FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\stv
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General Information
Symbol
Dmel\stv
Species
D. melanogaster
Name
starvin
Annotation Symbol
CG32130
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086708
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
starvin (stv) encodes a BAG family member that binds heat shock proteins. It plays roles in somatic muscles and is involved in the chaperone pathway essential for muscle maintenance. It also acts as co-chaperone of Hsp70 proteins during recovery from stress, including cold stress. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)00543

Key Links
Genomic Location
Cytogenetic map
70B2-70B2
Sequence location
Recombination map
3-40
RefSeq locus
NT_037436 REGION:13477541..13483515
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables heat shock protein binding
inferred from physical interaction with FLYBASE:Hsp67Bc; FB:FBgn0001229
(Carra et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables adenyl-nucleotide exchange factor activity
inferred from biological aspect of ancestor with PANTHER:PTN001748630
(GO Reference Genome Project, 2011-)
enables protein-folding chaperone binding
inferred from biological aspect of ancestor with PANTHER:PTN001748630
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR003103, InterPro:IPR036533, InterPro:IPR039773
(InterPro Project Members, 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein stabilization
inferred from biological aspect of ancestor with PANTHER:PTN001748630
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in Z disc
inferred from direct assay
(Arndt et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001748630
(GO Reference Genome Project, 2011-)
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000269156
(GO Reference Genome Project, 2011-)
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000269156
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000269156
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
starvin (stv) encodes a BAG family member that binds heat shock proteins. It plays roles in somatic muscles and is involved in the chaperone pathway essential for muscle maintenance. It also acts as co-chaperone of Hsp70 proteins during recovery from stress, including cold stress. [Date last reviewed: 2019-02-28]
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\stv for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A8JNS4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
stv-RA
FBtr0075806
NM_168551
3279
609
stv-RB
FBtr0075807
NM_168553
2496
516
stv-RC
FBtr0075808
NM_168552
2570
542
stv-RD
FBtr0075809
NM_168554
2491
516
stv-RE
FBtr0113425
NM_001104130
3357
635
stv-RF
FBtr0332078
NM_001274875
3282
610
stv-RG
FBtr0332079
NM_001274876
2499
516
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
stv-PA
FBpp0075548
66.0
609
6.47
Q9VU81
NP_729910
AAF49809
stv-PB
FBpp0075549
55.9
516
6.16
Q9VU83
NP_729912
AAF49808
stv-PC
FBpp0075550
58.8
542
5.91
Q9VU82
NP_729911
AAF49807
stv-PD
FBpp0075551
55.9
516
6.16
Q9VU83
NP_729913
AAF49806
stv-PE
FBpp0112337
68.9
635
6.28
A8JNS4
NP_001097600
ABW08536
stv-PF
FBpp0304388
66.1
610
6.47
M9PCD9
NP_001261804
AGB94497
stv-PG
FBpp0304389
55.9
516
6.16
Q9VU83
NP_001261805
AGB94498
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

516 aa isoforms: stv-PB, stv-PD, stv-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stv using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.85

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
embryonic/larval pharynx
(Arndt et al., 2010)
embryonic/larval gut
(Arndt et al., 2010)
larval somatic muscle
(Arndt et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

pharynx (phx), gut, and somatic muscles (sm).

(Arndt et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
located_in Z disc
inferred from direct assay
(Arndt et al., 2010)
Expression Deduced from Reporters
Reporter: PBac{754.P.FSVS-0}stvCPTI002824
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\stv in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of stv
Transgenic constructs containing regulatory region of stv
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4Mef2.PU
lethal (with stv1)
lethal (with stv2)
lethal (with stv3)
lethal (with stv3c)
lethal (with stv4)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of first instar larval stage | rescuable maternal effect (with stv1)
lethal - all die before end of first instar larval stage | rescuable maternal effect (with stv2)
lethal - all die before end of first instar larval stage | rescuable maternal effect (with stv3)
lethal - all die during P-stage | male, with Scer\GAL4en-e16E
partially lethal (with stv1)
partially lethal (with stv00543)
partially lethal - majority die, with Scer\GAL4twi.PG
partially lethal - majority die (with stv2)
partially lethal - majority die (with stv4)
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die | recessive
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
abnormal body size | P-stage, with Scer\GAL4Mef2.PR
abnormal body size | P-stage, with Scer\GAL4Mef2.PU
abnormal body size | P-stage, with Scer\GAL4Mef2.PU, stv1
abnormal body size | P-stage, with Scer\GAL4Mef2.PU, stvHMJ02221
abnormal body size | P-stage (with stv1)
abnormal body size | P-stage (with stv00543)
abnormal feeding behavior | larval stage | rescuable maternal effect (with stv1)
abnormal feeding behavior | larval stage | rescuable maternal effect (with stv2)
abnormal feeding behavior | larval stage | rescuable maternal effect (with stv3)
abnormal flight | dominant
abnormal learning | adult stage
abnormal locomotor behavior, with Scer\GAL4twi.PG
abnormal locomotor behavior | dominant
decreased body size | larval stage, with Scer\GAL4Mef2.PU
decreased size | adult stage, with Scer\GAL4en-e16E
decreased size | larval stage, with Scer\GAL4Mef2.PU
some die during first instar larval stage | rescuable maternal effect (with stv1)
some die during first instar larval stage | rescuable maternal effect (with stv2)
some die during first instar larval stage | rescuable maternal effect (with stv3)
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4en-e16E
Phenotype manifest in
Allele
chaeta | increased number, with Scer\GAL4pnr-MD237
larval somatic muscle | larval stage, with Scer\GAL4Mef2.PU
larval somatic muscle cell | third instar larval stage, with Scer\GAL4Mef2.PR
larval somatic muscle cell | third instar larval stage (with stv1)
larval somatic muscle cell | third instar larval stage (with stv00543)
mesonotum, with Scer\GAL4pnr-MD237
mouth hook (with stv1)
mouth hook (with stv3)
wing, with Scer\GAL4en-e16E
Z disc
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\BAG4
7 of 14
Yes
Yes
Hsap\BAG3
6 of 14
No
Yes
Hsap\BAG5
3 of 14
No
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Bag3
6 of 14
Yes
Yes
Rnor\Bag4
5 of 14
No
Yes
Rnor\Bag5
2 of 14
No
Yes
Mus musculus (laboratory mouse) (3)
Mmus\Bag4
7 of 14
Yes
Yes
Mmus\Bag3
6 of 14
No
Yes
Mmus\Bag5
3 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\bag4
6 of 13
Yes
Yes
Xtro\bag3
2 of 13
No
Yes
Xtro\agtrap
1 of 13
No
No
Xtro\maea
1 of 13
No
No
Xtro\tmem164
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\bag4
7 of 14
Yes
Yes
Drer\bag3
5 of 14
No
Yes
Drer\bag5
5 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP011762
7 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\BAG1
2 of 13
Yes
Yes
Atha\BAG2
2 of 13
Yes
Yes
Atha\BAG3
2 of 13
Yes
Yes
Atha\BAG4
2 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\bag101
2 of 12
Yes
Yes
Spom\bag102
2 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:stv. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 5 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    BAG4; BAG cochaperone 4
    7 of 14
    603884
        BAG3; BAG cochaperone 3
        6 of 14
        603883
        BAG5; BAG cochaperone 5
        3 of 14
        603885
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        stv
        enhanceable
        NdufA3
        (Pueyo et al., 2023)
        stv
        enhanceable
        Nuak
        (Brooks et al., 2020)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Atg8a
        enhanceable
        stv
        (Brooks et al., 2020)
        Cka
        enhanceable
        stv
        (Guo et al., 2023)
        GckIII
        enhanceable
        stv
        (Guo et al., 2023)
        Naus
        enhanceable
        stv
        (Guo et al., 2023)
        NdufA3
        enhanceable
        stv
        (Pueyo et al., 2023)
        Nuak
        enhanceable
        stv
        (Brooks et al., 2020)
        Nuak
        suppressible
        stv
        (Brooks et al., 2020)
        Slmap
        enhanceable
        stv
        (Guo et al., 2023)
        Strip
        enhanceable
        stv
        (Guo et al., 2023)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-40
        Cytogenetic map
        70B2-70B2
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        70B2-70B2
        Limits computationally determined from genome sequence between P{PZ}l(3)0422004220&P{lacW}l(3)j10B6j10B6 and P{PZ}stv00543
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        70B1-70B3
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        70B1-70B3
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        3-40

        (FlyBase, 2016)

        3-34.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (9)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (61)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            The gross morphology and function of somatic muscles is normal in stv mutants, but mutant larvae show a fully penetrant phenotype of failure to grow after hatching and a severely impaired ability to take up food.

            (Coulson et al., 2005)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: CG10745 CG14108

            (FlyBase Genome Annotators, 2002-2003)
            Additional comments

            Annotations CG10745 and CG14108 merged as CG32130 in release 3 of the genome annotation.

            (FlyBase Genome Annotators, 2002-2003)
            Nomenclature History
            Source for database identify of

            Source for identity of: stv CG32130 l(3)00543

            (Coulson et al., 2005)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (14)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 66 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (80)