaP_AGAP000662
2 of 12
No
No
Agam\AgaP_AGAP001577
2 of 12
No
No
Agam\AgaP_AGAP001671
2 of 12
No
No
Agam\AgaP_AGAP002460
2 of 12
No
No
Agam\AgaP_AGAP012976
2 of 12
No
No
Agam\AgaP_AGAP013032
2 of 12
No
No
Agam\AgaP_AGAP013297
2 of 12
No
No
Agam\AgaP_AGAP000569
1 of 12
No
No
Agam\AgaP_AGAP005903
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G07260
1 of 13
Yes
Yes
Atha\FHA2
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\HCM1
6 of 13
Yes
Yes
Scer\FKH1
5 of 13
No
No
Scer\FKH2
4 of 13
No
No
Scer\FHL1
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\fhl1
3 of 12
Yes
No
Spom\fkh2
3 of 12
Yes
No
Spom\mei4
3 of 12
Yes
No
Spom\sep1
3 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:fd102C. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
croc
7 of 13
fd59A
7 of 13
fd19B
6 of 13
FoxL1
6 of 13
slp1
6 of 13
fd96Ca
5 of 13
fd96Cb
5 of 13
FoxK
5 of 13
slp2
5 of 13
CG32006
4 of 13
fkh
4 of 13
jumu
4 of 13
bin
3 of 13
foxo
3 of 13
CHES-1-like
2 of 13
fd3F
2 of 13
FoxP
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 9 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FOXD1; forkhead box D1
    4 of 14
    601091
        FOXD2; forkhead box D2
        4 of 14
        602211
            FOXD3; forkhead box D3
            4 of 14
            611539
               
              FOXD4; forkhead box D4
              4 of 14
              601092
                  FOXD4L1; forkhead box D4 like 1
                  4 of 14
                  611084
                      FOXD4L3; forkhead box D4 like 3
                      4 of 14
                      611086
                          FOXD4L4; forkhead box D4 like 4
                          4 of 14
                          611085
                              FOXD4L5; forkhead box D4 like 5
                              4 of 14
                                  FOXD4L6; forkhead box D4 like 6
                                  4 of 14
                                      FOXE1; forkhead box E1
                                      4 of 14
                                      602617
                                      FOXE3; forkhead box E3
                                      4 of 14
                                      601094
                                      FOXG1; forkhead box G1
                                      4 of 14
                                      164874
                                      FOXI1; forkhead box I1
                                      4 of 14
                                      601093
                                      FOXI2; forkhead box I2
                                      4 of 14
                                      617202
                                          FOXI3; forkhead box I3
                                          4 of 14
                                          612351
                                            FOXJ2; forkhead box J2
                                            4 of 14
                                            619162
                                                FOXJ3; forkhead box J3
                                                4 of 14
                                                616035
                                                    FOXK1; forkhead box K1
                                                    4 of 14
                                                    616302
                                                        FOXK2; forkhead box K2
                                                        4 of 14
                                                        147685
                                                            FOXL1; forkhead box L1
                                                            4 of 14
                                                            603252
                                                            FOXS1; forkhead box S1
                                                            4 of 14
                                                            602939
                                                                FOXB1; forkhead box B1
                                                                3 of 14
                                                                619961
                                                                     
                                                                    FOXB2; forkhead box B2
                                                                    3 of 14
                                                                    619962
                                                                         
                                                                        FOXC1; forkhead box C1
                                                                        3 of 14
                                                                        601090
                                                                        FOXC2; forkhead box C2
                                                                        3 of 14
                                                                        602402
                                                                        FOXF1; forkhead box F1
                                                                        3 of 14
                                                                        601089
                                                                        FOXH1; forkhead box H1
                                                                        3 of 14
                                                                        603621
                                                                            FOXJ1; forkhead box J1
                                                                            3 of 14
                                                                            602291
                                                                            FOXL2; forkhead box L2
                                                                            3 of 14
                                                                            605597
                                                                            FOXM1; forkhead box M1
                                                                            3 of 14
                                                                            602341
                                                                                 
                                                                                FOXQ1; forkhead box Q1
                                                                                3 of 14
                                                                                612788
                                                                                    Functional Complementation Data
                                                                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                                    Interactions
                                                                                    Summary of Physical Interactions
                                                                                    Interaction Browsers
                                                                                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                                                    Please see the Physical Interaction reports below for full details
                                                                                    protein-protein
                                                                                    Physical Interaction
                                                                                    Assay
                                                                                    References
                                                                                    fd102C - Ubx
                                                                                    bimolecular fluorescence complementation, fluorescence microscopy
                                                                                    (Bischof et al., 2018)
                                                                                    Summary of Genetic Interactions
                                                                                    Interaction Browsers
                                                                                    Starting gene(s)
                                                                                    Interaction type
                                                                                    Interacting gene(s)
                                                                                    Reference
                                                                                    Starting gene(s)
                                                                                    Interaction type
                                                                                    Interacting gene(s)
                                                                                    Reference
                                                                                    External Data
                                                                                    Linkouts
                                                                                    DroID - A comprehensive database of gene and protein interactions.
                                                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                                    Pathways
                                                                                    Signaling Pathways (FlyBase)
                                                                                    Metabolic Pathways
                                                                                    FlyBase
                                                                                    External Links
                                                                                    External Data
                                                                                    Linkouts
                                                                                    Class of Gene
                                                                                    Genomic Location and Detailed Mapping Data
                                                                                    Chromosome (arm)
                                                                                    4
                                                                                    Recombination map
                                                                                    4-0
                                                                                    Cytogenetic map
                                                                                    102E3-102E3
                                                                                    Sequence location
                                                                                    FlyBase Computed Cytological Location
                                                                                    Cytogenetic map
                                                                                    Evidence for location
                                                                                    102E3-102E3
                                                                                    Experimentally Determined Cytological Location
                                                                                    Cytogenetic map
                                                                                    Notes
                                                                                    References
                                                                                    Experimentally Determined Recombination Data
                                                                                    Location

                                                                                    4-0

                                                                                    (FlyBase, 2016)
                                                                                    Left of (cM)
                                                                                    Right of (cM)
                                                                                    Notes
                                                                                    Stocks and Reagents
                                                                                    Stocks (13)
                                                                                    Genomic Clones (16)
                                                                                     

                                                                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                                                    cDNA Clones (3)
                                                                                     

                                                                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                                    cDNA clones, fully sequenced
                                                                                    BDGP DGC clones
                                                                                    Other clones
                                                                                    Drosophila Genomics Resource Center cDNA clones

                                                                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                                    cDNA Clones, End Sequenced (ESTs)
                                                                                    BDGP DGC clones
                                                                                      Other clones
                                                                                      RNAi and Array Information
                                                                                      Linkouts
                                                                                      DRSC - Results frm RNAi screens
                                                                                      Antibody Information
                                                                                      Laboratory Generated Antibodies
                                                                                       
                                                                                      Commercially Available Antibodies
                                                                                       
                                                                                      Cell Line Information
                                                                                      Publicly Available Cell Lines
                                                                                       
                                                                                        Other Stable Cell Lines
                                                                                         
                                                                                          Other Comments
                                                                                          Relationship to Other Genes
                                                                                          Source for database merge of
                                                                                          Additional comments
                                                                                          Nomenclature History
                                                                                          Source for database identify of

                                                                                          Source for identity of: fd102C CG11152

                                                                                          (Lee and Frasch, 2004)
                                                                                          Nomenclature comments
                                                                                          Etymology
                                                                                          Synonyms and Secondary IDs (6)
                                                                                          Datasets (0)
                                                                                          Study focus (0)
                                                                                          Experimental Role
                                                                                          Project
                                                                                          Project Type
                                                                                          Title
                                                                                          Study result (0)
                                                                                          Result
                                                                                          Result Type
                                                                                          Title
                                                                                          External Crossreferences and Linkouts ( 52 )
                                                                                          Sequence Crossreferences
                                                                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                                          Other crossreferences
                                                                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                                          FlyMine - An integrated database for Drosophila genomics
                                                                                          InterPro - A database of protein families, domains and functional sites
                                                                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                                          Linkouts
                                                                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                          DroID - A comprehensive database of gene and protein interactions.
                                                                                          DRSC - Results frm RNAi screens
                                                                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                          Flygut - An atlas of the Drosophila adult midgut
                                                                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                                          References (42)