Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hml using the Feature Mapper tool.
Isolated from a pullout assay for proteins contained in clots from larval hemolymph and identified by mass spec.
Staining of firstinstar larvae with a monoclonal antibody against Hml protein showed that this protein is expressed in hemocytes. A GFP report driven by Hml-GAL4 was used to further narrow Hml expression to a subset of larval plasmatocytes and crystal cells. No expression was detected in lamellocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hml in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hml CG7002
Mutants with reduced levels of Hml protein show a bleeding defect upon injury. This defect is not due to a defect in melanin production or in phenoloxidase activity.
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.