FlyBase Gene Report: Dmel\Exn

General Information

Symbol

Dmel\Exn

Species

D. melanogaster

Name

Ephexin

Annotation Symbol

CG42665

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261547

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

Ephexin (Exn) encodes a Eph-specific RhoGEF involved olfactory map formation. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

BcDNA:GH03693

Key Links

Genomic Location

Cytogenetic map

73E1-73E2

Sequence location

3L:16,970,013..16,994,388 [+]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:16970013..16994388

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from electronic annotation with InterPro:IPR000219, InterPro:IPR047271

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with FLYBASE:RhoGEF4; FB:FBgn0035761

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN002656129

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Greenberg and Hatini, 2011)

involved_in melanotic encapsulation of foreign target

inferred from mutant phenotype

(Howell et al., 2012)

involved_in regulation of neurotransmitter secretion

inferred from genetic interaction with FLYBASE:GluRIIA; FB:FBgn0004620,FLYBASE:cac; FB:FBgn0263111

(Frank et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in positive regulation of Rho protein signal transduction

inferred from sequence or structural similarity with FLYBASE:RhoGEF4; FB:FBgn0035761

(Gene Ontology Curators, 2002-)

involved_in regulation of actin cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN002656129

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in neuromuscular junction

inferred from direct assay

(Frank et al., 2009)

colocalizes_with presynaptic membrane

inferred from direct assay

(Frank et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Ephexin (Exn) encodes a Eph-specific RhoGEF involved olfactory map formation. [Date last reviewed: 2019-08-01]

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Exn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VVC6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Exn-RA

FBtr0302649

NM_140685

3499

1051

Exn-RB

FBtr0302647

NM_168705

3506

1051

Exn-RC

FBtr0302648

NM_168706

3475

1051

Exn-RD

FBtr0302650

NM_001202194

6887

2029

Exn-RE

FBtr0302651

NM_001104160

6987

2029

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Exn-PA

FBpp0291789

117.3

1051

7.57

FBpp0291787

117.3

1051

7.57

FBpp0291788

117.3

1051

7.57

FBpp0291790

225.0

2029

7.41

FBpp0291791

225.0

2029

7.41

Q9VVC6

NP_001097630

AAF49387

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1051 aa isoforms: Exn-PA, Exn-PB, Exn-PC

2029 aa isoforms: Exn-PD, Exn-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Exn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.18

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | faint | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 11 -- 12

clypeo-labral primordium

(Fisher et al., 2012)

epipharynx primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic epipharynx

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

prepupal stage P3

leg joint

(Greenberg and Hatini, 2011)

primary tracheal branch

(Greenberg and Hatini, 2011)

Additional Descriptive Data

Exn expression in stage P3 pupal leg discs is observed in the leg joints. The expression spans the joints and several cell diameters proximal and distal to the joint. Expression is also observed in the primary tracheal tube at the periphery of the leg.

(Greenberg and Hatini, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in neuromuscular junction

inferred from direct assay

(Frank et al., 2009)

colocalizes_with presynaptic membrane

inferred from direct assay

(Frank et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Exn in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Exn

View exonic expression by tissue for Dmel\Exn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261547

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39900/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261547

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261547

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3799

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Exn

Transgenic constructs containing regulatory region of Exn

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel7253

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Exn^GD8211

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Exn^GD11079

Other Phenotypes

Allele

abnormal immune response | larval stage

Exn^EY01953

abnormal neurophysiology | recessive | third instar larval stage

Exn^EY01953

increased size | adult stage, with Scer\GAL4^Ser.PGF

Phenotype manifest in

Allele

wing posterior compartment, with Scer\GAL4^Ser.PGF

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (56)

Hsap\NGEF

8 of 14

Yes

Hsap\ARHGEF15

6 of 14

Yes

Hsap\ARHGEF26

6 of 14

Yes

Hsap\ARHGEF5

5 of 14

Yes

Hsap\ARHGEF16

5 of 14

Yes

Hsap\ARHGEF19

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Ngef

8 of 14

Yes

Rnor\Arhgef15

6 of 14

Yes

Rnor\Arhgef26

6 of 14

Yes

Rnor\Arhgef16

5 of 14

Yes

Rnor\Arhgef19

5 of 14

Yes

Rnor\Arhgef5

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Spata13

1 of 14

Rnor\Vav2

1 of 14

Mus musculus (laboratory mouse) (35)

Mmus\Ngef

8 of 14

Yes

Mmus\Arhgef26

6 of 14

Yes

Mmus\Arhgef5

5 of 14

Yes

Mmus\Arhgef15

5 of 14

Yes

Mmus\Arhgef16

5 of 14

Yes

Mmus\Arhgef19

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Spata13

1 of 14

Mmus\Vav2

1 of 14

Xenopus tropicalis (Western clawed frog) (30)

Xtro\ngef

6 of 13

Yes

Xtro\arhgef26

4 of 13

Yes

Xtro\LOC116409847

4 of 13

Yes

Xtro\arhgef16

2 of 13

Yes

Xtro\asb13

2 of 13

Yes

Xtro\arhgef3.1

1 of 13

Yes

Xtro\arhgef4

1 of 13

Xtro\arhgef5

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\arhgef38

1 of 13

Yes

Xtro\c16orf87

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\prex1

1 of 13

Yes

Xtro\prex2

1 of 13

Xtro\rasgrf2

1 of 13

Yes

Xtro\rps6ka1

1 of 13

Xtro\trio

1 of 13

Danio rerio (Zebrafish) (45)

Drer\ngef

8 of 14

Yes

Drer\arhgef15b

7 of 14

Yes

Drer\arhgef15a

6 of 14

Yes

Drer\arhgef19

5 of 14

Yes

Drer\si:ch73-15b2.5

5 of 14

Yes

Drer\arhgef16

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-172h23.2

1 of 14

Drer\spata13

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\ephx-1

6 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP007452

8 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\ROM1

2 of 13

Yes

Scer\ROM2

2 of 13

Yes

Scer\NBP2

1 of 13

Scer\TUS1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\rgf1

2 of 12

Yes

Spom\rgf2

2 of 12

Yes

Spom\rgf3

2 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Exn. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (18)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Abi

1 of 13

CAP

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

pbl

1 of 13

POSH

1 of 13

RhoGEF3

1 of 13

sif

1 of 13

Vav

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Exn^EP3042

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NGEF; neuronal guanine nucleotide exchange factor

8 of 14

605991

ARHGEF15; Rho guanine nucleotide exchange factor 15

6 of 14

608504

BRAIN SMALL VESSEL DISEASE 5 WITH OSTEOPOROSIS; BSVD5

ARHGEF26; Rho guanine nucleotide exchange factor 26

6 of 14

617552

ARHGEF5; Rho guanine nucleotide exchange factor 5

5 of 14

600888

ARHGEF16; Rho guanine nucleotide exchange factor 16

5 of 14

618871

ARHGEF19; Rho guanine nucleotide exchange factor 19

5 of 14

612496

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Exn - Eph

two hybrid

(Frank et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

GluRIIA

suppressible

Exn|Eph

(Frank et al., 2009)

Psi

suppressible

Exn

(Zaytseva et al., 2023)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261547

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9Y150

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

73E1-73E2

Sequence location

3L:16,970,013..16,994,388 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

73E1-73E2

Limits computationally determined from genome sequence between P{PZ}Baldspot⁰²²⁸¹ and P{PZ}blot⁰¹⁶⁵⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-39.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17081

w¹¹¹⁸; P{EP}Exn^EP3042

37679

y¹ w^*; Mi{MIC}Exn^MI04469

44751

y¹ w^*; Mi{MIC}Exn^MI08123

52141

y¹ w^*; Mi{MIC}Exn^MI09202

15385

y¹ w^67c23; P{EPgy2}Exn^EY01953

17610

y¹ w^67c23; P{EPgy2}Exn^EY09825

83997

y¹ sc^* v¹ sev²¹; P{TKO.GS04107}attP40

NIG-Fly

3799R-3

P{NIG.3799R}3

14060R-3

P{NIG.14060R}3

HMJ21018

y¹ v¹; P{TRiP.HMJ21018}attP40/CyO

VDRC

v101144

P{KK104025}VIE-260B

v105885

P{KK100378}VIE-260B

More stocks available...

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (40)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261547

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261547

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.

(Junger et al., 2003)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG14060 Exn

(FlyBase Genome Annotators, 2010)

Additional comments

Annotations CG14060, CG3799 merged as CG42665 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Name Synonyms

CG3799

Ephexin

(Frank, 2014, Greenberg and Hatini, 2011, Williams, 2007.1.31)

ephexin

(Rothenberg et al., 2023, Frank et al., 2009)

Secondary FlyBase IDs

FBgn0027593
FBgn0036683

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39900

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VVC6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VVC6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261547

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39900/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261547

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261547

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42665

MARRVEL_MODEL - MARRVEL (model organism gene)

39900

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261547

DroID - A comprehensive database of gene and protein interactions.

FBgn0261547

DRSC - Results frm RNAi screens

FBgn0261547

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261547

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3799

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0261547

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011886

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9Y150

References (66)

The following external sites may use different assemblies or annotations than FlyBase.

-1.18

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