FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\spink09905
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General Information
Symbol
Dmel\spink09905
Species
D. melanogaster
Name
FlyBase ID
FBal0064248
Feature type
allele
Associated gene
Dmel\spin
Associated Insertion(s)
P{lacW}spink09905
Carried in Construct
Also Known As
l(2)k09905, Spin5, k09905
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}spink09905
Cytology
Description

P{lacW} insertion with the spin transcription unit.

(Sweeney and Davis, 2002)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neuronal ceroid lipofuscinosis
      CEA with spin10403
      (Hebbar et al., 2017)
      model of  sphingolipidosis
      CEA with spin10403
      (Hebbar et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike controls, spin10403/spink09905 and spin10403/spinDelta58 transheterozygotes accumulate lamellar/multi-lamellar whorls and lysosomes in the adult brain.

      (Hebbar et al., 2017)

      Homozygous larval instar eye imaginal discs show a number of defects in morphology and glial cell migration; in some cases glial cells are found anterior to the morphogenetic furrow and appear to migrate in a broad stream onto the eye imaginal disc, while in others, only a relatively thin stream of of glial cells overshoot anterior to the morphogenetic furrow. Hemizygous eye discs show defects where a duplication of the morphogenetic furrow and the corresponding field of photoreceptor neurons is seen at 90[o] to the normal eye field.

      (Yuva-Aydemir et al., 2011)

      65% of spinEP822/spink09905 stage 14 egg chambers show persisting nurse cell nuclei, compared to 7% in controls. 24% of egg chambers display a dumpless phenotype where nurse cell cytoplasm has not been transferred to the oocyte.

      77% of spink09905 germ line clone stage 14 egg chambers show persisting nurse cell nuclei. 14% of egg chambers display a dumpless phenotype where nurse cell cytoplasm has not been transferred to the oocyte.

      (Bass et al., 2009)

      Mutation is lethal at the pharate pupal stage. spink09905/+, spin10403/spink09905 and spink09905/Df(2R)Jp4 animals show a significant increase in bouton number at the larval neuromuscular junction (assayed at muscles 6/7 in hemisegment A3) compared to wild type. Quantal content at the neuromuscular junction is decreased by approximately 50% compared to wild type in spin10403/spink09905 animals. Quantal size is unaffected. Only 23% of spin10403/spink09905 animals are adult viable.

      (Sweeney and Davis, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Statement
      Reference

      spink09905/spin[+] is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Suppressor of
      Statement
      Reference

      spink09905/spin[+] is a suppressor of visible phenotype of Scer\GAL4sev.PU, Zzzz\CTGi480.UAS.cGa

      (Garcia-Lopez et al., 2008)
      Other
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      spink09905/spin[+] is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Suppressor of
      Statement
      Reference

      spink09905/spin[+] is a suppressor of eye phenotype of Scer\GAL4sev.PU, Zzzz\CTGi480.UAS.cGa

      (Garcia-Lopez et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of witA12, tkv7 or sax4 suppresses the increased bouton number seen at the neuromuscular junction in spin10403/spink09905 animals. spin10403/spink09905 animals which are also mutant for witA12/witB11, tkv7/tkvk16713 or sax4/Df(2R)cn7969 show a further decrease in bouton number, either to wild type or below wild type levels.

      (Sweeney and Davis, 2002)
      Xenogenetic Interactions
      Statement
      Reference

      spink09905 dominantly suppresses the rough eye phenotype caused by expression of Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4sev.PU.

      (Garcia-Lopez et al., 2008)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Complements: l(2)0507005070. Complements: spin10403. Complements: Rho1k02107b. Complements: bnchk02511. Complements: l(2)k15617k15617.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      References (12)