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FB2026_01
,
released March 12, 2026
splice factor that regulates the thermosensitive alternative splicing of timeless (tim) - AGO1 interacts with Psi to repress Myc transcription and inhibit developmental cell and tissue growth - Psi interacts with the mediator complex to modulate MYC transcription - Psi interaction with the U1 small nuclear ribonucleoprotein complex (snRNP) controls male courtship behavior by regulation splicing for fruitless - regulates splicing of the P-element transposase pre-mRNA by binding a pseudo-splice site upstream of the authentic splice site
Please see the JBrowse view of Dmel\Psi for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 3' UTR.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.33
6.5-7.0, 4.2, 2.8 (northern blot)
796 (aa); 97 (kD)
97 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Psi using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reference states 2-8 hr AEL
Isoform-specific expression patterns are observed. Sex-specific expression of alternative transcripts observed.
The 4.2kb Psi transcript is most highly expressed between 2 and 8 hours of embryogenesis and in somatic tissue culture cells. Lower levels are observed throughout development. Low levels are observed in ovaries and early embryos. The 6.5kb transcript is expressed weakly with the same pattern.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Psi in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Psi is required for viability, male fertility and cellular mRNA processing.
Psi is a tissue-specific regulator of IVS3 splicing in vivo.
Biochemical assays for RNA binding protein detect a 97kD protein, Psi, that interacts specifically with P-element 5' exon sequences previously implicated in the control of intron 3 (IVS3) splicing in vivo. Inhibition of IVS3 splicing in vivo can be correlated with binding of the 97kD protein to the 5' exon sequence as it preferentially interact with IVS3 and RNA that binds with the 97kD protein relieves inhibition of IVS3 splicing. IVS3 is not spliced in somatic Drosophila splicing extracts, but is accurately spliced in human cell extracts and when microinjected in Xenopus oocytes.
