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FB2026_01
,
released March 12, 2026
F-BAR proteins involved in regulation of membrane curvature and dynamics - regulation of dynamin-dependent endocytosis of E-cadherin during oogenesis - Cip4 acts downstream of Cdc42 to activate the WASP-WAVE-Arp2/3 pathway in the notum and the wing epithelium - Nostrin makes contact with microtubules through the kinesin Khc-73 for trafficking of recycling endosomes
Please see the JBrowse view of Dmel\Cip4 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cip4 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Cip4 protein is expressed at the cell borders in early embryos. From stage 13 to 16 it labels the brain, ventral midline and the surface epithelium, and the salivary glands in the latter stage only. In third instar larva it localises to the synaptic domains of the central nervous system. At the neuromuscular junction Cip4 is present at the postsynaptic domain of glutamatergic type I boutons.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Cip4 in JBrowse3-12
3-9.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Source for merge of: Cip4 CG11341
Release 1 annotation CG11341 corresponds to part of the release 3.2 annotation for Cip4 (CG15015).
Source for identity of: Cip4 CG15015
