FlyBase Gene Report: Dmel\dlp

General Information

Symbol

Dmel\dlp

Species

D. melanogaster

Name

dally-like

Annotation Symbol

CG32146

Feature Type

protein_coding_gene

FlyBase ID

FBgn0041604

Gene Model Status

Current

Stock Availability

57 publicly available

Gene Summary

dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Dally-like protein, dly

Key Links

Genomic Location

Cytogenetic map

70E5-70E7

Sequence location

3L:14,632,601..14,671,609 [+]

Recombination map

3-42

RefSeq locus

NT_037436 REGION:14632601..14671609

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (27 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables hedgehog family protein binding

inferred from direct assay

(Yan et al., 2010)

enables Wnt-protein binding

inferred from direct assay

(Yan et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (16 terms)

Terms Based on Experimental Evidence (13 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Rawson et al., 2005)

inferred from genetic interaction with FLYBASE:Sdc; FB:FBgn0010415

(Chanana et al., 2009)

involved_in compound eye development

inferred from mutant phenotype

(Rawson et al., 2005, Kirkpatrick et al., 2004)

involved_in epithelial cell migration, open tracheal system

inferred from genetic interaction with FLYBASE:bnl; FB:FBgn0014135

(Yan and Lin, 2007)

involved_in imaginal disc-derived wing margin morphogenesis

inferred from mutant phenotype

(Yan et al., 2009, Kirkpatrick et al., 2004)

involved_in neuromuscular junction development

inferred from mutant phenotype

(Johnson et al., 2006)

involved_in positive regulation of canonical Wnt signaling pathway

inferred from genetic interaction with FLYBASE:Notum; FB:FBgn0044028

(Han et al., 2005)

inferred from mutant phenotype

(Wang and Page-McCaw, 2014, Baeg et al., 2001)

inferred from genetic interaction with FLYBASE:dally; FB:FBgn0263930

(Baeg et al., 2001)

involved_in positive regulation of fibroblast growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:bnl; FB:FBgn0014135

(Yan and Lin, 2007)

involved_in positive regulation of smoothened signaling pathway

inferred from mutant phenotype

(Yan et al., 2010, Yao et al., 2006, Desbordes and Sanson, 2003, Lum et al., 2003)

inferred from genetic interaction with FLYBASE:dally; FB:FBgn0263930

(Avanesov and Blair, 2013)

involved_in positive regulation of Wnt signaling pathway

inferred from mutant phenotype

(Yan et al., 2009)

involved_in regulation of imaginal disc growth

inferred from mutant phenotype

(Hufnagel et al., 2007)

involved_in segment polarity determination

inferred from mutant phenotype

(Kirkpatrick et al., 2004, Desbordes and Sanson, 2003, Baeg et al., 2001)

involved_in segment specification

inferred from mutant phenotype

(Yan et al., 2010)

involved_in wing disc dorsal/ventral pattern formation

inferred from expression pattern

(Han et al., 2005)

inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084

(Han et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell migration

inferred from biological aspect of ancestor with PANTHER:PTN002247069

(GO Reference Genome Project, 2011-)

involved_in regulation of protein localization to membrane

inferred from biological aspect of ancestor with PANTHER:PTN002247069

(GO Reference Genome Project, 2011-)

involved_in regulation of signal transduction

inferred from electronic annotation with InterPro:IPR001863

(InterPro Project Members, 2004-)

Cellular Component (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Johnson et al., 2004)

located_in cell surface

inferred from direct assay

(Johnson et al., 2004)

located_in cytoneme

inferred from direct assay

(Bischoff et al., 2013)

located_in external side of plasma membrane

inferred from direct assay

(Wang and Page-McCaw, 2014)

located_in neuromuscular junction

inferred from direct assay

(Friedman et al., 2013, Ren et al., 2009, Johnson et al., 2006)

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in synapse

inferred from direct assay

(Johnson et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cell surface

inferred from biological aspect of ancestor with PANTHER:PTN002247069

(GO Reference Genome Project, 2011-)

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN000088172

(GO Reference Genome Project, 2011-)

located_in extracellular matrix

inferred from electronic annotation with InterPro:IPR001863

(InterPro Project Members, 2004-)

located_in plasma membrane

inferred from electronic annotation with InterPro:IPR001863

(InterPro Project Members, 2004-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN000088172

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

GLYPICANS

Pathway (FlyBase)

POSITIVE REGULATORS OF FGFR SIGNALING PATHWAY

POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY

POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Glypican

Summaries

Gene Snapshot

dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

GLYPICANS -: Glypicans are glycosylphosphatidylinositol (GPI) anchored heparan sulfate proteoglycans. Glypicans can bind growth factors and morphogens, regulating their extracellular distribution. (Adapted from FBrf0138451).

Pathway (FlyBase)

POSITIVE REGULATORS OF FGFR SIGNALING PATHWAY -: Positive regulators of Fibroblast Growth Factor Receptor signaling up-regulate the pathway, enhancing the activation of ERK kinase (rl) or acting on other effectors.
POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -: Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -: Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dlp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VUG1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

3ODN
6XTZ

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dlp-RA

FBtr0075679

NM_079347

3761

765

dlp-RC

FBtr0333032

NM_206353

3758

764

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

dlp-PA

FBpp0075431

85.3

765

5.59

FBpp0305246

85.2

764

5.68

Q7KUL1

NP_996075

AAS65005

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

Sdc protein and dlp protein show highly overlapping, yet distinct, patterns of endogenous expression in the developing CNS.

(Johnson et al., 2004)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Glypican

PDB - An information portal to biological macromolecular structures

3ODN
6XTZ

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dlp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dlp_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.94

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 2

organism | ubiquitous

(Baeg et al., 2001)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

organism | faint | ubiquitous

(Khare and Baumgartner, 2000)

embryonic stage 6

organism | striped

Comment: 2 anterior and 2 posterior stripes

(Khare and Baumgartner, 2000)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 7 -- 10

procephalic neurogenic region

(Khare and Baumgartner, 2000)

embryonic stage 8

organism | segmentally repeated

(Baeg et al., 2001)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 10 -- 11

organism | striped

Comment: 15 stripes

(Khare and Baumgartner, 2000)

clypeo-labral primordium | anterior

(Khare and Baumgartner, 2000)

gnathal primordium | anterior

(Khare and Baumgartner, 2000)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

large intestine primordium

Comment: reported as large intestine specific anlage

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13

embryonic/larval midgut primordium

(Khare and Baumgartner, 2000)

embryonic hindgut

(Khare and Baumgartner, 2000)

presumptive embryonic/larval central nervous system | faint

(Khare and Baumgartner, 2000)

embryonic stage 13 -- 16

embryonic epipharynx

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 17

organism

Comment: assayed 0-18 hr AEL

(Khare and Baumgartner, 2000)

pupal stage -- adult stage

organism

Comment: not detected in third instar larvae

(Khare and Baumgartner, 2000)

Additional Descriptive Data

dlp transcript accumulates in somatic cells at the posterior of the germarium, including precursors to both interfollicle and polar follicle cells. Unlike dally, dlp is not expresed in the oocyte associated follicular epithelium.

(Hayashi et al., 2012)

dlp transcript is ubiquitously but weakly expressed at embryonic stage 5. The pattern resolves into two strong anterior bands and two weak posterior bands by embryonic stage 6. The posterior bands fade by embryonic stage 7, while the anterior bands intensify in the procephalic neurogenic region. During germ band extension, dlp transcript is expressed in a pattern similar to that of wg at the same stage. Expression is observed in a pattern of fifteen stripes, in the procephalic neurogenic regions, at the anterior-most edge of the clypeo-labral primordium, and in the gnathal primordium. Double-labeling with en antibody reveals dlp expression overlaps both wg-expressing cells and wg target cells. At stage 13, dlp is expressed in the lining of the midgut, in the hindgut, and faintly in the central nervous system.

(Khare and Baumgartner, 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

presumptive embryonic/larval central nervous system & motor neuron

• axon

(Johnson et al., 2004)

lateral longitudinal fascicle & medial longitudinal fascicle

• axon

(Johnson et al., 2004)

symmetrical commissure & fascicle

• cell surface of axon

(Johnson et al., 2004)

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female & oogenesis

germarium | posterior

(Wang and Page-McCaw, 2014)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 17

lateral longitudinal fascicle

(Smart et al., 2011)

intermediate longitudinal fascicle

(Smart et al., 2011)

third instar larval stage

embryonic/larval CNS perineurial glial cell

(Kanai et al., 2018)

wandering third instar larval stage

embryonic/larval neuromuscular junction

• type I terminal bouton

(Dani et al., 2012)

wing disc | restricted

(Yan et al., 2010)

adult stage | female

germarium | posterior

(Hayashi et al., 2012)

stalk follicle cell | precursor

(Hayashi et al., 2012)

polar follicle cell | precursor

(Hayashi et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

dlp protein is localized to the posterior of the germarium, in a pattern inverse to that of wg..

(Wang and Page-McCaw, 2014)

At the larval neuromuscular junction, dlp protein shows a punctate expression pattern strongly concentrated in a halo-like array around the presynaptic membrane.

(Dani et al., 2012)

dlp levels drop significantly in the axons most medial to the midline. A gradient is observed with little dlp on medial axons and higher levels on the most lateral axons. This is in contrast to Sdc distribution, which peaks at a more medial location.

(Smart et al., 2011)

dlp protein expression is higher in the expression domains of hh and ptc in the wing disc.

(Yan et al., 2010)

also expressed at muscle insertions sites of embryonic CNS in stage 16 embryos

(Johnson et al., 2004)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Johnson et al., 2004)

located_in cell surface

inferred from direct assay

(Johnson et al., 2004)

located_in cytoneme

inferred from direct assay

(Bischoff et al., 2013)

located_in external side of plasma membrane

inferred from direct assay

(Wang and Page-McCaw, 2014)

located_in neuromuscular junction

inferred from direct assay

(Friedman et al., 2013, Ren et al., 2009, Johnson et al., 2006)

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in synapse

inferred from direct assay

(Johnson et al., 2006)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}dlp^CPTI000445

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

mushroom body spur

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

Comment: low expression in adult brain cortex

(Knowles-Barley, 2011.8.24)

adult optic lobe

Comment: low expression in optic lobe

(Knowles-Barley, 2011.8.24)

adult mushroom body

(Knowles-Barley, 2011.8.24)

fan-shaped body

Comment: low expression in fan-shaped body

(Knowles-Barley, 2011.8.24)

adult mushroom body gamma-lobe

(Knowles-Barley, 2011.8.24)

Reporter: PBac{681.P.FSVS-1}dlp^CPTI001218

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dlp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dlp

View exonic expression by tissue for Dmel\dlp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0041604

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39596/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0041604

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0041604

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0041604

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32146

Flygut - An atlas of the Drosophila adult midgut

FBgn0041604

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\dlp

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 33 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 39 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dlp

Transgenic constructs containing regulatory region of dlp

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)Exel6124

(Ryder, 2004.4.26)

Df(3L)fz-D21

(Kirkpatrick et al., 2004)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal, with Scer\GAL4^Act5C.PU

dlp^RNAi.UAS.cYa

lethal | embryonic stage | non-rescuable maternal effect

dlp^A187

lethal | larval stage

dlp^A187

lethal | recessive

lethal - all die before end of P-stage, with Scer\GAL4^ptc-559.1

dlp^UAS.cBa

partially lethal - majority die

partially lethal - majority die (with Df(3L)fz-D21)

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dlp^GD3592

viable, with Scer\GAL4^Mef2.PR

dlp^GD3592

viable, with Scer\GAL4^pnr-MD237

dlp^GD3592

viable, with Scer\GAL4^tin.CΔ4

dlp^GD3592

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal cell adhesion | oogenesis, with Scer\GAL4^slbo.2.6

dlp^HMS00903

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

dlp^HMS00903

abnormal cell number | larval stage, with Scer\GAL4^e33C

dlp^GD3592

abnormal cell number | oogenesis, with Scer\GAL4^C587

abnormal immune response | larval stage, with Scer\GAL4^e33C

dlp^GD3592

abnormal neuroanatomy, with Scer\GAL4²²¹

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

abnormal neuroanatomy (with Df(3L)fz-D21)

dlp¹

abnormal neuroanatomy (with dlp¹)

dlp²

abnormal neuroanatomy (with dlp²)

dlp¹

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav.PU

dlp^UAS.cBa

abnormal neuroanatomy | larval stage, with Scer\GAL4^how-24B

abnormal neuroanatomy | larval stage, with Scer\GAL4^how-24B, Scer\GAL4^sca.PU

dlp^UAS.cBa

abnormal neuroanatomy | larval stage, with Scer\GAL4^unspecified

dlp^UAS.cBa

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

dlp^UAS.cBa

abnormal neuroanatomy | third instar larval stage (with dlp¹)

dlp²

abnormal neuroanatomy | third instar larval stage (with dlp²)

dlp¹

abnormal neurophysiology (with Df(3L)fz-D21)

dlp¹

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^how-24B

dlp^UAS.cBa

abnormal neurophysiology | third instar larval stage (with dlp¹)

dlp²

abnormal neurophysiology | third instar larval stage (with dlp²)

dlp¹

abnormal starvation stress response | larval stage, with Scer\GAL4^how-24B

dlp^HMS00875

decreased size | adult stage, with Scer\GAL4^Ser.PGF

dlp^HMS00903

increased mortality during development, with Scer\GAL4^e33C

dlp^GD3592

increased size | oogenesis, with Scer\GAL4^C587

dlp^UAS.cBa

segment polarity phenotype (with dlp¹)

dlp²

segment polarity phenotype (with dlp²)

dlp¹

segment polarity phenotype | embryonic stage | non-rescuable maternal effect

dlp^A187

some die during pharate adult stage, with Scer\GAL4^ptc-559.1

dlp^UAS.cBa

visible

dlp^unspecified

visible, with Scer\GAL4^A9

dlp^UAS.Tag:HA

visible, with Scer\GAL4^bbg-C96

dlp^UAS.cBa

visible, with Scer\GAL4^en-e16E

visible, with Scer\GAL4^hh.PU

dlp^{UAS.Tag:SS(wg),GFP}

visible, with Scer\GAL4^pnr-MD237

dlp^GD3592

visible, with Scer\GAL4^salm-459.2

dlp^UAS.Tag:HA

visible | adult stage, with Scer\GAL4^Bx-MS1096

dlp^HMS00875

Phenotype manifest in

Allele

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

abdominal dorsal multidendritic neuron ddaD | third instar larval stage, with Scer\GAL4²²¹

abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4²²¹

border follicle cell, with Scer\GAL4^slbo.2.6

dlp^HMS00903

chaeta | increased number, with Scer\GAL4^pnr-MD237

dlp^GD3592

dendritic tree | third instar larval stage, with Scer\GAL4²²¹

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

denticle | ectopic | ventral (with dlp¹)

dlp²

denticle | ectopic | ventral (with dlp²)

dlp¹

egg chamber, with Scer\GAL4^C587

dlp^GD3592

embryonic/first instar larval cuticle

embryonic/first instar larval cuticle (with dlp¹)

dlp²

embryonic/first instar larval cuticle (with dlp²)

dlp¹

embryonic/larval lymph gland | larval stage, with Scer\GAL4^e33C

dlp^GD3592

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

dlp^UAS.cBa

embryonic segment

dlp^MH20

escort cell | decreased number, with Scer\GAL4^C587

dlp^UAS.cBa

escort cell | increased number, with Scer\GAL4^C587

eye

dlp^MH20

eye (with Df(3L)fz-D21)

dlp¹

eye photoreceptor cell & axon (with Df(3L)fz-D21)

dlp¹

eye photoreceptor cell & axon (with dlp¹)

dlp²

eye photoreceptor cell & axon (with dlp²)

dlp¹

female germ cell nucleus, with Scer\GAL4^C587

dlp^UAS.cBa

female germline cell | increased number, with Scer\GAL4^C587

dlp^UAS.cUa

female germline cyst | increased number, with Scer\GAL4^C587

dlp^UAS.cBa

female germline stem cell | decreased number, with Scer\GAL4^C587

first posterior wing cell

first posterior wing cell, with Scer\GAL4^hh.PU

dlp^{UAS.Tag:SS(wg),GFP}

germarium, with Scer\GAL4^C587

interommatidial bristle (with Df(3L)fz-D21)

dlp¹

lamellocyte | larval stage, with Scer\GAL4^e33C

dlp^GD3592

lamina plexus (with Df(3L)fz-D21)

dlp¹

lamina plexus (with dlp¹)

dlp²

lamina plexus (with dlp²)

dlp¹

mechanosensory chaeta | increased number

dlp^MH20

medulla (with Df(3L)fz-D21)

dlp¹

medulla (with dlp¹)

dlp²

medulla (with dlp²)

dlp¹

NMJ bouton | increased number | larval stage, with Scer\GAL4^how-24B

dlp^HMS00875

NMJ bouton | larval stage, with Scer\GAL4^elav.PU

dlp^UAS.cBa

NMJ bouton | larval stage, with Scer\GAL4^how-24B

dlp^UAS.cBa

NMJ bouton | larval stage, with Scer\GAL4^how-24B, Scer\GAL4^sca.PU

dlp^UAS.cBa

ommatidium (with Df(3L)fz-D21)

dlp¹

presynaptic active zone | larval stage, with Scer\GAL4^unspecified

dlp^UAS.cBa

presynaptic active zone | third instar larval stage (with dlp¹)

dlp²

presynaptic active zone | third instar larval stage (with dlp²)

dlp¹

sensory mother cell | somatic clone

dlp^A187

spectrosome | increased number, with Scer\GAL4^C587

dlp^UAS.cUa

spectrosome | increased number | oogenesis, with Scer\GAL4^C587

dlp^UAS.cBa

stalk follicle cell, with Scer\GAL4^C587

dlp^GD3592

type I bouton | third instar larval stage, with Scer\GAL4^how-24B

dlp^UAS.cBa

ventral denticle belt

dlp^MH20

wing

dlp^MH20

wing, with Scer\GAL4^A9

dlp^UAS.Tag:HA

wing, with Scer\GAL4^en-e16E

wing, with Scer\GAL4^salm-459.2

dlp^UAS.Tag:HA

wing disc (with Df(3L)fz-D21)

dlp¹

wing margin, with Scer\GAL4^A9

dlp^UAS.Tag:HA

wing margin, with Scer\GAL4^bbg-C96

dlp^UAS.cBa

wing margin, with Scer\GAL4^dpp.blk1

dlp^UAS.Tag:HA

wing margin, with Scer\GAL4^en-e16E

dlp^UAS.Tag:HA

wing margin | posterior, with Scer\GAL4^en-e16E

dlp^UAS.Tag:HA

wing margin bristle, with Scer\GAL4^ap-md544, dlp¹

dlp^UAS.cBa

wing margin bristle, with Scer\GAL4^ap-md544, dlp^UAS.cBa

dlp¹

wing margin bristle, with Scer\GAL4^nub-AC-62

dlp^UAS.cBa

wing margin bristle | cell non-autonomous | ectopic | somatic clone, with Scer\GAL4^αTub84B.PP

dlp^UAS.Tag:HA

wing margin bristle | ectopic

dlp^MH20

wing margin bristle | ectopic, with Scer\GAL4^Bx-MS1096

dlp^HMS00875

wing margin bristle | ectopic (with Df(3L)fz-D21)

dlp¹

wing margin bristle | ectopic (with dlp¹)

dlp²

wing margin bristle | ectopic (with dlp²)

dlp¹

wing margin bristle | increased number

dlp^MH20

wing margin bristle | increased number, with Scer\GAL4^sd-SG29.1

dlp^RNAi.Sym.UAS

wing margin bristle | posterior, with Scer\GAL4^en-e16E

dlp^UAS.Tag:HA

wing posterior compartment, with Scer\GAL4^Ser.PGF

dlp^HMS00903

wing sensillum, with Scer\GAL4^bbg-C96

dlp^UAS.cBa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\GPC1

11 of 14

Yes

Hsap\GPC4

11 of 14

Yes

Hsap\GPC6

11 of 14

Yes

Hsap\GPC2

10 of 14

Yes

Hsap\GPC3

2 of 14

Hsap\GPC5

2 of 14

Hsap\SYDE1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Gpc1

11 of 14

Yes

Rnor\Gpc2

11 of 14

Yes

Rnor\Gpc4

11 of 14

Yes

Rnor\Gpc6

11 of 14

Yes

Rnor\Gpc3

1 of 14

Rnor\Syde1

1 of 14

Mus musculus (laboratory mouse) (7)

Mmus\Gpc1

11 of 14

Yes

Mmus\Gpc4

11 of 14

Yes

Mmus\Gpc6

11 of 14

Yes

Mmus\Gpc2

9 of 14

Yes

Mmus\Gpc3

2 of 14

Mmus\Gpc5

2 of 14

Mmus\Syde1

1 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\gpc1

9 of 13

Yes

Xtro\gpc4

9 of 13

Yes

Xtro\gpc2

7 of 13

Yes

Xtro\gpc6

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (10)

Drer\gpc1a

11 of 14

Yes

Drer\gpc1b

11 of 14

Yes

Drer\gpc4

11 of 14

Yes

Drer\gpc6a

11 of 14

Yes

Drer\gpc6b

10 of 14

Yes

Drer\gpc2

5 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\gpn-1

13 of 14

Yes

Cele\lon-2

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP003559

12 of 12

Yes

Agam\AgaP_AGAP005799

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dlp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

dally

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

GPC4; glypican 4

model of Keipert syndrome

IEA

(FlyBase, 2019-)

GPC6; glypican 6

model of omodysplasia 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

dlp^HMS00903

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

dlp^A187

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Dear et al., 2017, Friedman et al., 2013)

dlp^UAS.cBa

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.YFP.cEa

(Godfrey et al., 2023)

modeled by Hsap\TARDBP^UAS.Tag:MYC

(Lehmkuhl et al., 2021)

modeled by Hsap\TARDBP^G298S.UAS

(Lehmkuhl et al., 2021)

modeled by TBPH^RNAi.UAS.cUa

(Lehmkuhl et al., 2021)

dlp^GLC01658

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.Tag:MYC

(Lehmkuhl et al., 2021)

modeled by Hsap\TARDBP^G298S.UAS

(Lehmkuhl et al., 2021)

modeled by TBPH^RNAi.UAS.cUa

(Lehmkuhl et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

11 of 14

11 of 14

KEIPERT SYNDROME; KPTS

Keipert syndrome

GPC6; glypican 6

11 of 14

604404

OMODYSPLASIA 1; OMOD1

omodysplasia 1

GPC2; glypican 2

10 of 14

618446

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

dlp - Lar

pull down, enzyme linked immunosorbent assay, affinity technology, inferred by author, tag visualisation

(Johnson et al., 2006)

dlp - Sema2b

surface plasmon resonance, predetermined participant

(Nourisanami et al., 2024)

dlp - Wnt2

anti tag coimmunoprecipitation, anti tag western blot

(Tu et al., 2020, Waghmare et al., 2020)

dlp - Wnt4

anti tag coimmunoprecipitation, anti tag western blot

(Tu et al., 2020, Waghmare et al., 2020)

dlp - Wnt6

anti tag coimmunoprecipitation, anti tag western blot

(Waghmare et al., 2020)

dlp - apolpp

anti tag coimmunoprecipitation, western blot, cosedimentation, anti tag western blot

(Eugster et al., 2007)

dlp - boi

colocalization, fluorescence microscopy, inferred by author

(Simon et al., 2021)

dlp - disp

anti bait coimmunoprecipitation, anti tag western blot

(Callejo et al., 2011)

dlp - hh

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Yan et al., 2010)

dlp - ihog

colocalization, fluorescence microscopy, inferred by author

(Simon et al., 2021)

dlp - ltl

anti bait coimmunoprecipitation, western blot

(Szuperák et al., 2011)

dlp - ptc

anti bait coimmunoprecipitation, anti tag western blot

(Yan et al., 2010)

dlp - wg

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation

(McGough et al., 2020, Waghmare et al., 2020, Yan et al., 2009)

RNA-protein

Physical Interaction

Assay

References

dlp - Hsap\TARDBP

anti tag coimmunoprecipitation, quantitative reverse transcription pcr, full identification by RNA sequencing

(Godfrey et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dlp

suppressible

arm

(Waghmare et al., 2020, Baeg et al., 2001)

dlp

enhanceable

dally

(Franch-Marro et al., 2005)

suppressible

(Tu et al., 2020)

enhanceable

(Waghmare et al., 2020)

dlp

enhanceable

Notum

(Kreuger et al., 2004)

dlp

enhanceable

Sulf1

(You et al., 2011)

dlp

suppressible

(Waghmare et al., 2020, Yan et al., 2010, Baeg et al., 2001)

dlp

suppressible

Wnt2

(Waghmare et al., 2020)

dlp

suppressible

Wnt4

(Waghmare et al., 2020)

dlp

suppressible

Wnt6

(Waghmare et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm

suppressible

dlp

(Tegeder et al., 2019)

dally

enhanceable

dlp

(Nakato et al., 2024, Baron et al., 2009)

dally

suppressible

dlp

(Nakato et al., 2024)

suppressible

(Tu et al., 2020)

suppressible

(Friedman et al., 2013)

Fmr1

suppressible

dlp|Sdc

(Friedman et al., 2013)

Hsepi

suppressible

dlp

(Dejima et al., 2013)

enhanceable

(Yao et al., 2006)

enhanceable

(Wang and Page-McCaw, 2014)

Mmp2

suppressible

dlp

(Wang and Page-McCaw, 2014)

Notum

suppressible

dlp

(Kirkpatrick et al., 2004)

Notum

enhanceable

dlp

(Kreuger et al., 2004)

Psi

suppressible

dlp

(Zaytseva et al., 2023)

Sdc

suppressible

dlp

(Chanana et al., 2009, Rawson et al., 2005, Johnson et al., 2004)

Sdc

enhanceable

dlp

(Chanana et al., 2009)

shf::Drer\wif1

enhanceable

dlp

(Avanesov et al., 2012)

suppressible

(Tu et al., 2020)

suppressible

(Tegeder et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64925

DroID - A comprehensive database of gene and protein interactions.

FBgn0041604

MIST (genetic) - An integrated Molecular Interaction Database

39596

MIST (protein-protein) - An integrated Molecular Interaction Database

39596

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF FGFR SIGNALING PATHWAY
POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY
POSITIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9GPL5

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-42

Cytogenetic map

70E5-70E7

Sequence location

3L:14,632,601..14,671,609 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70E5-70E7

Limits computationally determined from genome sequence between P{PZ}Mpcp⁰⁰⁵⁶⁴ and P{PZ}l(3)rO220^rO220

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

70F-70F

(Baeg, 2000.10.26)

70F-70F

(determined by in situ hybridisation)

(Baeg et al., 2001)

Experimentally Determined Recombination Data

Location

3-42

(FlyBase, 2016)

3-36.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (57)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

9160

w¹¹¹⁸; P{UAS-dlp.WT}3

94556

w^*; P{UAS-GFP-dlp.E}3

38831

w¹¹¹⁸; P{GMR52E04-GAL4}attP2

38842

w¹¹¹⁸; P{GMR52G03-GAL4}attP2

46041

w¹¹¹⁸; P{GMR53G07-GAL4}attP2

47944

w¹¹¹⁸; P{GMR54B10-GAL4}attP2

48196

w¹¹¹⁸; P{GMR53E05-GAL4}attP2

49396

w¹¹¹⁸; P{GMR53D04-GAL4}attP2

50452

w¹¹¹⁸; P{GMR53H03-GAL4}attP2

50456

w¹¹¹⁸; P{GMR53H12-GAL4}attP2

VDRC

v100268

P{KK107351}VIE-260B

v10299

w¹¹¹⁸; P{GD3592}v10299

More stocks available...

Genomic Clones (34)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (99)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD47466

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0041604

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE01911
RE03784
RE06247
RE09366
RE10694
RE11126
RE13119
RE13958
RE13981
RE16218
RE26017
RE28709
RE29419
RE30085
RE32810
RE32815
RE35095
RE38109
RE38866
RE41002
RE51933
RE52577
RE60054
RE60243
RE60537
RE62695
RE63140
RE63561
RE67761
RE68542
RE69062
RE70728
RE71184
RE73696

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0041604

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Dally-like_(13G8)

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dlp promotes long-distance wg signaling in the germarium.

(Wang and Page-McCaw, 2014)

The dlp core protein can interact with wg protein, the glycosaminoglycan chains that are attached in the dlp heparan sulfate proteoglycan enhance this interaction.

(Yan et al., 2009)

dlp shows a biphasic response, repressing short-range wg signalling and activating long-range wg signaling, and this biphasic response is seen regardless of whether its glycosylphosphatidylinositol linkage to the membrane can be cleaved. Rather, the transition from signaling activator to repressor is determined by the relative expression levels of dlp and fz2.

(Yan et al., 2009)

dlp is required for hh signalling during embryogenesis, and, in combination with dally is required for hh protein movement during wing disc development.

(Han et al., 2004)

dlp cooperates with Notum to limit wg signalling.

(Kirkpatrick et al., 2004)

dally and dlp are dispensable for wg signalling in embryos. dlp is required for hh signalling in the embryo and is required downstream of hh processing and either upstream or at the level of the ptc receptor.

(Desbordes and Sanson, 2003)

dlp may play a role in the extracellular distribution of wg protein.

(Baeg et al., 2001)

Inhibition of dlp gene activity implicates a function for dlp in wg protein reception and overexpression of dlp leads to an accumulation of extracellular wg protein.

(Baeg et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: dlp CG17703

(Misra, 2001.8.10)

Additional comments

Annotations CG17703, CG5031 merged as CG32146 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for identity of dally-like CG5031 was sequence comparison ( date:001216 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: dally-like CG5031

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG17703

CG32146

(Hosono et al., 2015, Yamamoto-Hino et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Derré et al., 2007, Metaxakis et al., 2005)

CG5031

(Molnar et al., 2006)

CT16138

(Hynes and Zhao, 2000)

D-gpcB

(Selleck et al., 2000)

DLP

(Melnikova and Golovnin, 2023, Das et al., 2013)

Dally-like

(Lee et al., 2016, Muha and Müller, 2013, Solis et al., 2013, Amoyel and Bach, 2012, Dani et al., 2012, Matunis et al., 2012, Selva et al., 2001)

Dlp

(Jiménez-Jiménez et al., 2024, Nourisanami et al., 2024, Shweta et al., 2024, Alvarez-Rodrigo et al., 2023, Godfrey et al., 2023, Daly et al., 2022, Gradilla and Guerrero, 2022, Kharrat et al., 2022, Hayes and Melrose, 2021, Kamimura and Maeda, 2021, Yang et al., 2021, Bai and Suzuki, 2020, Chou et al., 2020, Gou et al., 2020, Hayashi et al., 2020, McGough et al., 2020, Mii and Takada, 2020, Nishihara, 2020, Prince et al., 2020, Rust and Nystul, 2020, Tu et al., 2020, Kawaguchi et al., 2019, Powers and Srivastava, 2018, Gao et al., 2017, Kamimura and Maeda, 2017, Dear et al., 2016, Neto et al., 2016, Nagarajan et al., 2015, Yamamoto-Hino et al., 2015, Jumbo-Lucioni et al., 2014, Kim et al., 2014, Sytnikova et al., 2014, Chang et al., 2013, Friedman et al., 2013, Mbodj et al., 2013, Muha and Müller, 2013, Solis et al., 2013, Wang et al., 2013, Avanesov et al., 2012, Dani et al., 2012, Matunis et al., 2012, Raftery and Umulis, 2012, Callejo et al., 2011, Erickson, 2011, Port et al., 2011, Wang et al., 2011, Wu et al., 2010, Serpe et al., 2008, Vyas et al., 2008, Wang et al., 2008, Eugster et al., 2007, Gallet et al., 2007, Hufnagel et al., 2007, Su et al., 2007, Hufnagel et al., 2006, Johnson et al., 2006, McLellan et al., 2006, Wilson and Chuang, 2006, Häcker et al., 2005, Kirkbride, 2005, Guimond and Turnbull, 2004, Bussell, 2003, Giraldez et al., 2002)

Dly

(Chanana et al., 2006, Yan et al., 2004, Lin et al., 2003, Nybakken and Perrimon, 2002)

dlp

(Holmes et al., 2025, Mendoza Andrade et al., 2025, Avila et al., 2024, Collins et al., 2024, Cui et al., 2024, Ell et al., 2024, Li et al., 2024, Pignataro et al., 2024, Simon et al., 2024, Gude et al., 2023, Xu et al., 2023, Aguirre-Tamaral et al., 2022, Li et al., 2022, Waghmare and Page-McCaw, 2022, Girard et al., 2021, Lehmkuhl et al., 2021, Magny et al., 2021, McLaughlin et al., 2021, Morin-Poulard et al., 2021, Park et al., 2021, Rajasekaran et al., 2021, Shin et al., 2021, Cho et al., 2020, Parra and Johnston, 2020, Rushton et al., 2020, Statzer and Ewald, 2020, Tu et al., 2020, Waghmare et al., 2020, Wei et al., 2020, Brann et al., 2019, Cai et al., 2019, Drummond-Barbosa, 2019, Kamimura et al., 2019, Raza et al., 2019, Tegeder et al., 2019, Kanai et al., 2018, Lee et al., 2018, Yamamoto-Hino et al., 2018, Dear et al., 2017, González-Méndez et al., 2017, Kline et al., 2017, Poe et al., 2017, Transgenic RNAi Project members, 2017-, Upadhyay et al., 2017, Clandinin and Owens, 2016-, Dominguez et al., 2016, Nakato and Li, 2016, Norman et al., 2016, Yamazaki et al., 2016, Duff et al., 2015, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Kakugawa et al., 2015, Ahmad et al., 2014, Ashwal-Fluss et al., 2014, Wang and Page-McCaw, 2014, Avanesov and Blair, 2013, Dejima et al., 2013, Hattori et al., 2013, Sen et al., 2013, Webber et al., 2013, Zhang et al., 2013, Avanesov et al., 2012, Chen et al., 2012, Cho et al., 2012, Dani et al., 2012, Hayashi et al., 2012, Pennetier et al., 2012, Sánchez-Hernández et al., 2012, Chang et al., 2011, Chen et al., 2011, Dejima et al., 2011, Kim et al., 2011, Napoletano et al., 2011, Smart et al., 2011, Szuperák et al., 2011, Toku et al., 2011, Wang et al., 2011, Wojcinski et al., 2011, You et al., 2011, Hermle et al., 2010, Kleinschmit et al., 2010, Knowles-Barley et al., 2010, Liu et al., 2010, Vuilleumier et al., 2010, Williams et al., 2010, Yan et al., 2010, Baena-Lopez et al., 2009, Chanana et al., 2009, Guo and Wang, 2009, Hayashi et al., 2009, Hazelett et al., 2009, Ren et al., 2009, Tan et al., 2009, Yan et al., 2009, Yan et al., 2009, Baena-Lopez et al., 2008, Bornemann et al., 2008, Gallet et al., 2008, Williams et al., 2008, Yan and Lin, 2008, DasGupta et al., 2007, Derré et al., 2007, Yan and Lin, 2007, Zeitlinger et al., 2007, de Navas et al., 2006, Molnar et al., 2006, Wendler et al., 2006, Yao et al., 2006, Briscoe and Therond, 2005, DasGupta et al., 2005, Glise et al., 2005, Gorfinkiel et al., 2005, Nybakken et al., 2005, Torroja et al., 2005, Kreuger et al., 2004)

dly

(Belenkaya et al., 2004, Han et al., 2004, Han et al., 2003, Lin et al., 2002, Nakato and Kimata, 2002, Princivalle and de Agostini, 2002, Waldrip et al., 2002, Baeg et al., 2001)

Name Synonyms

D-glypican B

(Selleck et al., 2000)

Dally-like protein

(Bai and Suzuki, 2020, Nishihara, 2020, Dear et al., 2016, Avanesov and Blair, 2013, Friedman et al., 2013, Dejima et al., 2011, Port et al., 2011, Wang et al., 2011, Kirkbride, 2005)

Dallylike

(Sexton and Harrison, 2008)

dally-like

(Simões et al., 2022, Weigelt et al., 2020, Smart et al., 2011, Turner et al., 2011, Hermle et al., 2010, Baena-Lopez et al., 2009, Hayashi et al., 2009, Yan and Lin, 2008, Su et al., 2007, Yan and Lin, 2007, Zeitouni et al., 2007, Wendler et al., 2006, Burnette et al., 2005, Furlong, 2005, Torroja et al., 2005, Yamashita et al., 2004, Baeg et al., 2001, Khare and Baumgartner, 2000)

dally-like protein

(Upadhyay et al., 2017, Zhang et al., 2013, Erickson, 2011)

Secondary FlyBase IDs

FBgn0036434
FBgn0036435
FBgn0052146

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39596

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VUG1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VUG1

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0041604

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39596/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0041604

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0041604

FlyMine - An integrated database for Drosophila genomics

FBgn0041604

InterPro - A database of protein families, domains and functional sites

Glypican

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32146

MARRVEL_MODEL - MARRVEL (model organism gene)

39596

PDB - An information portal to biological macromolecular structures

3ODN
6XTZ

Linkouts

BioGRID - A database of protein and genetic interactions.

64925

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0041604

DroID - A comprehensive database of gene and protein interactions.

FBgn0041604

DRSC - Results frm RNAi screens

FBgn0041604

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Dally-like_(13G8)

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dlp_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0041604

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0041604

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32146

Flygut - An atlas of the Drosophila adult midgut

FBgn0041604

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0041604

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013355

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Wnt signaling pathway

MIST (genetic) - An integrated Molecular Interaction Database

39596

MIST (protein-protein) - An integrated Molecular Interaction Database

39596

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9GPL5

References (349)

The following external sites may use different assemblies or annotations than FlyBase.

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