FB2026_02 , released June 18, 2026
Gene: Dmel\prg
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General Information
Symbol
Dmel\prg
Species
D. melanogaster
Name
piragua
Annotation Symbol
CG9233
Feature Type
protein_coding_gene
FlyBase ID
FBgn0285971
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
piragua (prg) encodes a transcription factor that interacts genetically with fwe. It is required for embryonic dorsal closure and head involution as well as thorax and eye imaginal development. [Date last reviewed: 2019-03-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

fu2

Key Links
Genomic Location
Cytogenetic map
29D1-29D1
Sequence location
Recombination map
2-33
RefSeq locus
NT_033779 REGION:8464488..8466694
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN002810938
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002810938
(GO Reference Genome Project, 2011-)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR012934
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in dorsal closure
inferred from mutant phenotype
(Nazario-Yepiz and Riesgo-Escovar, 2017)
involved_in head involution
inferred from mutant phenotype
(Nazario-Yepiz and Riesgo-Escovar, 2017)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from biological aspect of ancestor with PANTHER:PTN001227002
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002810938
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR012934
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
piragua (prg) encodes a transcription factor that interacts genetically with fwe. It is required for embryonic dorsal closure and head involution as well as thorax and eye imaginal development. [Date last reviewed: 2019-03-28]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
May be involved in transcriptional regulation (PubMed:28011160). The function of this protein is unclear (PubMed:28011160, PubMed:34962606). According to one report, it is required for development and viability since mutants display defects in several developmental morphogenetic processes including dorsal closure and head involution, and die by the first instar larval stage (PubMed:28011160). It may also be involved in fwe-mediated cellular competition (PubMed:28011160). However, according to another report, it is not required for development or viability since mutants have no visible phenotype and are fertile (PubMed:34962606).
(UniProt, Q9VLK8)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\prg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VLK8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.45

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
prg-RA
FBtr0079674
NM_135388
1984
558
prg-RB
FBtr0332008
NM_001273324
2149
558
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
prg-PA
FBpp0079289
63.9
558
5.62
Q9VLK8
NP_609232
AAF52681
prg-PB
FBpp0304330
63.9
558
5.62
Q9VLK8
NP_001260253
AGB92789
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

558 aa isoforms: prg-PA, prg-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\prg using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.58

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 4 -- 14
ectoderm
(Nazario-Yepiz and Riesgo-Escovar, 2017)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 11
germ band
(Nazario-Yepiz and Riesgo-Escovar, 2017)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 14
mesoderm
(Nazario-Yepiz and Riesgo-Escovar, 2017)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
germline cell
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 16
endoderm
(Nazario-Yepiz and Riesgo-Escovar, 2017)
third instar larval stage
wing disc
(Nazario-Yepiz and Riesgo-Escovar, 2017)
eye-antennal disc
(Nazario-Yepiz and Riesgo-Escovar, 2017)
leg disc
(Nazario-Yepiz and Riesgo-Escovar, 2017)
eye disc anterior to the morphogenetic furrow
(Nazario-Yepiz and Riesgo-Escovar, 2017)
Additional Descriptive Data

png is expressed widely in the embryo throughout embryogenesis and is seen in all the germ layers.

(Nazario-Yepiz and Riesgo-Escovar, 2017)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 14
ectoderm
(Nazario-Yepiz and Riesgo-Escovar, 2017)
embryonic stage 9 -- 11
germ band
(Nazario-Yepiz and Riesgo-Escovar, 2017)
embryonic stage 13 -- 14
mesoderm
(Nazario-Yepiz and Riesgo-Escovar, 2017)
embryonic stage 16
endoderm
(Nazario-Yepiz and Riesgo-Escovar, 2017)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\prg in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of prg
Transgenic constructs containing regulatory region of prg
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7038
(Ryder, 2004.4.26)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (148)
Hsap\ZNF646
2 of 14
Yes
Yes
Hsap\BCL11B
1 of 14
No
No
Hsap\CTCFL
1 of 14
No
No
Hsap\GLI4
1 of 14
No
No
Hsap\KLF5
1 of 14
No
No
Hsap\KLF9
1 of 14
No
No
Hsap\MECOM
1 of 14
No
No
Hsap\MYNN
1 of 14
No
No
Hsap\PATZ1
1 of 14
No
Yes
Hsap\PRDM2
1 of 14
No
No
Hsap\PRDM4
1 of 14
No
No
Hsap\PRDM5
1 of 14
No
No
Hsap\PRDM6
1 of 14
No
No
Hsap\PRDM7
1 of 14
No
No
Hsap\PRDM9
1 of 14
No
No
Hsap\PRDM10
1 of 14
No
Yes
Hsap\PRDM12
1 of 14
No
No
5  
Hsap\PRDM13
1 of 14
No
No
Hsap\PRDM14
1 of 14
No
No
Hsap\PRDM15
1 of 14
No
Yes
Hsap\PRDM16
1 of 14
No
No
1  
Hsap\SALL1
1 of 14
No
No
Hsap\SCRT1
1 of 14
No
No
Hsap\SCRT2
1 of 14
No
No
1  
Hsap\SNAI1
1 of 14
No
No
Hsap\ZBTB4
1 of 14
No
Yes
Hsap\ZBTB6
1 of 14
No
No
Hsap\ZBTB7B
1 of 14
No
Yes
1  
Hsap\ZBTB11
1 of 14
No
No
Hsap\ZBTB14
1 of 14
No
No
Hsap\ZBTB16
1 of 14
No
Yes
Hsap\ZBTB17
1 of 14
No
Yes
Hsap\ZBTB37
1 of 14
No
No
Hsap\ZBTB38
1 of 14
No
Yes
Hsap\ZBTB44
1 of 14
No
No
Hsap\ZBTB49
1 of 14
No
Yes
Hsap\ZFAT
1 of 14
No
No
Hsap\ZFP3
1 of 14
No
No
Hsap\ZFP14
1 of 14
No
No
Hsap\ZFP62
1 of 14
No
No
Hsap\ZFP64
1 of 14
No
No
Hsap\ZFP69B
1 of 14
No
No
Hsap\ZFX
1 of 14
No
Yes
Hsap\ZKSCAN3
1 of 14
No
No
Hsap\ZKSCAN7
1 of 14
No
No
Hsap\ZKSCAN8
1 of 14
No
No
Hsap\ZNF8
1 of 14
No
No
Hsap\ZNF14
1 of 14
No
No
Hsap\ZNF26
1 of 14
No
No
Hsap\ZNF45
1 of 14
No
No
Hsap\ZNF79
1 of 14
No
No
Hsap\ZNF83
1 of 14
No
No
Hsap\ZNF84
1 of 14
No
No
Hsap\ZNF91
1 of 14
No
No
Hsap\ZNF98
1 of 14
No
No
Hsap\ZNF112
1 of 14
No
No
Hsap\ZNF132
1 of 14
No
No
Hsap\ZNF133
1 of 14
No
No
Hsap\ZNF184
1 of 14
No
No
Hsap\ZNF197
1 of 14
No
No
Hsap\ZNF221
1 of 14
No
No
Hsap\ZNF226
1 of 14
No
No
Hsap\ZNF234
1 of 14
No
No
Hsap\ZNF236
1 of 14
No
Yes
Hsap\ZNF239
1 of 14
No
Yes
Hsap\ZNF251
1 of 14
No
No
Hsap\ZNF256
1 of 14
No
No
Hsap\ZNF263
1 of 14
No
No
Hsap\ZNF268
1 of 14
No
No
Hsap\ZNF280A
1 of 14
No
No
Hsap\ZNF280B
1 of 14
No
No
Hsap\ZNF280C
1 of 14
No
No
Hsap\ZNF280D
1 of 14
No
No
Hsap\ZNF281
1 of 14
No
Yes
1  
Hsap\ZNF283
1 of 14
No
No
Hsap\ZNF284
1 of 14
No
No
Hsap\ZNF287
1 of 14
No
No
Hsap\ZNF319
1 of 14
No
Yes
Hsap\ZNF324
1 of 14
No
No
Hsap\ZNF335
1 of 14
No
No
Hsap\ZNF341
1 of 14
No
No
Hsap\ZNF345
1 of 14
No
No
Hsap\ZNF354B
1 of 14
No
No
Hsap\ZNF366
1 of 14
No
Yes
1  
Hsap\ZNF383
1 of 14
No
No
Hsap\ZNF384
1 of 14
No
No
1  
Hsap\ZNF396
1 of 14
No
Yes
Hsap\ZNF416
1 of 14
No
Yes
Hsap\ZNF420
1 of 14
No
No
Hsap\ZNF423
1 of 14
No
No
1  
Hsap\ZNF429
1 of 14
No
No
Hsap\ZNF431
1 of 14
No
No
Hsap\ZNF432
1 of 14
No
No
Hsap\ZNF441
1 of 14
No
No
Hsap\ZNF449
1 of 14
No
No
1  
Hsap\ZNF460
1 of 14
No
No
Hsap\ZNF480
1 of 14
No
No
Hsap\ZNF484
1 of 14
No
No
Hsap\ZNF492
1 of 14
No
No
Hsap\ZNF497
1 of 14
No
No
Hsap\ZNF502
1 of 14
No
No
Hsap\ZNF506
1 of 14
No
No
Hsap\ZNF519
1 of 14
No
No
Hsap\ZNF528
1 of 14
No
No
Hsap\ZNF530
1 of 14
No
No
Hsap\ZNF544
1 of 14
No
No
Hsap\ZNF546
1 of 14
No
No
Hsap\ZNF562
1 of 14
No
No
Hsap\ZNF568
1 of 14
No
No
Hsap\ZNF571
1 of 14
No
No
Hsap\ZNF578
1 of 14
No
No
Hsap\ZNF582
1 of 14
No
No
Hsap\ZNF585A
1 of 14
No
No
Hsap\ZNF585B
1 of 14
No
No
Hsap\ZNF599
1 of 14
No
No
Hsap\ZNF605
1 of 14
No
No
Hsap\ZNF615
1 of 14
No
No
Hsap\ZNF616
1 of 14
No
No
Hsap\ZNF619
1 of 14
No
No
Hsap\ZNF621
1 of 14
No
No
Hsap\ZNF623
1 of 14
No
No
Hsap\ZNF648
1 of 14
No
No
Hsap\ZNF660-ZNF197
1 of 14
No
No
Hsap\ZNF674
1 of 14
No
No
Hsap\ZNF710
1 of 14
No
No
Hsap\ZNF721
1 of 14
No
No
Hsap\ZNF726
1 of 14
No
No
Hsap\ZNF749
1 of 14
No
No
Hsap\ZNF766
1 of 14
No
Yes
Hsap\ZNF780B
1 of 14
No
No
Hsap\ZNF782
1 of 14
No
No
Hsap\ZNF784
1 of 14
No
Yes
Hsap\ZNF792
1 of 14
No
No
Hsap\ZNF829
1 of 14
No
No
Hsap\ZNF836
1 of 14
No
No
Hsap\ZNF841
1 of 14
No
No
Hsap\ZNF845
1 of 14
No
No
Hsap\ZNF875
1 of 14
No
No
Hsap\ZNF879
1 of 14
No
No
Hsap\ZNF880
1 of 14
No
No
Hsap\ZNF883
1 of 14
No
No
Hsap\ZSCAN2
1 of 14
No
No
Hsap\ZSCAN5C
1 of 14
No
No
Hsap\ZSCAN10
1 of 14
No
No
Hsap\ZSCAN18
1 of 14
No
Yes
Hsap\ZSCAN25
1 of 14
No
No
Hsap\ZSCAN31
1 of 14
No
No
Hsap\ZXDC
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (10)
Rnor\Fezf2
1 of 14
Yes
No
Rnor\Zbtb4
1 of 14
Yes
Yes
Rnor\Zbtb38
1 of 14
Yes
Yes
Rnor\Zfat
1 of 14
Yes
No
Rnor\Zfp280b
1 of 14
Yes
No
Rnor\Zfp280c
1 of 14
Yes
No
Rnor\Zfp280d
1 of 14
Yes
No
Rnor\Zfp507
1 of 14
Yes
Yes
Rnor\Zfp521
1 of 14
Yes
No
Rnor\Zfp646
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (13)
Mmus\Fezf2
1 of 14
Yes
No
1  
Mmus\Gm14443
1 of 14
Yes
No
Mmus\Gm32687
1 of 14
Yes
No
Mmus\Zbtb4
1 of 14
Yes
Yes
Mmus\Zbtb38
1 of 14
Yes
Yes
Mmus\Zfat
1 of 14
Yes
No
Mmus\Zfp251
1 of 14
Yes
Yes
Mmus\Zfp280b
1 of 14
Yes
No
Mmus\Zfp280c
1 of 14
Yes
No
Mmus\Zfp280d
1 of 14
Yes
No
Mmus\Zfp341
1 of 14
Yes
Yes
Mmus\Zfp507
1 of 14
Yes
Yes
Mmus\Zfp513
1 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (44)
Xtro\adprm.2
1 of 13
Yes
No
Xtro\klf5
1 of 13
Yes
No
Xtro\klf15
1 of 13
Yes
No
Xtro\LOC496795
1 of 13
Yes
No
Xtro\LOC100485704
1 of 13
Yes
No
Xtro\LOC100487768
1 of 13
Yes
Yes
Xtro\LOC100493797
1 of 13
Yes
No
Xtro\LOC100495895
1 of 13
Yes
No
Xtro\LOC100498327
1 of 13
Yes
Yes
Xtro\LOC101731232
1 of 13
Yes
No
Xtro\LOC116411620
1 of 13
Yes
Yes
Xtro\LOC116411624
1 of 13
Yes
No
Xtro\LOC116411645
1 of 13
Yes
No
Xtro\mynn
1 of 13
Yes
No
Xtro\patz1
1 of 13
Yes
Yes
Xtro\plag1
1 of 13
Yes
No
Xtro\pogz
1 of 13
Yes
No
Xtro\prdm2
1 of 13
Yes
Yes
Xtro\prdm6
1 of 13
Yes
Yes
Xtro\prdm10
1 of 13
Yes
Yes
Xtro\prdm14
1 of 13
Yes
No
Xtro\sall1
1 of 13
Yes
No
Xtro\siah3
1 of 13
Yes
No
Xtro\sp4
1 of 13
Yes
No
Xtro\tmem208
1 of 13
Yes
No
Xtro\ube2c
1 of 13
Yes
No
Xtro\vps28
1 of 13
Yes
No
Xtro\XB5795368
1 of 13
Yes
No
Xtro\zbtb14
1 of 13
Yes
Yes
Xtro\zbtb38
1 of 13
Yes
Yes
Xtro\znf180
1 of 13
Yes
No
Xtro\znf229
1 of 13
Yes
No
Xtro\znf280d
1 of 13
Yes
No
Xtro\znf319
1 of 13
Yes
Yes
Xtro\znf333
1 of 13
Yes
No
Xtro\znf341
1 of 13
Yes
No
Xtro\znf408
1 of 13
Yes
Yes
Xtro\znf420
1 of 13
Yes
No
Xtro\znf423
1 of 13
Yes
No
Xtro\znf574
1 of 13
Yes
No
Xtro\znf605
1 of 13
Yes
No
Xtro\znf628
1 of 13
Yes
No
Xtro\znf711
1 of 13
Yes
No
Xtro\zscan2
1 of 13
Yes
No
Danio rerio (Zebrafish) (27)
Drer\gfi1ab
1 of 14
Yes
No
Drer\LOC563292
1 of 14
Yes
Yes
Drer\LOC797319
1 of 14
Yes
No
Drer\LOC100333534
1 of 14
Yes
No
Drer\LOC100538196
1 of 14
Yes
No
Drer\LOC101884367
1 of 14
Yes
No
Drer\LOC101884750
1 of 14
Yes
No
Drer\LOC103910897
1 of 14
Yes
No
Drer\LOC108182171
1 of 14
Yes
No
Drer\LOC108190743
1 of 14
Yes
Yes
Drer\pogza
1 of 14
Yes
No
Drer\si:cabz01069022.1
1 of 14
Yes
Yes
Drer\si:ch211-79k12.2
1 of 14
Yes
Yes
Drer\si:ch211-142b24.6
1 of 14
Yes
Yes
Drer\si:ch211-148l7.4
1 of 14
Yes
Yes
Drer\si:ch211-202h22.10
1 of 14
Yes
Yes
Drer\si:ch211-216l23.1
1 of 14
Yes
No
Drer\si:ch211-261d7.6
1 of 14
Yes
Yes
Drer\zbtb4
1 of 14
Yes
Yes
Drer\zbtb41
1 of 14
Yes
No
Drer\zfat
1 of 14
Yes
No
Drer\zgc:162972
1 of 14
Yes
No
Drer\zgc:165514
1 of 14
Yes
Yes
Drer\zgc:173548
1 of 14
Yes
No
Drer\znf341
1 of 14
Yes
Yes
Drer\znf770
1 of 14
Yes
Yes
Drer\znf977
1 of 14
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\bcl-11
1 of 14
Yes
No
Cele\blmp-1
1 of 14
Yes
No
Cele\C04F5.9
1 of 14
Yes
Yes
Cele\egrh-2
1 of 14
Yes
No
Cele\ham-2
1 of 14
Yes
No
Cele\klu-1
1 of 14
Yes
No
Cele\lsy-27
1 of 14
Yes
No
Cele\pzf-1
1 of 14
Yes
No
Cele\set-17
1 of 14
Yes
No
Cele\ztf-25
1 of 14
Yes
No
Cele\ztf-28
1 of 14
Yes
No
Cele\ztf-29
1 of 14
Yes
No
Cele\ztf-30
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (36)
Agam\AgaP_AGAP009406
9 of 12
Yes
Yes
Agam\AgaP_AGAP000164
1 of 12
No
No
Agam\AgaP_AGAP002497
1 of 12
No
No
Agam\AgaP_AGAP002610
1 of 12
No
No
Agam\AgaP_AGAP002705
1 of 12
No
No
Agam\AgaP_AGAP003594
1 of 12
No
No
Agam\AgaP_AGAP003885
1 of 12
No
No
Agam\AgaP_AGAP004081
1 of 12
No
Yes
Agam\AgaP_AGAP004083
1 of 12
No
Yes
Agam\AgaP_AGAP004269
1 of 12
No
No
Agam\AgaP_AGAP004764
1 of 12
No
Yes
Agam\AgaP_AGAP005348
1 of 12
No
No
Agam\AgaP_AGAP005482
1 of 12
No
No
Agam\AgaP_AGAP005555
1 of 12
No
No
Agam\AgaP_AGAP005568
1 of 12
No
No
Agam\AgaP_AGAP005978
1 of 12
No
No
Agam\AgaP_AGAP006061
1 of 12
No
Yes
Agam\AgaP_AGAP006272
1 of 12
No
No
Agam\AgaP_AGAP006592
1 of 12
No
No
Agam\AgaP_AGAP006794
1 of 12
No
No
Agam\AgaP_AGAP008232
1 of 12
No
No
Agam\AgaP_AGAP008430
1 of 12
No
No
Agam\AgaP_AGAP008984
1 of 12
No
No
Agam\AgaP_AGAP009010
1 of 12
No
No
Agam\AgaP_AGAP009337
1 of 12
No
Yes
Agam\AgaP_AGAP009566
1 of 12
No
No
Agam\AgaP_AGAP010009
1 of 12
No
No
Agam\AgaP_AGAP010063
1 of 12
No
No
Agam\AgaP_AGAP010732
1 of 12
No
Yes
Agam\AgaP_AGAP011247
1 of 12
No
No
Agam\AgaP_AGAP011403
1 of 12
No
Yes
Agam\AgaP_AGAP011759
1 of 12
No
No
Agam\AgaP_AGAP011963
1 of 12
No
Yes
Agam\AgaP_AGAP012669
1 of 12
No
No
Agam\AgaP_AGAP012834
1 of 12
No
Yes
Agam\AgaP_AGAP013275
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\TFIIIA
1 of 13
Yes
No
Atha\YY1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CRZ1
1 of 13
Yes
No
Scer\ZAP1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:prg. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (62)
CG2202
3 of 13
CG10959
3 of 13
CG5245
2 of 13
CG6689
2 of 13
CG17328
2 of 13
Meics
2 of 13
trabl
2 of 13
Zif
2 of 13
Blimp-1
1 of 13
Cf2
1 of 13
CG1233
1 of 13
CG1529
1 of 13
CG1792
1 of 13
CG3407
1 of 13
CG6654
1 of 13
CG6813
1 of 13
CG7368
1 of 13
CG7386
1 of 13
CG7987
1 of 13
CG8159
1 of 13
CG8301
1 of 13
CG10274
1 of 13
CG11906
1 of 13
CG12299
1 of 13
CG14655
1 of 13
CG15269
1 of 13
CG17359
1 of 13
CG17568
1 of 13
CG17612
1 of 13
CG18011
1 of 13
CG30431
1 of 13
CG31388
1 of 13
CG31441
1 of 13
CG32767
1 of 13
cg
1 of 13
Clamp
1 of 13
crol
1 of 13
D19A
1 of 13
D19B
1 of 13
dwg
1 of 13
gl
1 of 13
grau
1 of 13
ham
1 of 13
idc
1 of 13
Kah
1 of 13
klu
1 of 13
l(3)neo38
1 of 13
M1BP
1 of 13
MTF-1
1 of 13
nom
1 of 13
odd
1 of 13
Opbp
1 of 13
ouib
1 of 13
Paris
1 of 13
pita
1 of 13
ranshi
1 of 13
Saft
1 of 13
Sag1
1 of 13
scrape
1 of 13
scrt
1 of 13
sna
1 of 13
wor
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    prg
    enhanceable
    fwe
    (Nazario-Yepiz and Riesgo-Escovar, 2017)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    fwe
    enhanceable
    prg
    (Nazario-Yepiz and Riesgo-Escovar, 2017)
    External Data
    Linkouts
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-33
    Cytogenetic map
    29D1-29D1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    29D1-29D1
    Limits computationally determined from genome sequence between P{lacW}l(2)k03706k03706&P{lacW}Acerk07704 and P{PZ}lmg03424
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    2-33

    (FlyBase, 2016)

    2-27.9

    (Comeron et al., 2012)

    2-

    (Riesgo-Escovar, 1999.9.23)
    Left of (cM)
    Right of (cM)
    Notes

    prg maps to 2L.

    (Riesgo-Escovar, 1999.9.23)
    Stocks and Reagents
    Stocks (14)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (61)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Nazario-Yepiz and Riesgo-Escovar, 2017)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          prg is involved in dorsal closure.

          (Gomez and Riesgo-Escovar, 1999)

          Lethal alleles result in death during late embryogenesis with a centrally located dorsal hole. A viable allele showing deficits in visual and olfactory driven behaviour has been isolated.

          (Gomez and Riesgo-Escovar, 1999)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: FU12 CG9233

          (Bayraktaroglu, 2000.8.7)

          Source for merge of: prg fu2

          (Nazario-Yepiz and Riesgo-Escovar, 2017)
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology

          Named 'piragua', which means 'small boat' in Spanish - a small fraction of mutant embryos sport a hole in the dorsal aspect of the cuticle, resembling such a vessel.

          (Nazario-Yepiz and Riesgo-Escovar, 2017)
          Synonyms and Secondary IDs (7)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 33 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (59)