FlyBase Gene Report: Dmel\ps

General Information

Symbol

Dmel\ps

Species

D. melanogaster

Name

pasilla

Annotation Symbol

CG42670

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261552

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

pasilla (ps) encodes a nuclear RNA binding protein implicated in splicing. It is expressed at high levels in the embryonic salivary gland and other tissues. Loss of function results in a significant reduction in secretory volume and secretory vesicles in the salivary gland and irregular gland morphology. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

l(3)10615

Key Links

Genomic Location

Cytogenetic map

85D16-85D17

Sequence location

3R:9,417,940..9,455,500 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:9417940..9455500

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables pre-mRNA intronic binding

inferred from direct assay

(Gill et al., 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000032600

(GO Reference Genome Project, 2011-)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR004087

(InterPro Project Members, 2004-)

enables RNA binding

inferred from electronic annotation with InterPro:IPR004088, InterPro:IPR036612

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in positive regulation of RNA splicing

inferred from direct assay

(Gill et al., 2017)

involved_in regulation of alternative mRNA splicing, via spliceosome

inferred from mutant phenotype

(Park et al., 2004)

inferred from high throughput mutant phenotype

(Park et al., 2004)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in mRNA splicing, via spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000815734

(GO Reference Genome Project, 2011-)

involved_in regulation of alternative mRNA splicing, via spliceosome

inferred from biological aspect of ancestor with PANTHER:PTN000815734

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Seshaiah et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000032600

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000032600

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion (By similarity). Plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance (PubMed:28525754).

(UniProt, A0A0B4KGY6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\ps for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KGY6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

ps-RB

FBtr0082037

NM_169283

4508

475

ps-RC

FBtr0082039

NM_169285

2619

561

ps-RD

FBtr0082038

NM_169284

2685

583

ps-RF

FBtr0111027

NM_001043227

3538

572

ps-RG

FBtr0111028

NM_169281

3301

572

ps-RH

FBtr0111029

NM_169280

3736

572

ps-RI

FBtr0111030

NM_001043226

4635

519

ps-RJ

FBtr0111031

NM_001043232

2558

539

ps-RK

FBtr0111032

NM_001043230

10086

550

ps-RL

FBtr0302691

NM_001202271

3964

758

ps-RM

FBtr0302694

NM_001202273

3238

550

ps-RN

FBtr0302692

NM_001202270

10124

572

ps-RO

FBtr0302693

NM_001202274

3514

572

ps-RP

FBtr0302695

NM_001202272

3472

550

ps-RQ

FBtr0334303

NM_001275485

2492

517

ps-RR

FBtr0334304

NM_001275486

3624

780

ps-RS

FBtr0344283

NM_001300323

10080

594

ps-RT

FBtr0344284

NM_001300324

2889

616

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

ps-PB

FBpp0081515

49.3

475

6.79

FBpp0081517

58.8

561

8.67

FBpp0081516

61.2

583

7.62

FBpp0110326

59.7

572

6.59

FBpp0110327

59.7

572

6.59

FBpp0110328

59.7

572

6.59

FBpp0110329

54.4

519

6.74

FBpp0110330

56.1

539

7.88

FBpp0110331

57.3

550

7.22

FBpp0291831

79.0

758

7.33

FBpp0291834

57.3

550

7.22

FBpp0291832

59.7

572

6.59

FBpp0291833

59.7

572

6.59

FBpp0291835

57.3

550

7.22

FBpp0306418

53.7

517

8.87

FBpp0306419

81.4

780

6.93

FBpp0310688

60.9

594

8.05

FBpp0310689

63.3

616

7.04

A0A0B4LI06

NP_001287253

AHN57252

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

572 aa isoforms: ps-PF, ps-PG, ps-PH, ps-PN, ps-PO

550 aa isoforms: ps-PK, ps-PM, ps-PP

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain.

(UniProt, A0A0B4KGY6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ps using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.16

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

amnioserosa primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

garland cell primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

fat body/gonad primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

Additional Descriptive Data

Isoform-specific expression patterns are observed. Sex-specific expression of alternative transcripts observed.

(Telonis-Scott et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 14

presumptive embryonic salivary gland

(Abrams and Andrew, 2005)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleus

inferred from direct assay

(Seshaiah et al., 2001)

Expression Deduced from Reporters

Reporter: P{GawB}DJ761

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval midgut enterocyte

Comment: anterior

(Lajeunesse et al., 2010)

adult stage

(Seroude, 2004.4.29)

Reporter: PBac{602.P.SVS-1}ps^CPTI000668

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

Reporter: PBac{602.P.SVS-1}ps^CPTI001063

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

Reporter: PBac{681.P.FSVS-1}ps^CPTI001261

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

spermatogenesis

primary spermatocyte

(Lowe et al., 2014)

Y chromosome loop

(Lowe et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ps in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ps

View exonic expression by tissue for Dmel\ps

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261552

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44258/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261552

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261552

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 30 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ps

Transgenic constructs containing regulatory region of ps

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene duplicated in

Tp(3;2)by62

(Seshaiah et al., 2001)

Gene disrupted in

Df(3R)by10

(Seshaiah et al., 2001)

Df(3R)by416

(Seshaiah et al., 2001)

Df(3R)GB104

(Seshaiah et al., 2001)

Gene not disrupted in

Tp(3;2)by62

(Seshaiah et al., 2001)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

ps^GD9202

lethal, with Scer\GAL4^VP16.otu

ps^HMS00310

lethal | female limited, with Scer\GAL4^dome-PG14

ps^HMS00310

lethal | pupal stage, with Scer\GAL4^pnr-MD237

ps^GD9202

lethal | recessive

ps¹⁰⁶¹⁵

lethal - all die before end of larval stage

ps^ΔMG

partially lethal - majority die, with Scer\GAL4^nub-AC-62

ps^HMS00310

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

ps^GD13818

Other Phenotypes

Allele

abnormal memory | adult stage

ps^ΔRLTS

abnormal sleep | adult stage | male, with Scer\GAL4^elav.PLu

ps^KK113243

visible, with Scer\GAL4^nub-AC-62

ps^HMS00310

Phenotype manifest in

Allele

amnioserosa

ps^unspecified

germ band

ps^unspecified

presumptive embryonic salivary gland

wing, with Scer\GAL4^nub-AC-62

ps^HMS00310

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\NOVA1

12 of 14

Yes

Hsap\NOVA2

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Nova1

13 of 14

Yes

Rnor\Nova2

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Nova1

12 of 14

Yes

Mmus\Nova2

10 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\nova2

10 of 13

Yes

Xtro\nova1

9 of 13

Yes

Xtro\aipl1

1 of 13

Yes

Xtro\aurkaip1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (15)

Drer\nova1

12 of 14

Yes

Drer\nova2

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (9)

Cele\nova-1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP002896

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (15)

Atha\BTR1L

9 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\PBP2

3 of 13

Yes

Scer\HEK2

2 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\rnc1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ps. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

mub

4 of 13

HnRNP-K

3 of 13

Imp

3 of 13

Psi

3 of 13

CG7878

1 of 13

Dp1

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

ps³

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

ps^j449

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NOVA1; NOVA alternative splicing regulator 1

12 of 14

602157

NOVA2; NOVA alternative splicing regulator 2

12 of 14

601991

NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT AUTISTIC FEATURES AND/OR STRUCTURAL BRAIN ABNORMALITIES; NEDASB

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

ps - orb2

pull down, anti tag western blot, electrophoretic mobility shift assay, autoradiography

(Gill et al., 2017)

ps - stau

anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization

(Laver et al., 2013)

protein-protein

Physical Interaction

Assay

References

ps - Rbp1-like

two hybrid

(Hu et al., 2017.6.13)

ps - msi

experimental knowledge based

(Guruharsha et al., 2011)

ps - p38a

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

ps - p38b

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

ps - p38c

anti tag coimmunoprecipitation, peptide massfingerprinting

(Belozerov et al., 2012)

ps - sm

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

peb

enhanceable

(Wilk et al., 2004)

pnr

enhanceable

(Pena-Rangel et al., 2002)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261552

MIST (protein-protein) - An integrated Molecular Interaction Database

44258

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

85D16-85D17

Sequence location

3R:9,417,940..9,455,500 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85D16-85D17

Limits computationally determined from genome sequence between P{PZ}ps¹⁰⁶¹⁵&P{PZ}Ras85D⁰⁶⁶⁷⁷ and P{EP}CG9393^EP3122

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

85D16-85D17

(Seshaiah, 2000.1.3)

85D15-85D17

(determined by in situ hybridisation)

(Spradling et al., 1999)

85D13-85D14

(determined by in situ hybridisation)

(Andrew, 1999.3.23)

85D15-85D17

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-46.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27516

y¹ v¹; P{TRiP.JF02666}attP2

63888

w¹¹¹⁸; PBac{IT.GAL4}ps^0907-G4

24562

w¹¹¹⁸; Mi{ET1}ps^MB04043/TM6C, Sb¹

84007

y¹ sc^* v¹ sev²¹; P{TKO.GS04128}attP40

Kyoto

124441

w¹¹¹⁸; P{RS3}ps^UM-8245-3

115066

w¹¹¹⁸; PBac{602.P.SVS-1}ps^CPTI001063

115117

w¹¹¹⁸; PBac{602.P.SVS-1}ps^CPTI000668

115221

w¹¹¹⁸; PBac{681.P.FSVS-1}ps^CPTI001261

8144R-3

16777R-1

v107912

v108666

More stocks available...

Genomic Clones (40)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (123)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP13670

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261552

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261552

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Gill et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

ps is required for normal apical secretion in the salivary gland.

(Seshaiah et al., 2001)

Identification: Via expression pattern in enhancer trap P{lacZ}ET85D recovered from a screen to identify downstream target genes of Scr.

(Andrew, 1999.3.23)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(3)10615 CG16765

(Pena-Rangel et al., 2002)

Source for merge of: ps CG16777

(FlyBase Genome Annotators, 2010)

Source for merge of: CG16776 CG18509

(FlyBase Genome Annotators, 2006, FlyBase, 1996-)

Source for merge of: ps CG16776

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: l(3)10615 BcDNA:RE47781

(FlyBase, 1996-)

Source for merge of: ps CG8144

(FlyBase, 1996-)

Additional comments

Annotations CG16765 and CG16777 merged as CG42670 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Source for merge of CG16776 CG18509 was sequence comparison ( date:001104 ).

(FlyBase Genome Annotators, 2006, FlyBase, 1996-)

Annotations CG8144 and CG16776 merged as CG8144 (which corresponds to ps) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of l(3)10615 BcDNA:RE47781 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Source for merge of ps CG8144 was sequence comparison ( date:001216 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

BcDNA:RE47781

CG16765

(Çiçek et al., 2016, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2006, Landis et al., 2001)

CG16776

(Luschnig, 2003.12.17)

CG16777

(Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5, Telonis-Scott et al., 2009)

CG18509

CG42670

(Hosono et al., 2015, Ellis and Carney, 2011, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)

CG8144

(Lin et al., 2015, Yano et al., 2012, McIntyre et al., 2006, Philipps et al., 2004)

EP(3)3406

(Pena-Rangel et al., 2002)

NOVA1

(Lindquist et al., 2011)

(Venables et al., 2012, Maruyama et al., 2011, Myat and Andrew, 2000)

Pasilla

(Roselli et al., 2021)

cg8144

(Lasko, 2000)

l(3)10615

(Wang et al., 2013, Wilk et al., 2004, Spradling et al., 1999)

(Dyson et al., 2025, Titlow et al., 2023, Joseph et al., 2022, McLaughlin et al., 2021, Pang et al., 2021, Xie et al., 2021, Aboukilila et al., 2020, Samuels et al., 2020, Sapiro et al., 2020, Fingerhut et al., 2019, Zirin et al., 2019, Gill et al., 2017, Hu et al., 2017.6.13, Lobell et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Loganathan et al., 2016, Fear et al., 2015, Li et al., 2015, Stoiber et al., 2015, Zang et al., 2015, Ashwal-Fluss et al., 2014, Djiane et al., 2013, Kwon et al., 2013, Salzman et al., 2013, Belozerov et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Brooks et al., 2011, Ellis and Carney, 2011, Lindquist et al., 2011, Telonis-Scott et al., 2009, Branco et al., 2008, McIntyre et al., 2006, Philipps et al., 2004)

Name Synonyms

Pasilla

(Gill et al., 2017, Lowe et al., 2014, Venables et al., 2012, Yano et al., 2012, Brooks et al., 2011, Maruyama et al., 2011, Redhouse et al., 2011, Kwon et al., 2003)

lethal (3) 10615

pasilla

(Laver et al., 2013, Branco et al., 2008, Burnette et al., 2005, Burnette et al., 2005, Kiesler et al., 2005, Andrew, 1999.3.23)

Secondary FlyBase IDs

FBgn0026188
FBgn0063674
FBgn0042204
FBgn0037695
FBgn0037693
FBgn0037692
FBgn0024515
FBan0008144
FBgn0037694

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 127 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44258

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KGY6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

A0A0B4KGY6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KGY6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261552

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44258/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261552

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261552

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42670

MARRVEL_MODEL - MARRVEL (model organism gene)

44258

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261552

DroID - A comprehensive database of gene and protein interactions.

FBgn0261552

DRSC - Results frm RNAi screens

FBgn0261552

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261552

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008998

MIST (protein-protein) - An integrated Molecular Interaction Database

44258

References (124)

The following external sites may use different assemblies or annotations than FlyBase.

0.16

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