FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term Wnt signaling pathway ID (Ontology) GO:0016055 (Gene Ontology)
Definition The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state.[ PubMed:11532397 ]
Also Known As "frizzled signaling pathway" ; "frizzled signalling pathway" ; "Wg signaling pathway" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      18
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 Wnt signaling pathway (all annotations which use CV term, excluding "NOT" statements)       3     18
     involved_in | Wnt signaling pathway       --      18
 NOT | involved_in | Wnt signaling pathway       --       2
Spanning Tree (Parents/Children)
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  signal transduction
   |__cell surface receptor signaling pathway
       |__Wnt signaling pathway  148 rec.
           |__canonical Wnt signaling pathway 130 rec.
           |   |__beta-catenin destruction complex disassembly
           |   |__canonical Wnt signaling pathway involved in heart development
           |   |__canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
           |   |__canonical Wnt signaling pathway involved in negative regulation of apoptotic process
           |   |__canonical Wnt signaling pathway involved in positive regulation of apoptotic process
           |   |__regulation of canonical Wnt signaling pathway(+) 109 rec.
           |__non-canonical Wnt signaling pathway 9 rec.
           |   |__Frizzled Nuclear Import pathway(+) 1 rec.
           |   |__non-canonical Wnt signaling pathway involved in heart development
           |   |__regulation of non-canonical Wnt signaling pathway(+) 1 rec.
           |   |__Wnt signaling pathway, calcium modulating pathway(+)
           |   |__Wnt signaling pathway, planar cell polarity pathway(+) 1 rec.
           |   |__Wnt signaling pathway, regulating spindle positioning
           |__regulation of Wnt signaling pathway 119 rec.
           |   |__negative regulation of Wnt signaling pathway(+) 52 rec.
           |   |__positive regulation of Wnt signaling pathway(+) 65 rec.
           |   |__regulation of canonical Wnt signaling pathway(+) 109 rec.
           |   |__regulation of non-canonical Wnt signaling pathway(+) 1 rec.
           |__Wnt signaling pathway involved in forebrain neuroblast division
           |__Wnt signaling pathway involved in heart development
           |   |__canonical Wnt signaling pathway involved in heart development
           |   |__non-canonical Wnt signaling pathway involved in heart development
           |__Wnt signaling pathway involved in somitogenesis
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Is a cell surface receptor signaling pathway
Part of
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Synonyms
  • "frizzled signaling pathway" EXACT
    "frizzled signalling pathway" EXACT
    "Wg signaling pathway" EXACT[ PubMed:8080429 ]
    "Wg signalling pathway" EXACT[ PubMed:8080429 ]
    "Wingless signaling pathway" EXACT[ PubMed:8080429 ]
    "Wingless signalling pathway" EXACT[ PubMed:8080429 ]
    "Wnt receptor signaling pathway" EXACT
    "Wnt receptor signalling pathway" EXACT
    "Wnt-activated signaling pathway" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-195721 "Signaling by WNT"