FlyBase Allele Report: Zzzz\CTG[i480.UAS.cGa]

General Information

Symbol

Zzzz\CTG^i480.UAS.cGa

Species

a. artificial

Name

FlyBase ID

FBal0283029

Feature type

allele

Associated gene

Zzzz\CTG

Associated Insertion(s)

Carried in Construct

P{UAS-CTG.i480.G}

Also Known As

UAS-i(CTG)480, UAS-(CTG)₄₈₀, UAS-i(CTG)₄₈₀, UAS-CTG480

Transgenic product class

short_tandem_repeat_expansion

(Garcia-Lopez et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

short_tandem_repeat_expansion

(Garcia-Lopez et al., 2008)

Mutagen

in vitro construct

(Garcia-Lopez et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-CTG.i480.G}

Cytology

Description

UASt regulatory sequences drive expression of 480 CTG repeats, in which the repeats are interrupted every 20 CTG unit by the sequence CTCGA.

(Garcia-Lopez et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Zzzz\CTG

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of myotonic dystrophy type 1

CEA

(García-Puga et al., 2024, Zhang et al., 2018, Cerro-Herreros et al., 2016, Luu et al., 2016, Bargiela et al., 2015, Nguyen et al., 2015, Wong et al., 2014, García-López et al., 2011, Garcia-Lopez et al., 2008)

CEC

(Llamusi et al., 2013)

model of neurodegenerative disease

CEA

(Peng et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of myotonic dystrophy type 1

is ameliorated by Atg8a^VDRC.cUa

(Bargiela et al., 2015)

is ameliorated by mTor^UAS.cUa

(Bargiela et al., 2015)

is ameliorated by Atg4a^KK108570

(Bargiela et al., 2015)

is ameliorated by Diap1^UAS.cUa

(Bargiela et al., 2015)

is exacerbated by Diap1^UAS.cUa

(Bargiela et al., 2015)

is ameliorated by mbl^C.UAS

(Bargiela et al., 2015)

is ameliorated by Atg7^GD11671

(Bargiela et al., 2015)

is ameliorated by Atg9^GD2029

(Bargiela et al., 2015)

is ameliorated by Atg8a^RNAi.UAS.cUa

(Bargiela et al., 2015)

is ameliorated by mir-277^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

is ameliorated by mir-304^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

is ameliorated by TBPH^NIG.10327R

(Llamusi et al., 2013)

is ameliorated by Zzzz\ABP1^ABP1c.UAS

(García-López et al., 2011)

is ameliorated by Zzzz\ABP1^ABP1r.UAS

(García-López et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Garcia-Lopez et al., 2008)

DMPK:n.3_prime_UTR[480CUG,interrupted]

(FlyBase curators, 2019-)

Variants Synonym(s)

DMPK, (CTG)n REPEAT EXPANSION, 3-PRIME UTR

DMPK:n.3_prime_UTR[480CTG,interrupted]

Associated human disease model(s)

myotonic dystrophy 1

External database links

ClinVar: 5049

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

abnormal locomotor behavior | larval stage, with Scer\GAL4^how-24B

(Luu et al., 2016)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^how-24B

(Nguyen et al., 2015)

abnormal size | adult stage, with Scer\GAL4^GMR.PU

(Wong et al., 2014)

abnormal size | adult stage, with Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016, Bargiela et al., 2015)

abnormal size | adult stage | heat sensitive, with Scer\GAL4^hs.PU

(Bargiela et al., 2015)

decreased rate of adult locomotory behavior, with Scer\GAL4^Mhc.PW

(García-Puga et al., 2024)

flightless, with Scer\GAL4^Mhc.PW

(Garcia-Lopez et al., 2008)

increased cell death | adult stage, with Scer\GAL4^Mhc.PW

(Bargiela et al., 2015)

increased cell death | adult stage | heat sensitive, with Scer\GAL4^hs.PU

(Bargiela et al., 2015)

partially lethal - majority die | female limited | heat sensitive, with Scer\GAL4^103Y

(Garcia-Lopez et al., 2008)

short lived, with Scer\GAL4^da.PU

(Garcia-Lopez et al., 2008)

short lived, with Scer\GAL4^Mhc.PW

(García-Puga et al., 2024, Cerro-Herreros et al., 2016, Bargiela et al., 2015, Fernandez-Costa et al., 2013, Garcia-Lopez et al., 2008)

some die during pupal stage | female limited | heat sensitive, with Scer\GAL4^103Y

(Garcia-Lopez et al., 2008)

visible, with Scer\GAL4^GMR.PU

(Zhang et al., 2016, Llamusi et al., 2013, Garcia-Lopez et al., 2008)

visible, with Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

visible, with Scer\GAL4^vg.PU

(Llamusi et al., 2013)

visible | adult stage, with Scer\GAL4^GMR.PF

(Nguyen et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.PU

(Luu et al., 2016, Wong et al., 2014)

visible | progressive, with Scer\GAL4^Mhc.PW

(Garcia-Lopez et al., 2008)

Phenotype Manifest In

adult somatic muscle cell of thorax | heat sensitive, with Scer\GAL4^hs.PU

(Bargiela et al., 2015)

adult subretinal glial cell, with Scer\GAL4^GMR.PU

(Garcia-Lopez et al., 2008)

eye, with Scer\GAL4^GMR.PU

(Luu et al., 2016, Zhang et al., 2016, Llamusi et al., 2013, Garcia-Lopez et al., 2008)

eye, with Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

eye | adult stage, with Scer\GAL4^GMR.PF

(Nguyen et al., 2015)

eye | adult stage, with Scer\GAL4^GMR.PU

(Wong et al., 2014)

indirect flight muscle cell, with Scer\GAL4^Mhc.PW

(Bargiela et al., 2015, Llamusi et al., 2013)

indirect flight muscle cell | adult stage, with Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

indirect flight muscle cell | progressive, with Scer\GAL4^Mhc.PW

(Garcia-Lopez et al., 2008)

interommatidial bristle, with Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

ommatidium, with Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

rhabdomere, with Scer\GAL4^GMR.PU

(Garcia-Lopez et al., 2008)

wing, with Scer\GAL4^Mhc.PW

(Garcia-Lopez et al., 2008)

wing | heat sensitive, with Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Detailed Description

Statement

Reference

The expression of Zzzz\CTG^i480.UAS.cGa under the control of Scer\GAL4^Mhc.PW leads to significant decreases in lifespan, adult climbing ability and flight distance, associated with a significant decrease in indirect flight muscle area, as compared to controls.

(Cerro-Herreros et al., 2016)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^GMR.PU results in external eye morphological phenotypes, including disorganized ommatidia and mechanosensory bristles, resulting in a glossy eye phenotype.

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^how-24B results in significant defects in larval locomotion, as compared to controls.

(Luu et al., 2016)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^GMR.PU results in eye neurodegeneration.

(Zhang et al., 2016)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^hs.PU results in a significant decrease in muscle area in dorsoventral sections of the thorax, and increased apoptosis and autophagy in adult muscle after induction via heat shock, as compared with controls. The muscle atrophy phenotype reverts over time after the heat shock treatment, and at 5 days after heat shock there is no significant difference in muscle area as compared to controls.

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW results in decreased survival of adults, a significant reduction in indirect flight muscle area, and a significant increase in apoptosis and autophagy in adult muscle, as compared to controls.

(Bargiela et al., 2015)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^GMR.PF results in a glossy and rough eye phenotype in adults and impaired locomotion (crawling) in third instar larvae when expressed under the Scer\GAL4^how-24B driver compare to controls expressing the Zzzz\CTG^60.Scer\UAS transgene.

(Nguyen et al., 2015)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^GMR.PU results in glossy and rough eyes along with reduced size of the eye.

(Wong et al., 2014)

Adult flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW show strongly reduced median survival.

(Fernandez-Costa et al., 2013)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^GMR.PU results in small, rough eyes.

At 25[o]C, 100% of flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^vg.PU show altered wing morphology, with phenotypes ranging from small size and notches to puckered wings. At 22[o]C, only 75% of flies show wing defects.

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW results in loss of total muscle area in the indirect flight muscles.

(Llamusi et al., 2013)

Expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of either Scer\GAL4^da.G32 or Scer\GAL4^Mhc.PW leads to a reduction in adult lifespan, as compared to controls.

(Garcia-Lopez et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, enhanceable by Diap1^UAS.cUa, Scer\GAL4^Mhc.PW

(Bargiela et al., 2015)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, enhanceable by mir-1^UASp.cSa/Scer\GAL4^Mhc.PW

(Fernandez-Costa et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by mbl^RNAi.UAS/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by Dek^k09907/Dek[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^103Y, Zzzz\CTG^i480.UAS.cGa has partially lethal - majority die | pupal stage | female limited | heat sensitive phenotype, enhanceable by mbl[+]/mbl^E27

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by mbl^k07103/mbl^E27

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by Diap1⁴/th[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by svp¹/svp[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by l(2)k10502[+]/Letm1^k10502

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by vkg[+]/vkg^k00236

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, enhanceable by Ref1[+]/Ref1⁰²²⁶⁷

(Garcia-Lopez et al., 2008)

NOT Enhanced by

Statement

Reference

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, non-enhanceable by mbl[+]/mbl^k07103

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, non-enhanceable by tsu^EP567

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, non-enhanceable by vkg⁰¹²⁰⁹

(Garcia-Lopez et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage phenotype, suppressible by Scer\GAL4^Mhc.PW/mir-304^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has abnormal flight phenotype, suppressible by mir-277^{sponge.V2.UAS.mCherry}/Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has abnormal locomotor behavior | adult stage phenotype, suppressible by mir-277^{sponge.V2.UAS.mCherry}/Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has abnormal flight phenotype, suppressible by Scer\GAL4^Mhc.PW/mir-304^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has abnormal locomotor behavior | adult stage phenotype, suppressible by Scer\GAL4^Mhc.PW/mir-304^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, suppressible by mir-277^{sponge.V2.UAS.mCherry}/Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, suppressible by Scer\GAL4^Mhc.PW/mir-304^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage phenotype, suppressible by mir-277^{sponge.V2.UAS.mCherry}/Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by mbl^C.UAS/Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by Diap1^UAS.cUa, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive by mTor^UAS.cUa/Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by Diap1^UAS.cUa, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, suppressible | heat sensitive by mTor^UAS.cUa/Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg4a^KK108570, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg7^GD11671, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg8a^RNAi.UAS.cUa, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has abnormal size | adult stage | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg9^GD2029, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, suppressible by Scer\GAL4^Mhc.PW/mTor^UAS.cUa

(Bargiela et al., 2015)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, suppressible by mir-10^UAS.cGa/Scer\GAL4^Mhc.PW

(Fernandez-Costa et al., 2013)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by Hsap\MBNL1^UAS.cGCa, Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by mbl^k07103/mbl^E27

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by cnc[+]/cnc^j5E7

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by cnc[+]/cnc⁰³⁹²¹

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by Nurf-38^k16102/Nurf-38[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by l(3)j8B6[+]/l(3)j8B6^j8B6

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by foi[+]/foi^j8E8

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by l(2)k08011[+]/coro^k08011

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by Csk^j1D8/Csk[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by spin^k09905/spin[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by Diap1^EP3308, Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, suppressible by l(2)k05911^k05911/l(2)k05911[+]

(Garcia-Lopez et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, non-suppressible by Atg9^GD2029, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has short lived phenotype, non-suppressible by mbl^C.UAS/Scer\GAL4^Mhc.PW

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, non-suppressible by mbl^C.UAS/Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, non-suppressible by Atg4a^KK108570, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, non-suppressible by Atg7^GD11671, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has increased cell death | adult stage | heat sensitive phenotype, non-suppressible by Atg8a^RNAi.UAS.cUa, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, non-suppressible by mbl[+]/mbl^k07103

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, non-suppressible by tsu^EP567

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has visible phenotype, non-suppressible by vkg⁰¹²⁰⁹

(Garcia-Lopez et al., 2008)

Other

Statement

Reference

Mical^RNAi.UAS.cUa, Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has lethal phenotype

(Llamusi et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by mbl^RNAi.UAS/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Nlg3^NIG.1062R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Pak3^NIG.14895R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Pur-α^NIG.1507R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by lilli^NIG.8817R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by fd3F^NIG.12632R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by cpa^NIG.10540R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Arp6^NIG.11678R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by spn-F^NIG.12114R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by sn^NIG.1536R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by bsf^NIG.10302R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by CG11560^NIG.11560R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by trsn^NIG.11761R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by cag^NIG.12346R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Aplip1^NIG.1200R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Scer\GAL4^GMR.PU/Sil1^NIG.10420R

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by CG1092^NIG.1092R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by KCNQ^NIG.12215R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by Pak3^NIG.14895R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by Scer\GAL4^vg.PU/fd3F^NIG.12632R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by Arp6^NIG.11678R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by Scer\GAL4^vg.PU/spn-F^NIG.12114R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by sn^NIG.1536R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by CG11560^NIG.11560R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by trsn^NIG.11761R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by Scer\GAL4^vg.PU/cag^NIG.12346R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by Aplip1^NIG.1200R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, enhanceable by KCNQ^NIG.12215R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Dek^k09907/Dek[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by mbl^k07103/mbl^E27

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by svp¹/svp[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Diap1⁴/th[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by l(2)k10502[+]/Letm1^k10502

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by vkg[+]/vkg^k00236

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, enhanceable by Ref1[+]/Ref1⁰²²⁶⁷

(Garcia-Lopez et al., 2008)

NOT Enhanced by

Statement

Reference

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, non-enhanceable by mbl[+]/mbl^k07103

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, non-enhanceable by tsu^EP567

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, non-enhanceable by vkg⁰¹²⁰⁹

(Garcia-Lopez et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has indirect flight muscle cell | adult stage phenotype, suppressible by mir-277^{sponge.V2.UAS.mCherry}/Scer\GAL4^Mhc.PW

(Cerro-Herreros et al., 2016)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has indirect flight muscle cell | adult stage phenotype, suppressible by Scer\GAL4^Mhc.PW/mir-304^{sponge.V2.UAS.mCherry}

(Cerro-Herreros et al., 2016)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive | partially by mbl^C.UAS/Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive | partially by Diap1^UAS.cUa, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive by mTor^UAS.cUa/Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg4a^KK108570, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg7^GD11671, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg8a^RNAi.UAS.cUa, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^hs.PU, Zzzz\CTG^i480.UAS.cGa has adult somatic muscle cell of thorax | heat sensitive phenotype, suppressible | heat sensitive | partially by Atg9^GD2029, Scer\GAL4^hs.PU

(Bargiela et al., 2015)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Gαs^NIG.2835R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Hrd3^NIG.10221R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by tup^NIG.10619R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by hyx^NIG.11990R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by e(y)3^NIG.12238R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Him^NIG.15064R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by βTub60D^NIG.3401R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by capt^NIG.5061R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Scgδ^NIG.14808R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by bt^RNAi.UAS.cUa/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by zormin^RNAi.UAS.cUa/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Dcr-2^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by TBPH^NIG.10327R/Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Cyp6a17^NIG.10241R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by CG10341^NIG.10341R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Pvf3^NIG.13781R, Scer\GAL4^GMR.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Nlg3^NIG.1062R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Gαs^NIG.2835R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Hrd3^NIG.10221R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Pur-α^NIG.1507R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by lilli^NIG.8817R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by tup^NIG.10619R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by hyx^NIG.11990R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by e(y)3^NIG.12238R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Him^NIG.15064R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by βTub60D^NIG.3401R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Scer\GAL4^vg.PU/capt^NIG.5061R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by cpa^NIG.10540R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Scer\GAL4^vg.PU/Scgδ^NIG.14808R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Scer\GAL4^vg.PU/bt^RNAi.UAS.cUa

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Mical^RNAi.UAS.cUa, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Scer\GAL4^vg.PU/zormin^RNAi.UAS.cUa

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Dcr-2^RNAi.UAS.cUa, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by bsf^NIG.10302R/Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Scer\GAL4^vg.PU/TBPH^NIG.10327R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Scer\GAL4^vg.PU/Sil1^NIG.10420R

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by CG1092^NIG.1092R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Cyp6a17^NIG.10241R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by CG10341^NIG.10341R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^vg.PU, Zzzz\CTG^i480.UAS.cGa has wing phenotype, suppressible by Pvf3^NIG.13781R, Scer\GAL4^vg.PU

(Llamusi et al., 2013)

Scer\GAL4^Mhc.PW, Zzzz\CTG^i480.UAS.cGa has indirect flight muscle cell phenotype, suppressible by Scer\GAL4^Mhc.PW/TBPH^NIG.10327R

(Llamusi et al., 2013)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Hsap\MBNL1^UAS.cGCa, Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by mbl^k07103/mbl^E27

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by cnc[+]/cnc^j5E7

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by cnc[+]/cnc⁰³⁹²¹

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Nurf-38^k16102/Nurf-38[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by l(3)j8B6[+]/l(3)j8B6^j8B6

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by foi[+]/foi^j8E8

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by l(2)k08011[+]/coro^k08011

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Csk^j1D8/Csk[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by spin^k09905/spin[+]

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by Diap1^EP3308, Scer\GAL4^sev.PU

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, suppressible by l(2)k05911^k05911/l(2)k05911[+]

(Garcia-Lopez et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, non-suppressible by mbl[+]/mbl^k07103

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, non-suppressible by tsu^EP567

(Garcia-Lopez et al., 2008)

Scer\GAL4^sev.PU, Zzzz\CTG^i480.UAS.cGa has eye phenotype, non-suppressible by vkg⁰¹²⁰⁹

(Garcia-Lopez et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The decreases in lifespan, in adult climbing ability, in flight ability and in indirect flight muscle area induced by the expression of Zzzz\CTG^i480.UAS.cGa under the control of Scer\GAL4^Mhc.PW are partially suppressed by the co-expression of either mir-277^{sponge.V2.UAS.mCherry} or mir-304^{sponge.V2.UAS.mCherry}.

(Cerro-Herreros et al., 2016)

Co-expression of mbl^C.Scer\UAS partially suppresses the decreased muscle area and increased autophagy, but not the increased apoptosis seen in flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^hs.PU in response to heat shock; but does not rescue the shortened lifespan of flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW.

Co-expression of Diap1^Scer\UAS.cUa partially suppresses the decreased muscle area and increased autophagy and apoptosis seen in flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^hs.PU in response to heat shock; but enhances the shortened lifespan of flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW.

Co-expression of Tor^Scer\UAS.cUa fully suppresses the decreased muscle area and increased autophagy and apoptosis seen in flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^hs.PU in response to heat shock; and partially rescues the shortened lifespan of flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW.

Co-expression of Atg4a^KK108570, Atg7^GD11671, Atg8a^VDRC.cUa, or Atg9^GD2029 partially suppresses the decreased muscle area, but not the increased apoptosis seen in flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^hs.PU in response to heat shock.

(Bargiela et al., 2015)

The reduced median lifespan of adult flies expressing Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^Mhc.PW is worsened further by co-expression of mir-1^{Scer\UAS.P\T.cSa} and significantly improved by expression of mir-10^Scer\UAS.cGa. Expression of mir-7^{Scer\UAS.T:Disc\RFP-DsRed2} decreases the lifespan of Zzzz\CTG^{i480.Scer\UAS.cGa}-expressing flies too, though the effect is quite mild and attributable to the toxicity of mir-7^{Scer\UAS.T:Disc\RFP-DsRed2} expression even on its own.

(Fernandez-Costa et al., 2013)

Co-expression of mbl^{dsRNA.Scer\UAS} enhances the eye defects caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^GMR.PU : eyes are smaller and rougher and show ommatidial fusion and occasionally contain necrotic dots.

(Llamusi et al., 2013)

Co-expression of Hsap\MBNL1^{Scer\UAS.cGCa} suppresses the eye defects caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU.

The eye defects caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU are not significantly modified by mbl^k07103/+ or by mbl^E27/+, but are enhanced by mbl^k07103/mbl^E27.

The rough eye phenotype caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU is suppressed if the flies are also heterozygous for one of cnc^j5E7, cnc⁰³⁹²¹, Nurf-38^k16102, l(3)j8B6^j8B6, foi^j8E8, coro^k08011, l(2)k00808^k00808 or l(2)k05911^k05911.

Co-expression of th^EP3308 suppresses the rough eye phenotype caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU.

The rough eye phenotype caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU is enhanced if the flies are also heterozygous for one of svp¹, vkg^k00236, th⁴, Ref1⁰²²⁶⁷, Dek^k09907 or l(2)k10502^k10502.

tsu^EP567 has no effect on the rough eye phenotype caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU.

vkg⁰¹²⁰⁹ has no effect on the rough eye phenotype caused by expression of Zzzz\CTG^{i480.Scer\UAS.cGa} under the control of Scer\GAL4^sev.PU.

(Garcia-Lopez et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Zzzz\CTG^{i480.Scer\UAS.cGa}

Zzzz\CTG^i480.UAS.cGa

Name Synonyms

Secondary FlyBase IDs

References (20)

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