FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sli550
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General Information
Symbol
Dmel\sli550
Species
D. melanogaster
Name
FlyBase ID
FBal0123699
Feature type
allele
Associated gene
Dmel\sli
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Battye et al., 2001)
Mutagen
ethyl methanesulfonate
(Battye et al., 2001)
Progenitor genotype
Cytology
Description

Deletion just carboxy to EGF repeat 6 resulting in frameshift causing premature stop codon 10 amino acids later.

(Battye et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:15,875,065..15,875,065 [-]
Comment:

A one base deletion causes a frameshift at P1191 or P1167 depending on the isoform and leads to early translation termination.

(Battye et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In stage 16 sli550 homozygous embryos, adjacent ventral nerve cord commissures are fused. This phenotype is never seen in sli550/+ embryos.

      (Onel et al., 2004)

      0.5% of expected mutant embryos hatch as first instar larvae. The latest observed stage of mutants is L1. Nerve cord length is 89% of embryo length. Midline guidance failure of repellence phenotype, evidenced by midline crossing, is moderate. Shows midline deviations in the most medial longitudial fascicle but retains a relatively intact lateral fascicle.

      (Battye et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Unlike sli550/+ embryos, sli550/+; Tp(3;Y)A81 embryos have a fused adjacent ventral nerve cord commissure phenotype, very similar to that seen in sli550 homozygous embryos. Mild fusion of commissures also occurs in sli550/+ embryos that also carry sizP1.Scer\UAS or sizP2.Scer\UAS with Scer\GAL4sim.PS. Fusion of ventral nerve cord commissures seen in sli550 homozygous embryos is largely suppressed by shiK44A.Scer\UAS; Scer\GAL4rho.PL.

      (Onel et al., 2004)

      Percentage of segments with midline crossovers in robo1/sli550 transheterozygotes is 48%.

      (Battye et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sli550
      slit550
      (Battye et al., 2001)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)