FlyBase Allele Report: Dmel\klu[G410]

General Information

Symbol

Dmel\klu^G410

Species

D. melanogaster

Name

FlyBase ID

FBal0064841

Feature type

allele

Associated gene

Dmel\klu

Associated Insertion(s)

P{GAL4}klu^G410

Carried in Construct

Also Known As

Klu-Gal4, klumpfuss-GAL4

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Klein and Campos-Ortega, 1997)

Progenitor genotype

Associated Insertion(s)

P{GAL4}klu^G410

Cytology

Description

Insertion of a P{GAL4} element.

(Klein and Campos-Ortega, 1997)

Allele components

Component

Use(s)

Inserted element

P{GAL4}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with klu^212lR51C)

(Kaspar et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

klu^G410/klu^212lR51C transheterozygotes show a neuroblast-loss phenotype.

(Berger et al., 2012)

klu^212lR51C/klu^G410 adults always lack the anterior supraalar and presutural bristles. The sensory organ precursor cells of both these types of bristles are absent in mutant wing imaginal discs.

(Kaspar et al., 2008)

Intermediate phenotype. klu^G410/klu^212lR51C flies lack the anterior sternopleural macrochaete and other surrounding bristles. The number of bristles on the proximal costa is strongly reduced compared to wild-type. The tarsal segments are reduced in size and segments 3-5 are fused together. The tibia is malformed. Activation of klu^{Scer\UAS.T:Hsap\MYC} by Scer\GAL4^klu-G410 in a klu^G410/klu^819lR5 or klu^G410/klu^212lR51C background leads to complete rescue of the bristle phenotype and partial rescue of the leg phenotype.

(Klein and Campos-Ortega, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

klu^G410/klu^212lR51C is rescued by klu^UAS.Tag:HA/Scer\GAL4^klu-G410

(Kaspar et al., 2008)

klu^G410/klu^212lR51C is rescued by Scer\GAL4^klu-G410/klu^{Δ1-400.UAS.Tag:HA}

(Kaspar et al., 2008)

klu^G410/klu^212lR51C is rescued by Scer\GAL4^klu-G410/klu^{Δ584-619.UAS.Tag:HA}

(Kaspar et al., 2008)

klu^G410/klu^212lR51C is rescued by klu^{Δ680-711.UAS.Tag:HA}/Scer\GAL4^klu-G410

(Kaspar et al., 2008)

Partially rescued by

klu^G410/klu^212lR51C is partially rescued by Scer\GAL4^klu-G410/klu^{Δ1-583.UAS.Tag:HA}

(Kaspar et al., 2008)

klu^G410/klu^819lR5 is partially rescued by Scer\GAL4^klu-G410/klu^UAS.Tag:MYC

(Klein and Campos-Ortega, 1997)

klu^G410/klu^212lR51C is partially rescued by Scer\GAL4^klu-G410/klu^UAS.Tag:MYC

(Klein and Campos-Ortega, 1997)

Not rescued by

klu^G410/klu^212lR51C is not rescued by Scer\GAL4^klu-G410/klu^{Δ583-803.UAS.Tag:HA}

(Kaspar et al., 2008)

Comments

Expression of either klu^{Scer\UAS.T:Ivir\HA1}, klu^{Δ1-400.Scer\UAS.T:Ivir\HA1}, klu^{Δ584-619.Scer\UAS.T:Ivir\HA1} or klu^{Δ680-711.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^klu-G410 rescues the bristle defects of klu^212lR51C/klu^G410 flies.

Expression of klu^{Δ1-583.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^klu-G410 does not rescue the bristle defects of klu^212lR51C/klu^G410 flies, but results in a higher survival rate.

Expression of klu^{Δ583-803.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^klu-G410 does not rescue the bristle defects of klu^212lR51C/klu^G410 flies.

(Kaspar et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

klu^G410

(Berger et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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