FlyBase Allele Report: Dmel\Iqsec[C1-28]

General Information

Symbol

Dmel\Iqsec^C1-28

Species

D. melanogaster

Name

FlyBase ID

FBal0175513

Feature type

allele

Associated gene

Dmel\Iqsec

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Onel et al., 2004)

Mutagen

ethyl methanesulfonate

(Onel et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic myoblast

(Dottermusch-Heidel et al., 2012)

embryonic myoblast (with Iqsec^U112)

(Dottermusch-Heidel et al., 2012)

larval ventral nerve cord commissure

(Onel et al., 2004)

Detailed Description

Statement

Reference

Homozygous stage 15 embryos show a strong defect in myoblast fusion.

siz^C1-28/siz^U112 embryos show a strong defect in myoblast fusion.

(Dottermusch-Heidel et al., 2012)

The number of commissural fibers crossing the ventral midline of stage 16 embryos is reduced in siz^C1-28 mutants. This effect is seen most strongly in abdominal segments A1-A4. The longitudinal connectives are also thinner.

(Onel et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Iqsec^U112/Iqsec^C1-28 has embryonic myoblast phenotype, suppressible | partially by CadN^M19

(Dottermusch-Heidel et al., 2012)

Iqsec^C1-28 has embryonic myoblast phenotype, suppressible | partially by Scer\GAL4^twi.PG/Arf1^Q71L.UAS

(Dottermusch-Heidel et al., 2012)

NOT suppressed by

Statement

Reference

Iqsec^C1-28 has embryonic myoblast phenotype, non-suppressible by Scer\GAL4^twi.PG/Arf6^Q67L.UAS

(Dottermusch-Heidel et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The defects in myoblast fusion seen in siz^C1-28/siz^U112 embryos are partially suppressed by CadN^M19 and multinucleate muscles are formed.

Expression of Arf51F^{Q67L.Scer\UAS} under the control of Scer\GAL4^twi.PG fails to rescue the defects in myoblast fusion seen in siz^C1-28 embryos.

Expression of Arf79F^{Q71L.Scer\UAS} under the control of Scer\GAL4^twi.PG partially rescues the defects in myoblast fusion seen in siz^C1-28 embryos.

(Dottermusch-Heidel et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Iqsec^C1-28 is rescued by Scer\GAL4^twi.PG/Iqsec^UAS.Tag:HA

(Dottermusch-Heidel et al., 2012)

Partially rescued by

Iqsec^C1-28 is partially rescued by Scer\GAL4^{kirre-rP298-G4}/Iqsec^UAS.Tag:HA

(Dottermusch-Heidel et al., 2012)

Iqsec^C1-28 is partially rescued by Scer\GAL4^sns.PS/Iqsec^UAS.Tag:HA

(Dottermusch-Heidel et al., 2012)

Comments

Expression of siz^{Scer\UAS.T:Ivir\HA1} under the control of either Scer\GAL4^sns.PS or Scer\GAL4^kirre-rP298 partially rescues the myoblast fusion defect seen in siz^C1-28 embryos.

Expression of siz^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^twi.PG almost completely rescues the myoblast fusion defect seen in siz^C1-28 embryos.

(Dottermusch-Heidel et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Hummel

(Onel et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Iqsec^C1-28

siz^C1-28

(Dottermusch-Heidel et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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