FlyBase Allele Report: Dmel\Iqsec[U112]

General Information

Symbol

Dmel\Iqsec^U112

Species

D. melanogaster

Name

FlyBase ID

FBal0095211

Feature type

allele

Associated gene

Dmel\Iqsec

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Onel et al., 2004)

Mutagen

ethyl methanesulfonate

(Hummel et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic myoblast

(Dottermusch-Heidel et al., 2012)

embryonic myoblast (with Iqsec^C1-28)

(Dottermusch-Heidel et al., 2012)

larval longitudinal connective | embryonic stage

(Onel et al., 2004)

larval ventral nerve cord commissure

(Hummel et al., 1999)

larval ventral nerve cord commissure | embryonic stage

(Onel et al., 2004)

midline glial cell

(Hummel et al., 1999)

symmetrical commissure

(Hummel et al., 1999)

Detailed Description

Statement

Reference

Homozygous stage 16 embryos show a strong defect in myoblast fusion.

siz^C1-28/siz^U112 embryos show a strong defect in myoblast fusion.

(Dottermusch-Heidel et al., 2012)

The number of commissural fibers crossing the ventral midline of stage 16 embryos is reduced in siz^U112 homozygotes and siz^U112/siz^C1-28 animals. This effect is seen most strongly in abdominal segments A1-A4. The longitudinal connectives are also thinner. In neuromeres with reduced commissures the midline glial cells migrate toward the connectives. The commissural phenotypes of these embryos are stronger than those of siz^C1-28 homozygotes. In stage 16 siz^U112/siz^C1-28 embryos many axons that usually cross the ventral midline fail to do so and show fasciculation defects.

(Onel et al., 2004)

Mutants show a variable reduction in the number of commissural fibers. Midline glial cell is initially normal but reduced later due to loss of commissural axons.

(Hummel et al., 1999)

3-5 neuromeres lack one or both commissures in homozygous embryos.

(Hummel et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Iqsec^U112 has larval ventral nerve cord commissure | embryonic stage phenotype, enhanceable by Df(1)RK2

(Onel et al., 2004)

Iqsec^U112 has larval ventral nerve cord commissure | embryonic stage phenotype, enhanceable by fra^23H9

(Onel et al., 2004)

Iqsec^U112 has larval ventral nerve cord commissure phenotype, enhanceable by fra^C1-62

(Hummel et al., 1999)

Suppressed by

Statement

Reference

Iqsec^U112/Iqsec^C1-28 has embryonic myoblast phenotype, suppressible | partially by CadN^M19

(Dottermusch-Heidel et al., 2012)

Iqsec^U112 has larval ventral nerve cord commissure | embryonic stage phenotype, suppressible by robo[+]/robo1^O1-103

(Onel et al., 2004)

Iqsec^U112 has larval ventral nerve cord commissure | embryonic stage phenotype, suppressible by sli⁵⁵⁰/sli[+]

(Onel et al., 2004)

Iqsec^U112 has larval ventral nerve cord commissure | embryonic stage phenotype, suppressible by Scer\GAL4^sim.PS/NetB^UAS.cHa

(Onel et al., 2004)

Enhancer of

Statement

Reference

Iqsec^U112 is an enhancer of larval ventral nerve cord commissure phenotype of fra^C1-62

(Hummel et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The defects in myoblast fusion seen in siz^C1-28/siz^U112 embryos are partially suppressed by CadN^M19 and multinucleate muscles are formed.

(Dottermusch-Heidel et al., 2012)

Reduction of ventral nerve cord commissures in stage 16 siz^U112 homozygous embryos is strongly enhanced by Df(1)RK2, and by fra^23H9. NetB^Scer\UAS.cHa; Scer\GAL4^sim.PS largely suppresses the reduction of ventral midline commissures in siz^U112 embryos. Reduction of ventral commissures in these embryos is also dominantly suppressed by sli⁵⁵⁰ and robo^O1-103.

(Onel et al., 2004)

siz^U112 fra^C1-62 double mutant embryos lack most commissural axons.

(Hummel et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Iqsec^U112 is rescued by Iqsec^P2.UAS/Scer\GAL4^sli.PS

(Onel et al., 2004)

Iqsec^U112 is rescued by Iqsec^P2.UAS/Scer\GAL4^sim.PS

(Onel et al., 2004)

Iqsec^U112 is rescued by Iqsec^P1.UAS/Scer\GAL4^sli.PS

(Onel et al., 2004)

Iqsec^U112 is rescued by Iqsec^P1.UAS/Scer\GAL4^sim.PS

(Onel et al., 2004)

Comments

Reduction of ventral nerve cord commissures in siz^U112 homozygotes is rescued by siz^P1.Scer\UAS or siz^P2.Scer\UAS with Scer\GAL4^sim.PS or Scer\GAL4^sli.PS.

(Onel et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Iqsec^U112

schizo^U112

(Hummel et al., 1999)

siz^U112

(Dottermusch-Heidel et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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