FlyBase Gene Report: Dmel\Sec71

General Information

Symbol

Dmel\Sec71

Species

D. melanogaster

Name

Secretory 71

Annotation Symbol

CG7578

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028538

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

BG:DS00797.7

Key Links

Genomic Location

Cytogenetic map

34D1-34D1

Sequence location

2L:13,793,521..13,799,674 [+]

Recombination map

2-49

RefSeq locus

NT_033779 REGION:13793521..13799674

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from direct assay

(Wang et al., 2017)

inferred from physical interaction with FLYBASE:Arf1; FB:FBgn0010348

(Wang et al., 2017)

enables small GTPase binding

inferred from physical interaction with FLYBASE:Arl1; FB:FBgn0000115

(Christis and Munro, 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from electronic annotation with InterPro:IPR000904, InterPro:IPR035999

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN008950430

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in Golgi to plasma membrane protein transport

inferred from genetic interaction with FLYBASE:Arf1; FB:FBgn0010348

(Wang et al., 2017)

involved_in positive regulation of endocytosis

inferred from mutant phenotype

(Wang et al., 2017)

involved_in positive regulation of neuron remodeling

inferred from mutant phenotype

(Wang et al., 2017)

inferred from genetic interaction with FLYBASE:Sec71; FB:FBgn0028538

(Wang et al., 2017)

inferred from genetic interaction with FLYBASE:Nrg; FB:FBgn0264975

(Wang et al., 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in ARF protein signal transduction

inferred by curator from GO:0005085

(Wang et al., 2017)

involved_in regulation of ARF protein signal transduction

inferred from electronic annotation with InterPro:IPR000904, InterPro:IPR035999

(InterPro Project Members, 2004-)

involved_in vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN008950430

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Wang et al., 2017)

located_in trans-Golgi network

inferred from direct assay

(Christis and Munro, 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN002240728

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ARF GUANINE NUCLEOTIDE EXCHANGE FACTORS -: ArfGEFs are Guanine Nucleotide Exchange Factors (GEFs) for ARF family GTPases. They are characterized by a central Sec7 catalytic domain domain with homology to yeast SEC7. (Adapted from PMID:15731001, FBrf0158741 and FBrf0220529).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sec71 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJW1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sec71-RA

FBtr0080537

NM_135831

5818

1653

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sec71-PA

FBpp0080114

187.8

1653

6.26

Q9VJW1

NP_609675

AAF53331

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VJW1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sec71 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sec71_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.94

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Wang et al., 2017)

located_in trans-Golgi network

inferred from direct assay

(Christis and Munro, 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sec71 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sec71

View exonic expression by tissue for Dmel\Sec71

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34785/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028538

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028538

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028538

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7578

Flygut - An atlas of the Drosophila adult midgut

FBgn0028538

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sec71

Transgenic constructs containing regulatory region of Sec71

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Sec71^GD9923

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sec71^GD9923

viable, with Scer\GAL4^tin.CΔ4

Sec71^GD9923

Other Phenotypes

Allele

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.PU

abnormal neuroanatomy | pupal stage | RU486 conditional, with Scer\GAL4^GSG2295

Sec71^DN.UAS

abnormal neuroanatomy | pupal stage | somatic clone

Sec71^Ex11

short lived, with Scer\GAL4^Mef2.PR

Sec71^GD9923

some die during pupal stage, with Scer\GAL4^pnr-MD237

Sec71^GD9923

Phenotype manifest in

Allele

dendritic tree | prepupal stage | somatic clone

Sec71^Ex11

dendritic tree | pupal stage, with Scer\GAL4^ppk.PU

dendritic tree | pupal stage | RU486 conditional, with Scer\GAL4^GSG2295

Sec71^DN.UAS

dendritic tree | pupal stage | somatic clone, with Scer\GAL4^109(2)80

Sec71^DN.UAS

embryonic/larval salivary gland, with Scer\GAL4^fkh.PU

exocyst | third instar larval stage, with Scer\GAL4^ppk.PU

Sec71^HMS00357

Golgi apparatus | third instar larval stage | RU486 conditional, with Scer\GAL4^GSG2295

Sec71^DN.UAS

larval dorsal multidendritic neuron ddaC | prepupal stage | somatic clone

Sec71^Ex11

larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^ppk.PU

larval dorsal multidendritic neuron ddaC | pupal stage | RU486 conditional, with Scer\GAL4^GSG2295

Sec71^DN.UAS

larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PU

Sec71^HMS00357

larval dorsal multidendritic neuron ddaC | third instar larval stage | RU486 conditional, with Scer\GAL4^GSG2295

Sec71^DN.UAS

larval dorsal multidendritic neuron ddaD | pupal stage | somatic clone, with Scer\GAL4^109(2)80

Sec71^DN.UAS

larval dorsal multidendritic neuron ddaE | pupal stage | somatic clone, with Scer\GAL4^109(2)80

Sec71^DN.UAS

secretory granule, with Scer\GAL4^fkh.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (17)

Hsap\ARFGEF1

14 of 14

Yes

Hsap\ARFGEF2

13 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (17)

Rnor\Arfgef1

14 of 14

Yes

Rnor\Arfgef2

13 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (17)

Mmus\Arfgef1

13 of 14

Yes

Mmus\Arfgef2

13 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\arfgef1

7 of 13

Yes

Xtro\arfgef2

6 of 13

Yes

Xtro\bcl7a

5 of 13

Xtro\fbxo8

2 of 13

Yes

Xtro\gbf1

2 of 13

Xtro\aldoa

1 of 13

Xtro\brcc3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (23)

Drer\arfgef1

14 of 14

Yes

Drer\arfgef2

13 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Drer\cyth4b

2 of 14

Drer\fbxo8

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\agef-1

13 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP008906

12 of 12

Yes

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT3G60860

13 of 13

Yes

Atha\EDA10

13 of 13

Yes

Atha\AT4G35380

11 of 13

Yes

Atha\AT4G38200

11 of 13

Yes

Atha\ATMIN7

10 of 13

Yes

3 of 13

3 of 13

3 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (6)

Scer\SEC7

12 of 13

Yes

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (7)

Spom\sec72

12 of 12

Yes

Spom\sec71

11 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sec71. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ARFGEF2; ARF guanine nucleotide exchange factor 2

model of periventricular nodular heterotopia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARFGEF1; ARF guanine nucleotide exchange factor 1

14 of 14

604141

DEVELOPMENTAL DELAY, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES, WITH OR WITHOUT SEIZURES; DEDISB

ARFGEF2; ARF guanine nucleotide exchange factor 2

13 of 14

605371

PERIVENTRICULAR HETEROTOPIA WITH MICROCEPHALY, AUTOSOMAL RECESSIVE; ARPHM

periventricular nodular heterotopia

GBF1; golgi brefeldin A resistant guanine nucleotide exchange factor 1

4 of 14

603698

CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2GG; CMT2GG

Charcot-Marie-Tooth disease dominant intermediate A

3 of 14

3 of 14

FBXO8; F-box protein 8

3 of 14

605649

IQSEC1; IQ motif and Sec7 domain ArfGEF 1

3 of 14

IQ MOTIF- AND SEC7 DOMAIN-CONTAINING PROTEIN 1; IQSEC1

INTELLECTUAL DEVELOPMENTAL DISORDER WITH SHORT STATURE AND BEHAVIORAL ABNORMALITIES; IDDSSBA

intellectual developmental disorder with short stature and behavioral abnormalities

IQSEC3; IQ motif and Sec7 domain ArfGEF 3

3 of 14

612118

PSD2; pleckstrin and Sec7 domain containing 2

3 of 14

620656

PSD3; pleckstrin and Sec7 domain containing 3

3 of 14

614440

PSD4; pleckstrin and Sec7 domain containing 4

3 of 14

614442

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sec71 - Arf1

enzymatic study, fluorescence technology, anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Wang et al., 2017)

Sec71 - Arl1

pull down, molecular weight estimation by staining, peptide massfingerprinting, anti tag western blot

(Christis and Munro, 2012)

Sec71 - Rab6

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Sec71

suppressible

Arf1

(Wang et al., 2017)

Sec71

suppressible

Nrg

(Wang et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60818

DroID - A comprehensive database of gene and protein interactions.

FBgn0028538

MIST (protein-protein) - An integrated Molecular Interaction Database

34785

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-49

Cytogenetic map

34D1-34D1

Sequence location

2L:13,793,521..13,799,674 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34D1-34D1

Limits computationally determined from genome sequence between P{lacW}CG7364^k07245 and P{lacW}Sos^k05224&P{lacW}RpII33^k05605

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-49

(FlyBase, 2016)

2-44.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

42398

y¹ w^*; Mi{MIC}Sec71^MI06473/CyO

92271

y¹ w^*; TI{CRIMIC.TG4.1}Sec71^{CR02446-TG4.1}/SM6a

50539

y¹ sc^* v¹ sev²¹; P{TRiP.GLC01657}attP40

Kyoto

206863

y¹ w^67c23; P{GSV6}Sec71^GS16990/SM1

NIG-Fly

7578R-1

P{NIG.7578R}1

M2L-3402

y¹ w¹¹¹⁸; Sec71^SK16 P{neoFRT}40A/CyO-Tb

M2L-3403

y¹ w¹¹¹⁸; Sec71^SK18 P{neoFRT}40A/CyO-Tb

2LG-1311

y² VhaAC39-1^cho-1 v¹; P{U6-Sec71.NIG.sgRNA.1}attP40/CyO

2LG-3288

y² VhaAC39-1^cho-1 v¹; P{U6-Sec71.NIG.sgRNA.2}attP40/CyO

VDRC

v100300

P{KK107637}VIE-260B

v33634

w¹¹¹⁸; P{GD9923}v33634

v342610

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02457}attP40/CyO-GFP

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD29171

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028538

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028538

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Wang et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : New stable cell line derived from S2-unspecified : CRISPR genome-edited cell lines were created carrying Sec71 mutations; the BFA-resistant M717L mutation or the BFA-hypersensitive F713Y mutation. These S2 cells were stably transfected with pMT-GalT-EGFP-T2A-tdTomato-Rab6 or pMT- GalT::EGFP-T2A-tdTomato::Rab11.
(Fujii et al., 2020)

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

"anon-34Da" probably corresponds to " BG:DS00797.7 " (based on its molecular map position), and " BG:DS00797.7 " may correspond to "l(2)34Db".

(Ashburner et al., 1999)

" BG:DS00797.7 " may correspond to "anon-34Da".

(Ashburner et al., 1999.10.12)

Nomenclature History

Source for database identify of

Source for identity of: BG:DS00797.7 CG7578

(Guan, 1999.11)

Source for identity of: sec71 CG7578

(Abrams and Andrew, 2005)

Source for identity of: Sec71 sec71

(FlyBase, 2009-)

Nomenclature comments

Etymology

Named "Sec71" after the S. cerevisiae ortholog.

(FlyBase, 2009-)

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

BG:DS00797.7

(Giot et al., 2003, Bolshakov et al., 2002, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

BIG1

(Cox et al., 2004)

CG7578

(National Institute of Genetics Fly Stocks, 2022-, Zeledon et al., 2019, Chang et al., 2015, Hosono et al., 2015, Christis and Munro, 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Bakal et al., 2007)

Sec71

(Durel et al., 2025, Furusawa and Emoto, 2021, Fujii et al., 2020, Robinson et al., 2020, Rui et al., 2020, Laffafian and Tepass, 2019, Zeledon et al., 2019, Crofton et al., 2018, Gene Disruption Project members, 2018-, Wang et al., 2017, Torres et al., 2014, Christis and Munro, 2012, Wang et al., 2012)

sec71

(Chang et al., 2015, Luck et al., 2014, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Wendler et al., 2010, Guo et al., 2008)

Name Synonyms

Sec71 ortholog

Secretory 71

Secondary FlyBase IDs

FBgn0027855

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34785

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJW1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VJW1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJW1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34785/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028538

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028538

FlyMine - An integrated database for Drosophila genomics

FBgn0028538

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7578

MARRVEL_MODEL - MARRVEL (model organism gene)

34785

Linkouts

BioGRID - A database of protein and genetic interactions.

60818

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028538

DroID - A comprehensive database of gene and protein interactions.

FBgn0028538

DRSC - Results frm RNAi screens

FBgn0028538

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sec71_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028538

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028538

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7578

Flygut - An atlas of the Drosophila adult midgut

FBgn0028538

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002423

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

MIST (protein-protein) - An integrated Molecular Interaction Database

34785

References (69)

The following external sites may use different assemblies or annotations than FlyBase.

3.94

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