FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\klu212lR51C
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General Information
Symbol
Dmel\klu212lR51C
Species
D. melanogaster
Name
FlyBase ID
FBal0061357
Feature type
allele
Associated gene
Dmel\klu
Associated Insertion(s)
Carried in Construct
Also Known As
kluR51, klu212IR51C
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Klein and Campos-Ortega, 1997, Yang et al., 1997)
Mutagen
P-element activity
(Yang et al., 1997)
Delta2-3 transposase
(Klein and Campos-Ortega, 1997)
Progenitor genotype
kluP212
(Klein and Campos-Ortega, 1997, Yang et al., 1997)
Cytology

Polytene chromosomes normal.

(Klein and Campos-Ortega, 1997)
Description

Deletion, with one breakpoint at the site of the P{lacZ} insertion in kluP212, removing at least three exons.

(Klein and Campos-Ortega, 1997)

Imprecise excision of the P{lacZ} element, deleting all or part of the three 3'-most exons of klu.

(Yang et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      antennal sense organ

      (Klein and Campos-Ortega, 1997)

      anterior sternopleural bristle

      (Klein and Campos-Ortega, 1997)

      anterior supraalar bristle (with kluG410)

      (Kaspar et al., 2008)

      basal cylinder

      (Klein and Campos-Ortega, 1997)

      femur

      (Klein and Campos-Ortega, 1997)

      larval neuroblast | larval stage (with klu09036)

      (Xiao et al., 2012)

      larval neuroblast | somatic clone | third instar larval stage

      (Berger et al., 2012)

      larval neuroblast | third instar larval stage (with kluG410)

      (Berger et al., 2012)

      larval RP2 motor neuron

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 1 neuromere

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 2 neuromere

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 3 neuromere

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 4 neuromere

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 5 neuromere

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 6 neuromere

      (Yang et al., 1997)

      larval RP2 motor neuron of abdominal 7 neuromere

      (Yang et al., 1997)

      macrochaeta

      (Klein and Campos-Ortega, 1997)

      medulla anlage | somatic clone

      (Suzuki et al., 2013)

      mesothoracic leg sensillum

      (Klein and Campos-Ortega, 1997)

      metatarsus | distal

      (Klein and Campos-Ortega, 1997)

      metathoracic leg sensillum

      (Klein and Campos-Ortega, 1997)

      neuroblast | ectopic | somatic clone

      (Suzuki et al., 2013)

      neuron | increased number | larval stage

      (Díaz-de-la-Peña et al., 2020)

      presutural bristle

      (Klein and Campos-Ortega, 1997)

      presutural bristle (with kluG410)

      (Kaspar et al., 2008)

      presutural bristle sensory mother cell (with kluG410)

      (Kaspar et al., 2008)

      pretarsus

      (Klein and Campos-Ortega, 1997)

      prothoracic leg sensillum

      (Klein and Campos-Ortega, 1997)

      sex comb

      (Klein and Campos-Ortega, 1997)

      subesophageal zone neuron

      (Losada-Pérez et al., 2010)

      supraalar bristle sensory mother cell (with kluG410)

      (Kaspar et al., 2008)

      tarsal segment

      (Klein and Campos-Ortega, 1997)

      tarsal segment 3

      (Klein and Campos-Ortega, 1997)

      tarsal segment 4

      (Klein and Campos-Ortega, 1997)

      tibia

      (Klein and Campos-Ortega, 1997)

      trochanter

      (Klein and Campos-Ortega, 1997)

      wing margin bristle

      (Klein and Campos-Ortega, 1997)
      Detailed Description
      Statement
      Reference

      Premature neuroblast differentiation is not observed in klu212lR51C mutant clones originating from a single type II neuroblast.

      (Janssens et al., 2014)

      Ectopic neuroblasts form in the inner region of the medulla primordium in homozygous mutant clones.

      (Suzuki et al., 2013)

      When klu212lR51C mutant MARCM clones are induced 30-48 hours after egg laying (AEL), a reduction of the size of neuroblasts is observed in larval brains.

      kluG410/klu212lR51C transheterozygotes show a neuroblast-loss phenotype.

      (Berger et al., 2012)

      klu212lR51C/klu09036 larval brains show premature loss of neuroblasts.

      (Xiao et al., 2012)

      There is an increase in the number of SELK neurons in klu212lR51C mutant animals.

      (Losada-Pérez et al., 2010)

      klu212lR51C/kluG410 adults always lack the anterior supraalar and presutural bristles. The sensory organ precursor cells of both these types of bristles are absent in mutant wing imaginal discs.

      (Kaspar et al., 2008)

      klu212lR51C/klu09036 and klu212lR51C/klu10052 larvae show a feeding defect in which food becomes lodged in the pharynx.

      (Melcher and Pankratz, 2005)

      Strong phenotype. Homozygous adults show fusions in the tarsal segments, the trochanter is fused to the femur, and the size of the leg segments is reduced. In the case of the first tarsal segment this reduction in size is probably due to loss of the distal region. The number of bristles in the region of the femur is less than normal and the sex comb is missing in males. The number of bristles on the antenna is reduced in klu212lR51C/Df(3L)vin2 flies and the basal cylinder of antennal segment 3 is severely reduced in size. The number of bristles on the proximal costa is severely reduced in klu212lR51C/Df(3L)kluXR19 flies. 70% of these flies lack the presutural bristle. kluG410/klu212lR51C flies lack the anterior sternopleural macrochaete and other surrounding bristles. The number of bristles on the proximal costa is strongly reduced compared to wild-type. The tarsal segments are reduced in size and segments 3-5 are fused together. The tibia is malformed. Activation of kluScer\UAS.T:Hsap\MYC by Scer\GAL4klu-G410 in a kluG410/klu212lR51C background leads to complete rescue of the bristle phenotype and partial rescue of the leg phenotype.

      (Klein and Campos-Ortega, 1997)

      99% of hemisegments T2-A1 have duplicated RP2 neurons in homozygous embryos, and duplications are seen in 26% of hemisegments A2-A8.

      (Yang et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      klu212lR51C is a suppressor of abnormal neuroanatomy | somatic clone phenotype of Df(2L)erm2/erm1

      (Janssens et al., 2014)

      klu[+]/klu212lR51C is a suppressor of visible | dominant phenotype of groE48

      (Kaspar et al., 2008)
      Other
      Statement
      Reference

      groE48/gro[+], klu212lR51C has visible | dominant phenotype

      (Kaspar et al., 2008)

      Df(3R)Espl22/+, klu212lR51C has visible | dominant phenotype

      (Kaspar et al., 2008)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      klu212lR51C has wing margin bristle phenotype, enhanceable by Df(1)ase-1

      (Klein and Campos-Ortega, 1997)
      Suppressor of
      Statement
      Reference

      klu212lR51C is a suppressor of type II neuroblast | increased number | somatic clone phenotype of Df(2L)erm2/erm1

      (Janssens et al., 2014)

      klu[+]/klu212lR51C is a suppressor of anterior postalar bristle phenotype of groE48

      (Kaspar et al., 2008)
      Other
      Statement
      Reference

      groE48/gro[+], klu212lR51C has presutural bristle phenotype

      (Kaspar et al., 2008)

      Df(3R)Espl22/+, klu212lR51C has presutural bristle phenotype

      (Kaspar et al., 2008)

      Df(1)ase-1, klu212lR51C has microchaeta & adult abdomen phenotype

      (Klein and Campos-Ortega, 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygous klu212lR51C suppresses the supernumerary neuroblast phenotype seen in erm1/Df(2L)erm2 mutant clones originating from a single type II neuroblast.

      (Janssens et al., 2014)

      54% of groE48/klu212lR51C and 71% of Df(3R)Espl22/klu212lR51C double heterozygotes show loss of the presutural bristle.

      klu212lR51C/+ partially suppresses the duplication of the anterior postalar bristle seen in groE48 and Df(3R)Espl22 heterozygotes: only 12% and 28% respectively of the double heterozygous flies show the duplication.

      (Kaspar et al., 2008)

      klu212lR51C dominantly suppresses the rough eye phenotype seen in In(1)rst3 flies.

      (Rusconi et al., 2004)

      The slight reduction in the number of anterior wing margin bristles seen in hemizygous klu212lR51C or Df(1)ase-1 single mutant flies is strongly enhanced in double mutant klu212lR51C; Df(1)ase-1 flies. In addition, abdominal microchaetae are missing in these double mutant flies.

      (Klein and Campos-Ortega, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      References (18)