FlyBase Allele Report: Dmel\Sdc[RNAi.WIZ.UAS]

General Information

Symbol

Dmel\Sdc^RNAi.WIZ.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0336320

Feature type

allele

Associated gene

Dmel\Sdc

Associated Insertion(s)

Carried in Construct

P{UAS-Sdc.RNAi.WIZ}

Key Links

Transgenic product class

RNAi_reagent

(Poe et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Poe et al., 2017)

Mutagen

in vitro construct

(Poe et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-Sdc.RNAi.WIZ}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi line that targets Sdc.

(Poe et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Sdc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Phenotype Manifest In

dendritic tree | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

distal dendrite | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

larval multidendritic class IV neuron | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Detailed Description

Statement

Reference

Expression of Sdc^{dsRNA.WIZ.Scer\UAS} in epidermic cells under the control of Scer\GAL4^hh-Gal4 results in a mild reduction in the terminal dendrite density and number in the adjacent class IV dendritic arborizing neurons within the intersegmental area of third instar larvae.

(Poe et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, enhanceable by dally^GD5918/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Enhancer of

Statement

Reference

Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4 is an enhancer of abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, enhanceable by dally^GD5918/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has dendritic tree | third instar larval stage | cell non-autonomous phenotype, enhanceable by dally^GD5918/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has distal dendrite | third instar larval stage | cell non-autonomous phenotype, enhanceable by dally^GD5918/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has dendritic tree | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has distal dendrite | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has dendritic tree | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS has distal dendrite | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Enhancer of

Statement

Reference

Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4 is an enhancer of larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4 is an enhancer of dendritic tree | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4 is an enhancer of distal dendrite | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, dally^GD5918

(Poe et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either Sdc^{dsRNA.WIZ.Scer\UAS} or dally^GD5918 alone in epidermic cells under the control of Scer\GAL4^hh-Gal4 results in only a mild reduction in the terminal dendrite density and number within the intersegmental area in the adjacent class IV dendritic arborizing neurons in third instar larvae, but the severity of the phenotype is much increased (the growth of high-order dendrites is almost completely abolished) if both Sdc^{dsRNA.WIZ.Scer\UAS} and dally^GD5918 are expressed simultaneously. Co-expression of dlp^GD3592 does not enhance the Sdc^{dsRNA.WIZ.Scer\UAS}-induced dendritic phenotype neither can further worsen the phenotype in larvae expressing both Sdc^{dsRNA.WIZ.Scer\UAS} and dally^GD5918.

(Poe et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sdc^RNAi.WIZ.UAS

Sdc^{dsRNA.WIZ.Scer\UAS}

Sdc^{dsRNA.WIZ.UAS}

Name Synonyms

Secondary FlyBase IDs

References (2)

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