l(3)64Aa, STK-D, SE20
type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction - modulates the probability of neurotransmitter release and readily releasable pools
Please see the JBrowse view of Dmel\wit for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wit using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Embryonic expression first observed at stage 11, primarily in the CNS and in the labral sensory complex primordia of the PNS; expression in restricted clusters of cells. Expression in CNS expands to include more cells and continues to end of embryogenesis. In stage 14 embryos, also expressed is scattered cells in the dorsal closure furrow. In stage 16 embryos, also expressed in the 'furrows' (constrictions?) of the developing midgut.
Expressed specifically in the nervous system from embryonic stages until third instar larvae. In embryos from stage 13 high levels of expression in the CNS, in later embryos highest in motor neurons; weak expression in sensory neurons of the PNS. In larvae, expressed in brain from first through third instars; expression in ventral nerve cord ceases during third instar. Expression also observed in all imaginal discs.
JBrowse - Visual display of RNA-Seq signals
View Dmel\wit in JBrowse3-10
3-8.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
wit appears to function as a presynaptic receptor that regulates synaptic size at the neuromuscular junction.
wit has a role in neuromuscular junction synapse assembly and activity.
Source for merge of: wit l(3)64Aa
Source for merge of: wit Stk-D
Source for merge of: wit SE20
Source for merge of: wit l(3)S126215
Source for merge of: wit CG10776
Source for merge of wit CG10776 was sequence comparison ( date:000401 ).
