FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term neuroblast NB5-4 ID (Ontology) FBbt:00001416 (Fly Anatomy)
Definition Neuroblast that most frequently delaminates at S4 (Schmid et al., 1997). In the embryo, one of these cells can be found in each hemisegment from S3-A10 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016) and in the male abdominal 9 neuromere (Birkholz et al., 2013). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 22 (Lacin and Truman, 2016).[ FlyBase:FBrf0098344 FlyBase:FBrf0112030 FlyBase:FBrf0180161 FlyBase:FBrf0221210 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As"lineage 22 neuroblast" ; "lineage NB5-4 neuroblast" ; "NB 22" (for all, see Synonyms field below)
CommentUsing DiI with antibody labelling, Schmidt et al. (1997) propose NB5-4 produces 5-9 thoracic neurons or 3-4 abdominal motorneurons with ipsilateral targets. Schmid et al. (1999), also use DiI with en-GFP, but find 2-3 large cells that match descriptions of CCAP/CAP+ neurosecretory cells, along with abdomen-specific interneurons. Also, Schmid et al. (1999) state that NB5-4 delaminates during S5, whilst Schmidt et al. (1997) find that delamination occurs over the period of S3/4 to S5, most frequently at S4, and as such we have chosen to define NB5-4 as a stage 4 neuroblast.
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VFB:FBbt_00001416
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
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 neuroblast NB5-4 (all annotations which use CV term, excluding "NOT" statements)
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central nervous system
 |__segmentally-repeated neuroblast__
neuroblast                           |
 |__stage 4 neuroblast_______________|
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB5-4  20 rec.
                                      |__abdominal neuroblast NB5-4
                                      |   |__abdominal 9 neuroblast NB5-4(+)
                                      |__labial neuroblast NB5-4
                                      |__thoracic neuroblast NB5-4
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VFB:FBbt_00001416