FB2026_03 , released September 17, 2026
CV Term Report
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Term neuroblast NB2-4 ID (Ontology) FBbt:00001411 (Fly Anatomy)
Definition Neuroblast that delaminates at S4 and generates a contralaterally projecting motorneuron and approximately 8 local interneurons (Schmid et al., 1999). In the embryo, one of these cells can be found in each hemisegment from T1-A8 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in T2-A1 (Lacin and Truman, 2016). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 18 (Lacin and Truman, 2016).[ FlyBase:FBrf0112030 FlyBase:FBrf0221210 FlyBase:FBrf0228122 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As"lineage 18 neuroblast" ; "lineage NB2-4 neuroblast" ; "NB 18" (for all, see Synonyms field below)
CommentBirkholz et al. (2015) suggest that NB2-4 generates postembryonic lineage 8 and NB3-4 generates postembryonic lineage 18, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB2-4 generates lineage 18. Lacin and Truman (2016) Fig1S1 shows postembryonic NB2-4 in T1, but text and Fig3 shows loss of NB2-4 in T1 in the late embryo.
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VFB:FBbt_00001411
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
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 neuroblast NB2-4 (all annotations which use CV term, excluding "NOT" statements)
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central nervous system
 |__segmentally-repeated neuroblast__
neuroblast                           |
 |__stage 4 neuroblast_______________|
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB2-4  24 rec.
                                      |__abdominal neuroblast NB2-4 2 rec.
                                      |   |__abdominal 1 neuroblast NB2-4
                                      |__thoracic neuroblast NB2-4
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segmentally-repeated neuroblast
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VFB:FBbt_00001411