F-BAR proteins involved in regulation of membrane curvature and dynamics - regulation of dynamin-dependent endocytosis of E-cadherin during oogenesis - Cip4 acts downstream of Cdc42 to activate the WASP-WAVE-Arp2/3 pathway in the notum and the wing epithelium - Nostrin makes contact with microtubules through the kinesin Khc-73 for trafficking of recycling endosomes
merge of CG15364, CG33224, and CG4040
Gene merge (multiple) based on EST/cDNA data.
RNA-Seq data support multiple isoforms with extended 3' UTRs of differing length, some of which appear to be stage and/or tissue specific.
Gene model reviewed during 5.45
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nost using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Nost in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Nost CG42388
Source for merge of: CG33224 CG4040 CG15364
Annotations CG33224, CG4040 and CG15364 merged as CG42388 in release 5.11 of the genome annotation.
The 5' part of release 2 annotation CG4040 (which was deleted in the release 3.1 version of CG4040) has been restored as a distinct annotation, CG33224, in release 3.2 of the genome annotation.
Named 'Nostrin' after the human ortholog.