FlyBase Gene Report: Dmel\CHES-1-like

General Information

Symbol

Dmel\CHES-1-like

Species

D. melanogaster

Name

Checkpoint suppressor 1-like

Annotation Symbol

CG12690

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029504

Gene Model Status

Current

Stock Availability

27 publicly available

Gene Summary

Checkpoint suppressor 1-like (CHES-1-like) encodes a transcription factor that regulates the division of cardiac progenitor cells and dpp transcription in testis. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

anon- EST:Posey7

Key Links

Genomic Location

Cytogenetic map

7B6-7B6

Sequence location

X:7,682,338..7,709,385 [-]

Recombination map

1-20

RefSeq locus

NC_004354 REGION:7682338..7709385

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables transcription cis-regulatory region binding

inferred from direct assay

(Zhu et al., 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN009188255

(GO Reference Genome Project, 2011-)

enables DNA-binding transcription factor activity

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456, InterPro:IPR047119

(InterPro Project Members, 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN009188255

(GO Reference Genome Project, 2011-)

enables sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in cellular response to hypoxia

inferred from mutant phenotype

(Lee et al., 2008)

involved_in embryonic heart tube development

inferred from mutant phenotype

(Ahmad et al., 2012)

involved_in mitotic G1 DNA damage checkpoint signaling

inferred from genetic interaction with FLYBASE:Mnn1; FB:FBgn0031885

(Busygina et al., 2006)

involved_in regulation of cell division

inferred from mutant phenotype

(Ahmad et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456, InterPro:IPR047119

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN009188255

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN009188255

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Checkpoint suppressor 1-like (CHES-1-like) encodes a transcription factor that regulates the division of cardiac progenitor cells and dpp transcription in testis. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

FORK HEAD BOX TRANSCRIPTION FACTORS -: The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CHES-1-like for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W3Q5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.42

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CHES-1-like-RA

FBtr0071079

NM_078516

5064

1268

CHES-1-like-RB

FBtr0112946

NM_206639

6451

1268

CHES-1-like-RC

FBtr0310287

NM_001272383

7773

1267

CHES-1-like-RD

FBtr0333203

NM_001272382

6398

1268

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CHES-1-like-PA

FBpp0071036

130.0

1268

8.26

FBpp0111859

130.0

1268

8.26

FBpp0301970

129.9

1267

8.26

FBpp0305405

130.0

1268

8.26

Q9W3Q5

NP_001259311

AGB95156

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1268 aa isoforms: CHES-1-like-PA, CHES-1-like-PB, CHES-1-like-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CHES-1-like using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.84

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 3

organism | ubiquitous | uniform

Comment: maternally deposited

(Ahmad et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

proventriculus anlage

(Fisher et al., 2012)

embryonic stage 8 -- 9

embryonic hemocyte primordium

(Lee and Frasch, 2004)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

embryonic stage 10 -- 12

presumptive embryonic salivary gland

(Lee and Frasch, 2004)

embryonic stage 11

somatic trunk mesoderm | dorsal

(Lee and Frasch, 2004)

cardiogenic mesoderm

(Ahmad et al., 2012)

fusion competent cell

(Ahmad et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

cardiogenic mesoderm

(Ahmad et al., 2012)

fusion competent cell

(Zhu et al., 2012)

embryonic stage 12

cardiogenic mesoderm

(Zhu et al., 2012)

embryonic stage 12 -- 14

somatic muscle primordium

(Lee and Frasch, 2004)

embryonic stage 13

embryonic hindgut | anterior

(Lee and Frasch, 2004)

endoderm

(Ahmad et al., 2012)

embryonic stage 13 -- 16

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

embryonic stage 16 -- 17

embryonic/larval salivary gland

(Ahmad et al., 2012)

Additional Descriptive Data

Ches-1-like transcript is first expressed at embryonic stage 8 occurs at stage 8, in the embryonic hemocyte primordium; this expression ends with the delamination and migration of embryonic hemocytes. Ches-1-like transcript is expressed in th salivary gland placodes from embryonic stage 10 though the invagination of the salivary gland primordia during stage 11-12. Expression is observed at stage 11 in the dorsal somatic mesoderm, continuing through stage 12 in a segmentally repeated pattern in the dorsoventral somatic muscle primordium. This pattern declines between stage 13 and 14, when transcript expression appears in the anterior embryonic hindgut.

(Lee and Frasch, 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CHES-1-like in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CHES-1-like

View exonic expression by tissue for Dmel\CHES-1-like

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029504

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31678/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029504

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029504

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029504

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12690

Flygut - An atlas of the Drosophila adult midgut

FBgn0029504

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 31 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CHES-1-like

Transgenic constructs containing regulatory region of CHES-1-like

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)CHES-1-like¹

(Ahmad et al., 2012)

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

CHES-1-like^GD4327

Sterility

Allele

male semi-fertile, with Scer\GAL4^VP16.bam

CHES-1-like^UAS.Tag:HA

male semi-fertile, with Scer\GAL4^{VP16.nanos.UTR}

CHES-1-like^UAS.Tag:HA

Other Phenotypes

Allele

hyperplasia | adult stage | male, with Scer\GAL4^VP16.bam

CHES-1-like^UAS.Tag:HA

hyperplasia | adult stage | male, with Scer\GAL4^{VP16.nanos.UTR}

CHES-1-like^UAS.Tag:HA

some die during pupal stage, with Scer\GAL4^pnr-MD237

CHES-1-like^GD4327

visible, with Scer\GAL4^Bx-MS1096

CHES-1-like^{UAS.ORF.GW.Tag:HA}

visible, with Scer\GAL4^GMR.PF

CHES-1-like^GS1023

visible | adult stage, with Scer\GAL4^Bx-MS1096

CHES-1-like^UAS.Tag:HA

visible | cold sensitive, with Scer\GAL4^Bx-MS1096

CHES-1-like^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PF

CHES-1-like^GS1023

larval cardial cell, with Scer\GAL4^HCH.Hand, Scer\GAL4^tin.D

CHES-1-like^KK101264

larval pericardial cell, with Scer\GAL4^HCH.Hand, Scer\GAL4^tin.D

CHES-1-like^KK101264

spermatid, with Scer\GAL4^{VP16.nanos.UTR}

CHES-1-like^UAS.Tag:HA

testis | adult stage, with Scer\GAL4^VP16.bam

CHES-1-like^UAS.Tag:HA

testis | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

CHES-1-like^UAS.Tag:HA

wing, with Scer\GAL4^Bx-MS1096

CHES-1-like^{UAS.ORF.GW.Tag:HA}

wing | cold sensitive, with Scer\GAL4^Bx-MS1096

CHES-1-like^{UAS.ORF.GW.Tag:HA}

wing blade, with Scer\GAL4^Bx-MS1096

CHES-1-like^UAS.Tag:HA

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (45)

Hsap\FOXN2

4 of 14

Yes

Hsap\FOXN3

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (38)

Rnor\Foxn3

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (44)

Mmus\Foxn2

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Mmus\Foxq1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (46)

Xtro\foxn2

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101730723

1 of 13

Yes

Xtro\nop2

1 of 13

Xtro\nr2f6

1 of 13

Xtro\ppard

1 of 13

Yes

Xtro\vegfd

1 of 13

Danio rerio (Zebrafish) (54)

Drer\si:ch211-145o7.3

5 of 14

Yes

Drer\foxk1

4 of 14

Drer\foxk2a

4 of 14

Drer\foxn2a

4 of 14

Yes

Drer\foxn2b

4 of 14

Yes

Drer\foxn3

4 of 14

Yes

Drer\ches1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\foxq1b

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\let-381

3 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP013178

8 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\AT3G07260

1 of 13

Yes

Atha\FHA2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\FKH2

2 of 13

Yes

Scer\FHL1

1 of 13

Scer\FKH1

1 of 13

Scer\HCM1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\fkh2

2 of 12

Yes

Spom\sep1

2 of 12

Yes

Spom\fhl1

1 of 12

Spom\mei4

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CHES-1-like. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

FoxK

4 of 13

slp1

3 of 13

slp2

3 of 13

bin

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

fkh

1 of 13

foxo

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

azoospermia and testicular germ cell cancer (postulated), FOXN3-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FOXN2; forkhead box N2

4 of 14

143089

FOXN3; forkhead box N3

4 of 14

602628

FOXD1; forkhead box D1

3 of 14

601091

FOXI1; forkhead box I1

3 of 14

601093

DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT; DFNB4

autosomal recessive nonsyndromic deafness 4

FOXI2; forkhead box I2

3 of 14

617202

FOXI3; forkhead box I3

3 of 14

612351

CRANIOFACIAL MICROSOMIA 2; CFM2

FOXK1; forkhead box K1

3 of 14

616302

FOXK2; forkhead box K2

3 of 14

147685

FOXQ1; forkhead box Q1

3 of 14

612788

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CHES-1-like

enhanceable

bam

(Yu et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zhu et al., 2005)

enhanceable

(Gregory et al., 2007)

Pvr

suppressible

CHES-1-like

(Zhu et al., 2005)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029504

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

UCH proteinases

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-20

Cytogenetic map

7B6-7B6

Sequence location

X:7,682,338..7,709,385 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7B6-7B6

Limits computationally determined from genome sequence between P{EP}CBP^EP1643&P{EP}EP1523^EP1523 and P{EP}CHES-1-like^EP1453

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-20

(FlyBase, 2016)

1-21.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (27)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41230

w¹¹¹⁸; P{GMR39H04-GAL4}attP2

50102

w¹¹¹⁸; P{GMR40H02-GAL4}attP2

75734

w¹¹¹⁸; P{R39H04-p65.AD}attP40

69443

w¹¹¹⁸; P{R39H04-GAL4.DBD}attP2

69816

w¹¹¹⁸; P{R40H02-GAL4.DBD}attP2

54671

w¹¹¹⁸; P{GMR39H04-lexA}attP40/CyO

26760

y¹ v¹; P{TRiP.JF02324}attP2

17217

w¹¹¹⁸ P{EP}CHES-1-like^EP1342

FlyORF

F004545

M{UAS-CHES-1-like.ORF-CC}ZH-21F

12690R-2

v105641

v15742

w¹¹¹⁸; P{GD4327}v15742

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (26)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029504

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029504

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

CHES-1-like is required during asymmetric cell division for the derivation of two distinct cardial cells types (svp-expressing cardial cell and svp-expressing pericardial cell) from their mutual precursor. It is also required in symmetric cell divisions that produce the tin-expressing cardial cells. CHES-1-like controls the division of the cardiac progenitors by regulating the activity of polo.

(Ahmad et al., 2012)

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: CHES-1-like CG12690

(Bayraktaroglu, 2000.4.12)

Source for merge of: CHES-1-like anon- EST:Posey7

(FlyBase Genome Annotators, 2005)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG12690

(Ni et al., 2011.7.19, Slack et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Lee et al., 2008, Gregory et al., 2007, Larschan et al., 2007, Larschan et al., 2007, Kim et al., 2004, Ramet et al., 2002)

Ches-1-like

(Burghardt et al., 2023, Ma et al., 2021, Lee and Frasch, 2004)

Ches1

(Busygina et al., 2006)

Dmches-1

(Mazet et al., 2003)

FoxN

(Lee and Frasch, 2004)

FoxN23

(Janssen et al., 2022)

anon-EST:Posey7

(Ashburner, 2004.6.30)

ches1

(Kottemann et al., 2006)

Name Synonyms

Checkpoint suppressor 1-like

(Schomburg et al., 2022)

Checkpoint suppressor homologue

(Schorpp, 1999.12.25)

ches-1-like

(Slack et al., 2010)

Secondary FlyBase IDs

FBgn0027673
FBgn0029954

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31678

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W3Q5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W3Q5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029504

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31678/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029504

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029504

FlyMine - An integrated database for Drosophila genomics

FBgn0029504

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12690

MARRVEL_MODEL - MARRVEL (model organism gene)

31678

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029504

DroID - A comprehensive database of gene and protein interactions.

FBgn0029504

DRSC - Results frm RNAi screens

FBgn0029504

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029504

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029504

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12690

Flygut - An atlas of the Drosophila adult midgut

FBgn0029504

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029504

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032748

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

UCH proteinases

References (85)

The following external sites may use different assemblies or annotations than FlyBase.

-1.84

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