FlyBase Allele Report: Hsap\FUS[R521C.UAS.Tag:HA]

General Information

Symbol

Hsap\FUS^{R521C.UAS.Tag:HA}

Species

H. sapiens

Name

FlyBase ID

FBal0261075

Feature type

allele

Associated gene

Hsap\FUS

Associated Insertion(s)

Carried in Construct

P{UAS-hFUS.R521C.HA}

Also Known As

FUS R521C, FUS^R521C, UAS-FUS-hR521C

Key Links

Transgenic product class

missense_variant

(Lanson et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Lanson et al., 2011)

Mutagen

in vitro construct

(Lanson et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-hFUS.R521C.HA}

Cytology

Description

Amino acid replacement: R521C.

(Lanson et al., 2011)

UAS regulatory sequences drive expression of mutated Hsap\FUS coding sequences.

(Lanson et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\FUS

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis

CEA

(Daigle et al., 2013, Shahidullah et al., 2013, Lanson et al., 2011)

model of neurodegenerative disease

CEA

(Uechi et al., 2018)

model of amyotrophic lateral sclerosis type 6

CEC

(Casci et al., 2019)

CEA

(Fortuna et al., 2021, Lin et al., 2021, Kankel et al., 2020, Markmiller et al., 2018, Periz et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodegenerative disease

is ameliorated by CG5445^UAS.cUa

(Uechi et al., 2018)

is ameliorated by Rpn11^UAS.cTa

(Uechi et al., 2018)

is exacerbated by CG5445^NIG.5445R

(Uechi et al., 2018)

model of amyotrophic lateral sclerosis type 6

is exacerbated by mbl^C.UAS

(Casci et al., 2019)

is exacerbated by Smn^GL00581

(Casci et al., 2019)

is ameliorated by mbl^GD13374

(Casci et al., 2019)

is ameliorated by Smn^UAS.Tag:FLAG

(Casci et al., 2019)

is ameliorated by mbl^KK107778

(Casci et al., 2019)

is ameliorated by Su(var)3-3^HMS00638

(Periz et al., 2015)

is ameliorated by Ube4B^JF02691

(Periz et al., 2015)

is ameliorated by Atx-1^f01201

(Kankel et al., 2020)

is ameliorated by Rala^HMS01365

(Kankel et al., 2020)

is ameliorated by Hsp110^d03562

(Kankel et al., 2020)

is ameliorated by Rgl^d03208

(Kankel et al., 2020)

is ameliorated by Setx^f05408

(Kankel et al., 2020)

is exacerbated by Strip^e04482

(Kankel et al., 2020)

is ameliorated by glo^f02674

(Kankel et al., 2020)

is ameliorated by heca^d10800

(Kankel et al., 2020)

is exacerbated by orb^d06989

(Kankel et al., 2020)

is exacerbated by pum^d04225

(Kankel et al., 2020)

is ameliorated by sas^d07239

(Kankel et al., 2020)

is ameliorated by d10800^d10800

(Kankel et al., 2020)

is ameliorated by Rbp6^d08411

(Markmiller et al., 2018)

is ameliorated by Rox8^e04432

(Markmiller et al., 2018)

is ameliorated by Su(var)205^c06825

(Markmiller et al., 2018)

is ameliorated by lig^HMJ23346

(Markmiller et al., 2018)

is ameliorated by shep^d07053

(Markmiller et al., 2018)

is ameliorated by Nup214^GD11084

(Lin et al., 2021)

is ameliorated by Nup54^KK102105

(Lin et al., 2021)

is ameliorated by Nup62^KK108318

(Lin et al., 2021)

is exacerbated by Nup62^UAS.cAa

(Lin et al., 2021)

is ameliorated by Nup98-96^KK100388

(Lin et al., 2021)

is exacerbated by Rm62^RNAi.UAS.cUa

(Fortuna et al., 2021)

is exacerbated by Rm62^unspecified

(Fortuna et al., 2021)

is ameliorated by Rm62^UAS.cUa

(Fortuna et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Lanson et al., 2011)

FUS:p.Arg521Cys

(FlyBase curators, 2019-)

Variants Synonym(s)

FUS:p.Arg517Cys

FUS:p.Arg520Cys

Associated human disease model(s)

amyotrophic lateral sclerosis 6 with or without frontotemporal dementia

External database links

ClinVar: FUS_16224

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PF

(Kim et al., 2018)

abnormal eye color, with Scer\GAL4^GMR.PU

(Kim et al., 2023)

abnormal eye color | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

abnormal locomotor behavior, with Scer\GAL4^VGlut1-OK371

(Lanson et al., 2011)

abnormal locomotor behavior | adult stage, with Scer\GAL4^{elav.Switch.PO}

(Fortuna et al., 2021)

abnormal locomotor behavior | adult stage, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

abnormal locomotor behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Lanson et al., 2011)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014, Daigle et al., 2013)

abnormal neuroanatomy | larval stage, with Scer\GAL4^Toll-6-D42

(Casci et al., 2019)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014)

abnormal neurophysiology, with Scer\GAL4^VGlut1-OK371

(Shahidullah et al., 2013)

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014)

lethal - all die before end of P-stage, with Scer\GAL4^VGlut1-OK371

(Daigle et al., 2013)

lethal - all die before end of pupal stage, with Scer\GAL4^Appl.G1a

(Lanson et al., 2011)

lethal - all die before end of pupal stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014)

short lived, with Scer\GAL4^{elav.Switch.PO}

(Fortuna et al., 2021)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Lanson et al., 2011)

some die during pupal stage, with Scer\GAL4^Appl.G1a

(Lanson et al., 2011)

visible, with Scer\GAL4^GMR.PF

(Kim et al., 2018, Daigle et al., 2013)

visible | adult stage, with Scer\GAL4^GMR.PU

(Fortuna et al., 2021, Kankel et al., 2020)

visible | adult stage, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

visible | adult stage | progressive, with Scer\GAL4^GMR.PF

(Casci et al., 2019)

visible | adult stage | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^Toll-6-D42

(Casci et al., 2019)

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014)

eye, with Scer\GAL4^GMR.PF

(Casci et al., 2019, Kim et al., 2018, Daigle et al., 2013, Lanson et al., 2011)

eye, with Scer\GAL4^GMR.PU

(Kim et al., 2023, Fortuna et al., 2021, Kankel et al., 2020)

eye | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Lanson et al., 2011)

larval brain | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Daigle et al., 2013)

NMJ bouton | larval stage, with Scer\GAL4^Toll-6-D42

(Casci et al., 2019)

ommatidium, with Scer\GAL4^GMR.PF

(Lanson et al., 2011)

presynaptic active zone, with Scer\GAL4^VGlut1-OK371

(Shahidullah et al., 2013)

presynaptic active zone | third instar larval stage, with Scer\GAL4^VGlut1-OK371

(Machamer et al., 2014)

retina, with Scer\GAL4^GMR.PF

(Casci et al., 2019, Lanson et al., 2011)

wing, with Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Detailed Description

Statement

Reference

The expression of Hsap\FUS^{R521C.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU results in eye degeneration. Adulthood-only expression under the control of Scer\GAL4^{elav.Switch.PO} and induced by RU486 results in a decrease in climbing ability.

(Fortuna et al., 2021)

Expressing Hsap\FUS^{R521C.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU leads to eye defects - rough-eye phenotype, eye degeneration and loss of pigmentation .

(Kankel et al., 2020)

Expressing Hsap\FUS^{R521C.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PF results in progressive eye degeneration: rough eye with loss of pigmentation; retinal degradation, length reduction, and separation from the lamina at the basal membrane.

Expressing Hsap\FUS^{R521C.UAS.Tag:HA} under the control of Scer\GAL4^Toll-6-D42 leads to more satellite boutons (but no change in the number of mature boutons or boutons size) in the larval neuromuscular junction.

(Casci et al., 2019)

The expression of Hsap\FUS^{R521C.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PF leads to a rough eye phenotype, with depigmentation.

(Kim et al., 2018)

Expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU induces age-dependent eye degeneration, manifested by loss of eye pigmentation in adult flies. Scer\GAL4^RapGAP1-OK6-driven expression results in wing expansion defects (but no eclosion defects) and severely impaired climbing ability.

(Uechi et al., 2018)

Expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} in motor neurons under the control of Scer\GAL4^VGlut-OK371 causes impaired larval motility.

Expression of Scer\GAL4^VGlut-OK371>Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} results in an approximately three-fold increase in the number of inter-bouton regions at third instar larval neuromuscular junctions compared with wild-type.

Scer\GAL4^VGlut-OK371>Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1}-expressing animals display an approximately 50% reduction in the number of presynaptic active zones compared with wild-type.

Compared with wild-type, third instar larvae expressing Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^VGlut-OK371 display an approximately 25% reduction in evoked excitatory junction potential (EJP) amplitude. Compared with wild-type, a greater than two-fold increase in mEJP frequency is observed in the transgenic flies. Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1}-expression does not cause a significant alteration in EJP kinetics.

(Machamer et al., 2014)

Motor neuron expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^VGlut-OK371 leads to larval paralysis and pupal lethality.

Expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} in motor neurons under the control of Scer\GAL4^VGlut-OK371 causes smaller brain size due to atrophy in third instar larvae.

(Daigle et al., 2013)

Over-shooting action potentials can be evoked in neurons expressing Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^VGlut-OK371 by injection of depolarising current via a recording electrode. Neurons fire repetitively in response to a sustained stimulus, with no apparent accommodation. In contrast to the evoked cell body action potentials, there is no statistically significant difference in the frequency of the spontaneous orthodromic action potentials recorded from the axons of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1}-expressing larvae and wild-type.

Neuronal expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^VGlut-OK371 appears to have little effect on the fast inward currents evoked by membrane depolarisation. The large, voltage-dependent outward currents are very similar in wild-type and Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} larvae and the conductance-voltage relationships of the peak outward currents are indistinguishable between Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} and wild-type larvae.

Pre-synaptic expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^VGlut-OK371) leads to a dramatic decrease in the amplitude of the excitatory junctional current. The rate of EJC decay in markedly increased in Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} expressing mutants compared to controls (decay time constants are approximately 35% of those in controls). This substantial change in decay kinetics, in combination with the decrease in EJC amplitude, results in an even more profound decrease in the integrated synaptic current. Synaptic transmission at the larval neuromuscular junction is severely impaired in Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} mutant flies.

The structure and shape of presynaptic active zones is aberrant in flies expressing Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^VGlut-OK371.

(Shahidullah et al., 2013)

Expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF results in a severe neurodegeneration in the eye, characterised by disorganised ommatidia and loss of mechanosensory bristles, correlated with vacuolar neurodegeneration with severe disruption of the retinal organization and thinning of the retina.

Expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} in the nervous system under the control of Scer\GAL4^Appl.G1a causes pupal lethality.

Induction of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} expression in adult neurons under the control of Scer\GAL4^{elav.Switch.PO} causes a severe decline in the survival rate after approximately 10 days RU486 treatment and exhibit drastically shortened life span when compared with untreated Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} and Scer\GAL4^{elav.Switch.PO} alone. Approximately 50% of the Scer\GAL4^{elav.Switch.PO}; Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} flies are dead within 18 days of RU486 treatment with all of the flies dead within 30 days (with an average life span of 17.4 days).

Induction of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} expression in adult neurons under the control of Scer\GAL4^{elav.Switch.PO} causes an age-dependent decline in climbing ability. These flies start showing impairment in the climbing behavior by day 10 and at day 20 less than 3% of these flies treated with RU486 are able to climb.

Expression of Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} in motor neurons under the control of Scer\GAL4^VGlut-OK371 causes a larval-crawling defect. These mutants display normal numbers of synaptic boutons.

(Lanson et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Rm62^unspecified

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Rm62^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by CG10077^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by pum^d04225/pum[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by orb[+]/orb^d06989

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Strip[+]/Strip^e04482

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by mbl^C.UAS, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Smn^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Hsap\UBQLN2^P525S.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by Hsap\UBQLN2^P525S.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

NOT Enhanced by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color phenotype, non-enhanceable by unc-5^GD3510, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color phenotype, non-enhanceable by unc-5^KK102074, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, non-enhanceable by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Suppressed by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rm62^UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO} has abnormal locomotor behavior | adult stage | RU486 conditional phenotype, suppressible by Rm62^UAS.cUa, Scer\GAL4^{elav.Switch.PO}

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible by Rm62^UAS.cUa, Scer\GAL4^{elav.Switch.PO}

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by eIF5B[+]/eIF5B^d02986

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Epac[+]/Epac^e00785

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ncoa6[+]/Ncoa6^e04200

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Klp98A[+]/Klp98A^c05668

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG8301^c06325/CG8301[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG14434[+]/CG14434^c04582

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by corto[+]/corto^c03244

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c07023^c07023/c07023[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02833[+]/d02833^d02833

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Moe^d04116/Moe[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02712^d02712/d02712[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02874^d02874/d02874[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ets98B[+]/Ets98B^c04522

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Fur1[+]/Fur1^d04883

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rgl^d03208/Rgl[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by SNF4Aγ^d05297/SNF4Agamma[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG8036[+]/Tkt^d05884

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d08551^d08551/d08551[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsc70Cb[+]/Hsp110^d06126

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02769[+]/d02769^d02769

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d07098[+]/d07098^d07098

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by mus201[+]/mus201^e01238

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Pld^HMS00529, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by lilli^JF02087, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by SF2^HMS00358, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by SF2^HM05199, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by d10800[+]/d10800^d10800

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Setx[+]/Setx^f05408

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ask1^HMS00464, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by dco[+]/dco^d06510

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsc70Cb[+]/Hsp110^d03562

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sas[+]/sas^d07239

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Atx-1^f01201/Atx-1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by glo^f02674/glo[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by lilli[+]/lilli^c00800

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Fife^d01275/Fife[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d00123[+]/d00123^d00123

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d02380^d02380/d02380[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by corn^c02909/corn[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Nedd4[+]/Nedd4^c01016

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c01295[+]/c01295^c01295

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d01345^d01345/d01345[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c04205[+]/c04205^c04205

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Plp[+]/Plp^d11666

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c01399^c01399/c01399[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by mrva[+]/mrva^d09937

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mnr^e00651/CG32521[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG5342[+]/CG5342^e01976

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG16890[+]/CG16890^e02098

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d00147^d00147/d00147[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by rdo^e02234/rdo[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by e00530^e00530/e00530[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Plp^d10223/Plp[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by or[+]/or^e02236

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG13334^e02535/CG13334[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hph^e00985/Hph[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Usp12-46^e02699/Usp12-46[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rbp9[+]/Rbp9^e02166

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d10376[+]/d10376^d10376

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by e04545^e04545/e04545[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG10011[+]/CG10011^f01587

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by peo^e02684/CG46338[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by NAT1^e04015/NAT1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG11842[+]/CG11842^e02284

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mis12^f03756/Mis12[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by RpS16[+]/RpS16^f06593

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by c04797^c04797/c04797[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sra^c03600/sra[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by nebu[+]/nebu^f03242

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ptpmeg[+]/Ptpmeg^c06293

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CG4393[+]/CG4393^c04473

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by CenG1A^c06703/CenG1A[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by kug^c05977/kug[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Prp18^c07155/Prp18[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Rala^HMS01365, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mtx2^d09179/CG8004[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by sNPF^c07042/sNPF[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by NetA[+]/NetA^d04075

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Kpc1^c06744/Kpc1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by GCC185[+]/GCC185^e02741

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by GstS1^e00777/GstS1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by DCTN5-p25[+]/DCTN5-p25^f02738

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Ptp61F[+]/Ptp61F^c05849

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by shn^c03635/shn[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Insep^e00355/CG32069[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by d06616[+]/d06616^d06616

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Mtp[+]/Mtp^d07488

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Dg^e02580/Dg[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by f03408^f03408/f03408[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by f05963[+]/f05963^f05963

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42 has abnormal neuroanatomy | larval stage phenotype, suppressible by mbl^KK107778, Scer\GAL4^Toll-6-D42

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Df(2R)Exel6066/+

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Df(2R)BSC154/+

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage | progressive phenotype, suppressible by mbl^KK107778, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Smn^GL00581, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6 has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, suppressible by Rpn11^UAS.cTa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, suppressible by Rpn11^UAS.cTa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

NOT suppressed by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color phenotype, non-suppressible by unc-5^GD3510, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color phenotype, non-suppressible by unc-5^KK102074, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Pka-R2^d02258/Pka-R2[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Rala^S25N.UAS, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6 has visible | adult stage phenotype, non-suppressible by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by CG5445^ΔUBA.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by CG5445^ΔFW.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, non-suppressible by CG5445^ΔUBA.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, non-suppressible by CG5445^ΔFW.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Rm62^unspecified

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Rm62^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG10077^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Strip[+]/Strip^e04482

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by pum^d04225/pum[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by orb[+]/orb^d06989

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by mbl^C.UAS, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by mbl^C.UAS, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Smn^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsap\UBQLN2^P525S.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

NOT Enhanced by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by unc-5^GD3510, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by unc-5^KK102074, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Hsap\UBQLN2^WT.UAS, Scer\GAL4^GMR.PF

(Kim et al., 2018)

Suppressed by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rm62^UAS.cUa, Scer\GAL4^GMR.PU

(Fortuna et al., 2021)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ask1^HMS00464, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Setx[+]/Setx^f05408

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by dco[+]/dco^d06510

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsc70Cb[+]/Hsp110^d03562

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by sas[+]/sas^d07239

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Atx-1^f01201/Atx-1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by glo^f02674/glo[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by lilli[+]/lilli^c00800

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02712^d02712/d02712[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Nedd4[+]/Nedd4^c01016

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG8301^c06325/CG8301[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02833[+]/d02833^d02833

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG14434[+]/CG14434^c04582

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02769[+]/d02769^d02769

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d08551^d08551/d08551[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Klp98A[+]/Klp98A^c05668

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Plp^d10223/Plp[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Plp[+]/Plp^d11666

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mrva[+]/mrva^d09937

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d10376[+]/d10376^d10376

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mnr^e00651/CG32521[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rbp9[+]/Rbp9^e02166

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by or[+]/or^e02236

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG5342[+]/CG5342^e01976

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG16890[+]/CG16890^e02098

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by rdo^e02234/rdo[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG13334^e02535/CG13334[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mus201[+]/mus201^e01238

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by comm3[+]/comm3^e03409

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by e04545^e04545/e04545[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Usp12-46^e02699/Usp12-46[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG11842[+]/CG11842^e02284

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mis12^f03756/Mis12[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NAT1^e04015/NAT1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by RpS16[+]/RpS16^f06593

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG4393[+]/CG4393^c04473

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG10011[+]/CG10011^f01587

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c04797^c04797/c04797[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ptpmeg[+]/Ptpmeg^c06293

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by sra^c03600/sra[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by kug^c05977/kug[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Kpc1^c06744/Kpc1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NetA[+]/NetA^d04075

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mtp[+]/Mtp^d07488

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Imp[+]/Imp^d08578

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by sNPF^c07042/sNPF[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by GstS1^e00777/GstS1[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Prp18^c07155/Prp18[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by GCC185[+]/GCC185^e02741

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Epac[+]/Epac^e00785

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by shn^c03635/shn[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ptp61F[+]/Ptp61F^c05849

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Mtx2^d09179/CG8004[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by eIF5B[+]/eIF5B^d02986

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DCTN5-p25[+]/DCTN5-p25^f02738

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d06616[+]/d06616^d06616

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Dg^e02580/Dg[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by f03408^f03408/f03408[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by f05963[+]/f05963^f05963

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Fife^d01275/Fife[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d01345^d01345/d01345[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ncoa6[+]/Ncoa6^e04200

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d00147^d00147/d00147[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d00123[+]/d00123^d00123

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Moe^d04116/Moe[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d02380^d02380/d02380[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ets98B[+]/Ets98B^c04522

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c07023^c07023/c07023[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c04205[+]/c04205^c04205

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corn^c02909/corn[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c01295[+]/c01295^c01295

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by SNF4Aγ^d05297/SNF4Agamma[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corto[+]/corto^c03244

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG8036[+]/Tkt^d05884

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by d07098[+]/d07098^d07098

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsc70Cb[+]/Hsp110^d06126

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hph^e00985/Hph[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by c01399^c01399/c01399[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Fur1[+]/Fur1^d04883

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Pld^HMS00529, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rgl^d03208/Rgl[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Rala^HMS01365, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by SF2^HM05199, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by SF2^HMS00358, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by lilli^JF02087, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by d10800[+]/d10800^d10800

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42 has embryonic/larval neuromuscular junction | larval stage phenotype, suppressible by mbl^KK107778, Scer\GAL4^Toll-6-D42

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42 has NMJ bouton | larval stage phenotype, suppressible by mbl^KK107778, Scer\GAL4^Toll-6-D42

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(2R)Exel6066/+

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Df(2R)BSC154/+

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by mbl^KK107778, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by mbl^KK107778, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Smn^GL00581, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, suppressible by Rpn11^UAS.cTa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

NOT suppressed by

Statement

Reference

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by unc-5^GD3510, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by unc-5^KK102074, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Pka-R2^d02258/Pka-R2[+]

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Rala^S25N.UAS, Scer\GAL4^GMR.PU

(Kankel et al., 2020)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6 has wing phenotype, non-suppressible by CG5445^UAS.cUa, Scer\GAL4^RapGAP1-OK6

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by CG5445^ΔUBA.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by CG5445^ΔFW.UAS, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The age-dependent eye pigmentation loss characteristic for adult flies expressing Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is exacerbated by co-expression of CG5445^NIG.5445R and ameliorated by co-expression of either Rpn11^Scer\UAS.cTa or CG5445^Scer\UAS.cUa but not by co-expression of CG5445^{ΔUBA.Scer\UAS} or CG5445^{ΔFW.Scer\UAS}.

The wing expansion defects observed in flies expressing Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1} with the Scer\GAL4^RapGAP1-OK6 driver are not rescued by co-expression of CG5445^Scer\UAS.cUa, whereas their poor climbing ability is significantly improved.

(Uechi et al., 2018)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\FUS^{R521C.Scer\UAS.T:Ivir\HA1}

Hsap\FUS^{R521C.UAS.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (16)

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