FlyBase Gene Report: Dmel\fz2

General Information

Symbol

Dmel\fz2

Species

D. melanogaster

Name

frizzled 2

Annotation Symbol

CG9739

Feature Type

protein_coding_gene

FlyBase ID

FBgn0016797

Gene Model Status

Current

Stock Availability

39 publicly available

Gene Summary

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles. (UniProt, Q9VVX3)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dfz2, Dfrz2, fz-2, Dfrizzled2, DFz-2

Key Links

Genomic Location

Cytogenetic map

75F9-76A3

Sequence location

3L:19,140,975..19,235,373 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:19140975..19235373

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (33 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables PDZ domain binding

inferred from physical interaction with FLYBASE:Grip; FB:FBgn0029830

(Ataman et al., 2006)

enables Wnt receptor activity

inferred from direct assay

(Rives et al., 2006, Cong et al., 2004, Bhanot et al., 1996)

inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084

(Schweizer and Varmus, 2003)

enables Wnt-protein binding

inferred from direct assay

(Bhanot et al., 1996)

inferred from physical interaction with UniProtKB:P09615

(Tang et al., 2012)

inferred from physical interaction with FLYBASE:Wnt2; FB:FBgn0004360,FLYBASE:Wnt4; FB:FBgn0010453,FLYBASE:wg; FB:FBgn0284084

(Wu and Nusse, 2002)

inferred from physical interaction with FLYBASE:wg; FB:FBgn0284084

(Piddini et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables transmembrane signaling receptor activity

inferred from electronic annotation with InterPro:IPR017981

(InterPro Project Members, 2004-)

enables Wnt receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000139394

(GO Reference Genome Project, 2011-)

enables Wnt-protein binding

inferred from biological aspect of ancestor with PANTHER:PTN000139394

(GO Reference Genome Project, 2011-)

Biological Process (22 terms)

Terms Based on Experimental Evidence (20 terms)

CV Term

Evidence

References

involved_in axon extension

inferred from mutant phenotype

(Srahna et al., 2006)

involved_in canonical Wnt signaling pathway

inferred from direct assay

(Cong et al., 2004, Schweizer and Varmus, 2003, Bhanot et al., 1996)

inferred from mutant phenotype

(Baig-Lewis et al., 2007, Zhang and Carthew, 1998)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Povelones and Nusse, 2005, Bhanot et al., 1999)

inferred from genetic interaction with FLYBASE:arr; FB:FBgn0000119

(Tolwinski et al., 2003)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085,FLYBASE:wg; FB:FBgn0284084

(Chen and Struhl, 1999)

involved_in cardioblast cell fate specification

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Bhanot et al., 1999)

involved_in cell migration

inferred from mutant phenotype

(Cohen et al., 2002)

involved_in chitin-based larval cuticle pattern formation

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Povelones and Nusse, 2005)

involved_in female gonad development

inferred from mutant phenotype

(Cohen et al., 2002)

involved_in Frizzled Nuclear Import pathway

inferred from mutant phenotype

(Mathew et al., 2005)

involved_in germ-line stem-cell niche homeostasis

inferred from mutant phenotype

(Wang et al., 2015)

involved_in imaginal disc-derived wing margin morphogenesis

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085,FLYBASE:wg; FB:FBgn0284084

(Chen and Struhl, 1999)

inferred from mutant phenotype

(Zhang and Carthew, 1998)

involved_in midgut development

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Bhanot et al., 1999)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Inaki et al., 2007)

involved_in neuron fate specification

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Bhanot et al., 1999)

involved_in regulation of axonogenesis

inferred from mutant phenotype

(Vandewalle et al., 2013)

involved_in regulation of hemocyte proliferation

inferred from mutant phenotype

(Sinenko et al., 2010)

involved_in retinal ganglion cell axon guidance

inferred from mutant phenotype

(Sato et al., 2006)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Harris and Beckendorf, 2007)

involved_in segment polarity determination

inferred from genetic interaction with FLYBASE:arr; FB:FBgn0000119

(Tolwinski et al., 2003)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Povelones and Nusse, 2005, Bhanot et al., 1999)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085,FLYBASE:wg; FB:FBgn0284084

(Chen and Struhl, 1999)

involved_in synapse organization

inferred from physical interaction with FLYBASE:Grip; FB:FBgn0029830

(Ataman et al., 2006)

involved_in synaptic target inhibition

inferred from mutant phenotype

(Inaki et al., 2007)

involved_in Wnt signaling pathway

inferred from direct assay

(Bhanot et al., 1996)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in canonical Wnt signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000139394

(GO Reference Genome Project, 2011-)

involved_in cell surface receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000539, InterPro:IPR017981

(InterPro Project Members, 2004-)

involved_in non-canonical Wnt signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000139394

(GO Reference Genome Project, 2011-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

colocalizes_with early endosome

inferred from direct assay

(Rives et al., 2006)

colocalizes_with late endosome

inferred from direct assay

(Rives et al., 2006)

located_in nucleus

inferred from direct assay

(Friedman et al., 2013)

located_in plasma membrane

inferred from direct assay

(Rives et al., 2006, Chen et al., 2004, Bhanot et al., 1996)

part_of Wnt signalosome

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000539, InterPro:IPR017981

(InterPro Project Members, 2004-)

non-traceable author statement

(Bhanot et al., 1996)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000139394

(GO Reference Genome Project, 2011-)

part_of Wnt-Frizzled-LRP5/6 complex

inferred from sequence or structural similarity with UniProtKB:Q61091

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

FRIZZLED-TYPE RECEPTORS

Pathway (FlyBase)

WNT-TCF SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor Fz/Smo family. (Q9VVX3)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

FRIZZLED-TYPE RECEPTORS -: The frizzled gene family belong to Class F GPCRs. Frizzled GPCRs are characterized by a large N-terminal extracellular domain containing a cysteine-rich ligand-binding domain. The frizzled genes were first identified in Drosophila. Frizzled proteins are receptors for secreted Wnt proteins, as well as other ligands, and also play a critical role in the regulation of cell polarity. Frizzleds function in three distinct signaling pathways - the planar cell polarity pathway, the canonical Wnt/β-catenin pathway, and the Wnt/calcium pathway. (Adapted from FBrf0222139).

Pathway (FlyBase)

WNT-TCF SIGNALING PATHWAY CORE COMPONENTS -: The canonical Wnt signaling pathway is initiated by the binding of a Wnt ligand to a frizzled family receptor on the cell surface. Activation of the pathway leads to the inhibition of cytoplasmic β-catenin (arm) degradation and its subsequent accumulation in the nucleus, where it regulates the transcription of target genes. (Adapted from FBrf0218499 and FBrf0223299).

Protein Function (UniProtKB)

(UniProt, Q9VVX3)

Summary (Interactive Fly)

transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene - maturation of a central brain flight circuit in requires Fz2/Ca++ signaling

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\fz2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VVX3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 6.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.44

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.02

Double stop-codon suppression (UGA, UAG) postulated; FBrf0216884, FBrf0243886.

Stop-codon suppression (UGA) postulated; FBrf0216884.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

fz2-RA

FBtr0075029

NM_079431

3673

694

fz2-RB

FBtr0075028

NM_168787

3839

694

fz2-RC

FBtr0112890

NM_001104173

5113

694

fz2-RD

FBtr0299586

NM_001144499

4597

694

fz2-RE

FBtr0330194

NM_001275107

4345

694

fz2-RF

FBtr0330195

NM_001275108

4448

806

fz2-RG

FBtr0332735

NM_001275109

5696

694

fz2-RH

FBtr0481734

NM_001414152

4448

826

Additional Transcript Data and Comments

Reported size (kB)

5.5 (northern blot)

(Bhanot et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

fz2-PA

FBpp0074796

75.5

694

8.25

FBpp0074795

75.5

694

8.25

FBpp0111803

75.5

694

8.25

FBpp0288861

75.5

694

8.25

FBpp0303227

75.5

694

8.25

FBpp0303228

85.4

806

8.13

FBpp0304981

75.5

694

8.25

FBpp0428488

87.6

826

8.13

UYI58711

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

694 aa isoforms: fz2-PA, fz2-PB, fz2-PC, fz2-PD, fz2-PE, fz2-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

694 (aa)

(Bhanot et al., 1996)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with ATP6AP2.

(UniProt, Q9VVX3)

Domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

The FZ domain is involved in binding with Wnt ligands.

(UniProt, Q9VVX3)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fz2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.82

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Bhanot et al., 1996)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

clypeo-labral anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 6

organism | 10-70% egg length

Comment: ~15-70% egg length

(Bhanot et al., 1996)

embryonic stage 7 -- 8

clypeo-labral anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 8

organism | segmentally repeated

(Bhanot et al., 1996)

embryonic stage 9 -- 10

clypeo-labral primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

dorsal epidermis primordium

Comment: reported as dorsal epidermis anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 9 -- 17

presumptive embryonic/larval central nervous system | presumptive

(Bhanot et al., 1996)

embryonic stage 10

procephalic neurogenic region

(Bhanot et al., 1996)

posterior midgut primordium

(Bhanot et al., 1996)

embryonic stage 11 -- 12

larval foregut atrium | precursor

Comment: reported as atrium primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 12 -- 16

visceral trunk mesoderm

(Bhanot et al., 1996)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

labral segment

(Fisher et al., 2012)

embryonic stage 13 -- 17

embryonic/larval hindgut

(Bhanot et al., 1996)

embryonic stage 17

embryonic/larval dorsal vessel

(Bhanot et al., 1996)

Additional Descriptive Data

fz2 transcript is first detected in a stripe at about 15-70% egg length in stage 6 embryos. By stage 8, a segmental expression pattern is visible, and at stage 10, 15 stripes are discernible in the presumptive head, trunk, posterior midgut primordium, in a subset of the cells at the anterior midgut invagination site, and in the procephalic lobe. At stage 12, fz2 expression is strong in the midgut and visceral mesoderm. Starting at stage 9, fz2 is also expressed in the central nervous system (CNS). At the end of embryogenesis, fz2 transcript is present in the CNS, the dorsal vessel, and the hindgut. Northern analysis shows that fz2 transcript is expressed in all developmental stages, with the highest levels during embryogenesis and in late larval and pupal life.

(Bhanot et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

presumptive embryonic/larval central nervous system | presumptive

(Bhanot et al., 1996)

embryonic stage 10

procephalic neurogenic region

(Bhanot et al., 1996)

posterior midgut primordium

(Bhanot et al., 1996)

embryonic stage 12 -- 16

visceral trunk mesoderm

(Bhanot et al., 1996)

embryonic stage 13 -- 17

embryonic/larval hindgut

(Bhanot et al., 1996)

embryonic stage 17

embryonic/larval dorsal vessel

(Bhanot et al., 1996)

first instar larval stage -- second instar larval stage

prohemocyte

(Sinenko et al., 2009)

embryonic/larval lymph gland

(Sinenko et al., 2009)

third instar larval stage

bouton | subset

(Packard et al., 2002)

adult stage

adult dopaminergic PAM neuron

(Agrawal and Hasan, 2015)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

fz2 protein is uniformly expressed in immature hemocyte precursors of the lymph gland during the first larval instar through mid-second instar. At mid-to-late second instar, fz2 protein expression is down-regulated in maturing hemocytes expressing the hemocyte marker Hml.

(Sinenko et al., 2009)

fz2 protein was observed in glutamatergic type 1b synaptic boutons at the larval neuromuscular junction. The protein was observed both pre- and post-synaptically although it was enriched in post-synaptic areas and co-localized with dlg1 protein staining.

(Packard et al., 2002)

fz2 protein expression is not detectable by immunolocalization at stage 6 of embryogenesis, when fz2 transcript is first detected. The transcript and protein expression patterns coincide on and after stage 9/10 of embryogenesis. fz2 protein is expressed in the embryonic central nervous system starting at stage 9, and continuing through the rest of embryogenesis. At stage 10, the posterior midgut primordium, and at stages 12-16, the visceral mesoderm, also expresses fz2 protein.

(Bhanot et al., 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with early endosome

inferred from direct assay

(Rives et al., 2006)

colocalizes_with late endosome

inferred from direct assay

(Rives et al., 2006)

located_in nucleus

inferred from direct assay

(Friedman et al., 2013)

located_in plasma membrane

inferred from direct assay

(Rives et al., 2006, Chen et al., 2004, Bhanot et al., 1996)

part_of Wnt signalosome

inferred from direct assay

(Yamazaki and Yanagawa, 2003)

Expression Deduced from Reporters

Reporter: P{GT1}fz2^BG01711

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male & spermatogenesis

cyst cell of testis

(Bunt et al., 2012)

spermatogenesis & adult stage | male

testis sheath muscle cell

(Bunt et al., 2012)

Reporter: P{lacW}SB227

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult abdominal segment | restricted

(Lawrence et al., 2002)

Reporter: PBac{768.FSVS-0}fz2^CPTI003490

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

ellipsoid body

(Knowles-Barley, 2011.8.24)

superior medial protocerebrum

(Knowles-Barley, 2011.8.24)

superior lateral protocerebrum

(Knowles-Barley, 2011.8.24)

fan-shaped body | restricted

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion | restricted

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fz2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\fz2

View exonic expression by tissue for Dmel\fz2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016797

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40090/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016797

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016797

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016797

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9739

Flygut - An atlas of the Drosophila adult midgut

FBgn0016797

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 51 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 71 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of fz2

Transgenic constructs containing regulatory region of fz2

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3L)469-6

(Wharton, 2008.8.25)

Df(3L)469-13

(Wharton, 2008.8.25)

Df(3L)fz2

(Bhanot et al., 1999)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

fz2^C2

lethal, with Scer\GAL4^en.PU

fz2^{2-2-2.UAS.Tag:MYC}

lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4^h-1J3

fz2^UAS.cCa

partially lethal (with Df(3L)fz2)

fz2^C2

partially lethal - majority die

fz2^CB02997

viable

fz2^C1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

fz2^GD2719

viable, with Scer\GAL4^pnr-MD237

fz2^GD2719

viable, with Scer\GAL4^tin.CΔ4

fz2^GD2719

viable (with Df(3L)fz2)

fz2^C2

Sterility

Allele

female sterile (with Df(3L)fz2)

fz2^C2

male sterile (with Df(3L)fz2)

fz2^C2

sterile

fz2^C1

Other Phenotypes

Allele

abnormal cell shape | embryonic stage, with Scer\GAL4^svp.PT

fz2^KK108242

abnormal neuroanatomy

fz2^C1

abnormal neuroanatomy, with Scer\GAL4^C57

fz2^{C.UAS.NLS.Tag:MYC}

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

fz2^{ECD.GPI.UAS.Tag:MYC}

abnormal neuroanatomy | adult stage, with Scer\GAL4^ato.3.6

fz2^UAS.N

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR95A09

fz2^{ECD.GPI.UAS.Tag:MYC}

abnormal neuroanatomy | P-stage, with Scer\GAL4^bsh.M.PT

fz2^{ECD.GPI.UAS.Tag:MYC}

abnormal neuroanatomy | P-stage, with Scer\GAL4^GMR69B02

fz2^{ECD.GPI.UAS.Tag:MYC}

abnormal neuroanatomy | P-stage, with Scer\GAL4^sens.F2

fz2^{ECD.GPI.UAS.Tag:MYC}

abnormal neuroanatomy | P-stage, with Scer\GAL4^sev.PM181

fz2^{ECD.GPI.UAS.Tag:MYC}

abnormal neuroanatomy | P-stage (with fz2^C1)

fz2^C2

abnormal neuroanatomy | P-stage (with fz2^C2)

fz2^C1

abnormal neuroanatomy | P-stage | somatic clone

fz2^C1

abnormal neuroanatomy | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

fz2^JF01259

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Mhc.PU

fz2^UAS.N

abnormal planar polarity, with Scer\GAL4^hs.2sev

fz2^UAS.N

decreased body size

fz2^C1

decreased cell death | pupal stage, with Scer\GAL4^GMR.PF

fz2^{ECD.GPI.UAS.Tag:MYC}

some die during pupal stage | heat sensitive, with Scer\GAL4^h-1J3

fz2^UAS.cCa

visible, with Scer\GAL4^69B

visible, with Scer\GAL4^71B

visible, with Scer\GAL4^bbg-C96

visible, with Scer\GAL4^Bx-MS1096

fz2^UAS.cCa

visible, with Scer\GAL4^C-765

fz2^UAS.cSa

visible, with Scer\GAL4^h-1J3

fz2^UAS.cCa

visible, with Scer\GAL4^unspecified

fz2^{ECD.GPI.UAS.Tag:MYC}

visible | somatic clone

fz2^αTub84B.PS

Phenotype manifest in

Allele

axon & dorsal cluster neuron

fz2^C1

bouton, with Scer\GAL4^C57

chaeta | ectopic & wing, with Scer\GAL4^bbg-C96

fz2^UAS.cCa

denticle row 1, with Scer\GAL4^en-e16E

fz2^UAS.cZa

dorsal denticle, with Scer\GAL4^da.G32

dorsal longitudinal indirect flight muscle cell | adult stage, with Scer\GAL4^Mhc.PW

fz2^UAS.N

embryonic/larval crystal cell | third instar larval stage, with Scer\GAL4^lz-gal4

fz2^{ECD.GPI.UAS.Tag:MYC}

embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4^Antp-10

fz2^{ECD.GPI.UAS.Tag:MYC}

embryonic epidermis | dorsal, with Scer\GAL4^da.G32

eye, with Scer\GAL4^hs.2sev

fz2^UAS.N

eye disc morphogenetic furrow | ectopic, with Scer\GAL4^dpp.blk1

fz2^UAS.N

eye photoreceptor cell

fz2^C1

eye photoreceptor cell, with Scer\GAL4^GMR.PF

fz2^{ECD.GPI.UAS.Tag:MYC}

eye photoreceptor cell | P-stage, with Scer\GAL4^GMR.PF

fz2^{ECD.GPI.UAS.Tag:MYC}

lamina

fz2^C1

lamina, with Scer\GAL4^GMR.PF

fz2^{ECD.GPI.UAS.Tag:MYC}

larval ostial pore | embryonic stage, with Scer\GAL4^svp.PT

fz2^KK108242

larval RP2 motor neuron, with Scer\GAL4^da.G32

fz2^{ECD.GPI.UAS.Tag:MYC}

larval RP2 motor neuron, with Scer\GAL4^hs.PB

fz2^{ECD.GPI.UAS.Tag:MYC}

leg | somatic clone

fz2^αTub84B.PS

lobula columnar neuron LC14 | adult stage, with Scer\GAL4^ato.3.6

fz2^UAS.N

lymph gland derived hemocyte | third instar larval stage, with Scer\GAL4^dome-PG14

fz2^{ECD.GPI.UAS.Tag:MYC}

macrochaeta | ectopic, with Scer\GAL4^69B

medulla | adult stage, with Scer\GAL4^ato.3.6

fz2^UAS.N

medulla | P-stage, with Scer\GAL4^bsh.M.PT

fz2^{ECD.GPI.UAS.Tag:MYC}

medulla | P-stage, with Scer\GAL4^GMR69B02

fz2^{ECD.GPI.UAS.Tag:MYC}

medulla | P-stage, with Scer\GAL4^sens.F2

fz2^{ECD.GPI.UAS.Tag:MYC}

medulla | P-stage, with Scer\GAL4^sev.PM181

fz2^{ECD.GPI.UAS.Tag:MYC}

medulla | P-stage (with fz2^C1)

fz2^C2

medulla | P-stage (with fz2^C2)

fz2^C1

medulla | P-stage | somatic clone

fz2^C1

medulla | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

fz2^JF01259

medulla intrinsic neuron Mi1 | adult stage, with Scer\GAL4^GMR95A09

fz2^{ECD.GPI.UAS.Tag:MYC}

medulla intrinsic neuron Mi1 | P-stage | somatic clone

fz2^C1

medulla intrinsic neuron Mi1 | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

fz2^JF01259

mitochondrial crista | adult stage, with Scer\GAL4^Mhc.PW

fz2^UAS.N

mitochondrion & bouton, with Scer\GAL4^C57

fz2^UAS.cCa

mitochondrion | adult stage, with Scer\GAL4^Mhc.PW

fz2^UAS.N

neuromuscular junction, with Scer\GAL4^C57

neuromuscular junction | third instar larval stage, with Scer\GAL4^Mhc.PU

fz2^UAS.N

neuron

fz2^C1

neuron, with Scer\GAL4^GMR.PF

fz2^{ECD.GPI.UAS.Tag:MYC}

NMJ bouton (with Df(3L)ED4782)

fz2^C1

ommatidium, with Scer\GAL4^hs.2sev

fz2^UAS.N

ovary

fz2^C1

photoreceptor cell R8 | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

fz2^JF01259

postsynaptic membrane, with Scer\GAL4^C57

fz2^UAS.cCa

presumptive embryonic salivary gland, with Scer\GAL4^fkh.PZ

fz2^UAS.N

stalk follicle cell | increased number | heat sensitive, with Scer\GAL4^hs.PB

fz2^UAS.cCa

t-bar, with Scer\GAL4^C57

fz2^UAS.cCa

wing, with Scer\GAL4^69B

wing, with Scer\GAL4^71B

wing, with Scer\GAL4^bbg-C96

wing, with Scer\GAL4^Bx-MS1096

wing, with Scer\GAL4^C-765

fz2^UAS.cSa

wing, with Scer\GAL4^h-1J3

fz2^UAS.cCa

wing, with Scer\GAL4^nub-AC-62

fz2^{GPI.UAS.Tag:MYC}

wing, with Scer\GAL4^sd-SG29.1

fz2^UAS.N

wing, with Scer\GAL4^unspecified

fz2^{ECD.GPI.UAS.Tag:MYC}

wing & macrochaeta, with Scer\GAL4^69B

wing | somatic clone

fz2^αTub84B.PS

wing margin, with Scer\GAL4^69B

fz2^UAS.N

wing margin, with Scer\GAL4^dpp.blk1

fz2^UAS.N

wing margin, with Scer\GAL4^sd-SG29.1

fz2^UAS.N

wing margin bristle, with Scer\GAL4^bbg-C96

fz2^UAS.N

wing margin bristle, with Scer\GAL4^nub-AC-62

fz2^{GPI.UAS.Tag:MYC}

wing margin bristle | ectopic, with Scer\GAL4^71B

wing margin bristle | ectopic, with Scer\GAL4^Bx-MS1096

wing margin bristle | ectopic, with Scer\GAL4^C-765

fz2^UAS.cSa

wing margin bristle | ectopic, with Scer\GAL4^dpp.blk1

fz2^{2-2-2.UAS.Tag:MYC}

wing margin bristle | ectopic, with Scer\GAL4^unspecified

fz2^{UAS.cTa.Tag:MYC}

wing margin bristle | ectopic | somatic clone

fz2^αTub84B.PS

wing sensillum | ectopic, with Scer\GAL4^69B

wing sensillum | ectopic, with Scer\GAL4^71B

fz2^UAS.cCa

wing sensillum | ectopic, with Scer\GAL4^h-1J3

fz2^UAS.cCa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (24)

Hsap\FZD5

14 of 14

Yes

Hsap\FZD8

11 of 14

Yes

Hsap\FRZB

4 of 14

Yes

Hsap\FZD9

4 of 14

Hsap\FZD10

4 of 14

Hsap\SFRP4

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Fzd5

13 of 14

Yes

Rnor\Fzd8

12 of 14

Yes

Rnor\Frzb

4 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Mfrp

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Fzd5

13 of 14

Yes

Mmus\Fzd8

12 of 14

Yes

Mmus\Frzb

4 of 14

Yes

Mmus\Fzd9

4 of 14

Mmus\Fzd10

4 of 14

Mmus\Sfrp4

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (26)

Xtro\fzd5

11 of 13

Yes

Xtro\fzd8

7 of 13

Yes

Xtro\fzd9

3 of 13

Yes

Xtro\frzb

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Xtro\corin

1 of 13

Xtro\cpz

1 of 13

Xtro\cradd.1

1 of 13

Yes

Xtro\fga

1 of 13

Xtro\frzb2

1 of 13

Yes

Xtro\fzd2

1 of 13

Xtro\galnt6.3

1 of 13

Yes

Xtro\hsdl2

1 of 13

Xtro\lman1

1 of 13

Xtro\mfrp

1 of 13

Yes

Xtro\pik3r3

1 of 13

Xtro\sfrp2

1 of 13

Yes

Xtro\sfrp5

1 of 13

Yes

Xtro\smo

1 of 13

Xtro\stoml2

1 of 13

Xtro\szl

1 of 13

Yes

Xtro\tlx1

1 of 13

Danio rerio (Zebrafish) (28)

Drer\fzd5

14 of 14

Yes

Drer\fzd8a

12 of 14

Yes

Drer\fzd8b

12 of 14

Yes

Drer\fzd9b

4 of 14

Drer\fzd10

4 of 14

Drer\frzb

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\szl

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\cfz-2

12 of 14

Yes

Cele\mom-5

3 of 14

Cele\sfrp-1

2 of 14

Yes

Cele\lin-17

1 of 14

Cele\mig-1

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\GPRFZ2

12 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Yes

Agam\GPRFZ1B

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:fz2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

6 of 13

fz3

5 of 13

fz4

5 of 13

smo

5 of 13

CG1632

2 of 13

Corin

2 of 13

mthl15

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

fz2^UAS.N

exacerbates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

fz2^{UAS.Tag:HA.GFP}

DOES NOT ameliorate Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lüchtenborg and Katanaev, 2014)

fz2^{C.UAS.NLS.Tag:MYC}

ameliorates early-onset Parkinson's disease

modeled by Psn^H185R

(Restrepo et al., 2022)

modeled by Psn^G228D

(Restrepo et al., 2022)

ameliorates amyotrophic lateral sclerosis type 2

modeled by Als2^Δ1, Als2^Δ73

(Kim et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FZD5; frizzled class receptor 5

14 of 14

601723

MICROPHTHALMIA/COLOBOMA 11; MCOPCB11

FZD8; frizzled class receptor 8

11 of 14

606146

FRZB; frizzled related protein

4 of 14

605083

OSTEOARTHRITIS SUSCEPTIBILITY 1; OS1

FZD9; frizzled class receptor 9

4 of 14

601766

FZD10; frizzled class receptor 10

4 of 14

606147

SFRP4; secreted frizzled related protein 4

4 of 14

606570

PYLE DISEASE; PYL

FZD1; frizzled class receptor 1

3 of 14

603408

FZD2; frizzled class receptor 2

3 of 14

600667

OMODYSPLASIA 2; OMOD2

omodysplasia 2

FZD3; frizzled class receptor 3

3 of 14

606143

FZD4; frizzled class receptor 4

3 of 14

604579

EXUDATIVE VITREORETINOPATHY 1; EVR1

exudative vitreoretinopathy 1

FZD6; frizzled class receptor 6

3 of 14

603409

NAIL DISORDER, NONSYNDROMIC CONGENITAL, 1; NDNC1

nonsyndromic congenital nail disorder 1

FZD7; frizzled class receptor 7

3 of 14

603410

SMO; smoothened, frizzled class receptor

3 of 14

601500

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

fz2

fluorescent resonance energy transfer

(Zhao et al., 2007)

fz2 - ATP6AP2

anti tag coimmunoprecipitation, anti tag western blot

(Buechling et al., 2010)

fz2 - Grip

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Mosca and Schwarz, 2010, Ataman et al., 2006)

fz2 - Impβ11

anti tag coimmunoprecipitation, anti tag western blot

(Mosca and Schwarz, 2010)

fz2 - Nct

proximity ligation assay, fluorescence microscopy

(Restrepo et al., 2022)

fz2 - Pen

anti tag coimmunoprecipitation, western blot

(Mosca and Schwarz, 2010)

fz2 - Psn

proximity ligation assay, fluorescence microscopy

(Restrepo et al., 2022)

fz2 - Ror

anti tag coimmunoprecipitation, anti tag western blot

(Ripp et al., 2018)

fz2 - Wnt2

affinity technology, enzyme linked immunosorbent assay, inferred by author

(Wu and Nusse, 2002)

fz2 - Wnt4

affinity technology, enzyme linked immunosorbent assay, inferred by author

(Wu and Nusse, 2002)

fz2 - dsh

pull down, western blot, two hybrid

(Wong et al., 2003, Yamazaki and Yanagawa, 2003)

fz2 - otk

anti tag coimmunoprecipitation, anti tag western blot

(Linnemannstöns et al., 2014)

fz2 - otk2

anti tag coimmunoprecipitation, anti tag western blot

(Linnemannstöns et al., 2014)

fz2 - wg

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot, fluorescent resonance energy transfer, fluorescence microscopy, affinity technology, enzyme linked immunosorbent assay, inferred by author, cross-linking study

(Hemalatha et al., 2016, Mulligan et al., 2012, Tang et al., 2012, Yan et al., 2009, Piddini et al., 2005, Wu and Nusse, 2002, Wesley, 1999, Bhanot et al., 1996)

RNA-protein

Physical Interaction

Assay

References

fz2 - Marf

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Li et al., 2016)

fz2 - par-6

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Speese et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

fz|fz2

suppressible

arm

(Chen and Struhl, 1999)

fz2

enhanceable

dally

(Lin and Perrimon, 1999)

fz2

suppressible

dally

(Lin and Perrimon, 1999)

fz2

enhanceable

dco

(Klein et al., 2006)

fz2

enhanceable

(Han et al., 2020, Chen and Struhl, 1999)

fz2|Wnt4|Wnt10

enhanceable

(Han et al., 2020)

fz2

suppressible

(Zhang and Carthew, 1998)

fz2

enhanceable

Gαo

(Katanaev and Tomlinson, 2006)

fz2

enhanceable

hid

(Sato et al., 2006)

suppressible

(Lee et al., 2009)

enhanceable

(Lee et al., 2009)

suppressible

(Tsai et al., 2012)

fz2

suppressible

LanA

(Tsai et al., 2012)

fz2

suppressible

nmo

(Zeng and Verheyen, 2004)

fz2

suppressible

shf

(Avanesov et al., 2012)

fz2

enhanceable

(Moline et al., 2000, Bhat, 1998, Zhang and Carthew, 1998)

fz2

suppressible

(Zhang and Carthew, 1998)

fz2

enhanceable

Wnk

(Serysheva et al., 2013)

fz2

suppressible

Wnk

(Serysheva et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dlp

enhanceable

fz2

(Waghmare et al., 2020)

suppressible

fz2

(Zhang and Carthew, 1998)

Gαo

enhanceable

fz2

(Katanaev and Tomlinson, 2006)

mam

enhanceable

fz2

(Helms et al., 1999)

Vang

enhanceable

fz|fz2

(Han et al., 2020)

suppressible

fz2

(Rousset et al., 2001, Moline et al., 2000)

enhanceable

dally|fz2

(Moline et al., 2000)

enhanceable

fz2

(Moline et al., 2000)

enhanceable

(Han et al., 2020)

enhanceable

(Srahna et al., 2006)

External Data

Subunit Structure (UniProtKB)

Interacts with ATP6AP2.

(UniProt, Q9VVX3 )

Linkouts

BioGRID - A database of protein and genetic interactions.

65366

DroID - A comprehensive database of gene and protein interactions.

FBgn0016797

MIST (genetic) - An integrated Molecular Interaction Database

40090

MIST (protein-protein) - An integrated Molecular Interaction Database

40090

Pathways

Signaling Pathways (FlyBase)

WNT-TCF SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VVX3

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

75F9-76A3

Sequence location

3L:19,140,975..19,235,373 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

75F9-76A3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

76A-76A

(Bhanot, 1996.7.30)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-42.4

(Comeron et al., 2012)

(Bhanot, 1996.7.30)

Left of (cM)

(Chen and Struhl, 1999)

Right of (cM)

Notes

Stocks and Reagents

Stocks (39)

Genomic Clones (84)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (430)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD10629

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0016797

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0016797

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Verboon et al., 2020, Chaudhary et al., 2019)

monoclonal

(Agrawal and Hasan, 2015)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

1A3G4
12A7

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.

(Jha et al., 2016)

fz2 is required for normal salivary gland migration in the embryo. It is required in the second phase of salivary gland migration, as the gland moves posteriorly within the embryo.

(Harris and Beckendorf, 2007)

wg and its receptors, arr and fz2, undergo endocytic trafficking in wing imaginal disc epithelial cells.

(Rives et al., 2006)

ChEST reveals this is a target of Mef2.

(Junion et al., 2005)

The fz2 receptor stimulates wg internalization, while arr targets internalized fz2/wg complexes to a degradative compartment.

(Piddini et al., 2005)

The wg morphogen gradient appears to be established by the cooperative action of fz and Heparan Sulfate Proteoglycan receptors.

(Baeg et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

fz and fz2 function as redundant receptors for wg during embryonic development.

(Bhanot et al., 1999)

Mutant embryos lacking maternal fz, zygotic fz and zygotic fz2 show defects in the epidermis, CNS, heart and midgut that are indistinguishable from the defects observed for wg mutants.

(Bhanot et al., 1999)

fz and fz2 are required during embryogenesis to maintain epidermal en and wg expression.

(Bhanot et al., 1999)

fz and fz2 are functionally redundant and act as the primary receptors for wg protein.

(Chen and Struhl, 1999)

wg signal transduction is abolished in virtually all cells lacking both fz and fz2 in embryos as well as in imaginal discs.

(Chen and Struhl, 1999)

fz2, together with dally modulates both short- and long-range activities of wg.

(Lin and Perrimon, 1999)

fz and fz2 play a partially redundant role in wg signalling during neurogenesis.

(Bhat, 1998)

dsh functions in both fz and fz2 signalling, but distinct dsh protein domains feature in the two pathways.

(Boutros et al., 1998)

High levels of fz2 protein stabilise wg protein, allowing it to reach cells far from its site of synthesis. The expression of fz2 is repressed by wg signaling, creating a gradient of decreasing wg protein stability moving toward the dorso-ventral boundary. The repression of fz2 is essential for the normal shape of the wg morphogen gradient as well as the response of cells to the wg signal. In contrast to other ligand-receptor relationships where the receptor limits diffusion of the ligand, fz2 broadens the range of wg protein action by protecting it from degradation.

(Cadigan et al., 1998)

fz and fz2 function redundantly, downstream of wg and upstream of sgg, in the wg signalling pathway in the establishment of segment polarity in the embryo.

(Kennerdell and Carthew, 1998)

fz2 and not fz acts in the wg signalling pathway for wing margin development.

(Zhang and Carthew, 1998)

A single dominant negative form of fz or fz2 can block more than one type of Wnt signalling pathway implying that truncated proteins of the Fz family lose some aspect of signaling specificity.

(Zhang and Carthew, 1998)

Casein kinase II (encoded by CkIIα and CkIIβ) phosphorylates dsh in vitro. This phosphorylation is regulated by fz2, implicating a role for Casein kinase II in wg signalling.

(Willert et al., 1997)

Studies of S2 cells transfected with fz2 demonstrate that fz2 can function as a receptor of wg.

(Bhanot et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (34)

Reported As

Symbol Synonym

CG9739

(Schertel et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Grieder et al., 2007)

D-Fz2

(Cavallo et al., 1997)

D-fz2

(Kirkpatrick et al., 2004)

DFZ2

(Rehn et al., 1998)

DFz-2

(Salinas, 2003, Pandur et al., 2002, Cohen et al., 2000)

DFz2

(Strutt et al., 2023, Luo et al., 2020, Kamimura and Maeda, 2017, Parchure et al., 2017, Bodaleo and Gonzalez-Billault, 2016, Hemalatha et al., 2016, Li et al., 2016, Jokhi et al., 2013, Koles and Budnik, 2012, Mulligan et al., 2012, Erickson, 2011, Hermle et al., 2010, Mukai et al., 2010, Korkut et al., 2009, Ataman et al., 2008, DasGupta et al., 2007, Ataman, 2006, Ataman et al., 2006, Rives et al., 2006, Eldar and Barkai, 2005, Wu and Nusse, 2005, Baeg et al., 2004, Cong et al., 2004, Zhai et al., 2004, Eldar et al., 2003, He, 2003, Schweizer and Varmus, 2003, Cohen and Wilder, 2002, Nybakken and Perrimon, 2002, Peifer and McEwen, 2002, Penton et al., 2002, Wehrli et al., 2002, Wu and Nusse, 2002, Wehrli et al., 2001, Bejsovec, 2000, Buratovich et al., 2000, Pawson and Nash, 2000, Rulifson et al., 2000, Uren et al., 2000, Wehrli et al., 2000, Bhat, 1999, Axelrod et al., 1998, Zhang and Carthew, 1998)

DFz2C

(Li et al., 2016)

Dfrz2

(Princivalle and de Agostini, 2002, Lecourtois and Vincent, 2000, Novak and Dedhar, 1999, Boutros et al., 1998)

Dfz2

(Wang et al., 2016, Kleinschmit et al., 2010, Sinenko et al., 2010, Lee et al., 2009, Sinenko et al., 2009, Chung et al., 2007, Inaki et al., 2007, Korolchuk et al., 2007, Madder and Strutt, 2007, Bovolenta et al., 2006, Katanaev and Tomlinson, 2006, Price, 2006, Sato et al., 2006, Cox et al., 2005, Desbordes et al., 2005, Marques, 2005, Bajpai et al., 2004, Chen et al., 2004, Huang and Klein, 2004, Marshall et al., 2004, Tabata and Takei, 2004, Johnston and Sanders, 2003, Ruden and Xiao, 2003, Yamazaki and Yanagawa, 2003, Tomlinson and Strapps, 2002, Buratovich and Wilder, 2001, Kumar and Moses, 2001, Alexander et al., 2000, Baeg and Perrimon, 2000, Christian, 2000, Moline et al., 2000, Nusse, 2000, Rives et al., 2000, Rulifson et al., 2000, Selleck, 2000, Strigini and Cohen, 2000, The and Perrimon, 2000, Ui-Tei et al., 2000, Wu et al., 2000, Anonymous, 1999, Bejsovec, 1999, Bhanot et al., 1999, Boutros and Mlodzik, 1999, Cadigan et al., 1999, Helms et al., 1999, Hsieh et al., 1999, Lin and Perrimon, 1999, Moline et al., 1999, Muller et al., 1999, Sato et al., 1999, Toyama, 1999, Toyama, 1999, Bhat, 1998, Cadigan et al., 1998, Dale, 1998, Jones, 1998, Kennerdell and Carthew, 1998, Martinez Arias, 1998, Perrimon and Nusse, 1998, Yanagawa et al., 1998, Ben-Ze'ev, 1997, Cadigan and Nusse, 1997, Cadigan and Nusse, 1997, Moon et al., 1997, Nusse, 1997, Nusse et al., 1997, Willert et al., 1997, Bhanot, 1996.7.30, Bhanot et al., 1996, Ingham, 1996, Perrimon, 1996, Saras and Heldin, 1996, Wang et al., 1996)

Dfz₂

(Baena-Lopez and Garcia-Bellido, 2006)

Dm Fz2

(Konikoff et al., 2010)

FZ2

(Ferrandon, 2013, Zhao et al., 2007, Dawes-Hoang and Wieschaus, 2001)

Frizzled 2

(Kamimura and Maeda, 2021)

Fz2R

(Kizhedathu et al., 2020)

dFz2

(Guo et al., 2025, Bharti et al., 2023, Verboon et al., 2020, Golovin et al., 2019, Luo et al., 2017, Serysheva et al., 2013, Dani et al., 2012, Tang et al., 2012, Tsai et al., 2012, Djiane and Mlodzik, 2010, Parker et al., 2008, Zhang et al., 2006, Baranski et al., 2001)

dfz(2)

(Galis et al., 2002)

dfz2

(Kim et al., 2021, Speese et al., 2012, Yanfeng et al., 2011, Mosca and Schwarz, 2010, Mathew et al., 2005, Mathew et al., 2005, Takada et al., 2005)

dfz2r

(Saldanha et al., 1998, Saldanha et al., 1998)

frizzled 2

(Jin et al., 2016)

frz2

(Ayroles et al., 2009)

fz-2

(Blanco et al., 2009, Hueber et al., 2007, Baonza and Freeman, 2002, Irvine and Vogt, 1997)

fz2

(Bischoff et al., 2025, Hingole et al., 2025, Wang et al., 2025, Cui et al., 2024, Peng et al., 2024, Corthals et al., 2023, Davidson et al., 2023, Titlow et al., 2023, Chen et al., 2022, Corrales et al., 2022, Li et al., 2022, Schlichting et al., 2022, Bonfini et al., 2021, Everetts et al., 2021, Hu et al., 2021, Kumar et al., 2021, Lehmkuhl et al., 2021, Liu et al., 2021, McLaughlin et al., 2021, Pang et al., 2021, Baker, 2020, Ewen-Campen et al., 2020, Han et al., 2020, Lecheta et al., 2020, Nye et al., 2020, Waghmare et al., 2020, Weiner et al., 2020, Bageritz et al., 2019, Bellosta and Soldano, 2019, Chaudhary et al., 2019, Everman et al., 2019, Gao et al., 2019, Meltzer et al., 2019, Cho et al., 2018, Ripp et al., 2018, Takahashi et al., 2018, Ewen-Campen et al., 2017, Fochler et al., 2017, Tian et al., 2017, Jha et al., 2016, Jin et al., 2016, Mottier-Pavie et al., 2016, Nakato and Li, 2016, Ugrankar et al., 2015, Wang et al., 2015, Yasunaga et al., 2015, Chen et al., 2014, Lüchtenborg et al., 2014, Reim et al., 2014, Kwon et al., 2013, Pancratov et al., 2013, Schertel et al., 2013, Vandewalle et al., 2013, Webber et al., 2013, Zhu and Zhang, 2013, Avanesov et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kuroda et al., 2012, Mackay et al., 2012, Strutt et al., 2012, Takahashi et al., 2012, Tunstall et al., 2012, Cho and Fischer, 2011, Jungreis et al., 2011, Slattery et al., 2011, Toku et al., 2011, Vincent et al., 2011, Cordero and Cagan, 2010, Singh et al., 2010, Ayroles et al., 2009, Hartmann et al., 2009, Piddini and Vincent, 2009, Tan et al., 2009, Yan et al., 2009, Yan et al., 2009, Lin et al., 2008, Wu et al., 2008, Bhat, 2007, Buszczak et al., 2007, Grieder et al., 2007, Grillenzoni et al., 2007, Harris and Beckendorf, 2007, Zeitlinger et al., 2007, Zhang et al., 2007, Casal et al., 2006, Friedman and Perrimon, 2006, Jaiswal et al., 2006, Ma et al., 2006, Manak et al., 2006, Morozova et al., 2006, Srahna et al., 2006, Cabernard and Affolter, 2005, Djiane et al., 2005, Takada et al., 2005, Lawrence et al., 2004)

Name Synonyms

D-frizzled2

(Fu et al., 2004, Anderson and Beddington, 1997)

DFrizzled2

(Martinez Arias, 2005)

Dfrizzled 2

(Wesley, 1999)

Dfrizzled2

(Sato et al., 2006, Cadigan, 2002, Cohen et al., 2002)

Dfrizzled2

(Baena-Lopez and Garcia-Bellido, 2006)

Drosophila Frizzled 2

(Marques, 2005)

Drosophila frizzled2

(Erickson, 2011)

Frizzled 2

(Warecki et al., 2025, Saito et al., 2018, Nakato and Li, 2016, Dani et al., 2012, Niehrs, 2012, Tunstall et al., 2012, Blanco et al., 2009, Tan et al., 2009, Yan et al., 2009, Franch-Marro et al., 2008, Lin et al., 2008, Inaki et al., 2007, Zhao et al., 2007, Cong et al., 2004)

Frizzled-2

(Bai and Suzuki, 2020, Bodaleo and Gonzalez-Billault, 2016, Nose, 2012, Korolchuk et al., 2007)

Frizzled2

(Khadilkar et al., 2020, Ahmad, 2017, Linnemannstöns et al., 2014, Aoyama et al., 2013, Mosca and Schwarz, 2010, Baig-Lewis et al., 2007, Bhat, 2007, DasGupta et al., 2007, Franch-Marro et al., 2007)

frizzled 2

(Waghmare and Page-McCaw, 2018, Mottier-Pavie et al., 2016, Yasunaga et al., 2015, Chen et al., 2014, Kuroda et al., 2012, Slattery et al., 2011, Harris and Beckendorf, 2007, Zhao et al., 2007)

frizzled-2

(Hueber et al., 2007, Huang and Klein, 2004)

frizzled2

(Baker, 2017, Jha et al., 2016, Yamazaki et al., 2016, Vandewalle et al., 2013, Slattery et al., 2011, Manak et al., 2006, Bhanot et al., 1996)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 75 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40090

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VVX3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VVX3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VVX3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0016797

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40090/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0016797

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0016797

FlyMine - An integrated database for Drosophila genomics

FBgn0016797

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9739

MARRVEL_MODEL - MARRVEL (model organism gene)

40090

Linkouts

BioGRID - A database of protein and genetic interactions.

65366

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0016797

DroID - A comprehensive database of gene and protein interactions.

FBgn0016797

DRSC - Results frm RNAi screens

FBgn0016797

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

1A3G4
12A7

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0016797

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0016797

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9739

Flygut - An atlas of the Drosophila adult midgut

FBgn0016797

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003407

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

40090

MIST (protein-protein) - An integrated Molecular Interaction Database

40090

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VVX3

References (499)

The following external sites may use different assemblies or annotations than FlyBase.

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