FlyBase Allele Report: Dmel\mbl[C.UAS]

General Information

Symbol

Dmel\mbl^C.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0141036

Feature type

allele

Associated gene

Dmel\mbl

Associated Insertion(s)

Carried in Construct

P{UAS-mbl.C}

Also Known As

UAS-MblC

Key Links

Transgenic product class

wild_type

(Garcia-Casado et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Garcia-Casado et al., 2002)

Mutagen

in vitro construct

(Garcia-Casado et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-mbl.C}

Cytology

Description

UASt regulatory sequences drive expression of the mbl C isoform.

(Garcia-Casado et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

mbl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates myotonic dystrophy type 1

modeled by Zzzz\CTG^i480.UAS.cGa

(Bargiela et al., 2015)

exacerbates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521H.UAS.Tag:HA}

(Casci et al., 2019)

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Casci et al., 2019)

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Casci et al., 2019)

modeled by Hsap\FUS^UAS.Tag:HA

(Casci et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult somatic muscle cell of thorax | heat sensitive, with Scer\GAL4^hs.PU

(Bargiela et al., 2015)

eye, with Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

eye, with Scer\GAL4^hs.2sev

(Llamusi et al., 2013, Vicente-Crespo et al., 2008, Garcia-Casado et al., 2002)

eye photoreceptor cell, with Scer\GAL4^hs.2sev

(Garcia-Casado et al., 2002)

ommatidium, with Scer\GAL4^hs.2sev

(Garcia-Casado et al., 2002)

wing, with Scer\GAL4^69B

(Garcia-Casado et al., 2002)

wing cell, with Scer\GAL4^e22c

(Vicente-Crespo et al., 2008)

wing vein | ectopic, with Scer\GAL4^69B

(Garcia-Casado et al., 2002)

wing vein L4, with Scer\GAL4^e22c

(Vicente-Crespo et al., 2008)

wing vein L5, with Scer\GAL4^e22c

(Vicente-Crespo et al., 2008)

Detailed Description

Statement

Reference

Expression of mbl^C.Scer\UAS under the control of Scer\GAL4^hs.PU results in a significant decrease in muscle area in dorsoventral sections of the thorax, and increased apoptosis and autophagy in adult muscle, after induction via heat shock, as compared to controls.

(Bargiela et al., 2015)

Expression of mbl^C.Scer\UAS under the control of Scer\GAL4^hs.2sev results in a rough eye phenotype.

(Llamusi et al., 2013)

mbl^E27 flies expressing mbl^C.Scer\UAS under the control of Scer\GAL4^da.G32 do not undergo larval molting and die as first instar larvae up to three days after hatching.

(Pascual et al., 2010)

Overexpression of mbl^C.Scer\UAS under the control of Scer\GAL4^hs.2sev generates a moderately rough eye phenotype.

Targeted expression of mbl^C.Scer\UAS to the posterior wing compartment by Scer\GAL4^e22c generates vein fusions and a lack of intervein material, affecting specially L4/5 veins.

(Vicente-Crespo et al., 2008)

Expression of mbl^C.Scer\UAS under the control of Scer\GAL4^da.G32 does not result in a reduction in the fraction of embryos that are able to hatch compared to controls.

(Vicente et al., 2007)

Expression of mbl^C.Scer\UAS under the control of Scer\GAL4^hs.2sev results in a rough eye phenotype. Severe polarity defects are seen and there is loss of photoreceptor cells within ommatidia. Expression of mbl^C.Scer\UAS under the control of Scer\GAL4^69B results in patches of ectopic vein material and ectopic veins in the wing.

(Garcia-Casado et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Suppressor of

Statement

Reference

mbl^C.UAS/Scer\GAL4^hs.PU is a suppressor | heat sensitive | partially of abnormal size | adult stage | heat sensitive phenotype of Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa

(Bargiela et al., 2015)

NOT Suppressor of

Statement

Reference

mbl^C.UAS/Scer\GAL4^Mhc.PW is a non-suppressor of short lived phenotype of Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa

(Bargiela et al., 2015)

mbl^C.UAS/Scer\GAL4^hs.PU is a non-suppressor of increased cell death | adult stage | heat sensitive phenotype of Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa

(Bargiela et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, enhanceable by Gαs^NIG.2835R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, enhanceable by TBPH^NIG.10327R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, enhanceable by CG10341^NIG.10341R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/TBPH^NIG.10327R

(Llamusi et al., 2013)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Hsp70Ab^EY01148

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by jumu^EY10708

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by CG15435^KG05006

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Ugt36D1^NP7067

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Ugt36D1^GS9130

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Hykk^NP1565

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Dp^EY09085

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by amos^Tft-RM11

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by tutl^k14703

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by tutl⁰¹⁰⁸⁵

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Dp^49Fk-1

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Dp^KG00660

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by tsu^EP567

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by amos^Roi-1

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/amos^UAS.cGa

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by bru1⁰¹²⁸⁴

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by bru1^BG01566

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by bru1^GS12289

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by bru1^PA

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Diap1⁴

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Diap1⁵

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by tsu^KG04415

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by nonA^4b18

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by nonA^f00870

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by rpr^GMR.PH

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, enhanceable by Traf4^GS2154

(Vicente-Crespo et al., 2008)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by fd3F^NIG.12632R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by βTub60D^NIG.3401R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by bsf^NIG.10302R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by cag^NIG.12346R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PU/Sil1^NIG.10420R

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by CG1092^NIG.1092R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by Cyp6a17^NIG.10241R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-enhanceable by Pvf3^NIG.13781R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, non-enhanceable by bsf^NIG.10302R/Scer\GAL4^hs.2sev

(Llamusi et al., 2013)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, suppressible by Dcr-2^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by jumu^L70

(Vicente-Crespo et al., 2008)

Scer\GAL4^e22c, mbl^C.UAS has wing vein L4 phenotype, suppressible by jumu^L70

(Vicente-Crespo et al., 2008)

Scer\GAL4^e22c, mbl^C.UAS has wing vein L5 phenotype, suppressible by jumu^L70

(Vicente-Crespo et al., 2008)

Scer\GAL4^e22c, mbl^C.UAS has wing cell phenotype, suppressible by jumu^L70

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Ref1⁰²²⁶⁷

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Traf4^EP578

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by tutl^GS13843

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by CG15435^GS11154

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Elp3^NP0434

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Elp3^KG02386

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Ugt36D1^KG03187

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Df(2L)TW137

(Vicente-Crespo et al., 2008)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, suppressible by Df(2L)sc19-8

(Vicente-Crespo et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by fd3F^NIG.12632R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by βTub60D^NIG.3401R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by bsf^NIG.10302R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by cag^NIG.12346R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by Scer\GAL4^GMR.PU/Sil1^NIG.10420R

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by CG1092^NIG.1092R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by Cyp6a17^NIG.10241R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, mbl^C.UAS has eye phenotype, non-suppressible by Pvf3^NIG.13781R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^hs.2sev, mbl^C.UAS has eye phenotype, non-suppressible by bsf^NIG.10302R/Scer\GAL4^hs.2sev

(Llamusi et al., 2013)

Enhancer of

Statement

Reference

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of retina phenotype of Hsap\FUS^{R518K.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of retina phenotype of Hsap\FUS^{R521C.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Casci et al., 2019)

mbl^C.UAS, Scer\GAL4^GMR.PF is an enhancer of retina phenotype of Hsap\FUS^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Casci et al., 2019)

Suppressor of

Statement

Reference

mbl^C.UAS/Scer\GAL4^hs.PU is a suppressor | heat sensitive | partially of adult somatic muscle cell of thorax | heat sensitive phenotype of Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa

(Bargiela et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of mbl^C.Scer\UAS partially suppresses the decreased muscle area and increased autophagy, but not the increased apoptosis seen in flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^hs.PU in response to heat shock; but does not rescue the shortened lifespan of flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW.

(Bargiela et al., 2015)

Complementation and Rescue Data

Rescues

mbl^C.UAS rescues mbl^E27

(Pascual et al., 2010)

Partially rescues

mbl^C.UAS/Scer\GAL4^da.G32 partially rescues mbl^E16/mbl^E27

(Vicente et al., 2007)

mbl^C.UAS/Scer\GAL4^Mef2.PR partially rescues mbl^E16/mbl^E27

(Vicente et al., 2007)

mbl^C.UAS/Scer\GAL4^da.G32 partially rescues mbl^E16/mbl^E27

(Monferrer and Artero, 2006)

Comments

The embryonic lethality of mbl^E16/mbl^E27 animals is partially rescued by expression of mbl^C.Scer\UAS under the control of Scer\GAL4^da.G32; 70.9% of the embryos hatch.

The embryonic lethality of mbl^E16/mbl^E27 animals is only slightly rescued by expression of mbl^C.Scer\UAS under the control of Scer\GAL4^Mef2.PR; 9.1% of the embryos hatch.

(Vicente et al., 2007)

71.43% of mbl^E16/mbl^E27 embryos expressing mbl^C.Scer\UAS under the control of Scer\GAL4^da.G32 hatch into larvae (in contrast to 0% of mbl^E16/mbl^E27 embryos) and the hypercontracted abdomen phenotype is greatly reduced.

(Monferrer and Artero, 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

mbl^C.Scer\UAS

mbl^C.UAS

mm^C.Scer\UAS

Name Synonyms

Secondary FlyBase IDs

References (14)

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