FlyBase Allele Report: Dmel\fz2[C2]

General Information

Symbol

Dmel\fz2^C2

Species

D. melanogaster

Name

FlyBase ID

FBal0179732

Feature type

allele

Associated gene

Dmel\fz2

Associated Insertion(s)

Carried in Construct

Also Known As

dfz2^C2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Chen et al., 2004)

Progenitor genotype

Cytology

Description

Amino acid replacement: ?516term.

(Chen et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:19,144,741..19,144,741 [-]

Nucleotide change:

C19144741T

Amino acid change:

Reported amino acid change:

?516term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Chen et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage (with fz2^C1)

(Han et al., 2020)

female sterile (with Df(3L)fz2)

(Ripp et al., 2018)

lethal

(Ripp et al., 2018)

male sterile (with Df(3L)fz2)

(Ripp et al., 2018)

partially lethal (with Df(3L)fz2)

(Linnemannstöns et al., 2014)

viable (with Df(3L)fz2)

(Ripp et al., 2018)

Phenotype Manifest In

medulla | P-stage (with fz2^C1)

(Han et al., 2020)

Detailed Description

Statement

Reference

fz2^C2/Df(3L)fz2 adults do not have defects in planar cell polarity.

(Ripp et al., 2018)

Trans-heterozygous fz2^C2/Df(3L)fz2 mutants are semi-lethal.

(Linnemannstöns et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

fz2^C2 has lethal phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz2^C2 has lethal phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has viable phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has sterile phenotype, non-enhanceable by Ror[+]/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has viable phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has sterile phenotype, non-enhanceable by Ror⁴/Ror⁴

(Ripp et al., 2018)

NOT suppressed by

Statement

Reference

Df(3L)fz2/fz2^C2 has viable phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has sterile phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has viable phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

Df(3L)fz2/fz2^C2 has sterile phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

fz2^C2 has lethal phenotype, non-suppressible by Ror[+]/Ror⁴

(Ripp et al., 2018)

fz2^C2 has lethal phenotype, non-suppressible by Ror⁴/Ror⁴

(Ripp et al., 2018)

NOT Enhancer of

Statement

Reference

fz2[+]/fz2^C2 is a non-enhancer of viable phenotype of Ror⁴

(Ripp et al., 2018)

NOT Suppressor of

Statement

Reference

fz2[+]/fz2^C2 is a non-suppressor of viable phenotype of Ror⁴

(Ripp et al., 2018)

Other

Statement

Reference

fz2^C2/fz2^C1, fz¹⁵ has abnormal neuroanatomy | P-stage phenotype

(Han et al., 2020)

Df(2R)D72, fz2^C2 has viable phenotype

(Linnemannstöns et al., 2014)

Df(2R)D72, fz2^C2 has male sterile phenotype

(Linnemannstöns et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

fz2^C2/fz2^C1, fz¹⁵ has medulla | P-stage phenotype

(Han et al., 2020)

fz2^C2, fz²¹ has wing margin bristle | somatic clone phenotype

(Chen et al., 2004)

fz2^C2, fz²¹ has wing margin | somatic clone phenotype

(Chen et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Flies double mutant for Df(2R)D72/Df(2R)D72; fz2^C2/+ are viable but male sterile.

(Linnemannstöns et al., 2014)

Somatic clones of cells homozygous for fz²¹ and fz2^C2 at the anterior wing margin block the formation of wing margin bristles and cause wing notching. These phenotypes are fully suppressed by fz^{1-1-1.αTub84B}, fz2^αTub84B.PC, fz^{ΔCRD.αTub84B.T:wg,T:Ivir\HA1} or fz2^{ΔCRD.αTub84B.T:wg,T:Ivir\HA1}.

(Chen et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dfz2^C2

(Wang et al., 2016, Chen et al., 2004)

dfz2^C2

(Linnemannstöns et al., 2014, Piddini et al., 2005)

fz2^C2

(Kanaoka et al., 2023, Han et al., 2020, Ripp et al., 2018, Mottier-Pavie et al., 2016, Bhat, 2007)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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