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FB2026_01
,
released March 12, 2026
benchwarmer, l(2)10403, l(2)k09905, diphthong, bnch
conserved transmembrane protein expressed in glia - mutants exhibit increased neural survival and altered sexual behavior - a putative lysosomal efflux permease with the hallmarks of a sugar transporter - essential for mTOR reactivation and lysosome reformation following prolonged starvation
Please see the JBrowse view of Dmel\spin for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.
Gene model reviewed during 5.50
Alternative translation stop created by use of multiphasic reading frames within coding region.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\spin using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
spin protein is detected ubiquitously in the larval eye disc, in vesicles within neurons and glial cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\spin in JBrowse2-77
2-81.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
spin is required both pre- and post-synaptically for normal synaptic growth at the neuromuscular junction.
Mutant females show strong rejection behaviour in response to male courtship. Mutants of both sexes show a decrease in viability and adult lifespan. Loss of spin gene function interferes with programmed cell death of neurons and nurse cells.
Identification: In a genetic screen for components of the muscle to nerve trans-synaptic signaling system.
spin may be a negative regulator of synaptic growth.
Loss-of-function mutations lead to an overgrowth of the neuromuscular synapse (50-150% increase in bouton number). Synaptic function is normal despite the large increase in synapse size.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation.
Mating behaviour of spin mutant females is studied.
bnch is an essential locus involved in PNS development.
Source for merge of: spin diphthong
Source for merge of: spin l(2)10403 l(2)k09905
Source for merge of: spin bnch l(2)W5
Source for merge of: spin CG8428
Source for merge of spin CG8428 was sequence comparison ( date:010104 ).
Some people may find "spinster" objectionable as a fly gene name because it is associated with a negative female stereotype.
The name 'benchwarmer' refers to the overall lower level of locomotor activity displayed by mutant adult escapers and honors athletes who play rarely and therefore sit on the bench.
