FB2026_02 , released June 18, 2026
Allele: Dmel\FoxL1mCh
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General Information
Symbol
Dmel\FoxL1mCh
Species
D. melanogaster
Name
FlyBase ID
FBal0325092
Feature type
allele
Associated gene
Dmel\FoxL1
Associated Insertion(s)
TI{mCherry}FoxL1mCh
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hanlon and Andrew, 2016)
Mutagen
gene targeting by homologous recombination
(Hanlon and Andrew, 2016)
CRISPR/Cas9
(Hanlon and Andrew, 2016)
Progenitor genotype
Associated Insertion(s)
TI{mCherry}FoxL1mCh
Cytology
Description

All but the N-terminal region of the FoxL1 ORF is replaced with the mCherry ORF, cloned in frame, resulting in a FoxL1 protein null allele that expresses mCherry in the same cells that normally express FoxL1.

(Hanlon and Andrew, 2016)
Allele components
Component
Use(s)
Inserted element
TI{mCherry}
Encoded product / tool
mCherry
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neither the FoxL1mCh heterozygous nor homozygous mutant embryos show any apparent defects in the muscle morphology.

      FoxL1CR10.5/FoxL1mCh or FoxL1del/FoxL1mCh transheterozygous embryos show high frequency of defects in the salivary gland lumen (including variations in lumen diameter, bending/folding or occasional branching of the lumen) as well as defects in germ cell migration compared to wild-type controls.

      (Hanlon and Andrew, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      FoxL1mCh
      (Hanlon and Andrew, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)