FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fz2C.UAS.NLS.Tag:MYC
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General Information
Symbol
Dmel\fz2C.UAS.NLS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0193068
Feature type
allele
Associated gene
Dmel\fz2
Associated Insertion(s)
Carried in Construct
P{fz2C.NLS.MYC}
Also Known As
UAS-myc-NLS-DFz2-C
Key Links
Transgenic product class
inframe_deletion
(Mathew et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Mathew et al., 2005)
Mutagen
in vitro construct
(Mathew et al., 2005, Mathew et al., 2005)
Progenitor genotype
Carried in construct
P{fz2C.NLS.MYC}
Cytology
Description

UAS sequences drive expression of amino acids 617 to 694 of fz2 with a Tag:MYC tag (MEQKLISEEDLNE) and an nuclear localization sequence tag (PKKKRKV) at its N terminus.

(Mathew et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fz2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of fz2C.Scer\UAS.NLS.T:Hsap\MYC, under the control of Scer\GAL4C57 increases the number of ghost boutons in post-synaptic neuromuscular junctions.

      (Ataman et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of fz2C.Scer\UAS.NLS.T:Hsap\MYC under the control of Scer\GAL4Mef2.PR fully rescues the increase in Ghost boutons, and partially rescues the total bouton number defect seen in ProsapD101/ProsapD101 mutants.

      (Harris et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      fz2C.UAS.NLS.Tag:MYC/Scer\GAL4BG487 fails to rescue Df(3L)ED4782/fz2C1

      (Mathew et al., 2005)

      fz2C.UAS.NLS.Tag:MYC/Scer\GAL4BG487 fails to rescue Df(3L)ED4782/fz2C1

      (Mathew et al., 2005)
      Comments

      The reduction in bouton number at neuromuscular junctions seen in fz2C1/Df(3L)ED4782 larvae is not rescued by fz2C.Scer\UAS.NLS.T:Hsap\MYC; Scer\GAL4BG487.

      (Mathew et al., 2005)

      fz2C.Scer\UAS.NLS.T:Hsap\MYC; Scer\GAL4BG487 fails to rescue the bouton phenotype seen at neuromuscular junctions in fz2C1/Df(3L)ED4782 larvae.

      (Mathew et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fz2C.Scer\UAS.NLS.T:Hsap\MYC
      fz2C.UAS.NLS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (7)