FlyBase Gene Report: Dmel\lqf

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\lqf

General Information

Symbol

Dmel\lqf

Species

D. melanogaster

Name

liquid facets

Annotation Symbol

CG8532

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028582

Gene Model Status

Stock Availability

19 publicly available

Gene Summary

liquid facets (lqf) encodes an epsin, which is an endocytic adaptor that contributes to endocytic network stability/regulation and membrane bending. It contributes to endocytosis and regulates the BMP and Notch signaling pathways. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Interactive Fly

Also Known As

Epsin, E(faf)bE25, l(3)S011027

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:7,528,780..7,540,012 [+]

Recombination map

3-21

RefSeq locus

NT_037436 REGION:7528780..7540012

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables clathrin binding

inferred from biological aspect of ancestor with PANTHER:PTN000263675

(GO Reference Genome Project, 2011-)

enables phospholipid binding

inferred from biological aspect of ancestor with PANTHER:PTN000263675

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in clathrin-dependent endocytosis

inferred from mutant phenotype

(Langridge and Struhl, 2017)

involved_in endocytosis

inferred from mutant phenotype

(Wang and Struhl, 2005, Overstreet et al., 2003)

involved_in macroautophagy

inferred from mutant phenotype

(Csikós et al., 2009)

involved_in negative regulation of cardioblast cell fate specification

inferred from mutant phenotype

(Tian et al., 2004)

involved_in positive regulation of BMP signaling pathway

inferred from genetic interaction with FLYBASE:wit; FB:FBgn0024179

(Vanlandingham et al., 2013)

involved_in positive regulation of Notch signaling pathway

inferred from mutant phenotype

(Xie et al., 2012, Windler and Bilder, 2010, Wang and Struhl, 2005)

inferred from genetic interaction with FLYBASE:Delta; FB:FBgn0000463,FLYBASE:N; FB:FBgn0004647

(Langridge and Struhl, 2017, Tian et al., 2004)

involved_in receptor-mediated endocytosis

inferred from mutant phenotype

(Csikós et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in endocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000263675

(GO Reference Genome Project, 2011-)

Cellular Component (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in autophagosome

inferred from direct assay

(Csikós et al., 2009)

located_in lysosome

inferred from direct assay

(Csikós et al., 2009)

located_in nuclear periphery

inferred from direct assay

(Csikós et al., 2009)

located_in postsynaptic membrane

inferred from direct assay

(Bao et al., 2008)

located_in presynaptic membrane

inferred from direct assay

(Bao et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of clathrin vesicle coat

inferred from biological aspect of ancestor with PANTHER:PTN000263675

(GO Reference Genome Project, 2011-)

is_active_in endosome

inferred from biological aspect of ancestor with PANTHER:PTN000263675

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000263675

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY

POSITIVE REGULATORS OF BMP SIGNALING PATHWAY

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

liquid facets (lqf) encodes an epsin, which is an endocytic adaptor that contributes to endocytic network stability/regulation and membrane bending. It contributes to endocytosis and regulates the BMP and Notch signaling pathways. [Date last reviewed: 2019-09-12]

Pathway (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
POSITIVE REGULATORS OF BMP SIGNALING PATHWAY -: Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.

Summary (Interactive Fly)

an epsin: a family of cargo-selective adapters that link mono-ubiquitinated cell-surface proteins with the endocytic machinery - regulates Notch ligand Delta's subcellular localization and activity

Interactive Fly

Gene Model and Products

Number of Transcripts

12

Number of Unique Polypeptides

7

Please see the JBrowse view of Dmel\lqf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VS85)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Antisense UTR: extended 3' UTR (one isoform) overlaps CDS of CG16998 on opposite strand.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0076795

4081

831

FBtr0076794

4146

824

FBtr0076797

4026

784

FBtr0076796

3968

824

FBtr0076798

4303

831

FBtr0112941

3606

640

FBtr0331833

3653

630

FBtr0331834

5759

784

FBtr0331835

3810

637

FBtr0331836

4183

791

FBtr0331837

3848

784

FBtr0331838

3475

630

Additional Transcript Data and Comments

Reported size (kB)

3.8, 3.6 (northern blot)

(Cadavid et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0076509

88.8

831

5.08

FBpp0076508

87.9

824

5.01

FBpp0089150

83.7

784

4.89

FBpp0076510

87.9

824

5.01

FBpp0089151

88.8

831

5.08

FBpp0111854

68.4

640

5.10

FBpp0304217

67.3

630

5.10

FBpp0304218

83.7

784

4.89

FBpp0304219

68.2

637

5.19

FBpp0304220

84.6

791

4.95

FBpp0304221

83.7

784

4.89

FBpp0304222

67.3

630

5.10

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

831 aa isoforms: lqf-PA, lqf-PE

824 aa isoforms: lqf-PB, lqf-PD

784 aa isoforms: lqf-PC, lqf-PH, lqf-PK

630 aa isoforms: lqf-PG, lqf-PL

Additional Polypeptide Data and Comments

Reported size (kDa)

784, 640 (aa)

(Cadavid et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lqf using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.54

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

(Cadavid et al., 2000)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval hypodermal muscle cell

• postsynaptic membrane

(Bao et al., 2008)

embryonic/larval hypodermal muscle cell

(Bao et al., 2008)

embryonic/larval motor neuron

• presynaptic membrane

(Bao et al., 2008)

embryonic/larval tracheal section

(Bao et al., 2008)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in autophagosome

inferred from direct assay

(Csikós et al., 2009)

located_in lysosome

inferred from direct assay

(Csikós et al., 2009)

located_in nuclear periphery

inferred from direct assay

(Csikós et al., 2009)

located_in postsynaptic membrane

inferred from direct assay

(Bao et al., 2008)

located_in presynaptic membrane

inferred from direct assay

(Bao et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lqf in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lqf

View exonic expression by tissue for Dmel\lqf

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028582

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38846/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028582

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028582

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028582

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8532

Flygut - An atlas of the Drosophila adult midgut

FBgn0028582

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 45 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lqf

Transgenic constructs containing regulatory region of lqf

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

(Csikós et al., 2009, Cadavid et al., 2000, Szeged Stock Center, 1998-, Deak et al., 1997, Fischer et al., 1997)

(Cadavid et al., 2000)

Gene partially disrupted in

Df(3L)CRIMIC-CR71051

(Gene Disruption Project members, 2018-)

(Koch et al., 2008)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

lqf^GD13955

lethal (with Df(3L)pbl-X1)

lqf^S011027

lethal | recessive

lethal - all die before end of pupal stage | recessive

lqf^S011027

lethal - all die during embryonic stage (with lqf^ARI)

lqf^L71

lethal - all die during embryonic stage (with lqf^L71)

lqf^ARI

partially lethal - majority live

lqf^7F1

lqf^FDD9

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

lqf^GD13955

viable, with Scer\GAL4^Mef2.PR

lqf^GD13955

viable, with Scer\GAL4^tin.CΔ4

lqf^GD13955

Other Phenotypes

Allele

abnormal developmental rate | heat sensitive, with Scer\GAL4^hs.PB

lqf^RNAi.UAS

neurogenic phenotype | embryonic stage

lqf^{UIM1.EA.ΔUIM2.GFP}

some die during embryonic stage (with lqf^ARI)

lqf^L71

some die during embryonic stage (with lqf^L71)

lqf^ARI

some die during pupal stage | recessive

lqf^S011027

visible | recessive | heat sensitive

lqf^FDD9

lqf^+t19G

Phenotype manifest in

Allele

dorsal vessel wall cell | increased number

embryonic/larval fat body

lqf^S011027

embryonic somatic muscle cell | dorsal

lqf^AG

lqf^{glrs.Tag:FLAG}

eye | heat sensitive

lqf^FDD9

eye photoreceptor cell

lqf^FDD9

eye photoreceptor cell & ommatidium | ectopic

lqf^FDD9

eye photoreceptor cell | cell non-autonomous | ectopic | somatic clone

lqf^FDD9

eye photoreceptor cell | somatic clone

lqf^ARI

leg sensillum | ectopic | heat sensitive

lqf^FDD9

lqf^L78A

mesothoracic tergum & chaeta | supernumerary

lqf^ARI

mesothoracic tergum & macrochaeta | supernumerary | somatic clone

lqf¹²²⁷

mitochondrial outer membrane

lqf^S011027

muscle cell of A1-7 dorsal acute muscle 1

lqf^AG

mystery cell | heat sensitive

lqf^FDD9

nurse cell | heat sensitive, with Scer\GAL4^hs.PB

lqf^RNAi.UAS

ommatidium | heat sensitive

lqf^FDD9

outer photoreceptor cell | ectopic

lqf^{glrs.Tag:FLAG}

photoreceptor cell R7

lqf^{glrs.Tag:FLAG}

photoreceptor neuron | ectopic | heat sensitive

lqf^FDD9

tarsal segment | heat sensitive

lqf^FDD9

wing | heat sensitive

lqf^FDD9

wing | somatic clone

lqf¹²²⁷

wing disc | larval stage

lqf^{UIM1.EA.ΔUIM2.GFP}

wing margin bristle | heat sensitive

lqf^FDD9

wing vein | heat sensitive

lqf^FDD9

wing vein | somatic clone

lqf¹²²⁷

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

13 of 14

Yes

Yes

1

12 of 14

No

Yes

2

11 of 14

No

Yes

1

4 of 14

No

Yes

2 of 14

No

No

1

1 of 14

No

Yes

1

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

13 of 14

Yes

Yes

2

11 of 14

No

Yes

11 of 14

No

Yes

5 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (7)

12 of 14

Yes

Yes

12 of 14

Yes

Yes

11 of 14

No

Yes

4 of 14

No

Yes

2 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (6)

10 of 13

Yes

Yes

9 of 13

No

Yes

4 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Danio rerio (Zebrafish) (9)

12 of 14

Yes

Yes

11 of 14

No

Yes

10 of 14

No

Yes

9 of 14

No

Yes

6 of 14

No

Yes

2 of 14

No

No

2 of 14

No

No

1 of 14

No

No

Drer\si:ch1073-340i21.3

1 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

10 of 14

Yes

Yes

2 of 14

No

No

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP007396

11 of 12

Yes

Yes

Agam\AgaP_AGAP004504

2 of 12

No

No

Arabidopsis thaliana (thale-cress) (6)

9 of 13

Yes

Yes

8 of 13

No

Yes

7 of 13

No

Yes

3 of 13

No

Yes

3 of 13

No

Yes

3 of 13

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (6)

11 of 13

Yes

Yes

11 of 13

Yes

Yes

4 of 13

No

Yes

3 of 13

No

Yes

3 of 13

No

Yes

1 of 13

No

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

9 of 12

Yes

Yes

Spom\SPCC794.11c

5 of 12

No

Yes

1 of 12

No

No

1 of 12

No

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lqf. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

13 of 14

12 of 14

11 of 14

ENTHD1; ENTH domain containing 1

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

(Overstreet et al., 2003)

(Overstreet et al., 2003)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, molecular weight estimation by staining

(Xie et al., 2012)

pull down, western blot

(Xie et al., 2012)

anti bait coimmunoprecipitation, western blot, pull down

(Xie et al., 2012, Koh et al., 2007)

pull down, western blot

(Xie et al., 2012)

anti tag coimmunoprecipitation, western blot

(Vanlandingham et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Cadavid et al., 2000)

enhanceable

(Eun et al., 2007)

enhanceable

(Cadavid et al., 2000)

enhanceable

(Eun et al., 2007, Cadavid et al., 2000)

enhanceable

(Tian et al., 2004)

suppressible

(Cadavid et al., 2000)

enhanceable

(Tian et al., 2004)

enhanceable

(Overstreet et al., 2004, Tian et al., 2004)

suppressible

(Cadavid et al., 2000)

suppressible

(Cho and Fischer, 2011)

enhanceable

(Eun et al., 2007)

enhanceable

(Cadavid et al., 2000)

enhanceable

(Eun et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Banks et al., 2011)

suppressible

(Banks et al., 2011)

suppressible

(Troost et al., 2023)

enhanceable

(Troost et al., 2023, Tian et al., 2004)

enhanceable

(Cadavid et al., 2000, Fischer et al., 1997)

suppressible

(Cadavid et al., 2000)

enhanceable

(Tian et al., 2004)

suppressible

(Cho and Fischer, 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64283

DroID - A comprehensive database of gene and protein interactions.

FBgn0028582

MIST (genetic) - An integrated Molecular Interaction Database

38846

MIST (protein-protein) - An integrated Molecular Interaction Database

38846

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY
POSITIVE REGULATORS OF BMP SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JNM3

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-21

Cytogenetic map

Sequence location

3L:7,528,780..7,540,012 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66A4-66A5

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66A-66A

(Lloyd et al., 2000)

66A3-66A4

(Cadavid, 1999.6.20)

66A-66A

(determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

3-21

(FlyBase, 2016)

3-17.6

(Comeron et al., 2012)

Left of (cM)

P{lacW}l(3)s5277^s5277

(Cadavid et al., 2000)

Right of (cM)

P{lacW}smid^j8A6

(Cadavid et al., 2000)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

25104

w^*; P{UASp-FLAG.lqf}3

57350

w^*; P{UAS-lqf.GFP.F}2

27522

y¹ v¹; P{TRiP.JF02672}attP2

81739

y¹ v¹; P{TKO.GS04676}attP40

90936

lqf^L71 P{neoFRT}80B/TM3, Sb¹

25106

w^*; lqf^ARI/TM6B, Tb¹

58130

y¹ v¹; P{TRiP.HMJ22079}attP40

92516

y¹ v¹; P{U6.2-lqf.dgRNA}attP40

57351

w^*; P{UAS-lqf.GFP.F}3/TM6B, Tb¹

8532R-1

v107300

P{KK108022}VIE-260B

v35948

w¹¹¹⁸; P{GD13955}v35948/TM3

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (78)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI19443

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028582

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028582

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Csikós et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

lqf is required for normal bulk endocytosis of Ser.

(Wang and Struhl, 2005)

lqf inhibits cardioblast development and promotes the development of fusion-competent myoblasts during embryonic development.

(Tian et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

The ENTH domain of lqf alone, and the ENTH-less remainder of lqf both have significant ability to function in Dl internalisation.

(Overstreet et al., 2003)

lqf functions in endocytosis of Dl in the developing eye.

(Overstreet et al., 2003)

lqf is ubiquitinated in vivo and is deubiquitinated by faf.

(Chen et al., 2002)

Area matching Drosophila EST AI259816. This EST has sequence similarity to Human Epsin gene.

(Davies, 2001.3.15)

faf and lqf facilitate endocytosis and antagonise ubiquitination. They function in common cells to generate an inhibitory signal that prevents ectopic photoreceptor cell determination.

(Cadavid et al., 2000)

Relationship to Other Genes

Source for database merge of

Source for merge of: lqf E(faf)bE25 l(3)S011027

(Cadavid et al., 2000)

Source for merge of: lqf anon-WO0118547.239

(FlyBase, 1996-)

Additional comments

Source for merge of lqf anon-WO0118547.239 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

The gene is named "liquid facets" after the appearance of the sectioned retina in clones of cells homozygous for lqf^BT.

(Cadavid et al., 2000)

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

0110/27

(Deak et al., 1997)

CG8532

(Trivedi et al., 2020, Jiang et al., 2016, Balakrishnan et al., 2015, Hosono et al., 2015, Fukuoh et al., 2014, Azad et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Norga et al., 2003, Verstreken and Bellen, 2000.9.4)

E(faf)bE25

(Fischer et al., 1997)

Epsin

(Pinot and Le Borgne, 2024, Papagiannouli, 2022, Hossain et al., 2008, Verstreken and Bellen, 2006, Kanwar and Fortini, 2004, Jafar-Nejad et al., 2002)

Iqf

(Yu et al., 2020)

LqF

(De Camilli et al., 2002)

Lqf

(Kamalesh et al., 2021, Bandyopadhyay et al., 2016, Franco et al., 2011, Mudiganti et al., 2010, Saj et al., 2010, Perdigoto et al., 2008, Vaccari et al., 2008, Xie, 2008, Koh et al., 2007, Eun and Fischer, 2006, Lee et al., 2006, Overstreet et al., 2003)

anon-WO0118547.239

dEpsin

(Ing et al., 2007)

epsin

(Oldham et al., 2002)

l(3)S011027

(Szeged Stock Center, 1998-)

lqf

(Hendricks and Liebl, 2024, Li et al., 2024, Troost et al., 2023, Parkhitko et al., 2021, Uçkun et al., 2021, Yu et al., 2020, Hunter et al., 2019, Meltzer et al., 2019, Raza et al., 2019, Swevers et al., 2018, Langridge and Struhl, 2017, Solis et al., 2017, Transgenic RNAi Project members, 2017-, Murtaza et al., 2015, Rister et al., 2015, Fischer, 2014.9.4, Martins et al., 2014, Zacharioudaki and Bray, 2014, Fleming et al., 2013, Strutt et al., 2013, Vanlandingham et al., 2013, Younger et al., 2013, Azad et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Xie et al., 2012, Banks et al., 2011, Cho and Fischer, 2011, Benhra et al., 2010, Windler and Bilder, 2010, Csikós et al., 2009, Hazelett et al., 2009, Weake et al., 2009, Bao et al., 2008, Eun et al., 2008, Fischer, 2008.8.15, Koch et al., 2008, Vaccari et al., 2008, Korolchuk et al., 2007, Jaekel and Klein, 2006, Millard and Wood, 2006, Polo and Di, 2006, Yang et al., 2005, Stanyon et al., 2004, Wang and Struhl, 2004)

Name Synonyms

Drosophila epsin

(Millard and Wood, 2006)

Enhancer of faf bE25

(Fischer et al., 1997)

Epsin

(Langridge and Struhl, 2017, Zacharioudaki and Bray, 2014, Koh et al., 2007, Wang and Struhl, 2004)

Epsin 1

(Bao et al., 2008)

Epsin1/Liquid facets

(Vanlandingham et al., 2013)

Liquid facets

(Saj et al., 2010, Bao et al., 2008, Perdigoto et al., 2008, Vaccari et al., 2008, Xie, 2008, Murphey and Godenschwege, 2002)

Liquid-Facets

(Bandyopadhyay et al., 2016)

epsin

(Langridge and Struhl, 2017, Banks et al., 2011, Csikós et al., 2009)

liquid facets

(Latcheva et al., 2019, Banks et al., 2011, Benhra et al., 2010, Csikós et al., 2009, Weake et al., 2009, Eun et al., 2007, Millard and Wood, 2006)

Secondary FlyBase IDs

FBgn0022808
FBgn0028209
FBgn0062152

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 93 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38846

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VS85

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VS85

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028582

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38846/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028582

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028582

FlyMine - An integrated database for Drosophila genomics

FBgn0028582

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8532

MARRVEL_MODEL - MARRVEL (model organism gene)

38846

Linkouts

BioGRID - A database of protein and genetic interactions.

64283

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028582

DroID - A comprehensive database of gene and protein interactions.

FBgn0028582

DRSC - Results frm RNAi screens

FBgn0028582

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028582

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028582

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8532

Flygut - An atlas of the Drosophila adult midgut

FBgn0028582

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028582

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005393

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

MIST (genetic) - An integrated Molecular Interaction Database

38846

MIST (protein-protein) - An integrated Molecular Interaction Database

38846

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JNM3

References (137)