FB2020_05, released Oct 14, 2020

Gene: Dmel\sens-2

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General Information
Symbol
Dmel\sens-2
Species
D. melanogaster
Name
senseless-2
Annotation Symbol
CG31632
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051632
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

sens2

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:6,821,934..6,838,995 [+]
Recombination map

2-22

RefSeq locus
NT_033779 REGION:6821934..6838995
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004701291
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004701291
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004701291
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nuclear chromatin
inferred from biological aspect of ancestor with PANTHER:PTN004701291
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\sens-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
sens-2-RA
FBtr0079341
NM_164716
3361
746
sens-2-RB
FBtr0345446
NM_001298763
3744
746
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
sens-2-PA
FBpp0078969
80.2
746
10.60
NP_723223
AAF52446
sens-2-PB
FBpp0311570
80.2
746
10.60
NP_001285692
AHN54207
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

746 aa isoforms: sens-2-PA, sens-2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sens-2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
posterior midgut primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic midgut chamber
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sens-2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sens-2
Transgenic constructs containing regulatory region of sens-2
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (88)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GFI1B
8 of 15
Yes
Yes
1  
Hsap\GFI1
7 of 15
No
Yes
2  
Hsap\LOC145783
1 of 15
No
Yes
Hsap\PEG3
1 of 15
No
Yes
Hsap\ZBTB6
1 of 15
No
Yes
Hsap\ZFP3
1 of 15
No
Yes
Hsap\ZFP37
1 of 15
No
No
Hsap\ZFP57
1 of 15
No
Yes
Hsap\ZFP69B
1 of 15
No
No
Hsap\ZFP69
1 of 15
No
No
Hsap\ZFP90
1 of 15
No
No
Hsap\ZIM2
1 of 15
No
Yes
Hsap\ZKSCAN2
1 of 15
No
Yes
1  
Hsap\ZNF3
1 of 15
No
Yes
Hsap\ZNF10
1 of 15
No
No
Hsap\ZNF19
1 of 15
No
No
Hsap\ZNF20
1 of 15
No
No
Hsap\ZNF22
1 of 15
No
Yes
Hsap\ZNF25
1 of 15
No
No
Hsap\ZNF35
1 of 15
No
No
Hsap\ZNF69
1 of 15
No
No
Hsap\ZNF70
1 of 15
No
No
Hsap\ZNF77
1 of 15
No
No
Hsap\ZNF79
1 of 15
No
Yes
Hsap\ZNF80
1 of 15
No
No
Hsap\ZNF124
1 of 15
No
No
Hsap\ZNF165
1 of 15
No
Yes
Hsap\ZNF177
1 of 15
No
No
Hsap\ZNF180
1 of 15
No
No
Hsap\ZNF248
1 of 15
No
No
Hsap\ZNF266
1 of 15
No
No
Hsap\ZNF280A
1 of 15
No
No
Hsap\ZNF280B
1 of 15
No
No
Hsap\ZNF280C
1 of 15
No
No
Hsap\ZNF280D
1 of 15
No
No
Hsap\ZNF329
1 of 15
No
No
Hsap\ZNF391
1 of 15
No
Yes
Hsap\ZNF404
1 of 15
No
No
Hsap\ZNF425
1 of 15
No
No
Hsap\ZNF436
1 of 15
No
No
Hsap\ZNF439
1 of 15
No
No
Hsap\ZNF440
1 of 15
No
No
Hsap\ZNF487
1 of 15
No
Yes
Hsap\ZNF491
1 of 15
No
No
Hsap\ZNF524
1 of 15
No
Yes
Hsap\ZNF529
1 of 15
No
No
Hsap\ZNF550
1 of 15
No
No
Hsap\ZNF554
1 of 15
No
No
Hsap\ZNF555
1 of 15
No
No
Hsap\ZNF556
1 of 15
No
No
Hsap\ZNF557
1 of 15
No
No
Hsap\ZNF558
1 of 15
No
No
Hsap\ZNF559
1 of 15
No
No
Hsap\ZNF559-ZNF177
1 of 15
No
No
Hsap\ZNF560
1 of 15
No
No
Hsap\ZNF566
1 of 15
No
No
Hsap\ZNF580
1 of 15
No
Yes
Hsap\ZNF582
1 of 15
No
No
Hsap\ZNF587B
1 of 15
No
Yes
Hsap\ZNF596
1 of 15
No
No
Hsap\ZNF599
1 of 15
No
No
Hsap\ZNF614
1 of 15
No
No
Hsap\ZNF619
1 of 15
No
No
Hsap\ZNF620
1 of 15
No
No
Hsap\ZNF669
1 of 15
No
No
Hsap\ZNF674
1 of 15
No
No
Hsap\ZNF683
1 of 15
No
No
Hsap\ZNF684
1 of 15
No
No
Hsap\ZNF688
1 of 15
No
Yes
Hsap\ZNF705A
1 of 15
No
No
Hsap\ZNF705B
1 of 15
No
No
Hsap\ZNF705D
1 of 15
No
No
Hsap\ZNF705E
1 of 15
No
No
Hsap\ZNF705F
1 of 15
No
Yes
Hsap\ZNF705G
1 of 15
No
No
Hsap\ZNF749
1 of 15
No
No
Hsap\ZNF764
1 of 15
No
Yes
Hsap\ZNF768
1 of 15
No
Yes
Hsap\ZNF778
1 of 15
No
Yes
Hsap\ZNF785
1 of 15
No
Yes
Hsap\ZNF846
1 of 15
No
No
Hsap\ZNF891
1 of 15
No
No
Hsap\ZSCAN2
1 of 15
No
No
Hsap\ZSCAN5A
1 of 15
No
Yes
Hsap\ZSCAN5B
1 of 15
No
Yes
Hsap\ZSCAN5C
1 of 15
No
Yes
Hsap\ZSCAN5DP
1 of 15
No
Yes
Hsap\ZSCAN9
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (58)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gfi1b
8 of 15
Yes
Yes
Mmus\Gfi1
6 of 15
No
Yes
1  
Mmus\2610008E11Rik
1 of 15
No
Yes
Mmus\2810021J22Rik
1 of 15
No
No
Mmus\A430033K04Rik
1 of 15
No
Yes
Mmus\AI987944
1 of 15
No
Yes
Mmus\AU041133
1 of 15
No
No
Mmus\Gm3854
1 of 15
No
Yes
Mmus\Gm4924
1 of 15
No
Yes
Mmus\Gm10139
1 of 15
No
Yes
Mmus\Gm10770
1 of 15
No
Yes
Mmus\Gm10772
1 of 15
No
Yes
Mmus\Gm14322
1 of 15
No
Yes
Mmus\Gm14325
1 of 15
No
Yes
Mmus\Gm14391
1 of 15
No
Yes
Mmus\Gm19965
1 of 15
No
Yes
Mmus\Gm21994
1 of 15
No
Yes
Mmus\Gm28363
1 of 15
No
Yes
Mmus\Gm45871
1 of 15
No
Yes
Mmus\Peg3
1 of 15
No
Yes
Mmus\Zbtb6
1 of 15
No
Yes
Mmus\Zbtb41
1 of 15
No
Yes
Mmus\Zfp2
1 of 15
No
No
Mmus\Zfp9
1 of 15
No
No
Mmus\Zfp37
1 of 15
No
No
Mmus\Zfp46
1 of 15
No
No
Mmus\Zfp57
1 of 15
No
Yes
Mmus\Zfp69
1 of 15
No
No
Mmus\Zfp78
1 of 15
No
No
Mmus\Zfp90
1 of 15
No
No
Mmus\Zfp105
1 of 15
No
No
Mmus\Zfp120
1 of 15
No
Yes
Mmus\Zfp157
1 of 15
No
Yes
Mmus\Zfp180
1 of 15
No
No
Mmus\Zfp248
1 of 15
No
No
Mmus\Zfp266
1 of 15
No
No
Mmus\Zfp280b
1 of 15
No
No
Mmus\Zfp280c
1 of 15
No
No
Mmus\Zfp280d
1 of 15
No
No
Mmus\Zfp322a
1 of 15
No
Yes
Mmus\Zfp329
1 of 15
No
No
Mmus\Zfp383
1 of 15
No
Yes
Mmus\Zfp524
1 of 15
No
Yes
Mmus\Zfp558
1 of 15
No
No
Mmus\Zfp566
1 of 15
No
No
Mmus\Zfp580
1 of 15
No
Yes
Mmus\Zfp597
1 of 15
No
Yes
Mmus\Zfp616
1 of 15
No
Yes
Mmus\Zfp626
1 of 15
No
Yes
Mmus\Zfp688
1 of 15
No
Yes
Mmus\Zfp709
1 of 15
No
No
Mmus\Zfp790
1 of 15
No
No
Mmus\Zfp810
1 of 15
No
No
Mmus\Zfp819
1 of 15
No
Yes
Mmus\Zfp882
1 of 15
No
Yes
Mmus\Zfp949
1 of 15
No
Yes
Mmus\Zfp961
1 of 15
No
Yes
Mmus\Zfp971
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (38)
Rnor\Gfi1
6 of 13
Yes
Yes
Rnor\Gfi1b
5 of 13
No
Yes
Rnor\LOC691170
1 of 13
No
Yes
Rnor\LOC100909461
1 of 13
No
Yes
Rnor\LOC100909869
1 of 13
No
Yes
Rnor\LOC102554315
1 of 13
No
Yes
Rnor\LOC102555635
1 of 13
No
No
Rnor\LOC103690173
1 of 13
No
No
Rnor\Peg3
1 of 13
No
Yes
Rnor\RGD1566386
1 of 13
No
Yes
Rnor\Zbtb6
1 of 13
No
Yes
Rnor\Zbtb41
1 of 13
No
Yes
Rnor\Zfp35
1 of 13
No
Yes
Rnor\Zfp37
1 of 13
No
Yes
Rnor\Zfp52
1 of 13
No
No
Rnor\Zfp61
1 of 13
No
Yes
Rnor\Zfp69
1 of 13
No
Yes
Rnor\Zfp78
1 of 13
No
No
Rnor\Zfp84
1 of 13
No
Yes
Rnor\Zfp90
1 of 13
No
No
Rnor\Zfp105
1 of 13
No
No
Rnor\Zfp136
1 of 13
No
Yes
Rnor\Zfp157
1 of 13
No
Yes
Rnor\Zfp180
1 of 13
No
No
Rnor\Zfp248
1 of 13
No
No
Rnor\Zfp280b
1 of 13
No
No
Rnor\Zfp280c
1 of 13
No
No
Rnor\Zfp280d
1 of 13
No
No
Rnor\Zfp329
1 of 13
No
No
Rnor\Zfp524
1 of 13
No
Yes
Rnor\Zfp566
1 of 13
No
Yes
Rnor\Zfp580
1 of 13
No
Yes
Rnor\Zfp617
1 of 13
No
Yes
Rnor\Zfp688
1 of 13
No
Yes
Rnor\Zfp709
1 of 13
No
Yes
Rnor\Zfp717
1 of 13
No
Yes
Rnor\Zfp819
1 of 13
No
No
Rnor\Zfp949
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\gfi1b
4 of 12
Yes
Yes
Xtro\gfi1
3 of 12
No
Yes
Xtro\zbtb6
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\gfi1aa
6 of 15
Yes
Yes
Drer\gfi1b
6 of 15
Yes
Yes
Drer\gfi1ab
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\pag-3
6 of 15
Yes
Yes
Cele\K11D2.4
2 of 15
No
Yes
Cele\pat-9
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\TFIIIA
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PZF1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\sfc2
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919081O )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001449
Drosophila simulans
Dsim\GD23433
Drosophila sechellia
Dsec\GM16223
Drosophila erecta
Dere\GG10437
Drosophila yakuba
Dyak\GE14143
Drosophila ananassae
Dana\GF15430
Drosophila pseudoobscura pseudoobscura
Dpse\GA16348
Drosophila persimilis
Dper\GL26188
Drosophila willistoni
Dwil\GK24242
Drosophila virilis
Dvir\GJ21268
Drosophila mojavensis
Dmoj\GI23984
Drosophila grimshawi
Dgri\GH13715
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915075P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022254
Musca domestica
House fly
Mdoa\17021250
Glossina morsitans
Tsetse fly
Gmor\GMOY011283
Glossina morsitans
Tsetse fly
Gmor\GMOY000179
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10848
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02920
Mayetiola destructor
Hessian fly
Mdes\Mdes009637
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001243
Anopheles gambiae
Malaria mosquito
Agam\AGAP009699
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002497
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012536
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06KT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003190
Bombyx mori
Silkmoth
Bmor\BGIBMGA006132
Danaus plexippus
Monarch butterfly
Dple\DPOGS211808-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211207-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012459
Heliconius melpomene
Postman butterfly
Hmel\HMEL002740
Apis florea
Little honeybee
Aflo\5779756916
Apis florea
Little honeybee
Aflo\2147668019
Apis mellifera
Western honey bee
Amel\Ame.2444
Apis mellifera
Western honey bee
Amel\GB45532
Apis mellifera
Western honey bee
Amel\GB40142
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14814
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24344
Bombus terrestris
Buff-tailed bumblebee
Bter\15204442
Bombus terrestris
Buff-tailed bumblebee
Bter\15205151
Linepithema humile
Argentine ant
Lhum\LH22736
Linepithema humile
Argentine ant
Lhum\LH22732
Linepithema humile
Argentine ant
Lhum\LH22733
Linepithema humile
Argentine ant
Lhum\LH22731
Linepithema humile
Argentine ant
Lhum\LH22063
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00178e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d2a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012936
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006344
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012937
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04049
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07154
Tribolium castaneum
Red flour beetle
Tcas\sens
Tribolium castaneum
Red flour beetle
Tcas\TC031695
Pediculus humanus
Human body louse
Phum\PHUM248190
Pediculus humanus
Human body louse
Phum\PHUM248200
Rhodnius prolixus
Kissing bug
Rpro\RPRC005969
Rhodnius prolixus
Kissing bug
Rpro\RPRC002026
Cimex lectularius
Bed bug
Clec\CLEC007060
Cimex lectularius
Bed bug
Clec\CLEC007062
Cimex lectularius
Bed bug
Clec\CLEC007061
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008148
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001809
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03531
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ELG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005595
Strigamia maritima
European centipede
Smar\SMAR005599
Strigamia maritima
European centipede
Smar\SMAR014254
Strigamia maritima
European centipede
Smar\SMAR005594
Ixodes scapularis
Black-legged tick
Isca\ISCW020916
Ixodes scapularis
Black-legged tick
Isca\ISCW001542
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69326.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78965.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69324.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g07180
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g01570
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_113215
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_113216
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0NDD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z166
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011342
Gallus gallus
Domestic chicken
Ggal\GFI1
Gallus gallus
Domestic chicken
Ggal\GFI1B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
sens
3 of 10
CG2712
1 of 10
CG14711
1 of 10
erm
1 of 10
klu
1 of 10
Prdm13
1 of 10
sqz
1 of 10
Zaf1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GFI1B; growth factor independent 1B transcriptional repressor
    8 of 15
    604383
     
    GFI1; growth factor independent 1 transcriptional repressor
    7 of 15
    600871
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      sens-2 - CG10654
      two hybrid array
      (Shokri et al., 2019)
      sens-2 - E(spl)mδ-HLH
      two hybrid array
      (Shokri et al., 2019)
      sens-2 - Hr78
      two hybrid array
      (Shokri et al., 2019)
      sens-2 - OdsH
      two hybrid array
      (Shokri et al., 2019)
      sens-2 - phol
      two hybrid array
      (Shokri et al., 2019)
      sens-2 - vis
      two hybrid array
      (Shokri et al., 2019)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map

      2-22

      Cytogenetic map
      27B4-27B4
      Sequence location
      2L:6,821,934..6,838,995 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      27B4-27B4
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-22

      (FlyBase, 2016)

      2-22.0

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (8)
      Genomic Clones (33)
      cDNA Clones (18)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: sens-2 CG31632

        (Jafar-Nejad and Bellen, 2004)
        Source for database merge of

        Source for merge of: CG11243 CG17373

        (FlyBase Genome Annotators, 2002-2003)
        Additional comments

        Annotations CG11243 and CG17373 merged as CG31632 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 31 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (8)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (42)