FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\dar1
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General Information
Symbol
Dmel\dar1
Species
D. melanogaster
Name
dendritic arbor reduction 1
Annotation Symbol
CG12029
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263239
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Summary
dendritic arbor reduction 1 (dar1) encodes a transcription factor in the Kruppel-like factor family. It determines the multipolar morphology of neurons by promoting the growth of dendrites (but not axons), in part by controlling the expression of regulators of microtubules and microtubule-based transport. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
63E5-63E6
Sequence location
Recombination map
3-8
RefSeq locus
NT_037436 REGION:3626352..3653442
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables sequence-specific DNA binding
inferred from direct assay
(Brown et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from sequence or structural similarity with MGI:MGI:1338056
(Ye et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in negative regulation of microtubule depolymerization
inferred from mutant phenotype
(Ye et al., 2011)
involved_in negative regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Ye et al., 2011)
involved_in positive regulation of dendrite extension
inferred from mutant phenotype
(Wang et al., 2015)
involved_in positive regulation of dendrite morphogenesis
inferred from mutant phenotype
(Wang et al., 2015, Ye et al., 2011, Ye et al., 2007)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Wang et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from sequence or structural similarity with MGI:MGI:1338056
(Ye et al., 2011)
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ye et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN009066117
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the krueppel C2H2-type zinc-finger protein family. (Q9VZN4)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
dendritic arbor reduction 1 (dar1) encodes a transcription factor in the Kruppel-like factor family. It determines the multipolar morphology of neurons by promoting the growth of dendrites (but not axons), in part by controlling the expression of regulators of microtubules and microtubule-based transport. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
SP1/KLF TRANSCRIPTION FACTORS -
The Sp1/KLF (Sp1-like/Kruppel-like factors) family of zinc finger proteins are DNA binding proteins. They can act as activators or repressors and some members bind sequences within Polycomb Response Elements (PREs). (Adapted from FBrf0188187).
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Protein Function (UniProtKB)
Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas (PubMed:21368042). Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC (PubMed:26490864).
(UniProt, Q9VZN4)
Summary (Interactive Fly)

zinc finger transcription factor that promotes dendrite growth in part by suppressing the expression of the microtubule-severing protein Spastin

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\dar1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VZN4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dar1-RB
FBtr0113134
NM_001104023
3526
751
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dar1-PB
FBpp0112047
82.3
751
7.80
Q9VZN4
NP_001097493
AAF47785
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dar1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.63

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13
presumptive embryonic/larval peripheral nervous system
(Ye et al., 2011)
abdominal dorsal bipolar neuron dbp
(Ye et al., 2011)
dendritic arborizing neuron | subset
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaA
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaB
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaC
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaD
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaE
(Ye et al., 2011)
abdominal dorsal multidendritic neuron ddaF
(Ye et al., 2011)
• nucleus
(Ye et al., 2011)
Additional Descriptive Data

dar1 protein is detected in the peripheral nervous system of stage 13 embryos, in neurons that have more than one primary neurite. These neurons include bipolar neurons (dbp) and dendritic arborizing neurons (ddaA, ddaB, ddaC, ddaD, ddaE and ddaF).

(Ye et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ye et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dar1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dar1
Transgenic constructs containing regulatory region of dar1
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4477
abnormal neuroanatomy, with Scer\GAL4eve.RN2
abnormal neuroanatomy, with Scer\GAL4P2.4.Pdf
abnormal neuroanatomy (with dar13010)
abnormal neuroanatomy (with dar13232)
abnormal neuroanatomy | larval stage | somatic clone
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | somatic clone, with Scer\GAL4477
Phenotype manifest in
Allele
adult Pdf neuron, with Scer\GAL4P2.4.Pdf
dendrite | increased number, with Scer\GAL4eve.RN2
dendrite | increased number, with Scer\GAL4P2.4.Pdf
dendritic arborizing neuron
dendritic arborizing neuron, with Scer\GAL4477
dendritic arborizing neuron (with dar13010)
dendritic arborizing neuron (with dar13232)
dendritic arborizing neuron | somatic clone
dendritic arborizing neuron | somatic clone, with Scer\GAL4477
embryonic/larval motor neuron, with Scer\GAL4eve.RN2
larval multidendritic class III neuron | somatic clone
larval multidendritic class I neuron | somatic clone
larval multidendritic class IV neuron | larval stage | somatic clone
larval multidendritic class IV neuron | somatic clone
neurite | increased number, with Scer\GAL4eve.RN2
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (83)
Hsap\KLF5
7 of 14
Yes
Yes
Hsap\KLF2
3 of 14
No
No
Hsap\KLF6
3 of 14
No
No
2  
Hsap\KLF7
3 of 14
No
No
1  
Hsap\KLF17
3 of 14
No
Yes
Hsap\KLF18
3 of 14
No
Yes
Hsap\KLF1
2 of 14
No
No
Hsap\KLF3
2 of 14
No
No
1  
Hsap\KLF4
2 of 14
No
No
Hsap\KLF8
2 of 14
No
No
Hsap\KLF10
2 of 14
No
No
Hsap\KLF11
2 of 14
No
No
Hsap\KLF12
2 of 14
No
No
1  
Hsap\KLF14
2 of 14
No
Yes
Hsap\WT1
2 of 14
No
Yes
2  
Hsap\EGR1
1 of 14
No
No
Hsap\EGR2
1 of 14
No
No
1  
Hsap\EGR3
1 of 14
No
No
Hsap\GLI2
1 of 14
No
No
2  
Hsap\KLF9
1 of 14
No
No
Hsap\KLF13
1 of 14
No
No
Hsap\KLF15
1 of 14
No
No
1  
Hsap\KLF16
1 of 14
No
No
Hsap\MECOM
1 of 14
No
No
Hsap\MTF1
1 of 14
No
No
1  
Hsap\SP1
1 of 14
No
No
0  
Hsap\SP2
1 of 14
No
No
Hsap\SP3
1 of 14
No
No
0  
Hsap\SP4
1 of 14
No
No
Hsap\SP5
1 of 14
No
No
Hsap\SP6
1 of 14
No
No
Hsap\SP7
1 of 14
No
No
Hsap\SP8
1 of 14
No
No
Hsap\SP9
1 of 14
No
No
Hsap\YY2
1 of 14
No
No
1  
Hsap\ZBTB7B
1 of 14
No
Yes
1  
Hsap\ZBTB20
1 of 14
No
No
Hsap\ZFP28
1 of 14
No
No
Hsap\ZIC1
1 of 14
No
No
1  
Hsap\ZIC2
1 of 14
No
No
Hsap\ZIC3
1 of 14
No
No
Hsap\ZIC5
1 of 14
No
No
Hsap\ZKSCAN1
1 of 14
No
No
Hsap\ZKSCAN3
1 of 14
No
No
Hsap\ZNF35
1 of 14
No
No
Hsap\ZNF45
1 of 14
No
No
Hsap\ZNF76
1 of 14
No
No
Hsap\ZNF100
1 of 14
No
No
Hsap\ZNF112
1 of 14
No
No
Hsap\ZNF143
1 of 14
No
Yes
Hsap\ZNF184
1 of 14
No
No
Hsap\ZNF226
1 of 14
No
No
Hsap\ZNF232
1 of 14
No
Yes
Hsap\ZNF234
1 of 14
No
No
Hsap\ZNF236
1 of 14
No
Yes
Hsap\ZNF263
1 of 14
No
No
Hsap\ZNF266
1 of 14
No
Yes
Hsap\ZNF316
1 of 14
No
No
Hsap\ZNF391
1 of 14
No
Yes
Hsap\ZNF396
1 of 14
No
Yes
Hsap\ZNF420
1 of 14
No
No
Hsap\ZNF454
1 of 14
No
No
Hsap\ZNF460
1 of 14
No
No
Hsap\ZNF467
1 of 14
No
No
Hsap\ZNF468
1 of 14
No
No
Hsap\ZNF510
1 of 14
No
No
Hsap\ZNF544
1 of 14
No
No
Hsap\ZNF559
1 of 14
No
No
Hsap\ZNF560
1 of 14
No
No
Hsap\ZNF574
1 of 14
No
No
Hsap\ZNF616
1 of 14
No
No
Hsap\ZNF658
1 of 14
No
No
Hsap\ZNF664
1 of 14
No
Yes
Hsap\ZNF675
1 of 14
No
No
Hsap\ZNF676
1 of 14
No
No
Hsap\ZNF730
1 of 14
No
No
Hsap\ZNF771
1 of 14
No
No
Hsap\ZNF787
1 of 14
No
No
Hsap\ZNF837
1 of 14
No
No
Hsap\ZNF879
1 of 14
No
No
Hsap\ZXDA
1 of 14
No
No
Hsap\ZXDB
1 of 14
No
No
Hsap\ZXDC
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
Rnor\Klf5
8 of 14
Yes
Yes
Rnor\Klf6
3 of 14
No
No
Rnor\Klf17
3 of 14
No
Yes
Rnor\Zfp352
3 of 14
No
Yes
Rnor\Zfp353
3 of 14
No
Yes
Rnor\Klf1
2 of 14
No
No
Rnor\Klf2
2 of 14
No
No
Rnor\Klf3
2 of 14
No
No
Rnor\Klf4
2 of 14
No
No
Rnor\Klf8
2 of 14
No
No
Rnor\Klf10
2 of 14
No
No
Rnor\Klf11
2 of 14
No
No
Rnor\Klf12
2 of 14
No
No
Rnor\Klf14
2 of 14
No
No
Rnor\Egr1
1 of 14
No
No
Rnor\Egr2
1 of 14
No
No
Rnor\Egr3
1 of 14
No
No
Rnor\Egr4
1 of 14
No
No
Rnor\Klf9
1 of 14
No
No
Rnor\Klf13
1 of 14
No
No
Rnor\Klf15
1 of 14
No
No
Rnor\Klf16
1 of 14
No
No
Rnor\LOC691254
1 of 14
No
No
Rnor\LOC100909688
1 of 14
No
No
Rnor\Mecom
1 of 14
No
No
Rnor\Sp1
1 of 14
No
No
Rnor\Sp2
1 of 14
No
No
Rnor\Sp3
1 of 14
No
No
Rnor\Sp4
1 of 14
No
No
Rnor\Sp5
1 of 14
No
No
Rnor\Sp7
1 of 14
No
No
Rnor\Sp8
1 of 14
No
No
Rnor\Wt1
1 of 14
No
Yes
Rnor\Zbtb7a
1 of 14
No
Yes
Rnor\Zfp26
1 of 14
No
No
Rnor\Zfp61
1 of 14
No
No
Rnor\Zfp113
1 of 14
No
Yes
Rnor\Zfp143
1 of 14
No
No
Rnor\Zfp236
1 of 14
No
Yes
Rnor\Zfp523
1 of 14
No
Yes
Rnor\Zfp879
1 of 14
No
No
Rnor\Zic1
1 of 14
No
No
Rnor\Zic2
1 of 14
No
No
Rnor\Zic3
1 of 14
No
No
Rnor\Zxdc
1 of 14
No
No
Mus musculus (laboratory mouse) (58)
Mmus\Klf5
8 of 14
Yes
Yes
Mmus\Klf3
3 of 14
No
No
Mmus\Klf6
3 of 14
No
No
Mmus\Klf8
3 of 14
No
No
Mmus\Klf12
3 of 14
No
No
Mmus\Klf17
3 of 14
No
Yes
Mmus\Gm12845
2 of 14
No
Yes
Mmus\Klf1
2 of 14
No
No
Mmus\Klf2
2 of 14
No
No
Mmus\Klf4
2 of 14
No
No
Mmus\Klf7
2 of 14
No
No
Mmus\Klf10
2 of 14
No
No
Mmus\Klf11
2 of 14
No
No
Mmus\Klf14
2 of 14
No
Yes
Mmus\Zfp352
2 of 14
No
Yes
Mmus\Egr1
1 of 14
No
No
Mmus\Egr2
1 of 14
No
No
Mmus\Egr3
1 of 14
No
No
Mmus\Egr4
1 of 14
No
No
Mmus\Gm2007
1 of 14
No
No
Mmus\Gm2026
1 of 14
No
No
Mmus\Gm4631
1 of 14
No
No
Mmus\Gm4724
1 of 14
No
No
Mmus\Gm6710
1 of 14
No
No
Mmus\Gm11007
1 of 14
No
Yes
Mmus\Gm14295
1 of 14
No
No
Mmus\Gm14308
1 of 14
No
No
Mmus\Gm14325
1 of 14
No
No
Mmus\Gm14391
1 of 14
No
No
Mmus\Gm14399
1 of 14
No
Yes
Mmus\Gm14412
1 of 14
No
No
Mmus\Gm14430
1 of 14
No
Yes
Mmus\Gm14434
1 of 14
No
No
Mmus\Klf9
1 of 14
No
No
Mmus\Klf13
1 of 14
No
No
Mmus\Klf15
1 of 14
No
No
Mmus\Klf16
1 of 14
No
No
Mmus\Mecom
1 of 14
No
No
Mmus\Prdm1
1 of 14
No
No
Mmus\Sp1
1 of 14
No
No
Mmus\Sp2
1 of 14
No
No
Mmus\Sp3
1 of 14
No
No
Mmus\Sp4
1 of 14
No
No
Mmus\Sp5
1 of 14
No
No
Mmus\Sp7
1 of 14
No
No
Mmus\Sp8
1 of 14
No
No
1  
Mmus\Wt1
1 of 14
No
No
Mmus\Zfp26
1 of 14
No
No
Mmus\Zfp113
1 of 14
No
Yes
Mmus\Zfp236
1 of 14
No
Yes
Mmus\Zfp523
1 of 14
No
Yes
Mmus\Zfp735
1 of 14
No
No
Mmus\Zfp931
1 of 14
No
Yes
Mmus\Zfp935
1 of 14
No
Yes
Mmus\Zic1
1 of 14
No
No
Mmus\Zic2
1 of 14
No
No
Mmus\Zic3
1 of 14
No
No
Mmus\Zxdc
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (48)
Xtro\klf5
6 of 13
Yes
Yes
Xtro\klf7
3 of 13
No
No
Xtro\lingo3
3 of 13
No
Yes
Xtro\pde6g
3 of 13
No
No
Xtro\znf534
3 of 13
No
Yes
Xtro\klf4
2 of 13
No
Yes
Xtro\klf10
2 of 13
No
No
Xtro\klf11
2 of 13
No
No
Xtro\klf12
2 of 13
No
No
Xtro\wt1
2 of 13
No
Yes
Xtro\asb8
1 of 13
No
No
Xtro\egr1
1 of 13
No
No
Xtro\egr3
1 of 13
No
No
Xtro\egr4
1 of 13
No
No
Xtro\has3
1 of 13
No
Yes
Xtro\klf3
1 of 13
No
No
Xtro\klf6
1 of 13
No
No
Xtro\klf9
1 of 13
No
Yes
Xtro\klf13
1 of 13
No
No
Xtro\klf15.2
1 of 13
No
No
Xtro\klf15
1 of 13
No
No
Xtro\klf17
1 of 13
No
Yes
Xtro\LOC496795
1 of 13
No
No
Xtro\LOC100493797
1 of 13
No
No
Xtro\LOC101731232
1 of 13
No
No
Xtro\LOC101731620
1 of 13
No
No
Xtro\LOC101734390
1 of 13
No
Yes
Xtro\LOC116406487
1 of 13
No
No
Xtro\mecom
1 of 13
No
No
Xtro\rhog
1 of 13
No
No
Xtro\sp3
1 of 13
No
No
Xtro\sp4
1 of 13
No
No
Xtro\sp5
1 of 13
No
No
Xtro\sp8
1 of 13
No
No
Xtro\sp9
1 of 13
No
No
Xtro\tmem128l
1 of 13
No
Yes
Xtro\XB5795368
1 of 13
No
No
Xtro\zbtb40
1 of 13
No
Yes
Xtro\zic2
1 of 13
No
No
Xtro\zic3
1 of 13
No
No
Xtro\zic5
1 of 13
No
No
Xtro\znf91
1 of 13
No
No
Xtro\znf143
1 of 13
No
Yes
Xtro\znf333
1 of 13
No
No
Xtro\znf367
1 of 13
No
Yes
Xtro\znf585a
1 of 13
No
No
Xtro\znf883l
1 of 13
No
No
Xtro\zxdc
1 of 13
No
Yes
Danio rerio (Zebrafish) (63)
Drer\klf5l
8 of 14
Yes
Yes
Drer\klf5b
7 of 14
No
Yes
Drer\klf5a
5 of 14
No
Yes
Drer\klf6a
3 of 14
No
No
Drer\klf6b
3 of 14
No
No
Drer\klf7a
3 of 14
No
No
Drer\klf7b
3 of 14
No
No
Drer\klf12a
3 of 14
No
No
Drer\klf1
2 of 14
No
No
Drer\klf2a
2 of 14
No
No
Drer\klf2b
2 of 14
No
No
Drer\klf3
2 of 14
No
No
Drer\klf8
2 of 14
No
No
Drer\klf11a
2 of 14
No
No
Drer\klf11b
2 of 14
No
No
Drer\klf12b
2 of 14
No
No
Drer\klf17
2 of 14
No
No
Drer\sp5a
2 of 14
No
No
Drer\sp5l
2 of 14
No
No
Drer\wt1a
2 of 14
No
Yes
Drer\wt1b
2 of 14
No
Yes
Drer\egr1
1 of 14
No
No
Drer\egr2a
1 of 14
No
No
Drer\egr2b
1 of 14
No
No
Drer\egr3
1 of 14
No
No
Drer\egr4
1 of 14
No
No
Drer\klf4
1 of 14
No
No
Drer\klf9
1 of 14
No
No
Drer\klf13
1 of 14
No
No
Drer\klf15
1 of 14
No
No
Drer\LOC100536922
1 of 14
No
No
Drer\LOC101884367
1 of 14
No
No
Drer\LOC108183847
1 of 14
No
Yes
Drer\LOC108184028
1 of 14
No
No
Drer\si:cabz01032454.3
1 of 14
No
No
Drer\si:ch73-367f21.4
1 of 14
No
No
Drer\si:ch211-117k10.3
1 of 14
No
No
Drer\si:ch211-142b24.6
1 of 14
No
Yes
Drer\si:ch211-161m3.4
1 of 14
No
No
Drer\si:ch1073-127d16.1
1 of 14
No
No
Drer\sp1
1 of 14
No
No
Drer\sp3a
1 of 14
No
No
Drer\sp3b
1 of 14
No
No
Drer\sp4
1 of 14
No
No
Drer\sp5b
1 of 14
No
No
Drer\sp6
1 of 14
No
No
Drer\sp7
1 of 14
No
No
Drer\sp8a
1 of 14
No
No
Drer\zgc:113119
1 of 14
No
Yes
Drer\zgc:153115
1 of 14
No
No
Drer\zgc:174275
1 of 14
No
Yes
Drer\zgc:174696
1 of 14
No
No
Drer\zic1
1 of 14
No
No
Drer\zic2a
1 of 14
No
No
Drer\zic2b
1 of 14
No
No
Drer\zic3
1 of 14
No
No
Drer\znf143a
1 of 14
No
Yes
Drer\znf236
1 of 14
No
Yes
Drer\znf384a
1 of 14
No
No
Drer\znf1043
1 of 14
No
No
Drer\znf1136
1 of 14
No
No
Drer\znf1137
1 of 14
No
No
Drer\znf1141
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\klf-2
7 of 14
Yes
Yes
Cele\klf-1
6 of 14
No
Yes
Cele\klf-3
2 of 14
No
No
Cele\che-1
1 of 14
No
No
Cele\egrh-1
1 of 14
No
No
Cele\egrh-2
1 of 14
No
No
Cele\klu-1
1 of 14
No
No
Cele\sptf-1
1 of 14
No
No
Cele\sptf-2
1 of 14
No
No
Cele\sptf-3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (17)
Agam\AgaP_AGAP007038
3 of 12
Yes
No
Agam\AgaP_AGAP004994
2 of 12
No
Yes
Agam\AgaP_AGAP010520
2 of 12
No
No
Agam\AgaP_AGAP013162
2 of 12
No
No
Agam\AgaP_AGAP000673
1 of 12
No
No
Agam\AgaP_AGAP000674
1 of 12
No
No
Agam\AgaP_AGAP002773
1 of 12
No
No
Agam\AgaP_AGAP004282
1 of 12
No
No
Agam\AgaP_AGAP004438
1 of 12
No
No
Agam\AgaP_AGAP004517
1 of 12
No
No
Agam\AgaP_AGAP004995
1 of 12
No
Yes
Agam\AgaP_AGAP007389
1 of 12
No
No
Agam\AgaP_AGAP008340
1 of 12
No
No
Agam\AgaP_AGAP009566
1 of 12
No
No
Agam\AgaP_AGAP009889
1 of 12
No
No
Agam\AgaP_AGAP011502
1 of 12
No
No
Agam\AgaP_AGAP011655
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ZAP1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\hsr1
1 of 12
Yes
Yes
Spom\scr1
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dar1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (16)
luna
7 of 13
CG42741
6 of 13
btd
4 of 13
Klf15
4 of 13
Sp1
4 of 13
cbt
3 of 13
CG3065
3 of 13
Cf2
2 of 13
Spps
2 of 13
sr
2 of 13
CG10462
1 of 13
CG12299
1 of 13
hkb
1 of 13
l(3)neo38
1 of 13
odd
1 of 13
zf30C
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KLF5; KLF transcription factor 5
    7 of 14
    602903
        KLF2; KLF transcription factor 2
        3 of 14
        602016
            KLF6; KLF transcription factor 6
            3 of 14
            602053
             
            KLF7; KLF transcription factor 7
            3 of 14
            604865
                 
                KLF17; KLF transcription factor 17
                3 of 14
                609602
                    KLF18; KLF transcription factor 18
                    3 of 14
                    621009
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        Summary of Genetic Interactions
                        Interaction Browsers
                        View in FlyBase Interactions Browser   View in MIST tool (external link)
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        dar1
                        suppressible
                        nudC
                        (Wang et al., 2015)
                        dar1
                        suppressible
                        nudE
                        (Wang et al., 2015)
                        dar1
                        suppressible
                        sw
                        (Wang et al., 2015)
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        kn
                        suppressible
                        dar1
                        (Ye et al., 2011)
                        External Data
                        Linkouts
                        DroID - A comprehensive database of gene and protein interactions.
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        FlyBase
                        External Links
                        External Data
                        Linkouts
                        Class of Gene
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        3L
                        Recombination map
                        3-8
                        Cytogenetic map
                        63E5-63E6
                        Sequence location
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        63E5-63E6
                        Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        Experimentally Determined Recombination Data
                        Location

                        3-8

                        (FlyBase, 2016)

                        3-7.2

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (24)
                        Genomic Clones (29)
                        cDNA Clones (2)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                          Drosophila Genomics Resource Center cDNA clones

                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                          cDNA Clones, End Sequenced (ESTs)
                          BDGP DGC clones
                            Other clones
                            RNAi and Array Information
                            Linkouts
                            Antibody Information
                            Laboratory Generated Antibodies
                             

                            polyclonal

                            (Ye et al., 2011)
                            Commercially Available Antibodies
                             
                            Cell Line Information
                            Publicly Available Cell Lines
                             
                              Other Stable Cell Lines
                               
                                Other Comments

                                dar1 belongs to the Kruppel (Kr)-like factor family.

                                (Ye et al., 2011)

                                Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.

                                (Ye et al., 2007)

                                Discussed during genetic analysis of the Ras64B-Rop region.

                                (Harrison et al., 1995)
                                Relationship to Other Genes
                                Source for database merge of

                                Source for merge of: dar1 CG12029 l(3)63Ed

                                (Ye et al., 2011)
                                Additional comments
                                Nomenclature History
                                Source for database identify of
                                Nomenclature comments
                                Etymology
                                Synonyms and Secondary IDs (7)
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                Study result (0)
                                Result
                                Result Type
                                Title
                                External Crossreferences and Linkouts ( 23 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                Other crossreferences
                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                Linkouts
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                DroID - A comprehensive database of gene and protein interactions.
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                References (49)