FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Iqsec
Open Close
General Information
Symbol
Dmel\Iqsec
Species
D. melanogaster
Name
IQ motif and Sec7 domain ArfGEF
Annotation Symbol
CG32434
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026179
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
IQ motif and Sec7 domain ArfGEF (Iqsec) encodes an Arf1 guanine nucleotide exchange factor involved in commissural axon guidance and myoblast fusion. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

loner, siz, schizo

Key Links
Genomic Location
Cytogenetic map
78A5-78B1
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:21034535..21075444
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables cadherin binding
inferred from direct assay
(Dottermusch-Heidel et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables guanyl-nucleotide exchange factor activity
inferred from electronic annotation with InterPro:IPR000904, InterPro:IPR035999
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:Q06836
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN008950430
(GO Reference Genome Project, 2011-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Richardson et al., 2007)
involved_in central nervous system development
inferred from mutant phenotype
(Hummel et al., 1999)
involved_in compound eye morphogenesis
inferred from genetic interaction with UniProtKB:P40946
(Johnson et al., 2011)
inferred from genetic interaction with UniProtKB:Q9Y154
(Johnson et al., 2011)
involved_in myoblast fusion
inferred from mutant phenotype
(Dottermusch-Heidel et al., 2012, Bulchand et al., 2010, Richardson et al., 2007, Chen et al., 2003)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in positive regulation of ARF protein signal transduction
inferred from sequence or structural similarity with UniProtKB:Q06836
(Gene Ontology Curators, 2002-)
involved_in regulation of ARF protein signal transduction
inferred from electronic annotation with InterPro:IPR000904, InterPro:IPR035999
(InterPro Project Members, 2004-)
involved_in regulation of postsynaptic neurotransmitter receptor internalization
inferred from biological aspect of ancestor with PANTHER:PTN000070822
(GO Reference Genome Project, 2011-)
involved_in vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN008950430
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in Golgi membrane
inferred from sequence or structural similarity with UniProtKB:Q06836
(Gene Ontology Curators, 2002-)
is_active_in postsynaptic density membrane
inferred from biological aspect of ancestor with PANTHER:PTN000070822
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
IQ motif and Sec7 domain ArfGEF (Iqsec) encodes an Arf1 guanine nucleotide exchange factor involved in commissural axon guidance and myoblast fusion. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS -
ArfGEFs are Guanine Nucleotide Exchange Factors (GEFs) for ARF family GTPases. They are characterized by a central Sec7 catalytic domain domain with homology to yeast SEC7. (Adapted from PMID:15731001, FBrf0158741 and FBrf0220529).
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Iqsec for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VP80)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Iqsec-RA
FBtr0078290
NM_206407
5314
1313
Iqsec-RB
FBtr0078289
NM_168881
5130
1325
Iqsec-RC
FBtr0111038
NM_001043153
4654
1210
Iqsec-RD
FBtr0301602
NM_001170016
4931
1220
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Iqsec-PA
FBpp0077948
142.9
1313
9.70
Q7KTX2
NP_996129
AAS65082
Iqsec-PB
FBpp0077947
144.0
1325
8.92
Q9VP80
NP_730594
AAF51675
Iqsec-PC
FBpp0110337
131.4
1210
9.39
Q6U9V3
NP_001036618
ABI31265
Iqsec-PD
FBpp0290817
132.7
1220
9.40
E1JI59
NP_001163487
ACZ94758
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Iqsec using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.02

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | gap expression pattern
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: PBac{810.P.FSVS-2}IqsecCPTI004536
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain
(Knowles-Barley, 2011.8.24)
adult mushroom body

Comment: slightly higher in adult mushroom body

(Knowles-Barley, 2011.8.24)
adult mushroom body gamma-lobe
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Iqsec in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 38 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Iqsec
Transgenic constructs containing regulatory region of Iqsec
Aberrations (Deficiencies and Duplications) ( 4 )
Inferred from experimentation ( 4 )
Gene disrupted in
Df(3L)ME107
(Chen et al., 2003)
Df(3L)Pc-MK
(Chen et al., 2003)
Gene not disrupted in
Df(3L)Pc-cp2
(Chen et al., 2003)
Df(3L)ri-XT1
(Chen et al., 2003)
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (17)
Hsap\IQSEC1
12 of 14
Yes
Yes
3  
Hsap\IQSEC2
10 of 14
No
Yes
Hsap\IQSEC3
9 of 14
No
Yes
Hsap\ARFGEF1
3 of 14
No
No
Hsap\ARFGEF2
3 of 14
No
No
Hsap\CYTH2
3 of 14
No
No
Hsap\CYTH3
3 of 14
No
No
Hsap\CYTH4
3 of 14
No
No
Hsap\GBF1
3 of 14
No
No
2  
Hsap\PSD2
3 of 14
No
No
Hsap\PSD3
3 of 14
No
No
Hsap\PSD4
3 of 14
No
No
1  
Hsap\FBXO8
2 of 14
No
No
Hsap\PSD
2 of 14
No
No
Hsap\ARFGEF3
1 of 14
No
No
Hsap\CYTH1
1 of 14
No
No
1  
Hsap\MON2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (16)
Rnor\Iqsec1
11 of 14
Yes
Yes
Rnor\Iqsec2
11 of 14
Yes
Yes
Rnor\Iqsec3
8 of 14
No
Yes
Rnor\Arfgef1
3 of 14
No
No
Rnor\Arfgef2
3 of 14
No
No
Rnor\Cyth2
3 of 14
No
No
Rnor\Cyth3
3 of 14
No
No
Rnor\Cyth4
3 of 14
No
No
Rnor\Gbf1
3 of 14
No
No
Rnor\Cyth1
2 of 14
No
No
Rnor\Fbxo8
2 of 14
No
No
Rnor\Psd2
2 of 14
No
No
Rnor\Psd4
2 of 14
No
No
Rnor\Arfgef3
1 of 14
No
No
Rnor\Psd3
1 of 14
No
No
Rnor\Psd
1 of 14
No
No
Mus musculus (laboratory mouse) (17)
Mmus\Iqsec2
11 of 14
Yes
Yes
Mmus\Iqsec1
10 of 14
No
Yes
Mmus\Iqsec3
8 of 14
No
Yes
Mmus\Arfgef1
3 of 14
No
No
Mmus\Arfgef2
3 of 14
No
No
Mmus\Cyth2
3 of 14
No
No
Mmus\Cyth3
3 of 14
No
No
Mmus\Cyth4
3 of 14
No
No
Mmus\Gbf1
3 of 14
No
No
Mmus\Cyth1
2 of 14
No
No
Mmus\Fbxo8
2 of 14
No
No
Mmus\Psd2
2 of 14
No
No
Mmus\Psd4
2 of 14
No
No
Mmus\Arfgef3
1 of 14
No
No
Mmus\Mon2
1 of 14
No
No
Mmus\Psd3
1 of 14
No
No
Mmus\Psd
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\iqsec3
8 of 13
Yes
Yes
Xtro\iqsec2
7 of 13
No
Yes
Xtro\iqsec1
6 of 13
No
Yes
Xtro\aldoa
1 of 13
No
No
Xtro\brcc3
1 of 13
No
Yes
Xtro\crip3
1 of 13
No
No
Xtro\cyth1
1 of 13
No
No
Xtro\fbxo8
1 of 13
No
No
Xtro\gbf1
1 of 13
No
No
Xtro\hnrnpa1
1 of 13
No
No
Xtro\nrl
1 of 13
No
No
Xtro\pcdh7
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\iqsec1a
12 of 14
Yes
Yes
Drer\iqsec1b
12 of 14
Yes
Yes
Drer\iqsec2b
10 of 14
No
Yes
Drer\LOC560461
10 of 14
No
Yes
Drer\iqsec3a
8 of 14
No
Yes
Drer\iqsec3b
8 of 14
No
Yes
Drer\arfgef1
3 of 14
No
No
Drer\arfgef2
3 of 14
No
No
Drer\cyth2
3 of 14
No
No
Drer\cyth3a
3 of 14
No
No
Drer\cyth4a
3 of 14
No
No
Drer\gbf1
3 of 14
No
No
Drer\cyth1b
2 of 14
No
No
Drer\cyth3b
2 of 14
No
Yes
Drer\cyth4b
2 of 14
No
No
Drer\arfgef3
1 of 14
No
No
Drer\cyth1a
1 of 14
No
No
Drer\fbxo8
1 of 14
No
No
Drer\LOC101886286
1 of 14
No
No
Drer\psd2
1 of 14
No
No
Drer\psd3l
1 of 14
No
No
Drer\psda
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\bris-1
11 of 14
Yes
Yes
Cele\grp-1
3 of 14
No
No
Cele\agef-1
1 of 14
No
No
Cele\efa-6
1 of 14
No
No
Cele\gbf-1
1 of 14
No
No
Cele\mon-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP011421
11 of 12
Yes
Yes
Agam\AgaP_AGAP001527
2 of 12
No
No
Agam\AgaP_AGAP008737
2 of 12
No
No
Agam\AgaP_AGAP008906
2 of 12
No
No
Agam\AgaP_AGAP000774
1 of 12
No
No
Agam\AgaP_AGAP007379
1 of 12
No
No
Agam\AgaP_AGAP008738
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\GN
3 of 13
Yes
No
Atha\GNL1
3 of 13
Yes
No
Atha\GNL2
3 of 13
Yes
No
Atha\AT3G60860
2 of 13
No
No
Atha\AT4G35380
2 of 13
No
No
Atha\AT4G38200
2 of 13
No
No
Atha\ATMIN7
2 of 13
No
No
Atha\EDA10
2 of 13
No
No
Atha\AT5G05710
1 of 13
No
No
Atha\PH1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\GEA1
4 of 13
Yes
No
Scer\GEA2
4 of 13
Yes
No
Scer\SEC7
2 of 13
No
No
Scer\SYT1
2 of 13
No
No
Scer\MON2
1 of 13
No
No
Scer\YEL1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\SPAC11E3.11c
3 of 12
Yes
Yes
Spom\SPBC211.03c
3 of 12
Yes
No
Spom\sec71
2 of 12
No
No
Spom\sec72
2 of 12
No
No
Spom\sec73
2 of 12
No
No
Spom\sec74
2 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Iqsec. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
Efa6
4 of 13
garz
4 of 13
Sec71
4 of 13
step
4 of 13
CG5937
2 of 13
mon2
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
IQSEC1; IQ motif and Sec7 domain ArfGEF 1
12 of 14
IQ MOTIF- AND SEC7 DOMAIN-CONTAINING PROTEIN 1; IQSEC1
 
IQSEC2; IQ motif and Sec7 domain ArfGEF 2
10 of 14
300522
IQSEC3; IQ motif and Sec7 domain ArfGEF 3
9 of 14
612118
      ARFGEF1; ARF guanine nucleotide exchange factor 1
      3 of 14
      604141
        ARFGEF2; ARF guanine nucleotide exchange factor 2
        3 of 14
        605371
        CYTH2; cytohesin 2
        3 of 14
        602488
            CYTH3; cytohesin 3
            3 of 14
            605081
                CYTH4; cytohesin 4
                3 of 14
                606514
                    GBF1; golgi brefeldin A resistant guanine nucleotide exchange factor 1
                    3 of 14
                    603698
                     
                    PSD2; pleckstrin and Sec7 domain containing 2
                    3 of 14
                    620656
                        PSD3; pleckstrin and Sec7 domain containing 3
                        3 of 14
                        614440
                            PSD4; pleckstrin and Sec7 domain containing 4
                            3 of 14
                            614442
                                 
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                Summary of Genetic Interactions
                                Interaction Browsers
                                View in FlyBase Interactions Browser   View in MIST tool (external link)
                                Please look at the allele data for full details of the genetic interactions
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Iqsec
                                suppressible
                                Arf1
                                (Dottermusch-Heidel et al., 2012)
                                Iqsec
                                enhanceable
                                blow
                                (Bulchand et al., 2010)
                                Iqsec
                                suppressible
                                CadN
                                (Dottermusch-Heidel et al., 2012)
                                Iqsec
                                enhanceable
                                fra
                                (Onel et al., 2004, Hummel et al., 1999)
                                Iqsec
                                suppressible
                                NetB
                                (Onel et al., 2004)
                                Iqsec
                                suppressible
                                robo1
                                (Onel et al., 2004)
                                Iqsec
                                suppressible
                                sli
                                (Onel et al., 2004)
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Arf6|Dcr-2
                                enhanceable
                                Iqsec
                                (Johnson et al., 2011)
                                cindr
                                enhanceable
                                Iqsec
                                (Johnson et al., 2011)
                                fra
                                enhanceable
                                Iqsec
                                (Hummel et al., 1999)
                                External Data
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                FlyBase
                                External Links
                                External Data
                                Linkouts
                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                Class of Gene
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3L
                                Recombination map
                                3-47
                                Cytogenetic map
                                78A5-78B1
                                Sequence location
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                78A5-78B1
                                Limits computationally determined from genome sequence between P{EP}fngEP3082&P{lacW}skdL7062 and P{lacW}l(3)L5541L5541
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                Experimentally Determined Recombination Data
                                Location

                                3-47

                                (FlyBase, 2016)

                                3-43.8

                                (Comeron et al., 2012)

                                3-51 +/- 3

                                (Hummel et al., 1999)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (17)
                                Genomic Clones (38)
                                cDNA Clones (50)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                  Drosophila Genomics Resource Center cDNA clones

                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                  cDNA Clones, End Sequenced (ESTs)
                                  BDGP DGC clones
                                  Other clones
                                  RNAi and Array Information
                                  Linkouts
                                  DRSC - Results frm RNAi screens
                                  Antibody Information
                                  Laboratory Generated Antibodies
                                   
                                  Commercially Available Antibodies
                                   
                                  Cell Line Information
                                  Publicly Available Cell Lines
                                   
                                    Other Stable Cell Lines
                                     
                                      Other Comments

                                      Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo.

                                      (Hummel et al., 1999)
                                      Relationship to Other Genes
                                      Source for database merge of

                                      Source for merge of: siz loner

                                      (Onel et al., 2004)

                                      Source for merge of: CG10577 CG12980 CG12981

                                      (FlyBase Genome Annotators, 2002-2003)
                                      Additional comments

                                      Annotations CG10577, CG12980 and CG12981 merged as CG32434 in release 3 of the genome annotation.

                                      (FlyBase Genome Annotators, 2002-2003)

                                      Source for identity of loner CG32434 was sequence comparison ( date:031005 ).

                                      (FlyBase, 1996-)
                                      Nomenclature History
                                      Source for database identify of

                                      Source for identity of: loner CG32434

                                      (FlyBase, 1996-)

                                      Source for identity of: Iqsec siz

                                      (FlyBoard ad hoc nomenclature committee, 2024.7.14)
                                      Nomenclature comments

                                      The original gene name "schizo" (siz) was changed to "IQ motif and Sec7 domain ArfGEF" (Iqsec) to reflect its homology to the human gene and eliminate its potentially offensive association with human conditions.

                                      (FlyBoard ad hoc nomenclature committee, 2024.7.14)
                                      Etymology

                                      "schizo" means "split" in German.

                                      (Hummel et al., 1999)
                                      Synonyms and Secondary IDs (13)
                                      Reported As
                                      Symbol Synonym
                                      CG10577
                                      (Brody et al., 2002)
                                      CG12980
                                      CG12981
                                      CG32434
                                      (Trivedi et al., 2020, Zeledon et al., 2019, Balakrishnan et al., 2015, Chang et al., 2015, Hosono et al., 2015, Abmayr and Pavlath, 2012, Aerts et al., 2010, Ni et al., 2010.12.1, Gupta et al., 2009, Keleman et al., 2009.8.5, Morozova et al., 2006, Cox et al., 2004, Lawniczak and Begun, 2004, Matyash et al., 2004, Milchanowski et al., 2004, Onel et al., 2004, Giot et al., 2003)
                                      Iqsec
                                      (FlyBoard ad hoc nomenclature committee, 2024.7.14)
                                      Loner
                                      (Dubey et al., 2020, Bothe and Baylies, 2016, Abmayr and Pavlath, 2012, Chen et al., 2007)
                                      Schizo
                                      (Abmayr and Pavlath, 2012)
                                      Siz
                                      (Rout et al., 2022)
                                      loner
                                      (Lee and Chen, 2019, Chabu et al., 2017, Wang et al., 2017, Bothe et al., 2014, Wang et al., 2012, Richardson et al., 2007, Rochlin et al., 2007, Reeves and Posakony, 2005, Richardson and Baylies, 2005, Chen and Olson, 2004, Chen et al., 2003, Donaldson, 2003, Taylor, 2003, FlyBase, 1996-)
                                      schizo
                                      (Lee and Chen, 2019, Wang et al., 2012)
                                      siz
                                      (Bischoff et al., 2025, Ecovoiu et al., 2022, Lee et al., 2018, Carbone et al., 2016, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Dottermusch-Heidel et al., 2012, Rodriguez et al., 2012, Carreira et al., 2011, Johnson et al., 2011, Aerts et al., 2010, Buszczak et al., 2007)
                                      Name Synonyms
                                      IQ motif and Sec7 domain ArfGEF
                                      (FlyBoard ad hoc nomenclature committee, 2024.7.14)
                                      Loner
                                      (Zeledon et al., 2019, Casanova, 2007)
                                      Schizo
                                      (Kotian et al., 2022, He et al., 2019, Johnson et al., 2011)
                                      dBRAG
                                      (Casanova, 2007)
                                      loner
                                      (Deng et al., 2015, Bulchand et al., 2010, Beckett and Baylies, 2007)
                                      schizo
                                      (Chang et al., 2015, Bulgakova et al., 2012, Dottermusch-Heidel et al., 2012, Edwards et al., 2009, Edwards et al., 2009, Gupta et al., 2009, Raghu et al., 2009, Casanova, 2007, Hummel et al., 1999)
                                      Secondary FlyBase IDs
                                      • FBgn0037047
                                      • FBgn0037048
                                      • FBgn0037049
                                      • FBgn0052434
                                      Datasets (0)
                                      Study focus (0)
                                      Experimental Role
                                      Project
                                      Project Type
                                      Title
                                      Study result (0)
                                      Result
                                      Result Type
                                      Title
                                      External Crossreferences and Linkouts ( 77 )
                                      Sequence Crossreferences
                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                      Other crossreferences
                                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                      FlyMine - An integrated database for Drosophila genomics
                                      InterPro - A database of protein families, domains and functional sites
                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                      MARRVEL_MODEL - MARRVEL (model organism gene)
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                      DroID - A comprehensive database of gene and protein interactions.
                                      DRSC - Results frm RNAi screens
                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                      Flygut - An atlas of the Drosophila adult midgut
                                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                      MIST (genetic) - An integrated Molecular Interaction Database
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      References (106)