FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Rab6
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General Information
Symbol
Dmel\Rab6
Species
D. melanogaster
Name
Rab6
Annotation Symbol
CG6601
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015797
Gene Model Status
Current
Stock Availability
25 publicly available
Gene Summary
Rab6 (Rab6) encodes a member of the Rab family, which are small Ras-like GTPases involved in vesicle trafficking. The Rab6 product localizes on late Golgi, and regulates vesicle trafficking within Golgi, post-Golgi, and endosome to Golgi. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)08323, wrt, warthog, DmRab6

Key Links
Genomic Location
Cytogenetic map
33C4-33C4
Sequence location
Recombination map
2-46
RefSeq locus
NT_033779 REGION:12107221..12109116
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (27 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables GTPase activity
inferred from direct assay
(Walden et al., 2011)
enables protein binding
inferred from physical interaction with FLYBASE:CG8578; FB:FBgn0030699
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:TBC1D5; FB:FBgn0038129
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:Evi5; FB:FBgn0262740
(Gillingham et al., 2014)
inferred from physical interaction with FLYBASE:Rich; FB:FBgn0028500
(Tong et al., 2011)
inferred from physical interaction with FLYBASE:BicD; FB:FBgn0000183
(Coutelis and Ephrussi, 2007)
inferred from physical interaction with UniProtKB:Q8IQQ4
(Fatalska et al., 2021)
inferred from physical interaction with FLYBASE:GCC88; FB:FBgn0037881,FLYBASE:Golgin97; FB:FBgn0086757
(Sinka et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(GO Reference Genome Project, 2011-)
Biological Process (17 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Tong et al., 2011)
involved_in compound eye morphogenesis
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
(Verheyen et al., 1996)
involved_in exocytosis
inferred from mutant phenotype
(Coutelis and Ephrussi, 2007)
involved_in germarium-derived egg chamber formation
inferred from mutant phenotype
(Coutelis and Ephrussi, 2007)
involved_in oocyte microtubule cytoskeleton polarization
inferred from mutant phenotype
(Coutelis and Ephrussi, 2007)
involved_in phototransduction
inferred from mutant phenotype
(Huang et al., 2015)
involved_in pole plasm oskar mRNA localization
inferred from mutant phenotype
(Coutelis and Ephrussi, 2007)
involved_in protein targeting to Golgi apparatus
inferred from mutant phenotype
(Fatalska et al., 2021)
involved_in R7 cell development
inferred from mutant phenotype
(Tong et al., 2011)
involved_in receptor recycling
inferred from mutant phenotype
(Ayala et al., 2018)
involved_in regulation of postsynaptic membrane potential
inferred from mutant phenotype
(Tong et al., 2011)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in intra-Golgi vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN001178908
(GO Reference Genome Project, 2011-)
involved_in intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(GO Reference Genome Project, 2011-)
involved_in Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
involved_in retrograde transport, endosome to Golgi
inferred from biological aspect of ancestor with PANTHER:PTN001178908
(GO Reference Genome Project, 2011-)
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN001178908
(GO Reference Genome Project, 2011-)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
located_in autophagosome
inferred from direct assay
(Ayala et al., 2018)
located_in cytoplasmic vesicle
inferred from direct assay
(Tong et al., 2011)
located_in Golgi apparatus
inferred from direct assay
(Ayala et al., 2018, Tong et al., 2011)
located_in lysosome
inferred from direct assay
(Ayala et al., 2018)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
located_in synapse
inferred from high throughput direct assay
(Chan et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in endomembrane system
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(GO Reference Genome Project, 2011-)
is_active_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN001178908
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rab family. (O18334)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rab6 (Rab6) encodes a member of the Rab family, which are small Ras-like GTPases involved in vesicle trafficking. The Rab6 product localizes on late Golgi, and regulates vesicle trafficking within Golgi, post-Golgi, and endosome to Golgi. [Date last reviewed: 2018-09-20]
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
Protein transport (PubMed:17329360, PubMed:17827179, PubMed:18833296, PubMed:21835342, PubMed:22928698, PubMed:33704067, PubMed:9685396). Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:21795785). Mediates membrane trafficking during egg chamber growth and organization, possibly upstream of exocyst component Sec5. Also during oogenesis, plays a role, together with BicD but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in the localization of oskar mRNA and in the anterodorsal secretion of grk. Required for anterograde opsin transport through the ER-Golgi complex. Plays a role, together with Rich, in regulating CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6 (PubMed:21835342). Necessary for proper development of bristle shafts of macrochaete and microchaete on the head, thorax and scutellum. Modulates Notch signaling (PubMed:10459009). As a key regulator of vesicular traffic, plays a critical role in the regulation of actin organization and is required for normal rates of phagocytic uptake during phagocytosis involved in defense against viral and fungal infection.
(UniProt, O18334)
Summary (Interactive Fly)

small GTPase required for membrane trafficking - required for organization and growth of the egg chamber and the polarization of the microtubule cytoskeleton and localization of oskar mRNA - involved in trafficking Notch protein during bristle development and rhodopsin the the eye

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18334)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.51

Gene model reviewed during 5.43

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab6-RA
FBtr0080361
NM_057824
1830
208
Rab6-RB
FBtr0346437
NM_001298940
1896
208
Additional Transcript Data and Comments
Reported size (kB)

1.157 (longest cDNA)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rab6-PA
FBpp0079943
23.5
208
4.97
O18334
NP_477172
AAF53168
Rab6-PB
FBpp0312096
23.5
208
4.97
O18334
NP_001285869
AHN54383
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

208 aa isoforms: Rab6-PA, Rab6-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

208 (aa)

(Satoh et al., 1997)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Rich and Act5C (PubMed:21835342, PubMed:22928698). Interacts with BicD (via C-terminal domain) (PubMed:17329360, PubMed:17827179). Interacts (in GTP-bound) with GCC1/CG10703 and cbs (PubMed:19001129). Interacts with Gorab (via C-terminus); binds to a Gorab homodimer, this interaction seems to be required for trans-Golgi localization of Gorab (PubMed:33704067).

(UniProt, O18334)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.99

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autophagosome
inferred from direct assay
(Ayala et al., 2018)
located_in cytoplasmic vesicle
inferred from direct assay
(Tong et al., 2011)
located_in Golgi apparatus
inferred from direct assay
(Ayala et al., 2018, Tong et al., 2011)
located_in lysosome
inferred from direct assay
(Ayala et al., 2018)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
located_in synapse
inferred from high throughput direct assay
(Chan et al., 2011)
Expression Deduced from Reporters
Reporter: PBac{I-SceI(FRT.Rab6-GAL4.ORF(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body | intense
(Jin et al., 2012)
eye disc | restricted
(Jin et al., 2012)
embryonic/larval optic stalk surface glial cell | intense
(Jin et al., 2012)
neuron of larval brain
(Chan et al., 2011)
glial cell | subset of larval brain
(Chan et al., 2011)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron | subset of larval ventral nerve cord
(Chan et al., 2011)
wing disc
(Chan et al., 2011)
eye disc
(Chan et al., 2011)
leg disc
(Chan et al., 2011)
leg disc | restricted
(Jin et al., 2012)
wing disc | restricted
(Jin et al., 2012)
pupal stage P6 -- P7
neuron of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
mushroom body

Comment: 30-40h APF

(Chan et al., 2011)
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe | faint

Comment: 30-40h APF

(Jin et al., 2012)
mushroom body | intense

Comment: 30-40h APF

(Jin et al., 2012)
eye photoreceptor cell | intense

Comment: 30-40h APF

(Jin et al., 2012)
adult stage
neuron of adult brain
(Chan et al., 2011)
adult mushroom body | intense
(Jin et al., 2012, Chan et al., 2011)
adult ensheathing glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell | intense
(Jin et al., 2012)
neuron of adult optic lobe | intense
(Jin et al., 2012)
adult antennal lobe | intense
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis | intense
(Jin et al., 2012)
neuron of lamina | intense
(Jin et al., 2012)
ellipsoid body | intense
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab6 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 58 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab6
Transgenic constructs containing regulatory region of Rab6
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die during embryonic stage
viable
Other Phenotypes
Allele
abnormal flight, with Scer\GAL4Mef2.PR
abnormal immune response | adult stage | dominant
abnormal neurophysiology
abnormal neurophysiology | adult stage | somatic clone
abnormal neurophysiology | somatic clone
increased cell death | adult stage | progressive | somatic clone
some die during larval stage | recessive
visible | cell non-autonomous | recessive | somatic clone
visible | dominant
visible | recessive
wild-type
Phenotype manifest in
Allele
actin cytoskeleton & egg chamber | germ-line clone
adult head & microchaeta | somatic clone | cell non-autonomous
adult thorax & microchaeta | somatic clone | cell non-autonomous
egg chamber | germline clone
eye | somatic clone
eye photoreceptor cell | somatic clone
female germline cyst | germline clone
Golgi apparatus & egg chamber | germ-line clone
hemocyte | adult stage
interocellar bristle
macrochaeta
macrochaeta | cell non-autonomous | somatic clone
microtubule cytoskeleton & egg chamber | germ-line clone
photoreceptor cell R7 | somatic clone
plasma membrane | germline clone | oogenesis
retina
retina | somatic clone
rhabdomere of eye photoreceptor cell | somatic clone
rhabdomere R1
rhabdomere R2
rhabdomere R3
rhabdomere R4
rhabdomere R5
rhabdomere R6
scutellar bristle
scutum & macrochaeta
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (82)
Hsap\RAB6A
12 of 14
Yes
Yes
Hsap\RAB6B
9 of 14
No
Yes
Hsap\RAB6C
7 of 14
No
Yes
Hsap\RAB6D
6 of 14
No
Yes
Hsap\RAB41
6 of 14
No
Yes
1  
Hsap\RAB34
2 of 14
No
No
Hsap\RAB36
2 of 14
No
No
Hsap\DIRAS1
1 of 14
No
No
1  
Hsap\DIRAS2
1 of 14
No
No
1  
Hsap\GEM
1 of 14
No
No
Hsap\HRAS
1 of 14
No
No
3  
Hsap\IFT22
1 of 14
No
Yes
Hsap\RAB1A
1 of 14
No
No
Hsap\RAB1B
1 of 14
No
No
Hsap\RAB1C
1 of 14
No
No
Hsap\RAB2A
1 of 14
No
No
1  
Hsap\RAB2B
1 of 14
No
No
Hsap\RAB3A
1 of 14
No
No
Hsap\RAB3B
1 of 14
No
No
Hsap\RAB3C
1 of 14
No
No
Hsap\RAB3D
1 of 14
No
No
Hsap\RAB4A
1 of 14
No
No
Hsap\RAB4B
1 of 14
No
No
Hsap\RAB5A
1 of 14
No
No
1  
Hsap\RAB5B
1 of 14
No
No
Hsap\RAB5C
1 of 14
No
No
1  
Hsap\RAB7A
1 of 14
No
No
5  
Hsap\RAB7B
1 of 14
No
No
Hsap\RAB8A
1 of 14
No
No
1  
Hsap\RAB8B
1 of 14
No
No
Hsap\RAB9A
1 of 14
No
No
1  
Hsap\RAB9B
1 of 14
No
No
1  
Hsap\RAB10
1 of 14
No
No
1  
Hsap\RAB11A
1 of 14
No
No
Hsap\RAB11B
1 of 14
No
No
1  
Hsap\RAB12
1 of 14
No
No
Hsap\RAB13
1 of 14
No
No
Hsap\RAB14
1 of 14
No
No
1  
Hsap\RAB15
1 of 14
No
No
Hsap\RAB17
1 of 14
No
No
Hsap\RAB19
1 of 14
No
No
Hsap\RAB21
1 of 14
No
No
Hsap\RAB22A
1 of 14
No
No
Hsap\RAB23
1 of 14
No
No
1  
Hsap\RAB24
1 of 14
No
No
Hsap\RAB25
1 of 14
No
No
Hsap\RAB26
1 of 14
No
No
Hsap\RAB27B
1 of 14
No
No
1  
Hsap\RAB28
1 of 14
No
No
Hsap\RAB30
1 of 14
No
No
1  
Hsap\RAB31
1 of 14
No
No
Hsap\RAB33A
1 of 14
No
No
Hsap\RAB35
1 of 14
No
No
Hsap\RAB37
1 of 14
No
No
Hsap\RAB39B
1 of 14
No
No
4  
Hsap\RAB43
1 of 14
No
No
1  
Hsap\RAB44
1 of 14
No
No
Hsap\RALA
1 of 14
No
No
1  
Hsap\RALB
1 of 14
No
No
1  
Hsap\RAN
1 of 14
No
No
Hsap\RAP1A
1 of 14
No
No
3  
Hsap\RAP1B
1 of 14
No
No
3  
Hsap\RAP2B
1 of 14
No
No
Hsap\RAP2C
1 of 14
No
No
Hsap\RASD1
1 of 14
No
No
1  
Hsap\RASD2
1 of 14
No
No
Hsap\RASEF
1 of 14
No
No
Hsap\RASL10A
1 of 14
No
No
Hsap\RASL10B
1 of 14
No
No
1  
Hsap\RASL11A
1 of 14
No
No
1  
Hsap\RASL11B
1 of 14
No
No
1  
Hsap\RASL12
1 of 14
No
No
Hsap\REM2
1 of 14
No
No
Hsap\RERG
1 of 14
No
No
Hsap\RERGL
1 of 14
No
No
Hsap\RHEB
1 of 14
No
No
1  
Hsap\RHEBL1
1 of 14
No
No
Hsap\RIT1
1 of 14
No
No
1  
Hsap\RIT2
1 of 14
No
No
Hsap\RRAD
1 of 14
No
No
1  
Hsap\RRAS2
1 of 14
No
No
2  
Hsap\RRAS
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (57)
Rnor\Rab6a
12 of 14
Yes
Yes
Rnor\Rab6b
9 of 14
No
Yes
Rnor\Rab34
2 of 14
No
No
Rnor\Rab36
2 of 14
No
No
Rnor\Diras1
1 of 14
No
No
Rnor\Diras2
1 of 14
No
No
Rnor\Gem
1 of 14
No
No
Rnor\Ift22
1 of 14
No
Yes
Rnor\Rab1a
1 of 14
No
No
Rnor\Rab1b
1 of 14
No
No
Rnor\Rab2a
1 of 14
No
No
Rnor\Rab3a
1 of 14
No
No
Rnor\Rab3b
1 of 14
No
No
Rnor\Rab3d
1 of 14
No
No
Rnor\Rab5al1
1 of 14
No
No
Rnor\Rab5a
1 of 14
No
No
Rnor\Rab5b
1 of 14
No
No
Rnor\Rab5c
1 of 14
No
No
Rnor\Rab7a
1 of 14
No
No
Rnor\Rab7b
1 of 14
No
No
Rnor\Rab8a
1 of 14
No
No
Rnor\Rab8b
1 of 14
No
No
Rnor\Rab9a
1 of 14
No
No
Rnor\Rab9b
1 of 14
No
No
Rnor\Rab11a
1 of 14
No
No
Rnor\Rab11b
1 of 14
No
No
Rnor\Rab12
1 of 14
No
No
Rnor\Rab13
1 of 14
No
No
Rnor\Rab14
1 of 14
No
No
Rnor\Rab15
1 of 14
No
No
Rnor\Rab17
1 of 14
No
No
Rnor\Rab21
1 of 14
No
No
Rnor\Rab22a
1 of 14
No
No
Rnor\Rab23
1 of 14
No
No
Rnor\Rab25
1 of 14
No
No
Rnor\Rab26
1 of 14
No
No
Rnor\Rab28
1 of 14
No
No
Rnor\Rab30
1 of 14
No
No
Rnor\Rab31
1 of 14
No
No
Rnor\Rab35
1 of 14
No
No
Rnor\Rab43
1 of 14
No
No
Rnor\Rala
1 of 14
No
No
Rnor\Ralb
1 of 14
No
No
Rnor\Rap1a
1 of 14
No
No
Rnor\Rap1b
1 of 14
No
No
Rnor\Rasl10a
1 of 14
No
No
Rnor\Rasl10b
1 of 14
No
No
Rnor\Rasl11a
1 of 14
No
No
Rnor\Rasl11b
1 of 14
No
No
Rnor\Rasl12
1 of 14
No
No
Rnor\Rem1
1 of 14
No
No
Rnor\Rem2
1 of 14
No
No
Rnor\Rergl
1 of 14
No
No
Rnor\Rerg
1 of 14
No
No
Rnor\Rit1
1 of 14
No
No
Rnor\Rit2
1 of 14
No
No
Rnor\Rrad
1 of 14
No
No
Mus musculus (laboratory mouse) (59)
Mmus\Rab6a
11 of 14
Yes
Yes
Mmus\Rab6b
9 of 14
No
Yes
Mmus\Rab34
2 of 14
No
No
Mmus\Rab36
2 of 14
No
No
Mmus\Diras1
1 of 14
No
No
Mmus\Diras2
1 of 14
No
No
Mmus\Gem
1 of 14
No
No
Mmus\Ift22
1 of 14
No
Yes
Mmus\Rab1a
1 of 14
No
No
1  
Mmus\Rab1b
1 of 14
No
No
Mmus\Rab2a
1 of 14
No
No
Mmus\Rab3a
1 of 14
No
No
Mmus\Rab3b
1 of 14
No
No
Mmus\Rab3d
1 of 14
No
No
Mmus\Rab5a
1 of 14
No
No
Mmus\Rab5b
1 of 14
No
No
Mmus\Rab5c
1 of 14
No
No
Mmus\Rab7b
1 of 14
No
No
Mmus\Rab7
1 of 14
No
No
Mmus\Rab8a
1 of 14
No
No
Mmus\Rab8b
1 of 14
No
No
Mmus\Rab9b
1 of 14
No
No
Mmus\Rab9
1 of 14
No
No
Mmus\Rab10
1 of 14
No
No
Mmus\Rab11a
1 of 14
No
No
Mmus\Rab11b
1 of 14
No
No
Mmus\Rab12
1 of 14
No
No
Mmus\Rab13
1 of 14
No
No
Mmus\Rab14
1 of 14
No
No
Mmus\Rab15
1 of 14
No
No
Mmus\Rab17
1 of 14
No
No
Mmus\Rab21
1 of 14
No
No
Mmus\Rab22a
1 of 14
No
No
Mmus\Rab23
1 of 14
No
No
Mmus\Rab24
1 of 14
No
No
Mmus\Rab25
1 of 14
No
No
Mmus\Rab26
1 of 14
No
No
Mmus\Rab28
1 of 14
No
No
Mmus\Rab30
1 of 14
No
No
Mmus\Rab31
1 of 14
No
No
Mmus\Rab35
1 of 14
No
No
Mmus\Rab42
1 of 14
No
No
Mmus\Rab43
1 of 14
No
No
Mmus\Rala
1 of 14
No
No
Mmus\Ralb
1 of 14
No
No
Mmus\Rap1a
1 of 14
No
No
Mmus\Rap1b
1 of 14
No
No
Mmus\Rasl10a
1 of 14
No
No
Mmus\Rasl10b
1 of 14
No
No
Mmus\Rasl11a
1 of 14
No
No
Mmus\Rasl11b
1 of 14
No
No
Mmus\Rasl12
1 of 14
No
No
Mmus\Rem1
1 of 14
No
No
Mmus\Rem2
1 of 14
No
No
Mmus\Rergl
1 of 14
No
No
Mmus\Rerg
1 of 14
No
No
Mmus\Rit1
1 of 14
No
No
Mmus\Rit2
1 of 14
No
No
Mmus\Rrad
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (46)
Xtro\rab6a
7 of 13
Yes
Yes
Xtro\rab41
5 of 13
No
Yes
Xtro\rab6b
4 of 13
No
Yes
Xtro\cplane2
1 of 13
No
Yes
Xtro\diras2
1 of 13
No
No
Xtro\diras3
1 of 13
No
No
Xtro\gem
1 of 13
No
No
Xtro\ift22
1 of 13
No
Yes
Xtro\LOC100488596
1 of 13
No
No
Xtro\MGC147600
1 of 13
No
Yes
Xtro\rab1a
1 of 13
No
No
Xtro\rab2b
1 of 13
No
No
Xtro\rab3a
1 of 13
No
No
Xtro\rab3b
1 of 13
No
No
Xtro\rab3c
1 of 13
No
No
Xtro\rab3d
1 of 13
No
No
Xtro\rab4b
1 of 13
No
No
Xtro\rab5b
1 of 13
No
No
Xtro\rab5d
1 of 13
No
No
Xtro\rab8b
1 of 13
No
No
Xtro\rab11b.1
1 of 13
No
No
Xtro\rab12
1 of 13
No
No
Xtro\rab19
1 of 13
No
No
Xtro\rab24
1 of 13
No
No
Xtro\rab26
1 of 13
No
No
Xtro\rab28
1 of 13
No
Yes
Xtro\rab29
1 of 13
No
No
Xtro\rab34
1 of 13
No
No
Xtro\rab35l
1 of 13
No
No
Xtro\rab35
1 of 13
No
No
Xtro\rab36
1 of 13
No
No
Xtro\rab39a
1 of 13
No
No
Xtro\rab39b
1 of 13
No
No
Xtro\ran
1 of 13
No
No
Xtro\rap1b
1 of 13
No
No
Xtro\rap2a
1 of 13
No
No
Xtro\rap2c
1 of 13
No
No
Xtro\rasd1
1 of 13
No
No
Xtro\rasd2
1 of 13
No
No
Xtro\rasl10b
1 of 13
No
No
Xtro\rasl11b
1 of 13
No
No
Xtro\rem2
1 of 13
No
No
Xtro\rergl
1 of 13
No
No
Xtro\rerg
1 of 13
No
No
Xtro\rhebl1
1 of 13
No
No
Xtro\rras
1 of 13
No
No
Danio rerio (Zebrafish) (83)
Drer\rab6a
10 of 14
Yes
Yes
Drer\rab6bb
10 of 14
Yes
Yes
Drer\rab41
10 of 14
Yes
Yes
Drer\rab6ba
9 of 14
No
Yes
Drer\rab34a
2 of 14
No
No
Drer\rab34b
2 of 14
No
No
Drer\rab36
2 of 14
No
No
Drer\cracr2aa
1 of 14
No
No
Drer\cracr2ab
1 of 14
No
No
Drer\diras1b
1 of 14
No
No
Drer\gem
1 of 14
No
No
Drer\ift22
1 of 14
No
Yes
Drer\LOC101885697
1 of 14
No
No
Drer\rab1aa
1 of 14
No
No
Drer\rab1ab
1 of 14
No
No
Drer\rab1ba
1 of 14
No
No
Drer\rab1bb
1 of 14
No
No
Drer\rab2a
1 of 14
No
No
Drer\rab3aa
1 of 14
No
No
Drer\rab3ab
1 of 14
No
No
Drer\rab3b
1 of 14
No
No
Drer\rab3da
1 of 14
No
No
Drer\rab3db
1 of 14
No
No
Drer\rab4b
1 of 14
No
No
Drer\rab5aa
1 of 14
No
No
Drer\rab5ab
1 of 14
No
No
Drer\rab5b
1 of 14
No
No
Drer\rab5c
1 of 14
No
No
Drer\rab7a
1 of 14
No
No
Drer\rab7b
1 of 14
No
No
Drer\rab8a
1 of 14
No
No
Drer\rab8b
1 of 14
No
No
Drer\rab9a
1 of 14
No
No
Drer\rab9b
1 of 14
No
No
Drer\rab10
1 of 14
No
No
Drer\rab11a
1 of 14
No
No
Drer\rab11al
1 of 14
No
No
Drer\rab11ba
1 of 14
No
No
Drer\rab11bb
1 of 14
No
No
Drer\rab12
1 of 14
No
No
Drer\rab13
1 of 14
No
No
Drer\rab14
1 of 14
No
No
Drer\rab14l
1 of 14
No
No
Drer\rab15
1 of 14
No
No
Drer\rab18a
1 of 14
No
No
Drer\rab21
1 of 14
No
No
Drer\rab22a
1 of 14
No
No
Drer\rab24
1 of 14
No
No
Drer\rab25a
1 of 14
No
No
Drer\rab25b
1 of 14
No
No
Drer\rab30
1 of 14
No
No
Drer\rab31
1 of 14
No
No
Drer\rab35a
1 of 14
No
No
Drer\rab35b
1 of 14
No
No
Drer\rab39ba
1 of 14
No
No
Drer\rab42b
1 of 14
No
No
Drer\rab43
1 of 14
No
No
Drer\rab44
1 of 14
No
No
Drer\ralaa
1 of 14
No
No
Drer\ralab
1 of 14
No
No
Drer\ralba
1 of 14
No
No
Drer\rap1aa
1 of 14
No
No
Drer\rap1ab
1 of 14
No
No
Drer\rap1b
1 of 14
No
No
Drer\rasd4
1 of 14
No
No
Drer\rasl10a
1 of 14
No
No
Drer\rasl11a
1 of 14
No
No
Drer\rasl11b
1 of 14
No
No
Drer\rasl12
1 of 14
No
No
Drer\rem1
1 of 14
No
No
Drer\rerg
1 of 14
No
No
Drer\rergla
1 of 14
No
No
Drer\rerglb
1 of 14
No
No
Drer\rit1
1 of 14
No
No
Drer\rrad
1 of 14
No
No
Drer\si:dkey-13a21.4
1 of 14
No
No
Drer\si:dkey-16l2.16
1 of 14
No
No
Drer\si:dkeyp-59c12.1
1 of 14
No
No
Drer\zgc:64022
1 of 14
No
No
Drer\zgc:100918
1 of 14
No
No
Drer\zgc:110699
1 of 14
No
No
Drer\zgc:171704
1 of 14
No
No
Drer\zgc:171927
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (42)
Cele\rab-6.2
13 of 14
Yes
Yes
Cele\rab-6.1
9 of 14
No
Yes
Cele\C56E6.2
2 of 14
No
Yes
Cele\4R79.2
1 of 14
No
Yes
Cele\aex-6
1 of 14
No
No
Cele\C52B11.5
1 of 14
No
No
Cele\chw-1
1 of 14
No
No
Cele\D1081.4
1 of 14
No
No
Cele\drn-1
1 of 14
No
No
Cele\F11A5.3
1 of 14
No
No
Cele\F20D6.8
1 of 14
No
No
Cele\ifta-2
1 of 14
No
Yes
Cele\K02E10.1
1 of 14
No
No
Cele\rab-1
1 of 14
No
No
Cele\rab-3
1 of 14
No
No
Cele\rab-5
1 of 14
No
No
Cele\rab-7
1 of 14
No
No
Cele\rab-8
1 of 14
No
No
Cele\rab-10
1 of 14
No
No
Cele\rab-11.1
1 of 14
No
No
Cele\rab-11.2
1 of 14
No
No
Cele\rab-14
1 of 14
No
No
Cele\rab-18
1 of 14
No
No
Cele\rab-19
1 of 14
No
No
Cele\rab-21
1 of 14
No
No
Cele\rab-28
1 of 14
No
No
Cele\rab-35
1 of 14
No
No
Cele\rab-37
1 of 14
No
No
Cele\ral-1
1 of 14
No
No
Cele\ran-1
1 of 14
No
No
Cele\rap-1
1 of 14
No
No
Cele\rap-2
1 of 14
No
No
Cele\rap-3
1 of 14
No
No
Cele\ras-1
1 of 14
No
No
Cele\ras-2
1 of 14
No
No
Cele\rheb-1
1 of 14
No
No
Cele\rsef-1
1 of 14
No
No
Cele\ssr-2
1 of 14
No
No
Cele\unc-108
1 of 14
No
No
Cele\W04C9.5
1 of 14
No
No
Cele\Y52B11A.4
1 of 14
No
No
Cele\Y71H2AM.12
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (39)
Agam\AgaP_AGAP011363
12 of 12
Yes
Yes
Agam\AgaP_AGAP006035
2 of 12
No
No
Agam\AgaP_AGAP000433
1 of 12
No
No
Agam\AgaP_AGAP000671
1 of 12
No
No
Agam\AgaP_AGAP001211
1 of 12
No
No
Agam\AgaP_AGAP001617
1 of 12
No
No
Agam\AgaP_AGAP001874
1 of 12
No
No
Agam\AgaP_AGAP001902
1 of 12
No
No
Agam\AgaP_AGAP002092
1 of 12
No
No
Agam\AgaP_AGAP002563
1 of 12
No
No
Agam\AgaP_AGAP002812
1 of 12
No
No
Agam\AgaP_AGAP003028
1 of 12
No
No
Agam\AgaP_AGAP003577
1 of 12
No
No
Agam\AgaP_AGAP004146
1 of 12
No
No
Agam\AgaP_AGAP004204
1 of 12
No
No
Agam\AgaP_AGAP004559
1 of 12
No
No
Agam\AgaP_AGAP005159
1 of 12
No
No
Agam\AgaP_AGAP005243
1 of 12
No
No
Agam\AgaP_AGAP005248
1 of 12
No
No
Agam\AgaP_AGAP005255
1 of 12
No
No
Agam\AgaP_AGAP005302
1 of 12
No
No
Agam\AgaP_AGAP005393
1 of 12
No
No
Agam\AgaP_AGAP006025
1 of 12
No
No
Agam\AgaP_AGAP006159
1 of 12
No
No
Agam\AgaP_AGAP006873
1 of 12
No
No
Agam\AgaP_AGAP007096
1 of 12
No
No
Agam\AgaP_AGAP007369
1 of 12
No
No
Agam\AgaP_AGAP007615
1 of 12
No
No
Agam\AgaP_AGAP007681
1 of 12
No
No
Agam\AgaP_AGAP007699
1 of 12
No
No
Agam\AgaP_AGAP007901
1 of 12
No
No
Agam\AgaP_AGAP008224
1 of 12
No
No
Agam\AgaP_AGAP008419
1 of 12
No
No
Agam\AgaP_AGAP008989
1 of 12
No
No
Agam\AgaP_AGAP009325
1 of 12
No
No
Agam\AgaP_AGAP009846
1 of 12
No
No
Agam\AgaP_AGAP010875
1 of 12
No
No
Agam\AgaP_AGAP011306
1 of 12
No
No
Agam\AgaP_AGAP012108
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (59)
Atha\RABH1d
12 of 13
Yes
Yes
Atha\RABH1e
12 of 13
Yes
Yes
Atha\RAB6A
11 of 13
No
Yes
Atha\RABH1c
10 of 13
No
Yes
Atha\RABH1a
6 of 13
No
Yes
Atha\ARA-2
1 of 13
No
No
Atha\ARA4
1 of 13
No
No
Atha\ARA6
1 of 13
No
No
Atha\ARA7
1 of 13
No
No
Atha\ArRABA1h
1 of 13
No
No
Atha\AT5G59840
1 of 13
No
No
Atha\ATFP8
1 of 13
No
No
Atha\GB2
1 of 13
No
No
Atha\RA-5
1 of 13
No
No
Atha\RAB1A
1 of 13
No
No
Atha\RAB1C
1 of 13
No
No
Atha\RAB7A
1 of 13
No
No
Atha\RAB7B
1 of 13
No
No
Atha\RAB8
1 of 13
No
No
Atha\RAB8C
1 of 13
No
No
Atha\RAB11c
1 of 13
No
No
Atha\RAB18
1 of 13
No
No
Atha\RABA1b
1 of 13
No
No
Atha\RABA1c
1 of 13
No
No
Atha\RABA1d
1 of 13
No
No
Atha\RABA1e
1 of 13
No
No
Atha\RABA1f
1 of 13
No
No
Atha\RABA1g
1 of 13
No
No
Atha\RABA1i
1 of 13
No
No
Atha\RABA2b
1 of 13
No
No
Atha\RABA2c
1 of 13
No
No
Atha\RABA2D
1 of 13
No
No
Atha\RABA3
1 of 13
No
No
Atha\RABA4a
1 of 13
No
No
Atha\RABA4B
1 of 13
No
No
Atha\RABA4C
1 of 13
No
No
Atha\RABA4D
1 of 13
No
No
Atha\RABA5a
1 of 13
No
No
Atha\RABA5b
1 of 13
No
No
Atha\RABA5d
1 of 13
No
No
Atha\RABA5E
1 of 13
No
No
Atha\RABA6b
1 of 13
No
No
Atha\RABB1a
1 of 13
No
No
Atha\RABB1C
1 of 13
No
No
Atha\RABC2A
1 of 13
No
No
Atha\RABE1c
1 of 13
No
No
Atha\RABE1e
1 of 13
No
No
Atha\RABG1
1 of 13
No
No
Atha\RABG3A
1 of 13
No
No
Atha\RABG3B
1 of 13
No
No
Atha\RABG3c
1 of 13
No
No
Atha\RABG3d
1 of 13
No
No
Atha\RABG3E
1 of 13
No
No
Atha\RAN2
1 of 13
No
No
Atha\RAN3
1 of 13
No
No
Atha\RAN4
1 of 13
No
No
Atha\RHA1
1 of 13
No
No
Atha\SGP1
1 of 13
No
Yes
Atha\SGP2
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (16)
Scer\YPT6
10 of 13
Yes
Yes
Scer\GSP1
1 of 13
No
No
Scer\GSP2
1 of 13
No
No
Scer\RAS1
1 of 13
No
No
Scer\RAS2
1 of 13
No
No
Scer\RSR1
1 of 13
No
No
Scer\SEC4
1 of 13
No
No
Scer\TEM1
1 of 13
No
Yes
Scer\VPS21
1 of 13
No
No
Scer\YPT1
1 of 13
No
No
Scer\YPT7
1 of 13
No
No
Scer\YPT10
1 of 13
No
No
Scer\YPT31
1 of 13
No
No
Scer\YPT32
1 of 13
No
No
Scer\YPT52
1 of 13
No
No
Scer\YPT53
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (11)
Spom\ryh1
10 of 12
Yes
Yes
Spom\rhb1
1 of 12
No
No
Spom\rho4
1 of 12
No
No
Spom\spg1
1 of 12
No
Yes
Spom\ypt1
1 of 12
No
No
Spom\ypt2
1 of 12
No
No
Spom\ypt3
1 of 12
No
No
Spom\ypt4
1 of 12
No
No
Spom\ypt5
1 of 12
No
No
Spom\ypt7
1 of 12
No
No
Spom\ypt71
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rab6. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (49)
Rab1
3 of 13
Rab5
3 of 13
Rab14
3 of 13
Rab18
3 of 13
Rab19
3 of 13
Rab21
3 of 13
RabX1
3 of 13
RabX5
3 of 13
CG4789
2 of 13
Rab2
2 of 13
Rab3
2 of 13
Rab4
2 of 13
Rab7
2 of 13
Rab8
2 of 13
Rab9Fb
2 of 13
Rab9
2 of 13
Rab10
2 of 13
Rab11
2 of 13
Rab23
2 of 13
Rab26
2 of 13
Rab30
2 of 13
Rab32
2 of 13
Rab35
2 of 13
Rab39
2 of 13
RabX2
2 of 13
RabX6
2 of 13
CG5160
1 of 13
CG8500
1 of 13
CG8519
1 of 13
CG8641
1 of 13
CG13375
1 of 13
CG14669
1 of 13
CG30158
1 of 13
CG42541
1 of 13
Rab9Db
1 of 13
Rab9D
1 of 13
Rab9E
1 of 13
Rab9Fa
1 of 13
Rab27
1 of 13
Rala
1 of 13
Ran-like
1 of 13
Ran
1 of 13
Rap1
1 of 13
Ras85D
1 of 13
Rgk1
1 of 13
Rgk2
1 of 13
Rgk3
1 of 13
Rheb
1 of 13
Ric
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    Rab6EP2397
    model of  retinal degeneration
    CEA
    (Huang et al., 2015)
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAB6A; RAB6A, member RAS oncogene family
    12 of 14
    179513
        RAB6B; RAB6B, member RAS oncogene family
        9 of 14
        615852
            RAB6C; RAB6C, member RAS oncogene family
            7 of 14
            612909
                RAB6D; RAB6D, member RAS oncogene family
                6 of 14
                    RAB41; RAB41, member RAS oncogene family
                    6 of 14
                         
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        Interaction Browsers
                        View in FlyBase Interactions Browser   View in MIST tool (external link)
                        Please see the Physical Interaction reports below for full details
                        RNA-RNA
                        Physical Interaction
                        Assay
                        References
                        Rab6 - mir-252
                        luminiscence technology
                        (Lim et al., 2023)
                        protein-protein
                        Physical Interaction
                        Assay
                        References
                        Rab6 - Arf1
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Bet3
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - BicD
                        pull down, peptide massfingerprinting, two hybrid, protein cross-linking with a bifunctional reagent, isothermal titration calorimetry, predetermined participant, molecular weight estimation by staining, anti tag coimmunoprecipitation, western blot, molecular sieving
                        (Gillingham et al., 2014, Gillingham et al., 2014, Liu et al., 2013, Dienstbier et al., 2009, Coutelis and Ephrussi, 2007, Januschke et al., 2007)
                        Rab6 - CG12702
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - CG14450
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - CG15098
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - CG18596
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - CG2736
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - CG30344
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - CG5555
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - CG8578
                        pull down, anti tag western blot, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - CG9577
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Cdc37
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - CenB1A
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - Cyp4ae1
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Egm
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Evi5
                        pull down, peptide massfingerprinting, two hybrid, anti tag western blot
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - GCC88
                        two hybrid, pull down, western blot
                        (Sinka et al., 2008)
                        Rab6 - Gdi
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - Golgin97
                        pull down, western blot, two hybrid, peptide massfingerprinting
                        (Gillingham et al., 2014, Sinka et al., 2008)
                        Rab6 - Gorab
                        isothermal titration calorimetry, predetermined participant, pull down, anti tag western blot, mass spectrometry study of hydrogen/deuterium exchange, peptide massfingerprinting
                        (Fatalska et al., 2021, Gillingham et al., 2014)
                        Rab6 - Gp93
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - KdelR
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Mad1
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Mcad
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Mec2
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Mhcl
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Mkk4
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Ocrl
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - Ost1
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - POLDIP2
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Rab1
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Rab2
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Rab5
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Rab7
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Rbcn-3A
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Rdh1
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Rich
                        pull down, anti tag western blot
                        (Tong et al., 2011)
                        Rab6 - Rint1
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - SERCA
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - SIDL
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - Sec71
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - SsRβ
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - TBC1D5
                        pull down, anti tag western blot
                        (Gillingham et al., 2014)
                        Rab6 - Trs23
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Trs33
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Tspo
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - Unc-76
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Vps13D
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - Vps26
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - Vps35
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - brun
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - cin
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - faf
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014, Gillingham et al., 2014)
                        Rab6 - garz
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - kri
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - porin
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - snz
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - sp3
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - spidey
                        experimental knowledge based
                        (Guruharsha et al., 2011)
                        Rab6 - sti
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - trio
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Rab6 - zip
                        pull down, peptide massfingerprinting
                        (Gillingham et al., 2014)
                        Summary of Genetic Interactions
                        Interaction Browsers
                        View in FlyBase Interactions Browser   View in MIST tool (external link)
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Dref
                        suppressible
                        Rab6
                        (Ida et al., 2009)
                        Kr
                        enhanceable
                        Rab6
                        (Abrell et al., 2000)
                        N
                        enhanceable
                        Rab6
                        (Purcell and Artavanis-Tsakonas, 1999, Verheyen et al., 1996)
                        Rich
                        enhanceable
                        Rab6
                        (Tong et al., 2011)
                        Rich
                        suppressible
                        Rab6
                        (Tong et al., 2011)
                        Snr1
                        suppressible
                        Rab6
                        (Tegeder et al., 2019)
                        External Data
                        Subunit Structure (UniProtKB)
                        Interacts with Rich and Act5C (PubMed:21835342, PubMed:22928698). Interacts with BicD (via C-terminal domain) (PubMed:17329360, PubMed:17827179). Interacts (in GTP-bound) with GCC1/CG10703 and cbs (PubMed:19001129). Interacts with Gorab (via C-terminus); binds to a Gorab homodimer, this interaction seems to be required for trans-Golgi localization of Gorab (PubMed:33704067).
                        (UniProt, O18334 )
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        MIST (genetic) - An integrated Molecular Interaction Database
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        FlyBase
                        External Links
                        External Data
                        Class of Gene
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        2L
                        Recombination map
                        2-46
                        Cytogenetic map
                        33C4-33C4
                        Sequence location
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        33C4-33C4
                        Limits computationally determined from genome sequence between P{lacW}Aats-thrk04203 and P{PZ}Rab608323
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        33B9-33B12
                        (Ozaki, 1996.4.3)
                        33D1-33D2
                        (determined by in situ hybridisation)
                        (Spradling et al., 1999)
                        33C-33D
                        (determined by in situ hybridisation)
                        (Shetty et al., 1998, O'Tousa, 1997.8.18)
                        33B9-33B12
                        (determined by in situ hybridisation)
                        (Satoh et al., 1997)
                        33B2-34A2
                        (Verheyen et al., 1996)
                        88C-88C
                        (determined by in situ hybridisation)
                        (Shetty et al., 1996)
                        33C5-33C6
                        33D1--2
                        (BDGP Project Members, 1994-1999)
                        Complementation mapped with undefined chromosomes.
                        (Verheyen et al., 1996)
                        Location to 88C1--88C11 in FBrf0085927 is in error.
                        (O'Tousa, 1997.8.18)
                        Experimentally Determined Recombination Data
                        Location

                        2-46

                        (FlyBase, 2016)

                        2-39.7

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (25)
                        Genomic Clones (18)
                         

                        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                        cDNA Clones (122)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        DRSC - Results frm RNAi screens
                        Antibody Information
                        Laboratory Generated Antibodies
                         

                        polyclonal

                        (Iwanami et al., 2016)
                        Commercially Available Antibodies
                         
                        Cell Line Information
                        Publicly Available Cell Lines
                         
                          Other Stable Cell Lines
                           

                          • New stable cell line derived from S2-unspecified : New stable cell line derived from S2-unspecified : CRISPR genome-edited cell lines were created carrying Sec71 mutations; the BFA-resistant M717L mutation or the BFA-hypersensitive F713Y mutation. These S2 cells were stably transfected with pMT-GalT-EGFP-T2A-tdTomato-Rab6 or pMT- GalT::EGFP-T2A-tdTomato::Rab11.

                            (Fujii et al., 2020)
                          Other Comments

                          dsRNA has been made from templates generated with primers directed against this gene.

                          (Kouranti et al., 2006)

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)

                          The Rab6 gene is an essential gene, however, it has limited effects on development beyond the larval stage. Only the mechanosensory bristles on the head, notum and scutellum are affected by Rab6 mutations.

                          (Purcell and Artavanis-Tsakonas, 1999)

                          Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

                          (Roch et al., 1998)

                          Rab6 is required for anterograde transport of rhodopsin through the ER-Golgi complex.

                          (Shetty et al., 1998)

                          Isolated from a Drosophila head cDNA library.

                          (Satoh et al., 1997)

                          Complementation group isolated in a screen for dominant enhancers and suppressors of Nact.sev or Nnucl.sev.

                          (Verheyen et al., 1996)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Rab6 wrt l(2)08323

                          (Purcell and Artavanis-Tsakonas, 1999)

                          Source for merge of: Rab6 l(2)08323

                          (Spradling et al., 1999)
                          Additional comments
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: Rab6 CG6601

                          (Zhong, 1999.11)
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (17)
                          Reported As
                          Symbol Synonym
                          136/6
                          (Roch et al., 1998)
                          AAF53168
                          (Armstrong, 2000)
                          CG6601
                          (National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Meadows, 2017.1.11, Çiçek et al., 2016, Dunst et al., 2015, Christis and Munro, 2012, Ni et al., 2011.7.19, Li et al., 2010, Ida et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Sinka et al., 2008, Zhang et al., 2007, Colicelli, 2004, Dunne et al., 2002, Verstreken and Bellen, 2000.9.4)
                          DRab6
                          (Satoh et al., 1997)
                          Dm Rab6
                          (Jekely, 2003)
                          DmRab6
                          (Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
                          Drab6
                          (Shetty et al., 1998)
                          O18334
                          (Rojas et al., 2012)
                          Rab6
                          (Hatton et al., 2025, Sasaki et al., 2025, Davis et al., 2024, Jang et al., 2024, Jejina et al., 2024, Kim et al., 2024, Sood et al., 2024, Barbaste et al., 2023, Lim et al., 2023, Maddison et al., 2023, Zhou et al., 2023, Zhou et al., 2023, Bernard et al., 2021, Ma and Brill, 2021, Ricolo et al., 2021, Smylla et al., 2021, Aboukilila et al., 2020, Chen et al., 2020, Fujii et al., 2020, Kitatani et al., 2020, Nakamura et al., 2020, Johnson and Andrew, 2019, Krämer et al., 2019, Lattner et al., 2019, Prince et al., 2019, Tegeder et al., 2019, Ayala et al., 2018, Billmann et al., 2018, Kelleher et al., 2018, Pichaud, 2018, Coutinho-Budd et al., 2017, Schopf and Huber, 2017, Caviglia et al., 2016, Iwanami et al., 2016, Kato et al., 2016, Ma et al., 2016, Dent et al., 2015, Van Bortle et al., 2015, Chung and Andrew, 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Torres et al., 2014, Wu et al., 2014, Kwon et al., 2013, Liu et al., 2013, O'Sullivan et al., 2013, Tian et al., 2013, Xiong and Bellen, 2013, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Ye et al., 2012, Finan et al., 2011, Friedman et al., 2011, Lee et al., 2011, Tong et al., 2011, Walden et al., 2011, Houalla et al., 2010, Li et al., 2010, Vielemeyer et al., 2010, Ida et al., 2009, Levis, 2009.3.18, Tan et al., 2009, Thomas et al., 2009, Jin et al., 2008, Sinka et al., 2008, Bakal et al., 2007, Coutelis and Ephrussi, 2007, Stuart et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Kouranti et al., 2006, Wu et al., 2005)
                          dRab6
                          (Dunne and Rabouille, 2001)
                          drab6
                          (Dunne et al., 2002)
                          l(2)08323
                          (Abrell et al., 2000, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
                          rab6
                          (Braun et al., 2021, Fatalska et al., 2021, Das and Cagan, 2017, Lammers et al., 2017, Huang et al., 2015, Jin et al., 2012, Chan et al., 2011, Dienstbier et al., 2009, Januschke et al., 2007, Guichet et al., 2006, Fre et al., 2001, Fortini and Bonini, 2000, Shetty et al., 1997, Ozaki, 1996.4.3, Shetty et al., 1996)
                          wrt
                          (Purcell and Artavanis-Tsakonas, 1999, Verheyen et al., 1996)
                          Name Synonyms
                          Rab protein 6
                          (Wang et al., 2006)
                          Rab-protein 6
                          Rab6
                          warthog
                          (Abrell et al., 2000, Purcell and Artavanis-Tsakonas, 1999, Verheyen et al., 1996)
                          Secondary FlyBase IDs
                          • FBgn0010648
                          • FBgn0019647
                          Datasets (1)
                          Study focus (1)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          • bait_protein
                          Rab_Effectors_interaction_map
                          Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 54 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          PDB - An information portal to biological macromolecular structures
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          MIST (genetic) - An integrated Molecular Interaction Database
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          References (172)