FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Rab1
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General Information
Symbol
Dmel\Rab1
Species
D. melanogaster
Name
Rab1
Annotation Symbol
CG3320
Feature Type
protein_coding_gene
FlyBase ID
FBgn0285937
Gene Model Status
Current
Stock Availability
22 publicly available
Gene Summary
Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis. [Date last reviewed: 2019-03-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Rab-protein 1, omelette, omt, dRab1, DmRab1

Key Links
Genomic Location
Cytogenetic map
93D2-93D2
Sequence location
Recombination map
3-71
RefSeq locus
NT_033777 REGION:21266029..21269060
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables Golgi transport complex binding
inferred from direct assay
(Sechi et al., 2017)
enables GTPase activity
inferred from mutant phenotype
(Sechi et al., 2017)
enables protein binding
inferred from physical interaction with UniProtKB:A1Z8W8
(Sechi et al., 2017)
inferred from physical interaction with UniProtKB:Q9VQ93
(Sechi et al., 2017)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Biological Process (17 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in anterograde axonal transport
inferred from mutant phenotype
(Cao et al., 2014)
involved_in carbohydrate homeostasis
inferred from mutant phenotype
(Cao et al., 2014)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from mutant phenotype
(Ke et al., 2018)
involved_in host-mediated suppression of symbiont invasion
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in mitotic cytokinesis
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in positive regulation of dendrite morphogenesis
inferred from mutant phenotype
(Ye et al., 2007)
involved_in positive regulation of insulin secretion
inferred from mutant phenotype
(Cao et al., 2014)
involved_in positive regulation of synapse pruning
inferred from mutant phenotype
(Wang et al., 2018)
involved_in protein localization to cleavage furrow
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in protein localization to Golgi apparatus
inferred from mutant phenotype
(Sechi et al., 2017)
involved_in protein secretion
inferred from genetic interaction with FLYBASE:Rab1; FB:FBgn0285937
(Ke et al., 2018)
inferred from mutant phenotype
(Ching et al., 2008)
involved_in regulation of cell migration
inferred from mutant phenotype
(Wang et al., 2010)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in autophagosome assembly
inferred from biological aspect of ancestor with PANTHER:PTN000636233
(GO Reference Genome Project, 2011-)
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport
traceable author statement
(Lecuit and Pilot, 2003)
involved_in intracellular protein transport
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(GO Reference Genome Project, 2011-)
involved_in Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cleavage furrow
inferred from mutant phenotype
(Sechi et al., 2017)
located_in cytoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ke et al., 2018)
located_in Golgi apparatus
inferred from mutant phenotype
(Sechi et al., 2017)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in endomembrane system
inferred from biological aspect of ancestor with PANTHER:PTN001292747
(GO Reference Genome Project, 2011-)
located_in vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis. [Date last reviewed: 2019-03-28]
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Summary (Interactive Fly)

controls membrane trafficking and contractile ring constriction during cytokinesis - regulates ER-to-Golgi transport - essential for dendrite pruning of ddaC neurons - promotes endocytosis and downregulation of the cell-adhesion molecule Neuroglian and thereby dendrite pruning - controls material delivery from Golgi to the plasma membrane

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O18332)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.02

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab1-RA
FBtr0084104
NM_169953
1804
205
Additional Transcript Data and Comments
Reported size (kB)

1.7 (longest cDNA)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rab1-PA
FBpp0083503
22.8
205
5.10
O18332
NP_732610
AAF55873
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

205 (aa)

(Satoh et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.00

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cleavage furrow
inferred from mutant phenotype
(Sechi et al., 2017)
located_in cytoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in endoplasmic reticulum exit site
inferred from direct assay
(Ke et al., 2018)
located_in Golgi apparatus
inferred from mutant phenotype
(Sechi et al., 2017)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
Expression Deduced from Reporters
Reporter: PBac{810.P.FSVS-2}Rab1CPTI004256
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted

Comment: No expression in central complex, antennal lobes and mushroom bodies.

(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
Reporter: PBac{810.P.FSVS-2}Rab1CPTI004394
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | faint | ubiquitous
(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
Reporter: PBac{I-SceI(FRT.Rab1-GAL4.ATG(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body | intense
(Jin et al., 2012)
eye disc | restricted
(Jin et al., 2012)
embryonic/larval optic stalk surface glial cell | intense
(Jin et al., 2012)
leg disc | restricted
(Jin et al., 2012)
wing disc | restricted
(Jin et al., 2012)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron of larval brain
(Chan et al., 2011)
glial cell | subset of larval brain
(Chan et al., 2011)
neuron | subset of larval ventral nerve cord
(Chan et al., 2011)
wing disc
(Chan et al., 2011)
eye disc
(Chan et al., 2011)
leg disc
(Chan et al., 2011)
pupal stage P6 -- P7
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe | faint

Comment: 30-40h APF

(Jin et al., 2012)
mushroom body

Comment: 30-40h APF

(Jin et al., 2012, Chan et al., 2011)
eye photoreceptor cell

Comment: 30-40h APF

(Jin et al., 2012)
neuron of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
adult stage
adult ensheathing glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell | intense
(Jin et al., 2012)
neuron of adult optic lobe | faint
(Jin et al., 2012)
adult mushroom body | intense
(Jin et al., 2012, Chan et al., 2011)
adult antennal lobe
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis | intense
(Jin et al., 2012)
neuron of lamina | intense
(Jin et al., 2012)
ellipsoid body
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
neuron of adult brain
(Chan et al., 2011)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab1
Transgenic constructs containing regulatory region of Rab1
Aberrations (Deficiencies and Duplications) ( 4 )
Inferred from experimentation ( 4 )
Gene disrupted in
Df(3R)ED10838
(Sechi et al., 2017)
Df(3R)ED10845
(Sechi et al., 2017)
Df(3R)e-F1
(Giansanti et al., 2004)
Gene not disrupted in
Df(3R)GC14
(Sechi et al., 2017)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal
lethal
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4Rab1.ATG
lethal (with Df(3R)ED10838)
lethal (with Df(3R)ED10845)
lethal - all die before end of larval stage
lethal - all die before end of larval stage (with Rab1e01287)
lethal - all die before end of larval stage (with Rab1S147213)
viable
Sterility
Allele
female sterile | germline clone | recessive
Other Phenotypes
Allele
abnormal body size, with Scer\GAL4Ilp2.PW
abnormal cytokinesis | adult stage | male (with Df(3R)ED10838)
abnormal cytokinesis | adult stage | male (with Rab1S147213)
abnormal cytokinesis | adult stage | male (with Rab1Z4144)
abnormal cytokinesis | male (with Df(3R)e-F1)
abnormal cytokinesis | male | recessive
abnormal developmental rate, with Scer\GAL4Ilp2.PW
abnormal heat stress response, with Scer\GAL4ppk.PG
abnormal meiotic cell cycle | male (with Df(3R)e-F1)
abnormal meiotic cell cycle | male | recessive
abnormal mitotic cell cycle | embryonic cycle, with Scer\GAL4VP16.mat.αTub67C
abnormal neuroanatomy
abnormal neuroanatomy | larval stage, with Scer\GAL4Ilp2.PW
abnormal neuroanatomy | prepupal stage P1 | somatic clone
abnormal neuroanatomy | prepupal stage P1 | somatic clone, with Scer\GAL4ppk.PU
abnormal neuroanatomy | pupal stage, with Scer\GAL4GSG2295
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neuroanatomy | pupal stage | somatic clone, with Scer\GAL4ppk.PU
abnormal neuroanatomy | third instar larval stage, with Hsim\VP16AD.nrv2, Scer\GAL4DBD.wrapper.932i
decreased size | embryonic cycle, with Scer\GAL4VP16.mat.αTub67C
increased size | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
short lived (with Df(3R)ED10838)
Phenotype manifest in
Allele
centrosome | embryonic cycle, with Scer\GAL4VP16.mat.αTub67C
cis-Golgi network | third instar larval stage, with Scer\GAL4Cg.PA
contractile ring & meiotic telophase I | male
contractile ring & meiotic telophase I | male (with Df(3R)e-F1)
contractile ring & meiotic telophase II | male
contractile ring & meiotic telophase II | male (with Df(3R)e-F1)
contractile ring | adult stage | male (with Df(3R)ED10838)
contractile ring | larval stage (with Df(3R)ED10838)
dendrite, with Scer\GAL4Ilp2.PW
dendrite & dendritic arborising neuron
dendritic tree | prepupal stage P1 | somatic clone
dendritic tree | prepupal stage P1 | somatic clone, with Scer\GAL4ppk.PU
dendritic tree | pupal stage, with Scer\GAL4GSG2295
dendritic tree | pupal stage | somatic clone
dendritic tree | pupal stage | somatic clone, with Scer\GAL4ppk.PU
embryonic/larval cell body glial cell | third instar larval stage, with Hsim\VP16AD.nrv2, Scer\GAL4DBD.wrapper.932i
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
endoplasmic reticulum | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
endoplasmic reticulum exit site | third instar larval stage, with Scer\GAL4Cg.PA
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
Golgi apparatus & photoreceptor cell, with Scer\GAL4hs.PB
Golgi apparatus | adult stage | male (with Df(3R)ED10838)
Golgi apparatus | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
larval dorsal multidendritic neuron ddaC | prepupal stage P1 | somatic clone
larval dorsal multidendritic neuron ddaC | prepupal stage P1 | somatic clone, with Scer\GAL4ppk.PU
larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4GSG2295
larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone
larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone, with Scer\GAL4ppk.PU
larval insulin secreting cell of pars intercerebralis, with Scer\GAL4Ilp2.PW
microvillus & photoreceptor cell, with Scer\GAL4hs.PB
mitotic spindle | embryonic cycle, with Scer\GAL4VP16.mat.αTub67C
Nebenkern
Nebenkern (with Df(3R)ED10838)
Nebenkern (with Df(3R)e-F1)
Nebenkern (with Rab1S147213)
Nebenkern (with Rab1Z4144)
nephrocyte | larval stage, with Scer\GAL4pros.PMG
nephrocyte diaphragm | larval stage, with Scer\GAL4pros.PMG
neuroblast | larval stage (with Df(3R)ED10838)
nucleus | larval stage, with Scer\GAL4pros.PMG
rough endoplasmic reticulum & photoreceptor cell, with Scer\GAL4hs.PB
spermatid (with Df(3R)ED10838)
spermatid (with Rab1S147213)
spermatid (with Rab1Z4144)
spermatid & nucleus | supernumerary
spermatid & nucleus | supernumerary (with Df(3R)e-F1)
spermatocyte (with Df(3R)ED10838)
spindle & meiotic telophase I | male
spindle & meiotic telophase I | male (with Df(3R)e-F1)
spindle & meiotic telophase II | male
spindle & meiotic telophase II | male (with Df(3R)e-F1)
spindle microtubule | embryonic cycle, with Scer\GAL4VP16.mat.αTub67C
vesicle | adult stage | male (with Df(3R)ED10838)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (101)
Hsap\RAB1A
13 of 14
Yes
Yes
Hsap\RAB1B
11 of 14
No
Yes
Hsap\RAB1C
7 of 14
No
Yes
Hsap\RAB19
3 of 14
No
No
Hsap\RAB12
2 of 14
No
Yes
Hsap\RAB15
2 of 14
No
No
Hsap\RAB30
2 of 14
No
No
1  
Hsap\RAB33A
2 of 14
No
Yes
Hsap\RAB33B
2 of 14
No
Yes
Hsap\RAB43
2 of 14
No
No
1  
Hsap\CPLANE2
1 of 14
No
Yes
Hsap\DIRAS1
1 of 14
No
No
1  
Hsap\DIRAS2
1 of 14
No
No
1  
Hsap\ERAS
1 of 14
No
No
Hsap\GEM
1 of 14
No
No
Hsap\HRAS
1 of 14
No
No
3  
Hsap\IFT27
1 of 14
No
No
Hsap\KRAS
1 of 14
No
No
2  
Hsap\MRAS
1 of 14
No
No
Hsap\NRAS
1 of 14
No
No
Hsap\RAB2A
1 of 14
No
No
1  
Hsap\RAB2B
1 of 14
No
No
Hsap\RAB3A
1 of 14
No
No
Hsap\RAB3B
1 of 14
No
No
Hsap\RAB3C
1 of 14
No
No
Hsap\RAB3D
1 of 14
No
No
Hsap\RAB4A
1 of 14
No
No
Hsap\RAB4B
1 of 14
No
No
Hsap\RAB5A
1 of 14
No
No
1  
Hsap\RAB5B
1 of 14
No
No
Hsap\RAB5C
1 of 14
No
No
1  
Hsap\RAB6A
1 of 14
No
No
Hsap\RAB6B
1 of 14
No
No
Hsap\RAB6C
1 of 14
No
No
Hsap\RAB6D
1 of 14
No
No
Hsap\RAB7A
1 of 14
No
No
5  
Hsap\RAB7B
1 of 14
No
No
Hsap\RAB8A
1 of 14
No
No
1  
Hsap\RAB8B
1 of 14
No
No
Hsap\RAB9A
1 of 14
No
No
1  
Hsap\RAB9B
1 of 14
No
No
1  
Hsap\RAB10
1 of 14
No
No
1  
Hsap\RAB11A
1 of 14
No
No
Hsap\RAB11B
1 of 14
No
No
1  
Hsap\RAB13
1 of 14
No
No
Hsap\RAB14
1 of 14
No
No
1  
Hsap\RAB17
1 of 14
No
No
Hsap\RAB18
1 of 14
No
No
1  
Hsap\RAB21
1 of 14
No
No
Hsap\RAB22A
1 of 14
No
No
Hsap\RAB23
1 of 14
No
No
1  
Hsap\RAB25
1 of 14
No
No
Hsap\RAB26
1 of 14
No
No
Hsap\RAB27A
1 of 14
No
No
1  
Hsap\RAB27B
1 of 14
No
No
1  
Hsap\RAB31
1 of 14
No
No
Hsap\RAB32
1 of 14
No
No
1  
Hsap\RAB34
1 of 14
No
No
Hsap\RAB35
1 of 14
No
No
Hsap\RAB36
1 of 14
No
No
Hsap\RAB37
1 of 14
No
No
Hsap\RAB38
1 of 14
No
No
Hsap\RAB39A
1 of 14
No
No
1  
Hsap\RAB39B
1 of 14
No
No
4  
Hsap\RAB40A
1 of 14
No
No
Hsap\RAB40AL
1 of 14
No
No
Hsap\RAB40B
1 of 14
No
No
2  
Hsap\RAB40C
1 of 14
No
No
1  
Hsap\RAB41
1 of 14
No
No
1  
Hsap\RAB42
1 of 14
No
No
Hsap\RAB44
1 of 14
No
No
Hsap\RABL2A
1 of 14
No
No
Hsap\RABL2B
1 of 14
No
No
Hsap\RABL3
1 of 14
No
No
Hsap\RABL6
1 of 14
No
No
Hsap\RALA
1 of 14
No
No
1  
Hsap\RALB
1 of 14
No
No
1  
Hsap\RAN
1 of 14
No
No
Hsap\RAP1A
1 of 14
No
No
3  
Hsap\RAP1B
1 of 14
No
No
3  
Hsap\RAP2A
1 of 14
No
No
Hsap\RAP2B
1 of 14
No
No
Hsap\RAP2C
1 of 14
No
No
Hsap\RASD1
1 of 14
No
No
1  
Hsap\RASD2
1 of 14
No
No
Hsap\RASEF
1 of 14
No
No
Hsap\RASL10A
1 of 14
No
No
Hsap\RASL10B
1 of 14
No
No
1  
Hsap\RASL11A
1 of 14
No
No
1  
Hsap\RASL11B
1 of 14
No
No
1  
Hsap\RASL12
1 of 14
No
No
Hsap\REM1
1 of 14
No
No
Hsap\REM2
1 of 14
No
No
Hsap\RERG
1 of 14
No
No
Hsap\RHEB
1 of 14
No
No
1  
Hsap\RHEBL1
1 of 14
No
No
Hsap\RIT1
1 of 14
No
No
1  
Hsap\RIT2
1 of 14
No
No
Hsap\RRAD
1 of 14
No
No
1  
Hsap\RRAS2
1 of 14
No
No
2  
Hsap\RRAS
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (73)
Rnor\Rab1a
12 of 14
Yes
Yes
Rnor\Rab1b
10 of 14
No
Yes
Rnor\Rab19
3 of 14
No
No
Rnor\Rab43
3 of 14
No
No
Rnor\Rab12
2 of 14
No
No
Rnor\Rab15
2 of 14
No
No
Rnor\Rab30
2 of 14
No
No
Rnor\Rab33a
2 of 14
No
Yes
Rnor\Rab33b
2 of 14
No
Yes
Rnor\Rab35
2 of 14
No
No
Rnor\Cplane2
1 of 14
No
Yes
Rnor\Diras1
1 of 14
No
No
Rnor\Diras2
1 of 14
No
No
Rnor\Ift27
1 of 14
No
No
Rnor\Rab2a
1 of 14
No
No
Rnor\Rab2b
1 of 14
No
No
Rnor\Rab3a
1 of 14
No
No
Rnor\Rab3b
1 of 14
No
No
Rnor\Rab3c
1 of 14
No
No
Rnor\Rab3d
1 of 14
No
No
Rnor\Rab4a
1 of 14
No
No
Rnor\Rab4b
1 of 14
No
No
Rnor\Rab5al1
1 of 14
No
No
Rnor\Rab5a
1 of 14
No
No
Rnor\Rab5b
1 of 14
No
No
Rnor\Rab5c
1 of 14
No
No
Rnor\Rab6a
1 of 14
No
No
Rnor\Rab6b
1 of 14
No
No
Rnor\Rab7a
1 of 14
No
No
Rnor\Rab7b
1 of 14
No
No
Rnor\Rab8a
1 of 14
No
No
Rnor\Rab8b
1 of 14
No
No
Rnor\Rab9a
1 of 14
No
No
Rnor\Rab9b
1 of 14
No
No
Rnor\Rab10
1 of 14
No
No
Rnor\Rab11a
1 of 14
No
No
Rnor\Rab11b
1 of 14
No
No
Rnor\Rab13
1 of 14
No
No
Rnor\Rab14
1 of 14
No
No
Rnor\Rab17
1 of 14
No
No
Rnor\Rab18
1 of 14
No
No
Rnor\Rab22a
1 of 14
No
No
Rnor\Rab23
1 of 14
No
No
Rnor\Rab25
1 of 14
No
No
Rnor\Rab26
1 of 14
No
No
Rnor\Rab27a
1 of 14
No
No
Rnor\Rab27b
1 of 14
No
No
Rnor\Rab31
1 of 14
No
No
Rnor\Rab32
1 of 14
No
No
Rnor\Rab34
1 of 14
No
No
Rnor\Rab36
1 of 14
No
No
Rnor\Rab37
1 of 14
No
No
Rnor\Rab39a
1 of 14
No
No
Rnor\Rab40b
1 of 14
No
No
Rnor\Rab40c
1 of 14
No
No
Rnor\Rab42
1 of 14
No
No
Rnor\Rab44
1 of 14
No
Yes
Rnor\Rabl2
1 of 14
No
No
Rnor\Rabl3
1 of 14
No
No
Rnor\Rabl6
1 of 14
No
No
Rnor\Ralb
1 of 14
No
No
Rnor\Ran
1 of 14
No
No
Rnor\Rap1a
1 of 14
No
No
Rnor\Rap1b
1 of 14
No
No
Rnor\Rasd1
1 of 14
No
No
Rnor\Rasd2
1 of 14
No
No
Rnor\Rasef
1 of 14
No
No
Rnor\Rasl2-9
1 of 14
No
No
Rnor\Rasl10a
1 of 14
No
No
Rnor\Rasl10b
1 of 14
No
No
Rnor\Rasl11a
1 of 14
No
No
Rnor\Rasl11b
1 of 14
No
No
Rnor\RGD1306195
1 of 14
No
No
Mus musculus (laboratory mouse) (74)
Mmus\Rab1a
12 of 14
Yes
Yes
1  
Mmus\Rab1b
11 of 14
No
Yes
Mmus\Rab19
3 of 14
No
No
Mmus\Rab43
3 of 14
No
No
Mmus\Rab12
2 of 14
No
Yes
Mmus\Rab15
2 of 14
No
No
Mmus\Rab30
2 of 14
No
No
Mmus\Rab33a
2 of 14
No
Yes
Mmus\Rab33b
2 of 14
No
Yes
Mmus\1700009N14Rik
1 of 14
No
No
Mmus\Cplane2
1 of 14
No
Yes
Mmus\Diras1
1 of 14
No
No
Mmus\Diras2
1 of 14
No
No
Mmus\Ift27
1 of 14
No
No
Mmus\Rab2a
1 of 14
No
No
Mmus\Rab2b
1 of 14
No
No
Mmus\Rab3a
1 of 14
No
No
Mmus\Rab3b
1 of 14
No
No
Mmus\Rab3c
1 of 14
No
No
Mmus\Rab3d
1 of 14
No
No
Mmus\Rab4a
1 of 14
No
No
Mmus\Rab4b
1 of 14
No
No
Mmus\Rab5a
1 of 14
No
No
Mmus\Rab5b
1 of 14
No
No
Mmus\Rab5c
1 of 14
No
No
Mmus\Rab6a
1 of 14
No
No
Mmus\Rab6b
1 of 14
No
No
Mmus\Rab7b
1 of 14
No
No
Mmus\Rab7
1 of 14
No
No
Mmus\Rab8a
1 of 14
No
No
Mmus\Rab8b
1 of 14
No
No
Mmus\Rab9b
1 of 14
No
No
Mmus\Rab9
1 of 14
No
No
Mmus\Rab10
1 of 14
No
No
Mmus\Rab11a
1 of 14
No
No
Mmus\Rab11b
1 of 14
No
No
Mmus\Rab13
1 of 14
No
No
Mmus\Rab14
1 of 14
No
No
Mmus\Rab17
1 of 14
No
No
Mmus\Rab18
1 of 14
No
No
Mmus\Rab21
1 of 14
No
No
Mmus\Rab22a
1 of 14
No
No
Mmus\Rab23
1 of 14
No
No
Mmus\Rab25
1 of 14
No
No
Mmus\Rab26
1 of 14
No
No
Mmus\Rab27a
1 of 14
No
No
Mmus\Rab27b
1 of 14
No
No
Mmus\Rab31
1 of 14
No
No
Mmus\Rab32
1 of 14
No
No
Mmus\Rab34
1 of 14
No
No
Mmus\Rab35
1 of 14
No
No
Mmus\Rab36
1 of 14
No
No
Mmus\Rab37
1 of 14
No
No
Mmus\Rab39b
1 of 14
No
No
Mmus\Rab39
1 of 14
No
No
Mmus\Rab40b
1 of 14
No
No
Mmus\Rab40c
1 of 14
No
No
Mmus\Rab42
1 of 14
No
No
Mmus\Rab44
1 of 14
No
No
Mmus\Rabl2
1 of 14
No
No
Mmus\Rabl3
1 of 14
No
No
Mmus\Rabl6
1 of 14
No
No
Mmus\Ralb
1 of 14
No
No
Mmus\Ran
1 of 14
No
No
Mmus\Rap1a
1 of 14
No
No
Mmus\Rap1b
1 of 14
No
No
Mmus\Rasd1
1 of 14
No
No
Mmus\Rasd2
1 of 14
No
No
Mmus\Rasef
1 of 14
No
No
Mmus\Rasl2-9
1 of 14
No
No
Mmus\Rasl10a
1 of 14
No
No
Mmus\Rasl10b
1 of 14
No
No
Mmus\Rasl11a
1 of 14
No
No
Mmus\Rasl11b
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (53)
Xtro\rab1a
10 of 13
Yes
Yes
Xtro\rab12
2 of 13
No
Yes
Xtro\rab19
2 of 13
No
No
Xtro\rab35l
2 of 13
No
No
Xtro\rab35
2 of 13
No
No
Xtro\cplane2
1 of 13
No
Yes
Xtro\diras2
1 of 13
No
No
Xtro\diras3
1 of 13
No
No
Xtro\gem
1 of 13
No
No
Xtro\gpr61
1 of 13
No
Yes
Xtro\ift27
1 of 13
No
Yes
Xtro\krasl
1 of 13
No
No
Xtro\kras
1 of 13
No
No
Xtro\LOC100488596
1 of 13
No
No
Xtro\MGC147600
1 of 13
No
Yes
Xtro\rab2a
1 of 13
No
No
Xtro\rab2b
1 of 13
No
No
Xtro\rab3a
1 of 13
No
No
Xtro\rab3b
1 of 13
No
No
Xtro\rab3c
1 of 13
No
No
Xtro\rab3d
1 of 13
No
No
Xtro\rab4b
1 of 13
No
No
Xtro\rab5b
1 of 13
No
No
Xtro\rab5d
1 of 13
No
No
Xtro\rab6b
1 of 13
No
No
Xtro\rab8b
1 of 13
No
No
Xtro\rab11b.1
1 of 13
No
No
Xtro\rab15
1 of 13
No
Yes
Xtro\rab18
1 of 13
No
No
Xtro\rab23
1 of 13
No
No
Xtro\rab26
1 of 13
No
No
Xtro\rab29
1 of 13
No
No
Xtro\rab30
1 of 13
No
No
Xtro\rab33a
1 of 13
No
Yes
Xtro\rab34
1 of 13
No
No
Xtro\rab36
1 of 13
No
No
Xtro\rab39a
1 of 13
No
No
Xtro\rab39b
1 of 13
No
No
Xtro\rab40b
1 of 13
No
No
Xtro\rabl2b
1 of 13
No
Yes
Xtro\rabl3
1 of 13
No
No
Xtro\ran
1 of 13
No
No
Xtro\rap1b
1 of 13
No
No
Xtro\rap2a
1 of 13
No
No
Xtro\rap2c
1 of 13
No
No
Xtro\rasd1
1 of 13
No
No
Xtro\rasd2
1 of 13
No
No
Xtro\rasl10b
1 of 13
No
No
Xtro\rem2
1 of 13
No
No
Xtro\rergl
1 of 13
No
No
Xtro\rerg
1 of 13
No
No
Xtro\rhebl1
1 of 13
No
No
Xtro\rras
1 of 13
No
No
Danio rerio (Zebrafish) (94)
Drer\rab1ab
12 of 14
Yes
Yes
Drer\rab1aa
11 of 14
No
Yes
Drer\rab1ba
11 of 14
No
Yes
Drer\rab1bb
11 of 14
No
Yes
Drer\zgc:171927
6 of 14
No
Yes
Drer\rab43
3 of 14
No
No
Drer\LOC555645
2 of 14
No
No
Drer\rab12
2 of 14
No
No
Drer\rab15
2 of 14
No
Yes
Drer\rab19
2 of 14
No
No
Drer\rab30
2 of 14
No
No
Drer\rab33a
2 of 14
No
Yes
Drer\rab33ba
2 of 14
No
Yes
Drer\rab35a
2 of 14
No
No
Drer\rab35b
2 of 14
No
No
Drer\si:dkey-16l2.16
2 of 14
No
No
Drer\zgc:101559
2 of 14
No
Yes
Drer\cplane2
1 of 14
No
Yes
Drer\cracr2aa
1 of 14
No
No
Drer\cracr2ab
1 of 14
No
No
Drer\diras1a
1 of 14
No
No
Drer\diras1b
1 of 14
No
No
Drer\ift27
1 of 14
No
Yes
Drer\LOC100330257
1 of 14
No
No
Drer\LOC101885697
1 of 14
No
No
Drer\rab2a
1 of 14
No
No
Drer\rab3aa
1 of 14
No
No
Drer\rab3ab
1 of 14
No
No
Drer\rab3c
1 of 14
No
No
Drer\rab3da
1 of 14
No
No
Drer\rab3db
1 of 14
No
No
Drer\rab4a
1 of 14
No
No
Drer\rab4b
1 of 14
No
No
Drer\rab5aa
1 of 14
No
No
Drer\rab5ab
1 of 14
No
No
Drer\rab5b
1 of 14
No
No
Drer\rab5c
1 of 14
No
No
Drer\rab6a
1 of 14
No
No
Drer\rab6ba
1 of 14
No
No
Drer\rab6bb
1 of 14
No
No
Drer\rab7a
1 of 14
No
No
Drer\rab7b
1 of 14
No
No
Drer\rab8a
1 of 14
No
No
Drer\rab8b
1 of 14
No
No
Drer\rab9a
1 of 14
No
No
Drer\rab9b
1 of 14
No
No
Drer\rab10
1 of 14
No
No
Drer\rab11a
1 of 14
No
No
Drer\rab11al
1 of 14
No
No
Drer\rab11ba
1 of 14
No
No
Drer\rab11bb
1 of 14
No
No
Drer\rab13
1 of 14
No
No
Drer\rab14
1 of 14
No
No
Drer\rab14l
1 of 14
No
No
Drer\rab18a
1 of 14
No
No
Drer\rab18b
1 of 14
No
No
Drer\rab21
1 of 14
No
No
Drer\rab22a
1 of 14
No
No
Drer\rab23
1 of 14
No
No
Drer\rab25a
1 of 14
No
No
Drer\rab25b
1 of 14
No
No
Drer\rab27a
1 of 14
No
No
Drer\rab27b
1 of 14
No
No
Drer\rab31
1 of 14
No
No
Drer\rab34a
1 of 14
No
No
Drer\rab34b
1 of 14
No
No
Drer\rab36
1 of 14
No
No
Drer\rab39ba
1 of 14
No
No
Drer\rab39bb
1 of 14
No
No
Drer\rab40b
1 of 14
No
No
Drer\rab40c
1 of 14
No
No
Drer\rab41
1 of 14
No
No
Drer\rab42a
1 of 14
No
No
Drer\rab42b
1 of 14
No
No
Drer\rabl2
1 of 14
No
No
Drer\rabl3
1 of 14
No
No
Drer\rabl6b
1 of 14
No
No
Drer\ralba
1 of 14
No
No
Drer\ran
1 of 14
No
No
Drer\rap1aa
1 of 14
No
No
Drer\rap1ab
1 of 14
No
No
Drer\rap1b
1 of 14
No
No
Drer\rasd1
1 of 14
No
No
Drer\rasd2
1 of 14
No
No
Drer\rasd3
1 of 14
No
No
Drer\rasd4
1 of 14
No
No
Drer\rasef
1 of 14
No
No
Drer\rasl10a
1 of 14
No
No
Drer\rasl11a
1 of 14
No
No
Drer\si:dkey-13a21.4
1 of 14
No
No
Drer\si:dkey-27j5.5
1 of 14
No
No
Drer\si:dkey-34d22.2
1 of 14
No
No
Drer\si:dkey-34d22.5
1 of 14
No
No
Drer\zgc:100918
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (45)
Cele\rab-1
13 of 14
Yes
Yes
Cele\rab-19
3 of 14
No
No
Cele\K02E10.1
2 of 14
No
No
Cele\rab-30
2 of 14
No
No
Cele\rab-33
2 of 14
No
Yes
Cele\rab-35
2 of 14
No
No
Cele\4R79.2
1 of 14
No
Yes
Cele\aex-6
1 of 14
No
No
Cele\D1081.4
1 of 14
No
No
Cele\drn-1
1 of 14
No
No
Cele\F08G12.1
1 of 14
No
No
Cele\F11A5.3
1 of 14
No
No
Cele\F11A5.4
1 of 14
No
No
Cele\F20D6.8
1 of 14
No
No
Cele\let-60
1 of 14
No
No
Cele\rab-3
1 of 14
No
No
Cele\rab-5
1 of 14
No
No
Cele\rab-6.1
1 of 14
No
No
Cele\rab-6.2
1 of 14
No
No
Cele\rab-7
1 of 14
No
No
Cele\rab-8
1 of 14
No
No
Cele\rab-10
1 of 14
No
No
Cele\rab-11.1
1 of 14
No
No
Cele\rab-11.2
1 of 14
No
No
Cele\rab-14
1 of 14
No
No
Cele\rab-18
1 of 14
No
No
Cele\rab-21
1 of 14
No
No
Cele\rab-37
1 of 14
No
No
Cele\rab-39
1 of 14
No
No
Cele\ral-1
1 of 14
No
No
Cele\ran-1
1 of 14
No
No
Cele\rap-1
1 of 14
No
No
Cele\rap-2
1 of 14
No
No
Cele\rap-3
1 of 14
No
No
Cele\ras-1
1 of 14
No
No
Cele\ras-2
1 of 14
No
No
Cele\rheb-1
1 of 14
No
No
Cele\rsef-1
1 of 14
No
No
Cele\ssr-2
1 of 14
No
No
Cele\T26C12.3
1 of 14
No
No
Cele\unc-108
1 of 14
No
No
Cele\W04C9.5
1 of 14
No
No
Cele\Y52B11A.4
1 of 14
No
No
Cele\Y71H2AM.12
1 of 14
No
No
Cele\Y116A8C.10
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (43)
Agam\AgaP_AGAP004146
12 of 12
Yes
Yes
Agam\AgaP_AGAP007096
3 of 12
No
No
Agam\AgaP_AGAP002092
2 of 12
No
No
Agam\AgaP_AGAP003028
2 of 12
No
No
Agam\AgaP_AGAP006873
2 of 12
No
No
Agam\AgaP_AGAP000433
1 of 12
No
No
Agam\AgaP_AGAP000671
1 of 12
No
No
Agam\AgaP_AGAP000841
1 of 12
No
No
Agam\AgaP_AGAP001211
1 of 12
No
No
Agam\AgaP_AGAP001617
1 of 12
No
No
Agam\AgaP_AGAP001874
1 of 12
No
No
Agam\AgaP_AGAP001902
1 of 12
No
No
Agam\AgaP_AGAP002219
1 of 12
No
No
Agam\AgaP_AGAP002563
1 of 12
No
No
Agam\AgaP_AGAP002812
1 of 12
No
No
Agam\AgaP_AGAP004204
1 of 12
No
No
Agam\AgaP_AGAP004559
1 of 12
No
No
Agam\AgaP_AGAP004769
1 of 12
No
No
Agam\AgaP_AGAP005159
1 of 12
No
No
Agam\AgaP_AGAP005243
1 of 12
No
No
Agam\AgaP_AGAP005248
1 of 12
No
No
Agam\AgaP_AGAP005255
1 of 12
No
No
Agam\AgaP_AGAP005302
1 of 12
No
No
Agam\AgaP_AGAP005393
1 of 12
No
No
Agam\AgaP_AGAP006025
1 of 12
No
No
Agam\AgaP_AGAP006035
1 of 12
No
No
Agam\AgaP_AGAP006159
1 of 12
No
No
Agam\AgaP_AGAP006354
1 of 12
No
No
Agam\AgaP_AGAP007369
1 of 12
No
No
Agam\AgaP_AGAP007615
1 of 12
No
No
Agam\AgaP_AGAP007681
1 of 12
No
No
Agam\AgaP_AGAP007699
1 of 12
No
No
Agam\AgaP_AGAP007901
1 of 12
No
No
Agam\AgaP_AGAP008419
1 of 12
No
No
Agam\AgaP_AGAP008989
1 of 12
No
No
Agam\AgaP_AGAP009325
1 of 12
No
No
Agam\AgaP_AGAP009846
1 of 12
No
No
Agam\AgaP_AGAP010875
1 of 12
No
No
Agam\AgaP_AGAP011306
1 of 12
No
No
Agam\AgaP_AGAP011363
1 of 12
No
No
Agam\AgaP_AGAP011565
1 of 12
No
No
Agam\AgaP_AGAP012108
1 of 12
No
No
Agam\AgaP_AGAP012348
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (61)
Atha\RA-5
11 of 13
Yes
Yes
Atha\RAB1A
10 of 13
No
Yes
Atha\RAB1C
10 of 13
No
Yes
Atha\ATFP8
9 of 13
No
Yes
Atha\ARA-2
1 of 13
No
No
Atha\ARA4
1 of 13
No
No
Atha\ARA6
1 of 13
No
No
Atha\ARA7
1 of 13
No
No
Atha\ArRABA1h
1 of 13
No
No
Atha\AT4G07524
1 of 13
No
Yes
Atha\AT5G59840
1 of 13
No
No
Atha\GB2
1 of 13
No
No
Atha\RAB6A
1 of 13
No
No
Atha\RAB7A
1 of 13
No
No
Atha\RAB7B
1 of 13
No
No
Atha\RAB8
1 of 13
No
No
Atha\RAB8C
1 of 13
No
No
Atha\RAB11c
1 of 13
No
No
Atha\RAB18
1 of 13
No
No
Atha\RABA1b
1 of 13
No
No
Atha\RABA1c
1 of 13
No
No
Atha\RABA1d
1 of 13
No
No
Atha\RABA1e
1 of 13
No
No
Atha\RABA1f
1 of 13
No
No
Atha\RABA1g
1 of 13
No
No
Atha\RABA1i
1 of 13
No
No
Atha\RABA2b
1 of 13
No
No
Atha\RABA2c
1 of 13
No
No
Atha\RABA2D
1 of 13
No
No
Atha\RABA3
1 of 13
No
No
Atha\RABA4a
1 of 13
No
No
Atha\RABA4B
1 of 13
No
No
Atha\RABA4C
1 of 13
No
No
Atha\RABA4D
1 of 13
No
No
Atha\RABA4E
1 of 13
No
No
Atha\RABA5a
1 of 13
No
No
Atha\RABA5b
1 of 13
No
No
Atha\RABA5d
1 of 13
No
No
Atha\RABA5E
1 of 13
No
No
Atha\RABA6a
1 of 13
No
No
Atha\RABA6b
1 of 13
No
No
Atha\RABB1a
1 of 13
No
No
Atha\RABB1C
1 of 13
No
No
Atha\RABC2A
1 of 13
No
No
Atha\RABC2b
1 of 13
No
No
Atha\RABE1c
1 of 13
No
No
Atha\RABE1e
1 of 13
No
No
Atha\RABG1
1 of 13
No
No
Atha\RABG3A
1 of 13
No
No
Atha\RABG3B
1 of 13
No
No
Atha\RABG3c
1 of 13
No
No
Atha\RABG3d
1 of 13
No
No
Atha\RABG3E
1 of 13
No
No
Atha\RABH1a
1 of 13
No
No
Atha\RABH1c
1 of 13
No
No
Atha\RABH1d
1 of 13
No
No
Atha\RABH1e
1 of 13
No
No
Atha\RAN2
1 of 13
No
No
Atha\RAN3
1 of 13
No
No
Atha\RAN4
1 of 13
No
No
Atha\RHA1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (15)
Scer\YPT1
11 of 13
Yes
Yes
Scer\GSP1
1 of 13
No
No
Scer\GSP2
1 of 13
No
No
Scer\RAS1
1 of 13
No
No
Scer\RAS2
1 of 13
No
No
Scer\RHB1
1 of 13
No
No
Scer\RSR1
1 of 13
No
No
Scer\SEC4
1 of 13
No
No
Scer\VPS21
1 of 13
No
No
Scer\YPT6
1 of 13
No
No
Scer\YPT7
1 of 13
No
No
Scer\YPT31
1 of 13
No
No
Scer\YPT32
1 of 13
No
No
Scer\YPT52
1 of 13
No
No
Scer\YPT53
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (8)
Spom\ypt1
11 of 12
Yes
Yes
Spom\ryh1
1 of 12
No
No
Spom\spi1
1 of 12
No
No
Spom\ypt2
1 of 12
No
No
Spom\ypt3
1 of 12
No
No
Spom\ypt5
1 of 12
No
No
Spom\ypt7
1 of 12
No
No
Spom\ypt71
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rab1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (53)
Rab19
5 of 13
Rab9Db
4 of 13
Rab9D
4 of 13
Rab9Fb
4 of 13
RabX2
4 of 13
CG4789
3 of 13
Rab5
3 of 13
Rab6
3 of 13
Rab9E
3 of 13
Rab9Fa
3 of 13
Rab14
3 of 13
Rab18
3 of 13
Rab21
3 of 13
Rab23
3 of 13
Rab30
3 of 13
Rab35
3 of 13
RabX1
3 of 13
Rab2
2 of 13
Rab3
2 of 13
Rab4
2 of 13
Rab7
2 of 13
Rab8
2 of 13
Rab9
2 of 13
Rab10
2 of 13
Rab11
2 of 13
Rab26
2 of 13
Rab27
2 of 13
Rab32
2 of 13
Rab39
2 of 13
RabX4
2 of 13
RabX5
2 of 13
RabX6
2 of 13
CG8500
1 of 13
CG8641
1 of 13
CG13375
1 of 13
CG14669
1 of 13
CG15399
1 of 13
CG30158
1 of 13
CG42541
1 of 13
Rab40
1 of 13
Rala
1 of 13
Ran-like
1 of 13
Ran
1 of 13
Rap1
1 of 13
Rap2l
1 of 13
Ras64B
1 of 13
Ras85D
1 of 13
Rgk1
1 of 13
Rgk2
1 of 13
Rgk3
1 of 13
Rheb
1 of 13
RhoL
1 of 13
Ric
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAB1A; RAB1A, member RAS oncogene family
    13 of 14
    179508
        RAB1B; RAB1B, member RAS oncogene family
        11 of 14
        612565
            RAB1C; RAB1C, member RAS oncogene family (pseudogene)
            7 of 14
                RAB19; RAB19, member RAS oncogene family
                3 of 14
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    Rab1 - ATPsynγ
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Arf1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Arl8
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Atpα
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - CG13220
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - CG1416
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - CG3566
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - COX4
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Chc
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Cisd
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Cog6
                    two hybrid
                    (Frappaolo et al., 2017)
                    Rab1 - Cog7
                    pull down, western blot, anti tag western blot
                    (Frappaolo et al., 2017, Sechi et al., 2017)
                    Rab1 - Cyp12d1-p
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - GM130
                    anti tag coimmunoprecipitation, western blot, two hybrid
                    (Liu et al., 2017, Sinka et al., 2008)
                    Rab1 - Gale
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Gdi
                    pull down, peptide massfingerprinting
                    (Gillingham et al., 2014)
                    Rab1 - Hel25E
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - KdelR
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Kr-h2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Ldh
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Mcad
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Mec2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Ocrl
                    pull down, peptide massfingerprinting
                    (Gillingham et al., 2014)
                    Rab1 - Ost1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Ost48
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Ostγ
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Rab2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Rab5
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Rab6
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Rab7
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - RabGGTb
                    enzymatic study, western blot
                    (Charng et al., 2014)
                    Rab1 - Rap1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Rdh1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - SERCA
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - ScsβA
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - ScsβG
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - SsRβ
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Tango1
                    anti tag coimmunoprecipitation, western blot
                    (Liu et al., 2017)
                    Rab1 - Tecr
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - Tspo
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - apolpp
                    pull down, peptide massfingerprinting
                    (Gillingham et al., 2014)
                    Rab1 - garz
                    anti tag coimmunoprecipitation, western blot, pull down, peptide massfingerprinting
                    (Sechi et al., 2017, Gillingham et al., 2014)
                    Rab1 - jagn
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - l(1)G0320
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - mt:CoII
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - p38b
                    anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Belozerov et al., 2012)
                    Rab1 - p38c
                    anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Belozerov et al., 2012)
                    Rab1 - sau
                    pull down, anti tag western blot, two hybrid, anti bait coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy
                    (Frappaolo et al., 2017, Sechi et al., 2017)
                    Rab1 - spidey
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Rab1 - strat
                    pull down, peptide massfingerprinting, experimental knowledge based
                    (Gillingham et al., 2014, Guruharsha et al., 2011)
                    Rab1 - temp
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Charng et al., 2014)
                    Rab1 - vib
                    pull down, western blot
                    (Frappaolo et al., 2017)
                    Rab1 - wal
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Summary of Genetic Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Rab1
                    suppressible
                    BicD
                    (Rollins and Blankenship, 2023)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Bet3
                    suppressible
                    Rab1
                    (Ke et al., 2018)
                    BicD
                    suppressible
                    Rab1
                    (Rollins and Blankenship, 2023)
                    cact
                    suppressible
                    Rab1
                    (Zang et al., 2015)
                    Cog7
                    suppressible
                    Rab1
                    (Frappaolo et al., 2017)
                    Spt-I
                    suppressible
                    Rab1
                    (Oswald et al., 2015)
                    Tl
                    suppressible
                    Rab1
                    (Zang et al., 2015)
                    Trs23
                    suppressible
                    Rab1
                    (Ke et al., 2018)
                    External Data
                    Linkouts
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    External Data
                    Linkouts
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map
                    3-71
                    Cytogenetic map
                    93D2-93D2
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    93D2-93D2
                    Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Location based on deficiency mapping.
                    (Giansanti et al., 2004)
                    93C6-93E1
                    (Giansanti et al., 2004)
                    93D1-93D5
                    (Ozaki, 1996.4.3)
                    93D1-93D5
                    (determined by in situ hybridisation)
                    (Satoh et al., 1997)
                    Experimentally Determined Recombination Data
                    Location

                    3-71

                    (FlyBase, 2016)

                    3-74.1

                    (Comeron et al., 2012)

                    3-

                    (Giansanti et al., 2004)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (22)
                    Genomic Clones (19)
                    cDNA Clones (219)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Otsuka et al., 2019, Liu et al., 2017, Sechi et al., 2017)
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          Mutants have reduced dendritic arbors but normal axonal growth in the class IV dendritic arborization (da) neurons.

                          (Ye et al., 2007)

                          dsRNA has been made from templates generated with primers directed against this gene.

                          (Kouranti et al., 2006)

                          dsRNA made from templates generated with primers directed against Rab1 that is transfected into S2 treated with Listeria monocytogenes reveals Rab1 to be involved in Listeria monocytogenes entry and vacuolar escape.

                          (Cheng et al., 2005)

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)

                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached.

                          (Kiger et al., 2003)

                          Isolated from a Drosophila head cDNA library.

                          (Satoh et al., 1997)

                          In photoreceptor cells Rab1 contributes to the maintenance of local cell structure by mediating vesicle transport between the rough endoplasmic reticulum (rER) and Golgi body.

                          (Satoh et al., 1997)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Rab1 omt

                          (Sechi et al., 2017)
                          Additional comments
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: Rab1 CG3320

                          (Gong, 1999.11)
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (19)
                          Reported As
                          Symbol Synonym
                          AAF55873
                          (Armstrong, 2000)
                          CG3320
                          (Laffafian and Tepass, 2019, Meadows, 2018.10.31, Kolkhof et al., 2017, Sechi et al., 2017, Çiçek et al., 2016, Dunst et al., 2015, McEachern et al., 2014, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Sinka et al., 2008, Zhang et al., 2007, Cermelli et al., 2006, Dorer et al., 2006, Colicelli, 2004, Dunne et al., 2002, Verstreken and Bellen, 2000.9.4)
                          DRAB1
                          (Kohno et al., 1994)
                          DRab1
                          (Satoh et al., 1997)
                          Dar6
                          (Puram and Bonni, 2013)
                          Dm Rab1
                          (Jekely, 2003)
                          DmRab1
                          (Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
                          O18332
                          (Rojas et al., 2012)
                          RAB1a
                          (Dorer et al., 2006)
                          Rab1
                          (Luo et al., 2025, Sasaki et al., 2025, Hodgson et al., 2024, Kim et al., 2024, Meyer et al., 2024, Zhang et al., 2024, Heigwer et al., 2023, Maddison et al., 2023, Titlow et al., 2023, Tsarouhas et al., 2023, Zhou et al., 2023, Gao et al., 2022, Hodgson et al., 2022, Song et al., 2022, Atienza-Manuel et al., 2021, Bouska and Bai, 2021, Furusawa and Emoto, 2021, Liguori et al., 2021, Ma and Brill, 2021, Ricolo et al., 2021, Feng et al., 2020, Kitatani et al., 2020, Naz et al., 2020, Rui et al., 2020, Hodgson et al., 2019, Krämer et al., 2019, Laffafian and Tepass, 2019, Otsuka et al., 2019, Artiushin et al., 2018, Bellec et al., 2018, Gene Disruption Project members, 2018-, Pichaud, 2018, Wang et al., 2018, Coutinho-Budd et al., 2017, Frappaolo et al., 2017, Liu et al., 2017, Schopf and Huber, 2017, Sechi et al., 2017, Solis et al., 2017, Transgenic RNAi Project members, 2017-, Alfa and Kim, 2016, Caviglia et al., 2016, Choudhury et al., 2016, Nässel and Vanden Broeck, 2016, Dent et al., 2015, Oswald et al., 2015, Van Bortle et al., 2015, White et al., 2015, Zang et al., 2015, Zirin et al., 2015, Charng et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Fan et al., 2013, Kwon et al., 2013, Macleod et al., 2013, Xiong and Bellen, 2013, Zhang et al., 2013, Belozerov et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rincon-Limas et al., 2012, Wang et al., 2012, Oberegelsbacher et al., 2011, Asensio et al., 2010, Kallappagoudar et al., 2010, Li et al., 2010, Winslow et al., 2010, Zhang et al., 2010, Hilger et al., 2009, Perkins et al., 2009.8.10, Thomas et al., 2009, Ching et al., 2008, Sinka et al., 2008, Buszczak et al., 2007, Li et al., 2007, Stuart et al., 2007, Ye et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Cermelli et al., 2006, Comet et al., 2006, Kouranti et al., 2006)
                          Rab1a
                          (Wang et al., 2010)
                          dRab1
                          (Solis et al., 2017, Dunne and Rabouille, 2001)
                          dar6
                          (Ye et al., 2007)
                          drab1
                          (Dunne et al., 2002)
                          omt
                          (Sechi et al., 2017, Lesch and Page, 2012)
                          rab1
                          (Meyer et al., 2022, Lammers et al., 2017, Kanamori et al., 2015, Lye et al., 2014, Sekine et al., 2013, Jin et al., 2012, Chan et al., 2011, Mudiganti et al., 2010, Zhang et al., 2010, Nairz et al., 2002, Ozaki, 1996.4.3)
                          Name Synonyms
                          Rab-protein 1
                          (McEachern et al., 2014, Jaspers et al., 2012, Cammarato et al., 2011)
                          Rab1
                          dendritic arbor reduction 6
                          (Ye et al., 2007)
                          omelette
                          (Sechi et al., 2017, Lesch and Page, 2012, Giansanti et al., 2004)
                          Secondary FlyBase IDs
                          • FBgn0016700
                          • FBgn0083070
                          Datasets (1)
                          Study focus (1)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          • bait_protein
                          Rab_Effectors_interaction_map
                          Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 38 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          References (182)