FlyBase Gene Report: Dmel\FoxL1

General Information

Symbol

Dmel\FoxL1

Species

D. melanogaster

Name

Forkhead box L1

Annotation Symbol

CG1132

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004895

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Forkhead box L1 (FoxL1) encodes a transcription factor that is expressed in ventral intersegmental muscle 5 and in the hindgut. FoxL1 product contributes to salivary gland morphology and the migration of tissues that migrate in close proximity to the FoxL1-expressing cells, such as hemocytes, germ cells and Malpighian tubules. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

fd64A, FD2

Key Links

Genomic Location

Cytogenetic map

64A4-64A4

Sequence location

3L:4,018,878..4,021,279 [+]

Recombination map

3-10

RefSeq locus

NT_037436 REGION:4018878..4021279

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000930906

(GO Reference Genome Project, 2011-)

enables DNA-binding transcription factor activity

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456

(InterPro Project Members, 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000930906

(GO Reference Genome Project, 2011-)

enables sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in positive regulation of gene expression

inferred from mutant phenotype

(Hanlon and Andrew, 2016)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in anatomical structure morphogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000930906

(GO Reference Genome Project, 2011-)

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN000930906

(GO Reference Genome Project, 2011-)

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000930906

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Hanlon and Andrew, 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000930906

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS -: The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).

Protein Function (UniProtKB)

Transcription factor (By similarity). Coordinates the placement and migration of various organs during embryogenesis, including the salivary glands, hemocytes, germ cells and Malpighian tubules (PubMed:27618755). Likely acts non-cell-autonomously to provide signaling cues from the mesoderm/musculature to nearby tissues (PubMed:27618755). Mediates salivary gland positioning, at least in part, through activation of the secreted signal Sema2a (PubMed:27618755).

(UniProt, Q02360)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\FoxL1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q02360)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FoxL1-RA

FBtr0073192

NM_079188

1372

365

FoxL1-RB

FBtr0309789

NM_001259680

1414

365

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FoxL1-PA

FBpp0073048

40.6

365

6.42

FBpp0301542

40.6

365

6.42

Q02360

NP_001246609

AFH04280

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

365 aa isoforms: FoxL1-PA, FoxL1-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FoxL1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

fd64A_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.90

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

mesoderm

(Hacker et al., 1992)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | posterior

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

(Hacker et al., 1992)

embryonic stage 7 -- 8

organism | posterior

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | posterior

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 12

hindgut proper primordium

(Hanlon and Andrew, 2016)

embryonic stage 11

muscle founder cell

(Zhu et al., 2012)

embryonic stage 11 -- 12

trunk visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 12 -- 14

somatic trunk mesoderm | segmentally repeated

(Hanlon and Andrew, 2016)

embryonic stage 13 -- 16

larval visceral muscle cell

(Fisher et al., 2012)

embryonic stage 13 -- 17

embryonic hindgut

(Hanlon and Andrew, 2016)

embryonic stage 15

visceral trunk mesoderm

(Hanlon and Andrew, 2016)

embryonic stage 15 -- 16

somatic trunk mesoderm of embryonic mesothoracic segment

(Hanlon and Andrew, 2016)

somatic trunk mesoderm of embryonic metathoracic segment

(Hanlon and Andrew, 2016)

Additional Descriptive Data

FoxL1 transcripts are expressed in the embryo from stage 9 in the hindgut. They are also expressed in a segmentally repeated pattern in the mesoderm that becomes largely restricted to T2 and T3 late in embryogenesis. They are also detected in the region of the visceral mesoderm where the gastric caeca form.

(Hanlon and Andrew, 2016)

fd64A transcripts are first observed in cells which comprise a ventral spot in a posterior position of the cellular blastoderm. These cells invaginate and demarcate the posterior portion of the mesoderm. In the extended germ band, expression is observed in 10 segmental pairs of cell clusters that are thought to be mesodermal. The transcripts are at low abundance.

(Hacker et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 17

muscle cell of larval thoracic ventral intersegmental muscle 5

(Hanlon and Andrew, 2016)

embryonic small intestine | surrounding

(Hanlon and Andrew, 2016)

embryonic stage 15

visceral trunk mesoderm

(Hanlon and Andrew, 2016)

muscle cell of embryonic/larval thoracic alary-related muscle T1

(Hanlon and Andrew, 2016)

Additional Descriptive Data

FoxL1 protein is detected in embryos in a muscle that was identified as prothoracic ventral intersegmental muscle 5 (VIS5). It is also detected in mesodermal cells surrounding the small intestine, in the region of the visceral mesoderm where the gastric caeca form, and in cells dorsal to the salivary gland likely to be alary muscle TARM T1.

(Hanlon and Andrew, 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Hanlon and Andrew, 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FoxL1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FoxL1

View exonic expression by tissue for Dmel\FoxL1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004895

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38471/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004895

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004895

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004895

Flygut - An atlas of the Drosophila adult midgut

FBgn0004895

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FoxL1

Transgenic constructs containing regulatory region of FoxL1

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3L)ΔGr64

(Slone et al., 2007)

Df(3L)Exel6099

(Ryder, 2004.4.26)

Df(3L)FoxL1

(Hanlon and Andrew, 2016)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority live | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

FoxL1^GD4344

viable, with Scer\GAL4^Mef2.PR

FoxL1^GD4344

viable, with Scer\GAL4^pnr-MD237

FoxL1^GD4344

viable, with Scer\GAL4^tin.CΔ4

FoxL1^GD4344

Other Phenotypes

Allele

visible, with Scer\GAL4^Bx-MS1096

FoxL1^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

embryonic/larval hemocyte (with FoxL1^CR10.5)

FoxL1^del

embryonic/larval hemocyte (with FoxL1^del)

FoxL1^CR10.5

embryonic/larval salivary gland | embryonic stage, with Scer\GAL4^fkh.PH

FoxL1^UAS.cHa

embryonic/larval salivary gland | embryonic stage, with Scer\GAL4^{kirre-rP298-G4}

FoxL1^UAS.cHa

embryonic/larval salivary gland | embryonic stage, with Scer\GAL4^sns.PK

FoxL1^UAS.cHa

embryonic/larval salivary gland | embryonic stage, with Scer\GAL4^twi.PG

FoxL1^UAS.cHa

embryonic/larval salivary gland | embryonic stage (with FoxL1^CR10.5)

embryonic/larval salivary gland | embryonic stage (with FoxL1^del)

embryonic/larval salivary gland | embryonic stage (with FoxL1^mCh)

embryonic Malpighian tubule, with Scer\GAL4^twi.PG

FoxL1^UAS.cHa

embryonic Malpighian tubule (with FoxL1^CR10.5)

FoxL1^del

embryonic Malpighian tubule (with FoxL1^del)

FoxL1^CR10.5

germline cell | embryonic stage, with Scer\GAL4^twi.PG

FoxL1^UAS.cHa

germline cell | embryonic stage (with FoxL1^CR10.5)

FoxL1^del

germline cell | embryonic stage (with FoxL1^del)

germline cell | embryonic stage (with FoxL1^mCh)

FoxL1^del

wing, with Scer\GAL4^Bx-MS1096

FoxL1^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (52)

Hsap\FOXL1

7 of 14

Yes

Hsap\FOXI1

5 of 14

Yes

Hsap\FOXI2

5 of 14

Yes

Hsap\FOXI3

5 of 14

Yes

Hsap\FOXS1

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

Yes

Hsap\FOXJ1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Hsap\FOXM1

3 of 14

Yes

Hsap\FOXQ1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\FOXR2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (44)

Rnor\Foxl1

7 of 14

Yes

Rnor\Foxi1

6 of 14

Yes

Rnor\Foxi3

6 of 14

Yes

Rnor\Foxc1

5 of 14

Rnor\Foxc2

5 of 14

Rnor\Foxs1

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Rnor\Foxd3

3 of 14

Rnor\Foxd4

3 of 14

Yes

Rnor\Foxe3

3 of 14

Rnor\Foxh1

3 of 14

Yes

Rnor\Foxi2

3 of 14

Yes

Rnor\Foxj2

3 of 14

Rnor\Foxm1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Foxr1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Upk2

1 of 14

Yes

Mus musculus (laboratory mouse) (45)

Mmus\Foxl1

7 of 14

Yes

Mmus\Foxi1

6 of 14

Yes

Mmus\Foxi2

6 of 14

Yes

Mmus\Foxc1

5 of 14

Mmus\Foxc2

5 of 14

Mmus\Foxi3

5 of 14

Yes

Mmus\Foxl3

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Mmus\Foxj1

3 of 14

Yes

Mmus\Foxj2

3 of 14

Mmus\Foxj3

3 of 14

Mmus\Foxm1

3 of 14

Yes

Mmus\Foxq1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Foxr2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (55)

Xtro\foxi1

5 of 13

Yes

Xtro\foxi2

5 of 13

Yes

Xtro\foxi4.1

5 of 13

Yes

Xtro\foxi4.2

5 of 13

Yes

Xtro\foxl1

5 of 13

Yes

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\foxj2

2 of 13

Xtro\foxk2

2 of 13

Xtro\foxl3-ot1

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\foxr1

1 of 13

Yes

Xtro\LOC101730723

1 of 13

Yes

Xtro\nop2

1 of 13

Xtro\nup214

1 of 13

Xtro\ppard

1 of 13

Yes

Xtro\vegfd

1 of 13

Danio rerio (Zebrafish) (63)

Drer\foxl1

7 of 14

Yes

Drer\foxi3a

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

Yes

Drer\foxi3b

5 of 14

Yes

Drer\foxl2b

5 of 14

Yes

Drer\foxl3

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\foxj3

3 of 14

Drer\foxm1

3 of 14

Yes

Drer\si:ch211-145o7.3

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\foxq1b

2 of 14

Yes

Drer\foxr1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\fkh-6

5 of 14

Yes

Cele\fkh-10

4 of 14

Cele\let-381

4 of 14

Cele\pes-1

4 of 14

Yes

Cele\unc-130

4 of 14

Cele\fkh-2

3 of 14

Cele\fkh-3

3 of 14

Yes

Cele\fkh-4

3 of 14

Yes

Cele\fkh-8

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\daf-16

1 of 14

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP006786

6 of 12

Yes

5 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\AT3G07260

1 of 13

Yes

Atha\FHA2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\FKH1

6 of 13

Yes

Scer\FKH2

5 of 13

Scer\HCM1

5 of 13

Scer\FHL1

2 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\mei4

7 of 12

Yes

Spom\sep1

6 of 12

Yes

Spom\fkh2

5 of 12

Spom\fhl1

3 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:FoxL1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

fkh

6 of 13

CG32006

4 of 13

jumu

4 of 13

bin

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

FOXL1; forkhead box L1

model of otosclerosis 11

IEA

(FlyBase, 2019-)

FOXI1; forkhead box I1

model of autosomal recessive nonsyndromic deafness 4

IEA

(FlyBase, 2019-)

FOXJ1; forkhead box J1

model of primary ciliary dyskinesia 43

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FOXL1; forkhead box L1

7 of 14

603252

OTOSCLEROSIS 11; OTSC11

otosclerosis 11

FOXI1; forkhead box I1

5 of 14

601093

DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT; DFNB4

autosomal recessive nonsyndromic deafness 4

FOXI2; forkhead box I2

5 of 14

617202

FOXI3; forkhead box I3

5 of 14

612351

CRANIOFACIAL MICROSOMIA 2; CFM2

FOXS1; forkhead box S1

5 of 14

602939

FOXC1; forkhead box C1

4 of 14

601090

FOXC2; forkhead box C2

4 of 14

602402

LYMPHEDEMA-DISTICHIASIS SYNDROME; LPHDST

lymphedema-distichiasis syndrome

FOXD1; forkhead box D1

4 of 14

601091

FOXD2; forkhead box D2

4 of 14

602211

FOXD3; forkhead box D3

4 of 14

611539

AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 1; AIS1

FOXD4; forkhead box D4

4 of 14

601092

FOXD4L1; forkhead box D4 like 1

4 of 14

611084

FOXD4L3; forkhead box D4 like 3

4 of 14

611086

FOXD4L4; forkhead box D4 like 4

4 of 14

611085

FOXD4L5; forkhead box D4 like 5

4 of 14

FOXD4L6; forkhead box D4 like 6

4 of 14

FOXE1; forkhead box E1

4 of 14

602617

Bamforth-Lazarus syndrome

FOXE3; forkhead box E3

4 of 14

601094

FOXG1; forkhead box G1

4 of 14

164874

RETT SYNDROME, CONGENITAL VARIANT

FOXK1; forkhead box K1

4 of 14

616302

FOXK2; forkhead box K2

4 of 14

147685

FOXF1; forkhead box F1

3 of 14

601089

ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS; ACDMPV

persistent fetal circulation syndrome

FOXH1; forkhead box H1

3 of 14

603621

FOXJ1; forkhead box J1

3 of 14

602291

CILIARY DYSKINESIA, PRIMARY, 43; CILD43

primary ciliary dyskinesia 43

FOXJ2; forkhead box J2

3 of 14

619162

FOXJ3; forkhead box J3

3 of 14

616035

FOXL2; forkhead box L2

3 of 14

605597

FOXL3; forkhead box L3

3 of 14

FOXM1; forkhead box M1

3 of 14

602341

FOXQ1; forkhead box Q1

3 of 14

612788

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

FoxL1 - CG42726

two hybrid array

(Shokri et al., 2019)

FoxL1 - dmrt99B

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63957

DroID - A comprehensive database of gene and protein interactions.

FBgn0004895

MIST (protein-protein) - An integrated Molecular Interaction Database

38471

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-10

Cytogenetic map

64A4-64A4

Sequence location

3L:4,018,878..4,021,279 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64A4-64A4

Limits computationally determined from genome sequence between P{PZ}Sc2⁰⁵⁶³⁴ and P{PZ}l(3)rG166^rG166

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

64A-64A

(determined by in situ hybridisation)

(Hacker et al., 1992)

Experimentally Determined Recombination Data

Location

3-10

(FlyBase, 2016)

3-8.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

67726

y¹ w^*; P{FoxL1-GFP.FPTB}attP40

59524

y¹ w^*; Mi{MIC}FoxL1^MI14505

79886

y¹ sc^* v¹ sev²¹; P{TOE.GS02121}attP40

62164

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05171}attP40

605464

y¹ w^*; TI{CRIMIC.TG4.2}FoxL1^{CR71488-TG4.2}/TM3, Sb¹ Ser¹

FlyORF

F003483

M{UAS-FoxL1.ORF-CC}ZH-21F

F000274

M{UAS-FoxL1.ORF.3xHA.GW}ZH-86Fb

VDRC

v100862

P{KK103831}VIE-260B

v30553

w¹¹¹⁸; P{GD4344}v30553

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT06062

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004895

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004895

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hanlon and Andrew, 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

(Clark et al., 1993)

The 110 amino acid domain is split by an intron in fd64A.

(Hacker et al., 1992)

One of seven genes identified on basis of sequence similarity to the 110 amino acid forkhead domain that is conserved in the rodent hepatocyte enriched nuclear transcription factor.

(Hacker et al., 1992)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: fd64A CG1132

(Shue, 1999.11)

Source for identity of: FoxL1 fd64A

(Hanlon and Andrew, 2016)

Nomenclature comments

Etymology

Named as 'FoxL1' after the most related mammalian protein.

(Hanlon and Andrew, 2016)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG1132

(Keleman et al., 2009.8.5, Perkins et al., 2009)

Dmfd2

(Mazet et al., 2003)

FD2

(Mazet et al., 2006, Mazet et al., 2006, Lee and Frasch, 2004, Kaufmann and Knoechel, 1996, Häcker, 1992.9.29, Hacker et al., 1992)

Fd64A

(Hanlon and Andrew, 2016)

FoxL1

(Janssen et al., 2022, Schomburg et al., 2022, Bilder et al., 2021, Shokri et al., 2019, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Hanlon and Andrew, 2016, Mazet et al., 2006, Mazet et al., 2006)

fd2

(Mazet et al., 2006, Mazet et al., 2006)

fd64A

(Sutton et al., 2024, Yue et al., 2022, Bischof et al., 2018, Karaiskos et al., 2017, Schertel et al., 2015, Zhu et al., 2012, Slone et al., 2007, Copley, 2005, Hoskins et al., 2005, Lee and Frasch, 2004)

foxL1

(Hanlon and Andrew, 2016)

Name Synonyms

Forkhead box L1

forkhead domain 64A

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38471

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

M96441

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q02360

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q02360

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

D3PFH7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q02360

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004895

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38471/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004895

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004895

FlyMine - An integrated database for Drosophila genomics

FBgn0004895

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1132

MARRVEL_MODEL - MARRVEL (model organism gene)

38471

Linkouts

BioGRID - A database of protein and genetic interactions.

63957

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004895

DroID - A comprehensive database of gene and protein interactions.

FBgn0004895

DRSC - Results frm RNAi screens

FBgn0004895

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

fd64A_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004895

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004895

Flygut - An atlas of the Drosophila adult midgut

FBgn0004895

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031071

MIST (protein-protein) - An integrated Molecular Interaction Database

38471

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

4.90

Report Sections