FB2026_02 , released June 18, 2026
Gene Group: ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS
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General Information
Name
ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS
Species
D. melanogaster
Symbol
ARFGEF
FlyBase ID
FBgg0000343
Date last reviewed
2015-08-04
Number of members
6
Description
Description
ArfGEFs are Guanine Nucleotide Exchange Factors (GEFs) for ARF family GTPases. They are characterized by a central Sec7 catalytic domain domain with homology to yeast SEC7. (Adapted from PMID:15731001, FBrf0158741 and FBrf0220529).
Notes on Group
Source Material
The ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS Gene Group has been compiled using the following publication(s): Zeledon et al., 2019, Casanova, 2007, and Cox et al., 2004 .
Key Gene Ontology (GO) terms
Molecular Function
guanyl-nucleotide exchange factor activity
Biological Process
regulation of ARF protein signal transduction
Cellular Component
Related Gene Groups
Parent group(s)
RAS SUPERFAMILY GUANINE NUCLEOTIDE EXCHANGE FACTORS
Other related group(s)
ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS
ARF GTPASES
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
ARFGEF
ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS
ADP-Ribosylation Factor Guanine nucleotide exchange factors
Arf-GEF
Secondary FlyBase ID(s)
References (4)