FlyBase Gene Report: Dmel\Klf15

General Information

Symbol

Dmel\Klf15

Species

D. melanogaster

Name

Kruppel-like factor 15

Annotation Symbol

CG2932

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025679

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Bteb2, dKlf15

Key Links

Genomic Location

Cytogenetic map

4D1-4D1

Sequence location

X:4,770,557..4,771,588 [-]

Recombination map

1-9

RefSeq locus

NC_004354 REGION:4770557..4771588

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables sequence-specific DNA binding

inferred from direct assay

(Brown et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004619861

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004619861

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in garland nephrocyte differentiation

inferred from mutant phenotype

(Ivy et al., 2015)

involved_in nephrocyte diaphragm assembly

inferred from mutant phenotype

(Ivy et al., 2015)

involved_in pericardial nephrocyte differentiation

inferred from mutant phenotype

(Ivy et al., 2015)

involved_in response to silver ion

inferred from mutant phenotype

(Ivy et al., 2015)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in positive regulation of transcription by RNA polymerase II

inferred from sequence or structural similarity with UniProtKB:Q9UIH9

(Gene Ontology Curators, 2002-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004619861

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN009066117

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q9UIH9

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

SP1/KLF TRANSCRIPTION FACTORS

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SP1/KLF TRANSCRIPTION FACTORS -: The Sp1/KLF (Sp1-like/Kruppel-like factors) family of zinc finger proteins are DNA binding proteins. They can act as activators or repressors and some members bind sequences within Polycomb Response Elements (PREs). (Adapted from FBrf0188187).
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Klf15 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q0IGQ2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Klf15-RA

FBtr0070735

NM_131957

1032

311

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Klf15-PA

FBpp0070703

34.8

311

4.99

Q0IGQ2

NP_572185

AAF45983

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Klf15 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bteb2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.19

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

garland cell primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval garland cell

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage -- third instar larval stage

larval pericardial cell

(Ivy et al., 2015)

adult stage

adult pericardial cell

• nucleus

(Ivy et al., 2015)

Additional Descriptive Data

Klf15 protein is localized to pericardial nephrocytes at larval and adult stages.

(Ivy et al., 2015)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Klf15-GAL4.I}

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage -- third instar larval stage

larval pericardial cell

(Ivy et al., 2015)

third instar larval stage

embryonic/larval garland cell

(Ivy et al., 2015)

adult stage

adult pericardial cell

(Ivy et al., 2015)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Klf15 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Klf15

View exonic expression by tissue for Dmel\Klf15

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025679

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31410/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025679

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025679

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025679

Flygut - An atlas of the Drosophila adult midgut

FBgn0025679

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Klf15

Transgenic constructs containing regulatory region of Klf15

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(1)ED6727

(Ivy et al., 2015)

Gene not duplicated in

Dp(1;3)DC120

(Ivy et al., 2015)

Dp(1;3)DC122

(Ivy et al., 2015)

Gene duplicated in

Dp(1;3)DC473

(Ivy et al., 2015)

Inferred from location ( 16 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Klf15^f06447

viable, with Scer\GAL4^pnr-MD237

Klf15^GD4165

Sterility

Allele

fertile

Klf15^f06447

Other Phenotypes

Allele

chemical sensitive | larval stage

Klf15^f06447

Phenotype manifest in

Allele

adult garland cell

Klf15^f06447

adult heart

Klf15^f06447

adult heart, with Scer\GAL4^Hand.PA

Klf15^JF02420

adult heart, with Scer\GAL4^Ugt36A1.PK

Klf15^JF02420

adult pericardial cell

Klf15^f06447

adult pericardial cell, with Scer\GAL4^Hand.PA

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

adult pericardial cell (with Df(1)ED6727)

Klf15^f06447

adult pericardial cell | increased number, with Scer\GAL4^Ugt36A1.PK

Klf15^UAS.cIa

embryonic/larval garland cell

Klf15^f06447

embryonic/larval garland cell | third instar larval stage

Klf15^f06447

larval pericardial cell

Klf15^f06447

nephrocyte diaphragm | larval stage

Klf15^f06447

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (84)

Hsap\KLF15

6 of 14

Yes

Hsap\KLF9

2 of 14

Yes

Hsap\KLF14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\LOC344065

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ZNF148

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (48)

Rnor\Klf15

6 of 14

Yes

Rnor\Klf14

3 of 14

Yes

Rnor\Klf9

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Zfp362

1 of 14

Rnor\Zfp647

1 of 14

Rnor\Zfp853

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Znf8

1 of 14

Rnor\Zxdc

1 of 14

Mus musculus (laboratory mouse) (69)

Mmus\Klf15

6 of 14

Yes

Mmus\Klf14

2 of 14

Yes

Mmus\Klf17

2 of 14

Mmus\B020011L13Rik

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zfp629

1 of 14

Mmus\Zfp668

1 of 14

Yes

Mmus\Zfp735

1 of 14

Mmus\Zfp809

1 of 14

Yes

Mmus\Zfp930

1 of 14

Mmus\Zfp931

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Zscan22

1 of 14

Mmus\Zxdb

1 of 14

Mmus\Zxdc

1 of 14

Xenopus tropicalis (Western clawed frog) (40)

Xtro\klf15.2

5 of 13

Yes

Xtro\klf15

4 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (54)

Drer\si:ch211-117k10.3

6 of 14

Yes

Drer\klf15

5 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:153115

1 of 14

Drer\zgc:173577

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\znf143a

1 of 14

Yes

Drer\znf143b

1 of 14

Yes

Drer\znf668

1 of 14

Yes

Drer\znf1041

1 of 14

Drer\znf1167

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\blmp-1

1 of 14

Yes

Cele\egrh-1

1 of 14

Yes

Cele\egrh-2

1 of 14

Yes

Cele\F10B5.3

1 of 14

Yes

Cele\klf-1

1 of 14

Yes

Cele\klf-2

1 of 14

Yes

Cele\klf-3

1 of 14

Yes

Cele\lin-29

1 of 14

Yes

Cele\pqm-1

1 of 14

Yes

Cele\ref-2

1 of 14

Yes

Cele\sptf-2

1 of 14

Yes

Cele\sptf-3

1 of 14

Yes

Cele\ztf-14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP004282

9 of 12

Yes

Agam\AgaP_AGAP013162

5 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\FZF1

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\scr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Klf15. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

CG42741

4 of 13

dar1

4 of 13

luna

4 of 13

btd

3 of 13

cbt

3 of 13

CG3065

3 of 13

Sp1

3 of 13

hkb

2 of 13

Spps

2 of 13

Cf2

1 of 13

CG11456

1 of 13

klu

1 of 13

l(3)neo38

1 of 13

lmd

1 of 13

pad

1 of 13

salm

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cardiomyopathy induced by nephrocyte loss/dysfunction

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Klf15^f06447

model of cardiomyopathy

CEA

(Hartley et al., 2016)

Klf15^JF02420

model of cardiomyopathy

CEA

(Hartley et al., 2016)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Klf15^f06447

model of cardiomyopathy

is ameliorated by SPARC^MI00329

(Hartley et al., 2016)

Klf15^JF02420

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KLF15; KLF transcription factor 15

6 of 14

606465

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Klf15 - CG14667

two hybrid array

(Shokri et al., 2019)

Klf15 - CrebA

two hybrid array

(Shokri et al., 2019)

Klf15 - Ets65A

two hybrid array

(Shokri et al., 2019)

Klf15 - Hr78

two hybrid array

(Shokri et al., 2019)

Klf15 - Irbp18

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Klf15

suppressible

SPARC

(Hartley et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm

suppressible

Klf15

(Tegeder et al., 2019)

Snr1

suppressible

Klf15

(Tegeder et al., 2019)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0025679

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O77251

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-9

Cytogenetic map

4D1-4D1

Sequence location

X:4,770,557..4,771,588 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4D1-4D1

Limits computationally determined from genome sequence between P{EP}CG2930^EP1352 and P{EP}EP425

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-9

(FlyBase, 2016)

1-8.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18979

w¹¹¹⁸ PBac{WH}Klf15^f06447

64802

w¹¹¹⁸; PBac{Klf15-GFP.FPTB}VK00033

27075

y¹ v¹; P{TRiP.JF02420}attP2

78734

y¹ sc^* v¹ sev²¹; P{TOE.GS02219}attP40

NIG-Fly

HMJ22943

y¹ v¹; P{TRiP.HMJ22943}attP40/CyO

VDRC

v110761

P{KK108739}VIE-260B

v342821

P{hsFLP}1, y1 w1118; P{HD_CFD02067}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025679

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025679

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Ivy et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Bteb2 CG2932

(Zhao, 1999.11)

Source for identity of: Klf15 Bteb2

(Ivy et al., 2015)

Nomenclature comments

FlyBase curator comment: Rename of 'Bteb2' to 'Klf15' agreed with Judith Kassis, corresponding author of FBrf0188187.

(Ivy et al., 2015)

Etymology

Named 'Klf15'/'Kruppel-like factor 15' after the mammalian ortholog.

(Ivy et al., 2015)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

*z FBgn0

(Selma-Soriano et al., 2020)

BTEB2

(Suske et al., 2005)

BteB2

(Brown et al., 2005)

Bteb2

(Beaver et al., 2022, Tegeder et al., 2019, Louie et al., 2016, Nadimpalli et al., 2015, Munoz-Descalzo et al., 2007, Brown et al., 2005, Hoskins et al., 2005)

CG2932

(National Institute of Genetics Fly Stocks, 2023-, Hartley et al., 2016, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31)

KLF

(Srinivasan and Mishra, 2020)

Klf15

(Meyer et al., 2024, Dow et al., 2022, Morin-Poulard et al., 2022, Bilder et al., 2021, Selma-Soriano et al., 2020, Cevik et al., 2019, Shokri et al., 2019, Troha et al., 2019, Transgenic RNAi Project members, 2017-, Ivy et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-)

dKLF15

(Odenthal and Brinkkoetter, 2019)

dKlf15

(Koehler and Huber, 2023, Ivy et al., 2015)

Name Synonyms

Bteb2

(Brown et al., 2005)

Kruppel-like factor 15

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 29 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31410

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q0IGQ2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q0IGQ2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025679

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31410/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025679

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025679

FlyMine - An integrated database for Drosophila genomics

FBgn0025679

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2932

MARRVEL_MODEL - MARRVEL (model organism gene)

31410

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025679

DroID - A comprehensive database of gene and protein interactions.

FBgn0025679

DRSC - Results frm RNAi screens

FBgn0025679

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Bteb2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025679

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025679

Flygut - An atlas of the Drosophila adult midgut

FBgn0025679

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004670

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O77251

References (52)

The following external sites may use different assemblies or annotations than FlyBase.

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