FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

cellular response to hypoxia

ID (Ontology)

GO:0071456 (Gene Ontology)

Definition

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

Also Known As

"cellular response to hypoxic stress" ; "cellular response to lowered oxygen tension"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
cellular response to hypoxia (all annotations which use CV term, excluding "NOT" statements)
involved_in \| cellular response to hypoxia

Spanning Tree (Parents/Children)

response to stress
 |__response to hypoxia___________________________
 |__cellular response to stress___________________|
response to decreased oxygen levels               |
 |__response to hypoxia___________________________|
 |__cellular response to decreased oxygen levels__|
cellular response to stimulus                     |
 |__cellular response to stress___________________|
cellular response to oxygen levels                |
 |__cellular response to decreased oxygen levels__|
                                                  cellular response to hypoxia  32 rec.
                                                   |__hypoxia-inducible factor-1alpha signaling pathway
                                                   |   |__regulation of hypoxia-inducible factor-1alpha signaling pathway(+)
                                                   |__intrinsic apoptotic signaling pathway in response to hypoxia
                                                   |   |__regulation of hypoxia-induced intrinsic apoptotic signaling pathway(+)
                                                   |__regulation of cellular response to hypoxia 3 rec.
                                                       |__negative regulation of cellular response to hypoxia(+) 1 rec.
                                                       |__positive regulation of cellular response to hypoxia

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	response to hypoxia cellular response to stress cellular response to decreased oxygen levels
Part of
Synonyms & Secondary IDs
Synonyms
	"cellular response to hypoxic stress" EXACT "cellular response to lowered oxygen tension" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-1234174 "Cellular response to hypoxia"