DRab5, l(2)k08232, Rab-protein 5, DmRab5
Rab family GTPase - required for fusion of endocytic vesicles with endosomes - required for endocytosis of vesicles at the synapse - required for tracheal maturation - regulates JAK/STAT activity, functions in endosomal transport to promotes wingless signaling - promotes F-actin reorganization in oogenesis
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab5 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Rab5 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Rab5 l(2)k08232
An increase in the proportion of binucleated cells is seen following transfection of S2 cells with dsRNA made from templates generated with primers directed against this gene.
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against Rab5 that is transfected into S2 treated with Listeria monocytogenes reveals Rab5 to be involved in Listeria monocytogenes entry and vacuolar escape.
Rab5 is necessary for the formation of an apical cap, made of basement membrane components, over the surface of the anterior polar cells in stage 8 egg chambers.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.