FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Strip
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General Information
Symbol
Dmel\Strip
Species
D. melanogaster
Name
Striatin interacting protein
Annotation Symbol
CG11526
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035437
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Striatin interacting protein (Strip) encodes an intracellular protein and component of the STRIPAK PP2A protein complex. It is involved in Hippo signaling, endosome maturation, and microtubule regulation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
63D1-63D1
Sequence location
Recombination map
3-8
RefSeq locus
NT_037436 REGION:3322025..3328871
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein kinase binding
inferred from physical interaction with FLYBASE:hep; FB:FBgn0010303
(La Marca et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein-macromolecule adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000326293
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in axon extension
inferred from mutant phenotype
(Sakuma et al., 2014)
involved_in endosome organization
inferred from mutant phenotype
(Sakuma et al., 2014)
involved_in microtubule cytoskeleton organization
inferred from mutant phenotype
(Sakuma et al., 2015)
involved_in negative regulation of hippo signaling
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Neal et al., 2020, Sakuma et al., 2016)
inferred from mutant phenotype
(Neal et al., 2022, Zheng et al., 2017)
involved_in negative regulation of JNK cascade
inferred from mutant phenotype
(La Marca et al., 2019)
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(La Marca et al., 2019)
involved_in negative regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Sakuma et al., 2016)
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(La Marca et al., 2019)
involved_in positive regulation of Ras protein signal transduction
inferred from high throughput genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Ashton-Beaucage et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN000326293
(GO Reference Genome Project, 2011-)
involved_in negative regulation of hippo signaling
inferred from biological aspect of ancestor with PANTHER:PTN000326293
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(La Marca et al., 2019)
part_of FAR/SIN/STRIPAK complex
inferred from direct assay
(Ashton-Beaucage et al., 2014, Ribeiro et al., 2010)
located_in presynapse
inferred from direct assay
(Sakuma et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000326293
(GO Reference Genome Project, 2011-)
part_of FAR/SIN/STRIPAK complex
inferred from biological aspect of ancestor with PANTHER:PTN000326293
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Striatin interacting protein (Strip) encodes an intracellular protein and component of the STRIPAK PP2A protein complex. It is involved in Hippo signaling, endosome maturation, and microtubule regulation. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
NEGATIVE REGULATORS OF TNFalpha-EIGER SIGNALING PATHWAY -
Negative regulators of Tumor Necrosis Factor α (TNFα) signaling pathway down-regulate the activation of the pathway triggered by Eiger (egr).
Gene Group (FlyBase)
STRIATIN-INTERACTING PHOSPHATASE AND KINASE COMPLEX -
Striatin interacting phosphatase and kinase (STRIPAK)/STRIPAK-like complexes contain a protein phosphatase type 2A (mts), a striatin (Cka) and other regulatory subunits. Kinases, such as GckIII, are often associated with the complex (FBrf0211636). The STRIPAK complex has a regulatory role in many signaling pathways and cellular processes. (Adapted from FBrf0223805).
Summary (Interactive Fly)

a component of the striatin-interacting phosphatase and kinase (STRIPAK) complex that regulates axon elongation, cytoskeletal stability, and cell signaling - required to ensure the proper development of synaptic boutons at the Drosophila neuromuscular junction - a molecular platform for the early endosome organization that has important roles in neuronal morphogenesis - negatively regulates the Hippo and clock pathways

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Strip for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8IRD5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Strip-RA
FBtr0073083
NM_168023
3596
882
Strip-RB
FBtr0073084
NM_139549
3161
927
Strip-RC
FBtr0332058
NM_001274437
3792
882
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Strip-PA
FBpp0072945
99.7
882
5.09
Q9VZQ9
NP_728867
AAF47760
Strip-PB
FBpp0072946
104.7
927
5.61
Q8IRD5
NP_647806
AAN11560
Strip-PC
FBpp0304368
99.7
882
5.09
Q9VZQ9
NP_001261366
AGB94061
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

882 aa isoforms: Strip-PA, Strip-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Strip using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.03

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval neuromuscular junction
(Sakuma et al., 2016)
Additional Descriptive Data

Strip is localized at presynaptic sites adjacent to the neuronal membrane. It is excluded from the muscle subsynaptic reticulum.

(Sakuma et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(La Marca et al., 2019)
part_of FAR/SIN/STRIPAK complex
inferred from direct assay
(Ashton-Beaucage et al., 2014, Ribeiro et al., 2010)
located_in presynapse
inferred from direct assay
(Sakuma et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Strip in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Strip
Transgenic constructs containing regulatory region of Strip
Aberrations (Deficiencies and Duplications) ( 14 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Df(3L)HR119
lethal, with Df(3L)HR232
lethal (with Df(3L)1227)
lethal (with Df(3L)ED208)
lethal - all die before end of P-stage, with Scer\GAL4da.G32
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3L)BSC129)
viable (with Df(3L)BSC368)
viable (with Df(3L)ED4293)
viable (with Df(3L)Exel6094)
viable (with Df(3L)Exel6095)
viable (with Df(3L)Exel6096)
viable (with Df(3L)Exel6097)
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR
fertile
male sterile, with Scer\GAL4VP16.nanos.UTR
Other Phenotypes
Allele
abnormal cell number | third instar larval stage
abnormal cell shape | third instar larval stage
abnormal neuroanatomy, with Scer\GAL4477, Scer\GAL4ppk.PU
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4RapGAP1-OK6
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4RapGAP1-OK6, StripRNAi.UAS.9
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4RapGAP1-OK6, StripRNAi.UAS
abnormal neurophysiology | third instar larval stage, with Scer\GAL4RapGAP1-OK6
abnormal size | male | recessive | third instar larval stage
abnormal size | male | third instar larval stage, with Df(3L)HR232
abnormal size | male | third instar larval stage, with Scer\GAL4C587
abnormal size | male | third instar larval stage, with Scer\GAL4tj.PU
abnormal size | male | third instar larval stage (with Df(3L)tc-1)
abnormal size | male | third instar larval stage (with Stripdogi)
abnormal size | male | third instar larval stage (with Stripjam)
abnormal size | spermatogenesis, with Scer\GAL4VP16.nanos.UTR
atrophy | pupal stage, with Scer\GAL4Mef2.PR
increased body size | P-stage, with Scer\GAL4Mef2.PR
increased cell death | third instar larval stage
increased occurrence of cell division | third instar larval stage
increased size | pupal stage, with Scer\GAL4Mef2.PR
some die during larval stage, with Scer\GAL4da.G32
some die during P-stage, with Scer\GAL4da.G32
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
actin filament | third instar larval stage, with Scer\GAL4elav.PU
adult antennal lobe projection neuron DL1 adPN | somatic clone
adult lateral horn | adult stage | somatic clone
alpha/beta Kenyon cell | adult stage | somatic clone
antennal lobe projection neuron | somatic clone
autophagosome | increased number | larval stage, with Scer\GAL4Mef2.PR
axon | adult stage | somatic clone
cyst cell of testis | third instar larval stage
dendrite, with Scer\GAL4477, Scer\GAL4ppk.PU
dendrite | adult stage | somatic clone
developing neuron | ectopic | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
embryonic/larval hypodermal muscle | larval stage, with Scer\GAL4Mef2.PR
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4elav.PU
eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
gonad | male | third instar larval stage
gonad | male | third instar larval stage, with Df(3L)HR232
gonad | male | third instar larval stage, with Scer\GAL4C587
gonad | male | third instar larval stage, with Scer\GAL4tj.PU
gonad | male | third instar larval stage (with Df(3L)tc-1)
gonad | male | third instar larval stage (with Stripdogi)
gonad | male | third instar larval stage (with Stripjam)
indirect flight muscle cell | pupal stage, with Scer\GAL4Mef2.PR
investment cone, with Scer\GAL4VP16.nanos.UTR
male germline cyst | third instar larval stage
male germline stem cell | third instar larval stage
multidendritic neuron, with Scer\GAL4477, Scer\GAL4ppk.PU
mushroom body | adult stage | somatic clone
myotube | pupal stage, with Scer\GAL4Mef2.PR
NMJ bouton | increased number, with Scer\GAL4RapGAP1-OK6
NMJ bouton | increased number, with Scer\GAL4RapGAP1-OK6, StripRNAi.UAS.9
NMJ bouton | increased number, with Scer\GAL4RapGAP1-OK6, StripRNAi.UAS
peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
sarcomere | larval stage, with Scer\GAL4Mef2.PR
seminal vesicle, with Scer\GAL4VP16.nanos.UTR
spermatocyte | third instar larval stage
spermatogonium | third instar larval stage
spermatozoon | absent, with Scer\GAL4VP16.nanos.UTR
terminal epithelium of testis, with Scer\GAL4VP16.nanos.UTR
ventral longitudinal muscle 3 | larval stage, with Scer\GAL4Mef2.PR
ventral longitudinal muscle 4 | larval stage, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\STRIP1
14 of 14
Yes
Yes
Hsap\STRIP2
13 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Strip1
14 of 14
Yes
Yes
Rnor\Strip2
11 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Strip1
13 of 14
Yes
Yes
 
1  
Mmus\Strip2
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\strip1
11 of 13
Yes
Yes
Xtro\strip2
10 of 13
No
Yes
Danio rerio (Zebrafish) (2)
Drer\strip1
13 of 14
Yes
Yes
Drer\strip2
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\farl-11
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP007902
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\FAR11
8 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC27B12.04c
8 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Strip. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    STRIP1; striatin interacting protein 1
    14 of 14
    617918
        STRIP2; striatin interacting protein 2
        13 of 14
        617919
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Dmel gene
            Ortholog showing functional complementation
            Supporting References
            Strip
            Mmus\Strip1
            (Sakuma et al., 2014)
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Strip
            anti tag coimmunoprecipitation, anti tag western blot
            (Ashton-Beaucage et al., 2014)
            Strip - Cka
            anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, peptide massfingerprinting
            (La Marca et al., 2019, Andreazza et al., 2015, Ashton-Beaucage et al., 2014, Ribeiro et al., 2010)
            Strip - Clk
            anti bait coimmunoprecipitation, anti tag western blot
            (Andreazza et al., 2015)
            Strip - DCTN1-p150
            anti bait coimmunoprecipitation, western blot, pull down, anti tag western blot, two hybrid
            (Sakuma et al., 2014)
            Strip - Dhc64C
            anti tag coimmunoprecipitation, western blot
            (Neisch et al., 2017)
            Strip - Dscam1
            anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
            (Sakuma et al., 2015)
            Strip - Fgop2
            anti tag coimmunoprecipitation, anti tag western blot
            (Ashton-Beaucage et al., 2014)
            Strip - Mob4
            anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
            (Ashton-Beaucage et al., 2014, Ribeiro et al., 2010)
            Strip - Nuak
            anti tag coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy
            (Guo et al., 2023)
            Strip - Rab5
            anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
            (Sakuma et al., 2014)
            Strip - Rassf
            anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
            (Shen et al., 2022, Ribeiro et al., 2010)
            Strip - Slik
            anti tag coimmunoprecipitation, anti tag western blot
            (De Jamblinne et al., 2020)
            Strip - Tbcd
            anti bait coimmunoprecipitation, western blot
            (Sakuma et al., 2015)
            Strip - hep
            anti bait coimmunoprecipitation, western blot
            (La Marca et al., 2019)
            Strip - hpo
            anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
            (Sakuma et al., 2016, Ribeiro et al., 2010)
            Strip - spri
            anti bait coimmunoprecipitation, anti tag western blot, two hybrid, anti tag coimmunoprecipitation, western blot, pull down
            (Sakuma et al., 2014)
            Strip - stv
            proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, western blot
            (Guo et al., 2023)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Strip
            suppressible
            bsk
            (La Marca et al., 2019)
            Strip
            enhanceable
            DCTN1-p150
            (Sakuma et al., 2014)
            Strip
            suppressible
            egr
            (La Marca et al., 2019)
            Strip
            suppressible
            ena
            (Sakuma et al., 2016)
            Strip
            suppressible
            hpo
            (Sakuma et al., 2016)
            Strip
            enhanceable
            Nuak
            (Guo et al., 2023)
            Strip
            suppressible
            Rab5
            (Sakuma et al., 2014)
            Strip
            enhanceable
            Rab5
            (Sakuma et al., 2014)
            Strip
            enhanceable
            spri
            (Sakuma et al., 2014)
            Strip
            enhanceable
            stv
            (Guo et al., 2023)
            Strip
            suppressible
            Tak1
            (La Marca et al., 2019)
            Strip
            enhanceable
            Tbcd
            (Sakuma et al., 2015)
            Strip
            suppressible
            Traf6
            (La Marca et al., 2019)
            Strip
            suppressible
            wts
            (Sakuma et al., 2016)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Dscam1
            suppressible
            Strip
            (Sakuma et al., 2015)
            PXo
            suppressible
            Strip
            (Xu et al., 2023)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-8
            Cytogenetic map
            63D1-63D1
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            63D1-63D1
            Limits computationally determined from genome sequence between P{PZ}l(3)0680306803 and P{PZ}kst01318
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            3-8

            (FlyBase, 2016)

            3-6.7

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (8)
            Genomic Clones (13)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (81)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Guo et al., 2023, Sakuma et al., 2014)

              monoclonal

              (Sakuma et al., 2014)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Strip is required for normal axon elongation during morphogenesis of the olfactory projection neurons. Together with Gl it is involved in clustering of early endosomes prior to their fusion to form mature early endosomes. It appears to be involved in spri-mediated Rab5 activation by stabilising spri protein. It thus acts as a molecular linker between retrograde transport and Rab5 activity in early endosome organisation.

                  (Sakuma et al., 2014)
                  Relationship to Other Genes
                  Source for database merge of
                  Additional comments
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: Strip CG11526

                  (Ashton-Beaucage et al., 2014)
                  Nomenclature comments
                  Etymology

                  Named 'Strip'/'Striatin interacting protein' on the basis of its human counterpart.

                  (Ashton-Beaucage et al., 2014)
                  Synonyms and Secondary IDs (5)
                  Datasets (0)
                  Study focus (0)
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                  External Crossreferences and Linkouts ( 41 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  References (60)