FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\klu
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General Information
Symbol
Dmel\klu
Species
D. melanogaster
Name
klu transcription factor
Annotation Symbol
CG12296
Feature Type
protein_coding_gene
FlyBase ID
FBgn0013469
Gene Model Status
Current
Stock Availability
35 publicly available
Gene Summary
transcription factor - zinc finger - early growth response family - involved in determination of the identities of secondary precursor cells within neuroblast lineages in the central nervous system - a genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS (Interactive Fly, klu )
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

klumpfuss, l(3)10052, l(3)09036

Key Links
Genomic Location
Cytogenetic map
68A1-68A1
Sequence location
Recombination map
3-34
RefSeq locus
NT_037436 REGION:10981171..11009188
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables cis-regulatory region sequence-specific DNA binding
inferred from direct assay
(Janssens et al., 2017)
enables DNA-binding transcription repressor activity, RNA polymerase II-specific
inferred from direct assay
(Anderson et al., 2017)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Anderson et al., 2017)
enables sequence-specific DNA binding
inferred from mutant phenotype
(Janssens et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN002812688
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002812688
(GO Reference Genome Project, 2011-)
Biological Process (12 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in larval feeding behavior
inferred from mutant phenotype
(Melcher and Pankratz, 2005)
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Anderson et al., 2017)
involved_in neuroblast development
inferred from mutant phenotype
(Berger et al., 2012)
involved_in neurogenesis
inferred from mutant phenotype
(Xiao et al., 2012)
involved_in neuronal stem cell population maintenance
inferred from mutant phenotype
(Xiao et al., 2012)
involved_in positive regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Rusconi et al., 2004)
involved_in positive regulation of neuroblast proliferation
inferred from mutant phenotype
(Berger et al., 2012)
involved_in R7 cell differentiation
inferred from direct assay
(Anderson et al., 2017)
involved_in regulation of neuroblast proliferation
inferred from genetic interaction with UniProtKB:Q9VQ56
(Janssens et al., 2014)
inferred from mutant phenotype
(Janssens et al., 2017)
inferred from genetic interaction with UniProtKB:P42124
(Janssens et al., 2017)
inferred from genetic interaction with UniProtKB:Q26263
(Janssens et al., 2017)
inferred from genetic interaction with UniProtKB:Q94517
(Janssens et al., 2017)
involved_in regulation of stem cell division
inferred from mutant phenotype
(Berger et al., 2012)
involved_in sensory organ precursor cell fate determination
inferred from mutant phenotype
(Kaspar et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002812688
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Yang et al., 1997)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Summary (Interactive Fly)

transcription factor - zinc finger - early growth response family - involved in determination of the identities of secondary precursor cells within neuroblast lineages in the central nervous system - a genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\klu for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PF84)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.46

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
klu-RA
FBtr0076247
NM_057714
3870
803
klu-RB
FBtr0330080
NM_001274761
3870
818
klu-RC
FBtr0333361
NM_001274762
4437
803
klu-RD
FBtr0345346
NM_001300095
4792
803
Additional Transcript Data and Comments
Reported size (kB)

4.9, 4.5 (northern blot)

(Klein and Campos-Ortega, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
klu-PA
FBpp0075976
88.6
803
7.19
Q9VTD3
NP_477062
AAF50119
klu-PB
FBpp0303113
90.2
818
7.29
M9PF84
NP_001261690
AGB94384
klu-PC
FBpp0305553
88.6
803
7.19
Q9VTD3
NP_001261691
AGB94385
klu-PD
FBpp0311501
88.6
803
7.19
Q9VTD3
NP_001287024
AHN58049
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

803 aa isoforms: klu-PA, klu-PC, klu-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

750 (aa)

(Klein and Campos-Ortega, 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\klu using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.44

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic ganglion mother cell
(Fisher et al., 2012)
embryonic neuroblast of central brain primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain surface glial cell
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic neuroblast of embryonic central brain
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
neuroblast of ventral nervous system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
neuroblast
(Klein and Campos-Ortega, 1997)
proneural cluster
(Klein and Campos-Ortega, 1997)
scutum | presumptive
(Klein and Campos-Ortega, 1997)
leg disc | restricted
(Klein and Campos-Ortega, 1997)
antennal disc | restricted
(Klein and Campos-Ortega, 1997)
larval brain | restricted
(Klein and Campos-Ortega, 1997)
humeral disc | restricted
(Klein and Campos-Ortega, 1997)
wing disc | restricted
(Klein and Campos-Ortega, 1997)
eye disc | restricted
(Klein and Campos-Ortega, 1997)
embryonic/larval optic lobe | restricted
(Klein and Campos-Ortega, 1997)
wing vein L1 | presumptive
(Klein and Campos-Ortega, 1997)
scutellum | precursor
(Klein and Campos-Ortega, 1997)
tarsal segment | precursor
(Klein and Campos-Ortega, 1997)
eye disc posterior to the morphogenetic furrow
(Klein and Campos-Ortega, 1997)
wandering third instar larval stage
wing pouch | restricted
(Molnar et al., 2012)
wing hinge primordium | restricted
(Molnar et al., 2012)
pupal stage
photoreceptor neuron

Comment: low level of expression

(Rusconi et al., 2004)
primary pigment cell

Comment: high level of expression

(Rusconi et al., 2004)
secondary pigment cell
(Rusconi et al., 2004)
tertiary pigment cell
(Rusconi et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Klein and Campos-Ortega, 1997)
single cell RNA-seq
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
enteroblast
(Xu et al., 2019)
Additional Descriptive Data

klu expression never observed in cone cells or bristle groups. During the early stages of interommatidial PCD (24â 28 h APF), adjoining secondary pigment cell and tertiary pigment cell precursors began to show differing levels of klu mRNA; this difference is even more dramatic at stages of maximal PCD (28â 30 h).

(Rusconi et al., 2004)

klu transcripts are expressed in a complex and dynamic pattern throughout much of larval and imaginal development. The imaginal disc pattern is described in detail. Early in third instar larvae, expression is observed in the prospective wing area of the wing disc. Shortly thereafter, it is restricted to the prospective margin and hinge of the wing. About the same time, expression is observed in the anlagen of the notum and scutellum. Expression is observed in most proneural clusters at or shortly after the time of ac expression. klu expression in these regions precedes the appearance of SOPs and is not continued in the SOPs themselves. Expression in leg discs also starts early in the third instar. The klu expression domain occupies a wedge-like sector encompassing about 1/3 of the circumference of the leg disc. Expression is in rings corresponding to the anlagen of the leg segments. Expression in the antennal and dorsal prothoracic discs also occurs in concentric domains. In eye discs, expression starts behind the morphogenetic furrow and extends through the whole anlage. Expression in the larval brain is restricted to the neuroblasts and the proliferation zone of the optic lobes.

(Klein and Campos-Ortega, 1997)

klu transcripts are detected from early stages onward with a peak at 10-12 hours of embryogenesis.

(Klein and Campos-Ortega, 1997)
Marker for
 
enteroblast
(Xu et al., 2019)
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic brain | restricted
(Yang et al., 1997)
larval ventral nerve cord | restricted
(Yang et al., 1997)
epidermis | restricted
(Yang et al., 1997)
pre-blastoderm stage
organism
• nucleus
(Yang et al., 1997)
embryonic stage 9 -- 11
tritocerebral neuroblast | subset
(Urbach and Technau, 2003)
deutocerebral neuroblast | subset
(Urbach and Technau, 2003)
protocerebral neuroblast | subset
(Urbach and Technau, 2003)
embryonic stage 9 -- 15
thoracic neuroblast NB5-6
(Losada-Pérez et al., 2013)
embryonic stage 10 -- 11
neuroblast NB5-3
(Yang et al., 1997)
neuroblast NB5-6
(Yang et al., 1997)
neuroblast NB3-5
(Yang et al., 1997)
neuroblast NB5-2
(Yang et al., 1997)
neuroblast NB7-4
(Yang et al., 1997)
neuroblast NB7-1
(Yang et al., 1997)
embryonic stage 10 -- 17
procephalic segment
(Yang et al., 1997)
neuroblast
(Yang et al., 1997)
embryonic stage 11
neuroblast NB6-1
(Yang et al., 1997)
neuroblast NB1-1
(Yang et al., 1997)
longitudinal glioblast
(Yang et al., 1997)
neuroblast NB3-1
(Yang et al., 1997)
neuroblast NB5-4

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB6-2
(Yang et al., 1997)
neuroblast NB1-2
(Yang et al., 1997)
neuroblast NB7-2
(Yang et al., 1997)
neuroblast NB4-2
(Yang et al., 1997)
neuroblast NB7-3

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB5-1

Comment: late stage 11

(Yang et al., 1997)
ganglion mother cell GMC4-2b
(Yang et al., 1997)
neuroblast NB2-1
(Yang et al., 1997)
neuroblast NB3-3

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB4-3

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB4-1
(Yang et al., 1997)
neuroblast NB3-2
(Yang et al., 1997)
neuroblast NB2-4

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB2-5
(Yang et al., 1997)
neuroblast NB5-5

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB4-4

Comment: late stage 11

(Yang et al., 1997)
neuroblast NB2-2
(Yang et al., 1997)
embryonic stage 12
apterous-expressing neuron of the lateral cluster of the thorax Ap1
(Losada-Pérez et al., 2013)
embryonic stage 13 -- 14
apterous-expressing neuron of the lateral cluster of the thorax Ap2
(Losada-Pérez et al., 2013)
embryonic stage 14 -- 15
apterous-expressing neuron of the lateral cluster of the thorax Ap3
(Losada-Pérez et al., 2013)
embryonic stage 15 -- 17
apterous-expressing neuron of the lateral cluster of the thorax Ap4
(Losada-Pérez et al., 2013)
embryonic stage 16
embryonic/larval posterior spiracle
(Yang et al., 1997)
third instar larval stage
medulla forming neuroblast | subset
(Suzuki et al., 2013)
type I neuroblast | subset of larval brain
(Xiao et al., 2012)
type II neuroblast | subset of larval brain
(Xiao et al., 2012)
intermediate neuronal progenitor | subset of larval brain
(Xiao et al., 2012)
photoreceptor cell R7
(Anderson et al., 2017)
eye disc
(Anderson et al., 2017)
wandering third instar larval stage
ganglion mother cell | subset of larval outer optic anlage
(Suzuki et al., 2013)
Additional Descriptive Data

klu-protein is expressed in the developing larval medulla in lateral neuroblasts adjacent to l(1)sc-positive neuroepithelium and gradually weakened in neuroblasts located in more medial regions. klu-protein is also detected in a small number of ganglion mother cells in the medulla anlage.

(Suzuki et al., 2013)

klu protein is first detected before the syncytial blastoderm stage. Staining disappears after cellularization. Expression reappears at stage 10 in a subset of neuroblasts and in the procephalic region. klu protein is also expressed in some ganglion mother cells including GMC4-2b.

(Yang et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Yang et al., 1997)
Expression Deduced from Reporters
Reporter: P{GAL4}kluG410
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval posterior spiracle
(Hombria et al., 2005)
embryonic stage 9 -- 17
neuroblast
(Klein and Campos-Ortega, 1997)
embryonic stage 14
posterior spiracle primordium
(Hu and Castelli-Gair, 1999)
larval stage -- pupal stage
leg disc | restricted
(Bishop et al., 1999)
third instar larval stage
imaginal disc
(Klein and Campos-Ortega, 1997)
humeral disc | restricted
(Klein and Campos-Ortega, 1997)
eye-antennal disc | restricted
(Klein and Campos-Ortega, 1997)
eye disc posterior to the morphogenetic furrow
(Klein and Campos-Ortega, 1997)
leg disc | restricted
(Klein and Campos-Ortega, 1997)
proneural cluster
(Klein and Campos-Ortega, 1997)
presumptive scutellum
(Klein and Campos-Ortega, 1997)
wing pouch
(Klein and Campos-Ortega, 1997)
mesothoracic tergum primordium
(Klein and Campos-Ortega, 1997)
presumptive wing margin
(Klein and Campos-Ortega, 1997)
wing hinge primordium
(Klein and Campos-Ortega, 1997)
presumptive tegula
(Klein and Campos-Ortega, 1997)
presumptive wing vein

Comment: veins 3 and 4

(Klein and Campos-Ortega, 1997)
presumptive tarsal segment 2
(Klein and Campos-Ortega, 1997)
presumptive tarsal segment 3
(Klein and Campos-Ortega, 1997)
presumptive tarsal segment 4
(Klein and Campos-Ortega, 1997)
presumptive tarsal segment 5
(Klein and Campos-Ortega, 1997)
neuroblast of larval brain
(Klein and Campos-Ortega, 1997)
embryonic/larval optic lobe | restricted

Comment: proliferation zone

(Klein and Campos-Ortega, 1997)
adult stage
leg joint
(Bishop et al., 1999)
adult enterocyte
(Reiff et al., 2019)
enteroblast of posterior adult midgut epithelium
(Reiff et al., 2019)
Reporter: P{lacW}kluP212
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 11
deutocerebral neuroblast | subset
(Urbach and Technau, 2003)
tritocerebral neuroblast | subset
(Urbach and Technau, 2003)
protocerebral neuroblast | subset
(Urbach and Technau, 2003)
embryonic stage 9 -- 17
neuroblast
(Klein and Campos-Ortega, 1997)
third instar larval stage
embryonic/larval optic lobe | restricted
(Klein and Campos-Ortega, 1997)
eye disc | restricted
(Klein and Campos-Ortega, 1997)
antennal disc | restricted
(Klein and Campos-Ortega, 1997)
proneural cluster
(Klein and Campos-Ortega, 1997)
neuroblast
(Klein and Campos-Ortega, 1997)
scutum | presumptive
(Klein and Campos-Ortega, 1997)
wing disc | restricted
(Klein and Campos-Ortega, 1997)
wing vein L1 | presumptive
(Klein and Campos-Ortega, 1997)
humeral disc | restricted
(Klein and Campos-Ortega, 1997)
larval brain | restricted
(Klein and Campos-Ortega, 1997)
leg disc | restricted
(Klein and Campos-Ortega, 1997)
imaginal disc
(Klein and Campos-Ortega, 1997)
scutellum | precursor
(Klein and Campos-Ortega, 1997)
tarsal segment | precursor
(Klein and Campos-Ortega, 1997)
eye disc posterior to the morphogenetic furrow
(Klein and Campos-Ortega, 1997)
Reporter: P{lacW}kluP819
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 17
neuroblast
(Klein and Campos-Ortega, 1997)
third instar larval stage
embryonic/larval optic lobe | restricted
(Klein and Campos-Ortega, 1997)
neuroblast
(Klein and Campos-Ortega, 1997)
eye disc | restricted
(Klein and Campos-Ortega, 1997)
scutum | presumptive
(Klein and Campos-Ortega, 1997)
wing disc | restricted
(Klein and Campos-Ortega, 1997)
antennal disc | restricted
(Klein and Campos-Ortega, 1997)
humeral disc | restricted
(Klein and Campos-Ortega, 1997)
proneural cluster
(Klein and Campos-Ortega, 1997)
larval brain | restricted
(Klein and Campos-Ortega, 1997)
imaginal disc
(Klein and Campos-Ortega, 1997)
leg disc | restricted
(Klein and Campos-Ortega, 1997)
scutellum | precursor
(Klein and Campos-Ortega, 1997)
tarsal segment | precursor
(Klein and Campos-Ortega, 1997)
eye disc posterior to the morphogenetic furrow
(Klein and Campos-Ortega, 1997)
Reporter: P{PZ}klu10052
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval cuticle
(Meister and Braun, 1995.10)
imaginal disc
(Meister and Braun, 1995.10)
larval brain
(Meister and Braun, 1995.10)
epidermis
(Meister and Braun, 1995.10)
larval somatic muscle cell
(Meister and Braun, 1995.10)
embryonic/larval hindgut
(Meister and Braun, 1995.10)
adult stage
third segment of antenna
(Vosshall, 1998.8.10)
adult brain | restricted
(Vosshall, 1998.8.10)
adult central complex
(Vosshall, 1998.8.10)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\klu in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of klu
Transgenic constructs containing regulatory region of klu
Aberrations (Deficiencies and Duplications) ( 15 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
partially lethal - majority die
partially lethal - majority die | recessive
viable
Other Phenotypes
Allele
abnormal feeding behavior | first instar larval stage
abnormal feeding behavior | larval stage
abnormal feeding behavior | larval stage (with Df(3L)kluXR19)
abnormal feeding behavior | larval stage (with klu212lR51C)
abnormal feeding behavior | larval stage (with klu09036)
abnormal feeding behavior | larval stage (with klu10052)
abnormal neuroanatomy, with Scer\GAL4GMR9D11
abnormal neuroanatomy | larval stage, with Scer\GAL4GMR9D11
abnormal neuroanatomy | larval stage, with Scer\GAL4wor.PA
abnormal neuroanatomy | larval stage (with klu212lR51C)
abnormal neuroanatomy | larval stage (with klu09036)
abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4Act5C.PP
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4insc-Mz1407
decreased body size | larval stage
decreased cell death
decreased cell growth rate, with Scer\GAL4hs.PB
decreased cell number | larval stage, with Scer\GAL4elav-C155
decreased cell size, with Scer\GAL4insc-Mz1407
decreased cell size | somatic clone
increased cell death, with Scer\GAL4GMR.PF
increased cell number, with Scer\GAL4insc-Mz1407
increased cell number | larval stage
visible
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4Bx-MS1096-KE
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4klu-G410
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-537.4
visible (with klu212lR51C)
visible (with kluG410)
visible | cold sensitive, with Scer\GAL4Bx-MS1096
visible | recessive
visible | somatic clone, with Scer\GAL4Tub.PU
Phenotype manifest in
Allele
adult head, with Scer\GAL4ey.PH
adult head, with Scer\GAL4pnr-MD237
adult thorax, with Scer\GAL4pnr-MD237
antennal sense organ
anterior sternopleural bristle
anterior supraalar bristle (with klu212lR51C)
anterior supraalar bristle (with kluG410)
basal cylinder
chaeta, with Scer\GAL4klu-G410
chaeta | ectopic, with Scer\GAL4Bx-MS1096-KE
chaeta | ectopic, with Scer\GAL4klu-G410
chaeta | ectopic, with Scer\GAL4sca-537.4
chaeta | ectopic | somatic clone, with Scer\GAL4Tub.PU
chaeta | increased number, with Scer\GAL4klu-G410
chaeta | somatic clone | increased number, with Scer\GAL4Tub.PU
external sensory organ precursor cell, with Scer\GAL4klu-G410
external sensory organ precursor cell, with Scer\GAL4sca-537.4
external sensory organ precursor cell | increased number, with Scer\GAL4klu-G410
external sensory organ precursor cell | somatic clone | increased number, with Scer\GAL4Act5C.PI
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
femur
ganglion mother cell GMC4-2b
interommatidial bristle, with Scer\GAL4GMR.PF
larval neuroblast | larval stage (with klu212lR51C)
larval neuroblast | larval stage (with klu09036)
larval neuroblast | somatic clone | third instar larval stage
larval neuroblast | third instar larval stage, with Scer\GAL4insc-Mz1407
larval neuroblast | third instar larval stage (with klu212lR51C)
larval neuroblast | third instar larval stage (with kluG410)
larval RP2 motor neuron
larval RP2 motor neuron, with Scer\GAL4ftz.ng
larval RP2 motor neuron of abdominal 1 neuromere
larval RP2 motor neuron of abdominal 2 neuromere
larval RP2 motor neuron of abdominal 3 neuromere
larval RP2 motor neuron of abdominal 4 neuromere
larval RP2 motor neuron of abdominal 5 neuromere
larval RP2 motor neuron of abdominal 6 neuromere
larval RP2 motor neuron of abdominal 7 neuromere
lens, with Scer\GAL4GMR.PF
macrochaeta
macrochaeta | increased number, with Scer\GAL4klu-G410
medulla anlage | somatic clone
mesothoracic leg sensillum
metatarsus | distal
metathoracic leg sensillum
microchaeta | increased number, with Scer\GAL4klu-G410
neuroblast | ectopic | somatic clone
neuron | decreased number | larval stage, with Scer\GAL4elav-C155
neuron | increased number | larval stage
ommatidium
ommatidium | heat sensitive
ommatidium | somatic clone, with Scer\GAL4Tub.PU
presutural bristle
presutural bristle (with klu212lR51C)
presutural bristle (with kluG410)
presutural bristle sensory mother cell (with klu212lR51C)
presutural bristle sensory mother cell (with kluG410)
pretarsus
prothoracic leg sensillum
retina, with Scer\GAL4GMR.PF
rhabdomere R7, with Scer\GAL4Rh3.PP
salivary gland, with Scer\GAL4hs.PB
sex comb
subesophageal zone neuron
supraalar bristle sensory mother cell (with klu212lR51C)
supraalar bristle sensory mother cell (with kluG410)
tarsal segment
tarsal segment 3
tarsal segment 4
tibia
trichome of the posterior wing margin | increased number, with Scer\GAL4klu-G410
trochanter
type II neuroblast, with Scer\GAL4GMR9D11
type II neuroblast | increased number, with Scer\GAL4wor.PA
type II neuroblast | larval stage | increased number, with Scer\GAL4GMR9D11
type II neuroblast | larval stage | increased number, with Scer\GAL4wor.PA
type II neuroblast | larval stage | somatic clone | increased number, with Scer\GAL4Act5C.PP
type II neuroblast | third instar larval stage, with Scer\GAL4insc-Mz1407
type I neuroblast | third instar larval stage, with Scer\GAL4insc-Mz1407
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4Bx-MS1096-KE
wing | cold sensitive, with Scer\GAL4Bx-MS1096
wing margin bristle
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (165)
Hsap\ZBTB7A
2 of 14
Yes
Yes
1  
Hsap\ZBTB14
2 of 14
Yes
Yes
Hsap\ANP32A
1 of 14
No
No
Hsap\ANP32B
1 of 14
No
No
Hsap\ANP32C
1 of 14
No
No
Hsap\ANP32D
1 of 14
No
No
Hsap\BCL6B
1 of 14
No
Yes
Hsap\CFAP410
1 of 14
No
No
Hsap\CNTRL
1 of 14
No
No
Hsap\DRC3
1 of 14
No
No
Hsap\EGR1
1 of 14
No
No
Hsap\EGR3
1 of 14
No
No
Hsap\FEZF2
1 of 14
No
No
Hsap\IKZF2
1 of 14
No
No
Hsap\KLF9
1 of 14
No
No
Hsap\KLF11
1 of 14
No
No
Hsap\KLF12
1 of 14
No
No
1  
Hsap\KLF17
1 of 14
No
No
Hsap\KLF18
1 of 14
No
No
Hsap\LRRC23
1 of 14
No
No
Hsap\LRRC46
1 of 14
No
No
Hsap\LRRC56
1 of 14
No
No
Hsap\LRRC61
1 of 14
No
No
Hsap\MECOM
1 of 14
No
No
Hsap\MYNN
1 of 14
No
No
Hsap\MZF1
1 of 14
No
No
Hsap\OSR1
1 of 14
No
No
Hsap\PRDM6
1 of 14
No
No
Hsap\PRDM12
1 of 14
No
No
5  
Hsap\RREB1
1 of 14
No
No
1  
Hsap\SALL1
1 of 14
No
No
Hsap\SCRT1
1 of 14
No
No
Hsap\SCRT2
1 of 14
No
No
1  
Hsap\SNAI1
1 of 14
No
No
Hsap\SNRPA1
1 of 14
No
No
2  
Hsap\SP1
1 of 14
No
No
0  
Hsap\SP4
1 of 14
No
No
Hsap\SP6
1 of 14
No
No
Hsap\WT1
1 of 14
No
No
2  
Hsap\ZBTB5
1 of 14
No
Yes
Hsap\ZBTB7B
1 of 14
No
Yes
1  
Hsap\ZBTB7C
1 of 14
No
Yes
Hsap\ZBTB17
1 of 14
No
Yes
Hsap\ZBTB38
1 of 14
No
Yes
Hsap\ZBTB43
1 of 14
No
Yes
Hsap\ZBTB44
1 of 14
No
No
Hsap\ZBTB46
1 of 14
No
Yes
Hsap\ZBTB49
1 of 14
No
Yes
Hsap\ZFP3
1 of 14
No
No
Hsap\ZFP14
1 of 14
No
No
Hsap\ZFP28
1 of 14
No
No
Hsap\ZFP69
1 of 14
No
No
Hsap\ZFP90
1 of 14
No
No
Hsap\ZFP92
1 of 14
No
No
Hsap\ZKSCAN8
1 of 14
No
No
Hsap\ZNF2
1 of 14
No
No
Hsap\ZNF8
1 of 14
No
No
Hsap\ZNF34
1 of 14
No
Yes
Hsap\ZNF45
1 of 14
No
No
Hsap\ZNF57
1 of 14
No
Yes
Hsap\ZNF74
1 of 14
No
No
Hsap\ZNF75A
1 of 14
No
No
Hsap\ZNF76
1 of 14
No
No
Hsap\ZNF79
1 of 14
No
No
Hsap\ZNF92
1 of 14
No
No
Hsap\ZNF112
1 of 14
No
No
Hsap\ZNF121
1 of 14
No
Yes
Hsap\ZNF132
1 of 14
No
No
Hsap\ZNF135
1 of 14
No
No
Hsap\ZNF143
1 of 14
No
Yes
Hsap\ZNF155
1 of 14
No
No
Hsap\ZNF169
1 of 14
No
No
Hsap\ZNF181
1 of 14
No
Yes
Hsap\ZNF184
1 of 14
No
No
Hsap\ZNF197
1 of 14
No
No
Hsap\ZNF205
1 of 14
No
No
Hsap\ZNF214
1 of 14
No
No
Hsap\ZNF224
1 of 14
No
No
Hsap\ZNF226
1 of 14
No
No
Hsap\ZNF234
1 of 14
No
No
Hsap\ZNF236
1 of 14
No
Yes
Hsap\ZNF251
1 of 14
No
No
Hsap\ZNF263
1 of 14
No
No
Hsap\ZNF274
1 of 14
No
No
Hsap\ZNF281
1 of 14
No
Yes
1  
Hsap\ZNF287
1 of 14
No
No
Hsap\ZNF302
1 of 14
No
Yes
Hsap\ZNF311
1 of 14
No
No
Hsap\ZNF316
1 of 14
No
No
Hsap\ZNF320
1 of 14
No
No
Hsap\ZNF324
1 of 14
No
No
Hsap\ZNF329
1 of 14
No
No
Hsap\ZNF341
1 of 14
No
No
Hsap\ZNF366
1 of 14
No
Yes
1  
Hsap\ZNF367
1 of 14
No
No
Hsap\ZNF383
1 of 14
No
No
Hsap\ZNF396
1 of 14
No
Yes
Hsap\ZNF397
1 of 14
No
No
Hsap\ZNF417
1 of 14
No
No
Hsap\ZNF420
1 of 14
No
No
Hsap\ZNF425
1 of 14
No
No
Hsap\ZNF426
1 of 14
No
Yes
Hsap\ZNF430
1 of 14
No
No
Hsap\ZNF431
1 of 14
No
No
Hsap\ZNF443
1 of 14
No
No
Hsap\ZNF454
1 of 14
No
No
Hsap\ZNF460
1 of 14
No
No
Hsap\ZNF467
1 of 14
No
No
Hsap\ZNF468
1 of 14
No
No
Hsap\ZNF470
1 of 14
No
No
Hsap\ZNF483
1 of 14
No
Yes
Hsap\ZNF486
1 of 14
No
No
Hsap\ZNF493
1 of 14
No
No
Hsap\ZNF497
1 of 14
No
No
Hsap\ZNF500
1 of 14
No
No
Hsap\ZNF506
1 of 14
No
No
Hsap\ZNF517
1 of 14
No
Yes
Hsap\ZNF528
1 of 14
No
No
Hsap\ZNF557
1 of 14
No
No
Hsap\ZNF562
1 of 14
No
No
Hsap\ZNF570
1 of 14
No
No
Hsap\ZNF572
1 of 14
No
No
Hsap\ZNF582
1 of 14
No
No
Hsap\ZNF587
1 of 14
No
No
Hsap\ZNF595
1 of 14
No
No
Hsap\ZNF616
1 of 14
No
No
Hsap\ZNF623
1 of 14
No
No
Hsap\ZNF626
1 of 14
No
No
Hsap\ZNF648
1 of 14
No
No
Hsap\ZNF660-ZNF197
1 of 14
No
No
Hsap\ZNF668
1 of 14
No
Yes
Hsap\ZNF674
1 of 14
No
No
Hsap\ZNF689
1 of 14
No
No
Hsap\ZNF691
1 of 14
No
No
Hsap\ZNF695
1 of 14
No
No
Hsap\ZNF717
1 of 14
No
No
Hsap\ZNF721
1 of 14
No
No
Hsap\ZNF726
1 of 14
No
No
Hsap\ZNF740
1 of 14
No
Yes
Hsap\ZNF749
1 of 14
No
No
Hsap\ZNF766
1 of 14
No
Yes
Hsap\ZNF770
1 of 14
No
Yes
Hsap\ZNF772
1 of 14
No
No
Hsap\ZNF776
1 of 14
No
No
Hsap\ZNF778
1 of 14
No
No
Hsap\ZNF784
1 of 14
No
Yes
Hsap\ZNF790
1 of 14
No
No
Hsap\ZNF792
1 of 14
No
No
Hsap\ZNF821
1 of 14
No
No
Hsap\ZNF829
1 of 14
No
No
Hsap\ZNF835
1 of 14
No
No
Hsap\ZNF836
1 of 14
No
No
Hsap\ZNF841
1 of 14
No
No
Hsap\ZNF860
1 of 14
No
No
Hsap\ZNF876P
1 of 14
No
Yes
Hsap\ZNF879
1 of 14
No
No
Hsap\ZNF880
1 of 14
No
No
Hsap\ZSCAN2
1 of 14
No
No
Hsap\ZSCAN5B
1 of 14
No
Yes
Hsap\ZSCAN12
1 of 14
No
No
Hsap\ZSCAN20
1 of 14
No
No
Hsap\ZSCAN22
1 of 14
No
No
Hsap\ZSCAN25
1 of 14
No
No
Hsap\ZSCAN30
1 of 14
No
Yes
Hsap\ZSCAN31
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
Rnor\Egr1
1 of 14
Yes
No
Rnor\Egr3
1 of 14
Yes
No
Rnor\Egr4
1 of 14
Yes
No
Rnor\Fezf2
1 of 14
Yes
No
Rnor\LOC100360380
1 of 14
Yes
No
Rnor\LOC100362054
1 of 14
Yes
No
Rnor\LOC102546648
1 of 14
Yes
No
Rnor\LOC102551340
1 of 14
Yes
No
Rnor\LOC102552527
1 of 14
Yes
No
Rnor\Mzf1
1 of 14
Yes
No
Rnor\Prdm1
1 of 14
Yes
No
Rnor\Scrt1
1 of 14
Yes
No
Rnor\Scrt2
1 of 14
Yes
No
Rnor\Vom1r42
1 of 14
Yes
Yes
Rnor\Wt1
1 of 14
Yes
Yes
Rnor\Zbtb5
1 of 14
Yes
Yes
Rnor\Zbtb7a
1 of 14
Yes
Yes
Rnor\Zbtb17
1 of 14
Yes
Yes
Rnor\Zbtb43
1 of 14
Yes
No
Rnor\Zbtb49
1 of 14
Yes
Yes
Rnor\Zfp7
1 of 14
Yes
No
Rnor\Zfp26
1 of 14
Yes
No
Rnor\Zfp28
1 of 14
Yes
No
Rnor\Zfp84
1 of 14
Yes
Yes
Rnor\Zfp90
1 of 14
Yes
No
Rnor\Zfp108
1 of 14
Yes
No
Rnor\Zfp112
1 of 14
Yes
No
Rnor\Zfp143
1 of 14
Yes
No
Rnor\Zfp161
1 of 14
Yes
No
Rnor\Zfp169
1 of 14
Yes
No
Rnor\Zfp184
1 of 14
Yes
No
Rnor\Zfp316
1 of 14
Yes
No
Rnor\Zfp354c
1 of 14
Yes
No
Rnor\Zfp366
1 of 14
Yes
Yes
Rnor\Zfp367
1 of 14
Yes
Yes
Rnor\Zfp422
1 of 14
Yes
No
Rnor\Zfp467
1 of 14
Yes
Yes
Rnor\Zfp516
1 of 14
Yes
Yes
Rnor\Zfp566
1 of 14
Yes
Yes
Rnor\Zfp772
1 of 14
Yes
Yes
Rnor\Zfp821
1 of 14
Yes
No
Rnor\Zfp954
1 of 14
Yes
Yes
Rnor\Znf740
1 of 14
Yes
Yes
Rnor\Zscan4f
1 of 14
Yes
No
Rnor\Zscan25
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (67)
Mmus\5730507C01Rik
1 of 14
Yes
No
Mmus\Bcl6b
1 of 14
Yes
Yes
Mmus\Egr1
1 of 14
Yes
No
Mmus\Egr2
1 of 14
Yes
No
Mmus\Egr3
1 of 14
Yes
No
Mmus\Egr4
1 of 14
Yes
No
Mmus\Fezf2
1 of 14
Yes
No
1  
Mmus\Gm5141
1 of 14
Yes
No
Mmus\Gm15446
1 of 14
Yes
No
Mmus\Mzf1
1 of 14
Yes
No
Mmus\Patz1
1 of 14
Yes
Yes
Mmus\Rslcan18
1 of 14
Yes
Yes
Mmus\Scrt1
1 of 14
Yes
No
Mmus\Scrt2
1 of 14
Yes
No
Mmus\Yy2
1 of 14
Yes
No
Mmus\Zbtb5
1 of 14
Yes
Yes
Mmus\Zbtb7a
1 of 14
Yes
Yes
Mmus\Zbtb14
1 of 14
Yes
Yes
Mmus\Zbtb17
1 of 14
Yes
No
Mmus\Zbtb43
1 of 14
Yes
Yes
Mmus\Zbtb49
1 of 14
Yes
Yes
Mmus\Zfp7
1 of 14
Yes
No
Mmus\Zfp26
1 of 14
Yes
No
Mmus\Zfp37
1 of 14
Yes
No
Mmus\Zfp61
1 of 14
Yes
No
Mmus\Zfp69
1 of 14
Yes
Yes
Mmus\Zfp81
1 of 14
Yes
Yes
Mmus\Zfp84
1 of 14
Yes
No
Mmus\Zfp90
1 of 14
Yes
No
Mmus\Zfp93
1 of 14
Yes
No
Mmus\Zfp108
1 of 14
Yes
No
Mmus\Zfp112
1 of 14
Yes
No
Mmus\Zfp143
1 of 14
Yes
No
Mmus\Zfp184
1 of 14
Yes
No
Mmus\Zfp202
1 of 14
Yes
Yes
Mmus\Zfp267
1 of 14
Yes
No
Mmus\Zfp281
1 of 14
Yes
Yes
Mmus\Zfp287
1 of 14
Yes
Yes
Mmus\Zfp316
1 of 14
Yes
No
Mmus\Zfp358
1 of 14
Yes
No
Mmus\Zfp366
1 of 14
Yes
Yes
Mmus\Zfp367
1 of 14
Yes
Yes
Mmus\Zfp386
1 of 14
Yes
Yes
Mmus\Zfp422
1 of 14
Yes
Yes
Mmus\Zfp454
1 of 14
Yes
No
Mmus\Zfp467
1 of 14
Yes
Yes
Mmus\Zfp516
1 of 14
Yes
Yes
Mmus\Zfp558
1 of 14
Yes
No
Mmus\Zfp560
1 of 14
Yes
Yes
Mmus\Zfp566
1 of 14
Yes
Yes
Mmus\Zfp616
1 of 14
Yes
No
Mmus\Zfp729b
1 of 14
Yes
No
Mmus\Zfp740
1 of 14
Yes
Yes
Mmus\Zfp759
1 of 14
Yes
No
Mmus\Zfp790
1 of 14
Yes
Yes
Mmus\Zfp821
1 of 14
Yes
No
Mmus\Zfp954
1 of 14
Yes
Yes
Mmus\Zfp955a
1 of 14
Yes
Yes
Mmus\Zic5
1 of 14
Yes
No
Mmus\Zscan4b
1 of 14
Yes
Yes
Mmus\Zscan4c
1 of 14
Yes
Yes
Mmus\Zscan4d
1 of 14
Yes
Yes
Mmus\Zscan4e
1 of 14
Yes
Yes
Mmus\Zscan4f
1 of 14
Yes
Yes
Mmus\Zscan4-ps1
1 of 14
Yes
Yes
Mmus\Zscan4-ps3
1 of 14
Yes
Yes
Mmus\Zscan25
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (53)
Xtro\ano1
1 of 13
Yes
No
Xtro\anp32a
1 of 13
Yes
No
Xtro\anp32b
1 of 13
Yes
No
Xtro\cfap410
1 of 13
Yes
No
Xtro\cntrl
1 of 13
Yes
No
Xtro\cxcl9
1 of 13
Yes
Yes
Xtro\cyb561d1
1 of 13
Yes
No
Xtro\dnaaf1
1 of 13
Yes
No
Xtro\dnaaf11
1 of 13
Yes
No
Xtro\drc3
1 of 13
Yes
No
Xtro\e4f1
1 of 13
Yes
Yes
Xtro\egr1
1 of 13
Yes
No
Xtro\egr3
1 of 13
Yes
No
Xtro\gli1
1 of 13
Yes
No
Xtro\gzf1
1 of 13
Yes
No
Xtro\klf5
1 of 13
Yes
No
Xtro\klf7
1 of 13
Yes
No
Xtro\klf10
1 of 13
Yes
No
Xtro\klf11
1 of 13
Yes
No
Xtro\klf12
1 of 13
Yes
No
Xtro\LOC496795
1 of 13
Yes
No
Xtro\LOC100496074
1 of 13
Yes
No
Xtro\LOC100498327
1 of 13
Yes
Yes
Xtro\LOC101731232
1 of 13
Yes
No
Xtro\LOC116406487
1 of 13
Yes
No
Xtro\LOC116411608
1 of 13
Yes
No
Xtro\lrrc9
1 of 13
Yes
Yes
Xtro\lrrc56
1 of 13
Yes
No
Xtro\mnat1
1 of 13
Yes
No
Xtro\ovol2
1 of 13
Yes
No
Xtro\parp6
1 of 13
Yes
Yes
Xtro\prdm6
1 of 13
Yes
Yes
Xtro\sall1
1 of 13
Yes
No
Xtro\siah3
1 of 13
Yes
No
Xtro\sp3
1 of 13
Yes
No
Xtro\sp4
1 of 13
Yes
No
Xtro\vps28
1 of 13
Yes
No
Xtro\XB22063318
1 of 13
Yes
Yes
Xtro\zbtb45
1 of 13
Yes
Yes
Xtro\zic2
1 of 13
Yes
No
Xtro\znf177
1 of 13
Yes
No
Xtro\znf180
1 of 13
Yes
No
Xtro\znf229
1 of 13
Yes
No
Xtro\znf281
1 of 13
Yes
Yes
Xtro\znf282
1 of 13
Yes
No
Xtro\znf420
1 of 13
Yes
No
Xtro\znf524
1 of 13
Yes
No
Xtro\znf526
1 of 13
Yes
No
Xtro\znf568
1 of 13
Yes
No
Xtro\znf574
1 of 13
Yes
No
Xtro\znf628
1 of 13
Yes
No
Xtro\znf821
1 of 13
Yes
Yes
Xtro\znf865
1 of 13
Yes
No
Danio rerio (Zebrafish) (57)
Drer\bcl6b
1 of 14
Yes
Yes
Drer\egr1
1 of 14
Yes
No
Drer\egr3
1 of 14
Yes
No
Drer\gfi1b
1 of 14
Yes
No
Drer\klf9
1 of 14
Yes
No
Drer\klf11a
1 of 14
Yes
No
Drer\klf11b
1 of 14
Yes
No
Drer\LOC100006216
1 of 14
Yes
Yes
Drer\LOC100148466
1 of 14
Yes
No
Drer\LOC100150619
1 of 14
Yes
No
Drer\LOC100330321
1 of 14
Yes
No
Drer\LOC100333534
1 of 14
Yes
No
Drer\LOC100537361
1 of 14
Yes
No
Drer\LOC101884037
1 of 14
Yes
No
Drer\LOC108183930
1 of 14
Yes
No
Drer\LOC110439430
1 of 14
Yes
No
Drer\patz1
1 of 14
Yes
Yes
Drer\prdm4
1 of 14
Yes
No
Drer\prdm15
1 of 14
Yes
Yes
Drer\sall1a
1 of 14
Yes
No
Drer\sall4
1 of 14
Yes
No
Drer\scrt1a
1 of 14
Yes
No
Drer\scrt1b
1 of 14
Yes
No
Drer\si:cabz01021433.2
1 of 14
Yes
Yes
Drer\si:cabz01063885.1
1 of 14
Yes
Yes
Drer\si:cabz01069022.1
1 of 14
Yes
Yes
Drer\si:cabz01071911.3
1 of 14
Yes
Yes
Drer\si:ch73-144d13.7
1 of 14
Yes
Yes
Drer\si:ch73-266f23.3
1 of 14
Yes
No
Drer\si:dkey-182i3.9
1 of 14
Yes
Yes
Drer\si:dkeyp-2e4.2
1 of 14
Yes
Yes
Drer\si:dkeyp-69b9.6
1 of 14
Yes
Yes
Drer\si:dkeyp-113d7.10
1 of 14
Yes
Yes
Drer\zbtb7b
1 of 14
Yes
Yes
Drer\zbtb7c
1 of 14
Yes
Yes
Drer\zbtb14
1 of 14
Yes
Yes
Drer\zbtb17
1 of 14
Yes
Yes
Drer\zbtb43
1 of 14
Yes
Yes
Drer\zbtb49
1 of 14
Yes
Yes
Drer\zgc:66448
1 of 14
Yes
Yes
Drer\zgc:113209
1 of 14
Yes
No
Drer\zgc:113220
1 of 14
Yes
Yes
Drer\zgc:113348
1 of 14
Yes
Yes
Drer\zgc:174624
1 of 14
Yes
No
Drer\znf76
1 of 14
Yes
Yes
Drer\znf281a
1 of 14
Yes
No
Drer\znf281b
1 of 14
Yes
No
Drer\znf319b
1 of 14
Yes
Yes
Drer\znf341
1 of 14
Yes
Yes
Drer\znf367
1 of 14
Yes
No
Drer\znf408
1 of 14
Yes
Yes
Drer\znf740b
1 of 14
Yes
Yes
Drer\znf770
1 of 14
Yes
Yes
Drer\znf821
1 of 14
Yes
No
Drer\znf865
1 of 14
Yes
No
Drer\znf1113
1 of 14
Yes
No
Drer\znf1141
1 of 14
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\klu-1
5 of 14
Yes
Yes
Cele\bcl-11
1 of 14
No
No
Cele\egrh-3
1 of 14
No
No
Cele\F33H2.3
1 of 14
No
No
Cele\K10D2.8
1 of 14
No
No
Cele\klf-2
1 of 14
No
No
Cele\klu-2
1 of 14
No
No
Cele\mog-2
1 of 14
No
No
Cele\phlp-2
1 of 14
No
No
Cele\scrt-1
1 of 14
No
No
Cele\T19H12.2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (30)
Agam\AgaP_AGAP009899
6 of 12
Yes
Yes
Agam\AgaP_AGAP001083
1 of 12
No
No
Agam\AgaP_AGAP001132
1 of 12
No
No
Agam\AgaP_AGAP002610
1 of 12
No
No
Agam\AgaP_AGAP004081
1 of 12
No
Yes
Agam\AgaP_AGAP004269
1 of 12
No
No
Agam\AgaP_AGAP004282
1 of 12
No
No
Agam\AgaP_AGAP004438
1 of 12
No
No
Agam\AgaP_AGAP004651
1 of 12
No
No
Agam\AgaP_AGAP005075
1 of 12
No
No
Agam\AgaP_AGAP006061
1 of 12
No
Yes
Agam\AgaP_AGAP006794
1 of 12
No
No
Agam\AgaP_AGAP007670
1 of 12
No
No
Agam\AgaP_AGAP007915
1 of 12
No
No
Agam\AgaP_AGAP008232
1 of 12
No
No
Agam\AgaP_AGAP008984
1 of 12
No
No
Agam\AgaP_AGAP009482
1 of 12
No
Yes
Agam\AgaP_AGAP009483
1 of 12
No
Yes
Agam\AgaP_AGAP009889
1 of 12
No
No
Agam\AgaP_AGAP010009
1 of 12
No
No
Agam\AgaP_AGAP010063
1 of 12
No
No
Agam\AgaP_AGAP010684
1 of 12
No
No
Agam\AgaP_AGAP011247
1 of 12
No
No
Agam\AgaP_AGAP011262
1 of 12
No
No
Agam\AgaP_AGAP011544
1 of 12
No
No
Agam\AgaP_AGAP012385
1 of 12
No
No
Agam\AgaP_AGAP012594
1 of 12
No
No
Agam\AgaP_AGAP012669
1 of 12
No
No
Agam\ODD_a
1 of 12
No
No
Agam\ODD_b
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (31)
Atha\AT1G02030
1 of 13
Yes
No
Atha\AT1G49900
1 of 13
Yes
Yes
Atha\AT2G28200
1 of 13
Yes
Yes
Atha\AT2G28710
1 of 13
Yes
Yes
Atha\AT2G45120
1 of 13
Yes
No
Atha\AT3G10470
1 of 13
Yes
Yes
Atha\AT3G29340
1 of 13
Yes
No
Atha\AT3G46070
1 of 13
Yes
Yes
Atha\AT3G46080
1 of 13
Yes
Yes
Atha\AT3G49930
1 of 13
Yes
No
Atha\AT3G50690
1 of 13
Yes
No
Atha\AT3G53600
1 of 13
Yes
Yes
Atha\AT3G53820
1 of 13
Yes
Yes
Atha\AT3G60580
1 of 13
Yes
No
Atha\AT4G04404
1 of 13
Yes
Yes
Atha\AT4G16610
1 of 13
Yes
Yes
Atha\AT5G03510
1 of 13
Yes
Yes
Atha\AT5G04390
1 of 13
Yes
Yes
Atha\AT5G56200
1 of 13
Yes
Yes
Atha\AT5G61470
1 of 13
Yes
No
Atha\DAZ1
1 of 13
Yes
No
Atha\DAZ2
1 of 13
Yes
Yes
Atha\RHL41
1 of 13
Yes
Yes
Atha\STZ
1 of 13
Yes
No
Atha\U2A'
1 of 13
Yes
No
Atha\ZAT6
1 of 13
Yes
No
Atha\ZAT7
1 of 13
Yes
Yes
Atha\ZAT11
1 of 13
Yes
Yes
Atha\ZF1
1 of 13
Yes
No
Atha\ZF2
1 of 13
Yes
No
Atha\ZF3
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\FZF1
1 of 13
Yes
No
Scer\NRG1
1 of 13
Yes
Yes
Scer\NRG2
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:klu. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (33)
CG2712
2 of 13
Clamp
2 of 13
btd
1 of 13
CG1233
1 of 13
CG3065
1 of 13
CG3407
1 of 13
CG3847
1 of 13
CG4318
1 of 13
CG7963
1 of 13
CG7987
1 of 13
CG12071
1 of 13
CG12299
1 of 13
CG14711
1 of 13
CG15208
1 of 13
CG15269
1 of 13
CG17568
1 of 13
CG18476
1 of 13
CG31441
1 of 13
CG44002
1 of 13
gl
1 of 13
Klf15
1 of 13
Kr-h1
1 of 13
Mapmodulin
1 of 13
pad
1 of 13
prg
1 of 13
Saft
1 of 13
scrape
1 of 13
scrt
1 of 13
sens-2
1 of 13
sqz
1 of 13
U2A
1 of 13
wor
1 of 13
Zaf1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    klu
    suppressible
    Apc2
    (Komori et al., 2014)
    klu
    suppressible
    arm
    (Komori et al., 2014)
    klu
    suppressible
    brat
    (Xiao et al., 2012)
    klu
    suppressible
    N
    (Xiao et al., 2012)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ac
    enhanceable
    klu
    (Klein and Campos-Ortega, 1997)
    brat
    enhanceable
    klu
    (Janssens et al., 2014)
    brat
    suppressible
    klu
    (Xiao et al., 2012)
    dx
    enhanceable
    klu
    (Kankel et al., 2007)
    Egfr
    suppressible
    klu
    (Rusconi et al., 2004)
    erm
    suppressible
    klu
    (Janssens et al., 2014)
    erm
    enhanceable
    klu
    (Janssens et al., 2014)
    grim
    suppressible
    klu
    (Rusconi et al., 2004)
    gro
    suppressible
    klu
    (Kaspar et al., 2008)
    H
    suppressible
    klu
    (Protzer et al., 2008, Müller et al., 2005)
    hid
    suppressible
    klu
    (Rusconi et al., 2004)
    mam
    enhanceable
    klu
    (Kankel et al., 2007)
    N
    enhanceable
    klu
    (Xiao et al., 2012, Kankel et al., 2007)
    N
    suppressible
    klu
    (Xiao et al., 2012)
    Ras85D
    enhanceable
    klu
    (Rusconi et al., 2004)
    Ras85D
    suppressible
    klu
    (Rusconi et al., 2004)
    rpr
    suppressible
    klu
    (Rusconi et al., 2004)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-34
    Cytogenetic map
    68A1-68A1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    68A1-68A1
    Limits computationally determined from genome sequence between P{lacW}tnaL6731 and P{PZ}klu09036
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    68A1-68A2
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    68A-68A
    (determined by in situ hybridisation)
    (Klein and Campos-Ortega, 1993)
    68A1-68A2
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    3-34

    (FlyBase, 2016)

    3-28.2

    (Comeron et al., 2012)

    3-

    (Klein and Campos-Ortega, 1993)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (35)
    Genomic Clones (37)
    cDNA Clones (53)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Yang et al., 1997)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          klu functions to maintain the identity of type II neuroblasts in the larval brain.

          (Xiao et al., 2012)

          klu is both required and sufficient for programmed cell death in the pupal retina and is differentially expressed in the cells that choose the life or death cell fate.

          (Rusconi et al., 2004)

          Candidate gene for sex comb tooth number quantitative trait locus.

          (Macdonald and Goldstein, 1999)

          Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.

          (Braun et al., 1997)

          klu is required for proper specification and differentiation in a variety of cells, including the sensory organ mother cells and those of the distal parts of tarsal segments.

          (Klein and Campos-Ortega, 1997)

          klu functions to differentiate between the identities of two secondary precursor cells within one neuroblast lineage.

          (Yang et al., 1997)

          klu acts to specify the identity of ganglion mother cell GMC4-2b and to make it distinct from GMC4-2a.

          (Yang et al., 1997)

          Phenotypic analysis and genetic interaction studies indicate that the klu gene product is involved in at least two steps of bristle development.

          (Klein and Campos-Ortega, 1993)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: klu l(3)09036

          (Spradling et al., 1999)
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments

          The original gene name "klumpfuss" (klu) was changed to "klu transcription factor" (klu) to eliminate its potentially offensive association with human conditions.

          (FlyBoard ad hoc nomenclature committee, 2024.7.14)
          Etymology

          "klumpfuss", meaning "club-foot", is named on the basis of the leg defects found in mutants.

          (Klein and Campos-Ortega, 1997)
          Synonyms and Secondary IDs (11)
          Reported As
          Symbol Synonym
          CG12296
          (Fujikawa et al., 2009, Perkins et al., 2009, Chen et al., 2008, Molnar et al., 2006, Kanuka et al., 2005)
          KLU
          (Blatti et al., 2015)
          Klu
          (Pollington et al., 2023, Ray et al., 2022, Boumard and Bardin, 2021, Rossi et al., 2021, Maurange, 2020, Mira and Morante, 2020, Sato et al., 2019, Doe, 2017, Suzuki and Sato, 2017, Yasugi and Nishimura, 2016, Singari et al., 2014, Terhzaz et al., 2014, Suzuki et al., 2013, McDonald et al., 2003)
          P09036
          (Makunin et al., 2002)
          klu
          (FlyBoard ad hoc nomenclature committee, 2024.7.14, Sood et al., 2024, Josserand et al., 2023, Hultmark and Andó, 2022, Karki et al., 2022, Saha et al., 2022, Bilder et al., 2021, DeAngelis et al., 2021, Hung et al., 2021, Ma et al., 2021, Rajan et al., 2021, DeLuca et al., 2020, Díaz-de-la-Peña et al., 2020, Hood et al., 2020, Hung et al., 2020, Koranteng et al., 2020, Rust et al., 2020, Bageritz et al., 2019, Banerjee et al., 2019, Brunet Avalos et al., 2019, Ray et al., 2019, Sapar and Han, 2019, Bischof et al., 2018, Clemson et al., 2018, Komori et al., 2018, Loewen et al., 2018, Teets and Hahn, 2018, Anderson et al., 2017, Fochler et al., 2017, Heseding et al., 2017, Janssens et al., 2017, Transgenic RNAi Project members, 2017-, Blick et al., 2016, Clandinin and Owens, 2016-, Malartre, 2016, Sarov et al., 2016, Loedige et al., 2015, Nadimpalli et al., 2015, Schertel et al., 2015, Eroglu et al., 2014, Janssens et al., 2014, Komori et al., 2014, Singari et al., 2014, Whitaker et al., 2014, de Celis et al., 2013.9.11, Gasque et al., 2013, Kwon et al., 2013, Terriente-Felix et al., 2013, Terriente-Felix et al., 2013, Berger et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Xiao et al., 2012, Jungreis et al., 2011, Losada-Pérez et al., 2010, Fujikawa et al., 2009, Parrish et al., 2009, Chen et al., 2008, Christensen et al., 2008.12.28, Hutchins et al., 2008, Kaspar et al., 2008, Protzer et al., 2008, Rusconi et al., 2008, Hutchins and Rusconi, 2007, Kankel et al., 2007, Rusconi et al., 2007, Zaffo et al., 2007, Molnar et al., 2006, Anonymous, 2005, Kanuka et al., 2005, Melcher and Pankratz, 2005)
          l(3)09036
          (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
          l(3)10052
          (Braun et al., 1997, Yang et al., 1997)
          Name Synonyms
          Klumpfuss
          (Berger et al., 2012)
          klu transcription factor
          (FlyBoard ad hoc nomenclature committee, 2024.7.14)
          klumpfuss
          (Earl et al., 2020, Malartre, 2016, Kim et al., 2014, Singari et al., 2014, Itskov and Ribeiro, 2013, Terriente-Felix et al., 2013, Losada-Pérez et al., 2010, Chen et al., 2008, Colomb et al., 2008, Hutchins et al., 2008, Kaspar et al., 2008, Rusconi et al., 2008, Copeland et al., 2007, Kankel et al., 2007, Anonymous, 2005, Melcher and Pankratz, 2005, McDonald et al., 2003, Klein and Campos-Ortega, 1993)
          klumphuss
          (Yang et al., 1997)
          Secondary FlyBase IDs
          • FBgn0010931
          • FBgn0010938
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 53 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (184)