FlyBase Allele Report: Dmel\dlp[GD3592]

General Information

Symbol

Dmel\dlp^GD3592

Species

D. melanogaster

Name

FlyBase ID

FBal0209361

Feature type

allele

Associated gene

Dmel\dlp

Associated Insertion(s)

Carried in Construct

P{GD3592}

Also Known As

UAS-dlp-RNAi, UAS-dlp^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD3592}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD3592

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | larval stage, with Scer\GAL4^e33C

(Rodrigues et al., 2021)

abnormal cell number | oogenesis, with Scer\GAL4^C587

(Waghmare et al., 2020)

abnormal immune response | larval stage, with Scer\GAL4^e33C

(Rodrigues et al., 2021)

abnormal neuroanatomy, with Scer\GAL4²²¹

(Hattori et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

increased mortality during development, with Scer\GAL4^e33C

(Rodrigues et al., 2021)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

abdominal dorsal multidendritic neuron ddaD | third instar larval stage, with Scer\GAL4²²¹

(Hattori et al., 2013)

abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4²²¹

(Hattori et al., 2013)

chaeta | increased number, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

dendritic tree | third instar larval stage, with Scer\GAL4²²¹

(Hattori et al., 2013)

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PG

(Hattori et al., 2013)

egg chamber, with Scer\GAL4^C587

(Wang and Page-McCaw, 2014)

embryonic/larval lymph gland | larval stage, with Scer\GAL4^e33C

(Rodrigues et al., 2021)

escort cell | increased number, with Scer\GAL4^C587

(Waghmare et al., 2020)

female germline stem cell | decreased number, with Scer\GAL4^C587

(Waghmare et al., 2020)

lamellocyte | larval stage, with Scer\GAL4^e33C

(Rodrigues et al., 2021)

stalk follicle cell, with Scer\GAL4^C587

(Wang and Page-McCaw, 2014)

Detailed Description

Statement

Reference

Expression of dlp^GD3592 in epidermic cells under the control of Scer\GAL4^hh-Gal4 does not induce any significant change in the terminal dendrite density and number in the adjacent class IV dendritic arborizing neurons within the intersegmental area of third instar larvae.

(Poe et al., 2017)

Expression of dlp^GD3592 under the control of Scer\GAL4^C587 results in encapsulation defects in 58.3% of germaria. Compound follicles without intervening stalk cells are seen.

(Wang and Page-McCaw, 2014)

The expression of dlp^GD3592 under the control of Scer\GAL4²²¹, in combination with Dicer-2 for efficient RNAi, results in third instar larval class I abdominal dorsal multidendritic ddaD and ddaE neurons exhibiting dendrite branch misrouting, as compared to controls; expression under the control of Scer\GAL4^ppk.PG, in combination with Dicer-2 for efficient RNAi, results in third instar larval class IV abdominal dorsal multidendritic ddaC neurons exhibiting abnormal dendritic terminals and dendritic branch misrouting, as compared to controls.

(Hattori et al., 2013)

Adults expressing dlp^GD3592 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in extra bristles on the notum in 0% or 0-10% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 0-10% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

3592

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of dendritic tree | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of distal dendrite | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of dendritic tree | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of distal dendrite | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of dendritic tree | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of distal dendrite | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918

(Poe et al., 2017)

dlp^GD3592/Scer\GAL4^hh-Gal4 is a non-enhancer of larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

Suppressor of

Statement

Reference

dlp^GD3592, Scer\GAL4^nub-AC-62 is a suppressor of wing phenotype of Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

dlp^GD3592, Scer\GAL4^nub-AC-62 is a suppressor of wing margin bristle phenotype of Drer\wif1^UAS.cAa, Scer\GAL4^nub-AC-62

(Avanesov et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of dlp^GD3592 suppresses the wing defects seen when Drer\wif1^Scer\UAS.cAa is expressed under the control of Scer\GAL4^nub-AC-62. Scalloping of the wing margin is almost completely eliminated and more margin bristles are retained.

(Avanesov et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v10299

w¹¹¹⁸; P{GD3592}v10299

Notes on Origin

Discoverer